HRP20030079B1 - POSTUPAK PRIPRAVE NOVOG β-KRISTALNOG OBLIKA TERC-BUTILAMINSKE SOLI PERINDOPRILA - Google Patents

POSTUPAK PRIPRAVE NOVOG β-KRISTALNOG OBLIKA TERC-BUTILAMINSKE SOLI PERINDOPRILA

Info

Publication number
HRP20030079B1
HRP20030079B1 HR20030079A HRP20030079A HRP20030079B1 HR P20030079 B1 HRP20030079 B1 HR P20030079B1 HR 20030079 A HR20030079 A HR 20030079A HR P20030079 A HRP20030079 A HR P20030079A HR P20030079 B1 HRP20030079 B1 HR P20030079B1
Authority
HR
Croatia
Prior art keywords
preparation
crystalline form
novel
butylamine salt
pharmaceutical compositions
Prior art date
Application number
HR20030079A
Other languages
English (en)
Inventor
Pfeiffer Bruno
Ginot Yves-Michel
Coquerel G�rard
Beilles St�phane
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of HRP20030079A2 publication Critical patent/HRP20030079A2/hr
Publication of HRP20030079B1 publication Critical patent/HRP20030079B1/hr
Publication of HRP20030079B8 publication Critical patent/HRP20030079B8/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Postupak dobivanja ß kristalnog oblika terc-butilaminske soli perindoprila formule (I): naznačen time što se otopina terc-butilaminske soli perindoprila u diklormetanu zagrijava uz refluks, a potom se naglo hladi do 0°C, a dobivena krutina se prikupi filtracijom. Patent sadrži još 2 patentna zahtjeva.
HR20030079A 2000-07-06 2003-02-06 POSTUPAK PRIPRAVE NOVOG β-KRISTALNOG OBLIKA TERC-BUTILAMINSKE SOLI PERINDOPRILA HRP20030079B8 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0008792A FR2811319B1 (fr) 2000-07-06 2000-07-06 Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
PCT/FR2001/002168 WO2001087836A1 (fr) 2000-07-06 2001-07-06 Nouvelle forme cristalline $g(b) du sel de tert-butylamine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent

Publications (3)

Publication Number Publication Date
HRP20030079A2 HRP20030079A2 (en) 2003-04-30
HRP20030079B1 true HRP20030079B1 (hr) 2007-12-31
HRP20030079B8 HRP20030079B8 (hr) 2008-09-30

Family

ID=8852171

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20030079A HRP20030079B8 (hr) 2000-07-06 2003-02-06 POSTUPAK PRIPRAVE NOVOG β-KRISTALNOG OBLIKA TERC-BUTILAMINSKE SOLI PERINDOPRILA
HR20060361A HRP20060361A8 (hr) 2000-07-06 2006-10-20 NOVI ß-KRISTALNI OBLIK TERC-BUTILAMINSKE SOLI PERINDOPRILA, POSTUPAK ZA NJEGOVU PRIPRAVU I FARMACEUTSKI PRIPRAVCI KOJI GA SADRŽE

Family Applications After (1)

Application Number Title Priority Date Filing Date
HR20060361A HRP20060361A8 (hr) 2000-07-06 2006-10-20 NOVI ß-KRISTALNI OBLIK TERC-BUTILAMINSKE SOLI PERINDOPRILA, POSTUPAK ZA NJEGOVU PRIPRAVU I FARMACEUTSKI PRIPRAVCI KOJI GA SADRŽE

Country Status (36)

Country Link
US (2) US20040029813A1 (hr)
EP (2) EP1676839A3 (hr)
JP (2) JP3592297B2 (hr)
KR (1) KR100513571B1 (hr)
CN (1) CN1328260C (hr)
AP (1) AP1407A (hr)
AR (1) AR029571A1 (hr)
AT (1) ATE324367T1 (hr)
AU (2) AU2001276419B2 (hr)
BG (1) BG66131B1 (hr)
BR (1) BR0112244A (hr)
CA (1) CA2415442C (hr)
CZ (1) CZ301765B6 (hr)
DE (1) DE60119107T2 (hr)
DK (1) DK1294689T3 (hr)
EA (1) EA004874B1 (hr)
EE (1) EE05285B1 (hr)
ES (1) ES2262666T3 (hr)
FR (1) FR2811319B1 (hr)
GE (1) GEP20043360B (hr)
HK (1) HK1058200A1 (hr)
HR (2) HRP20030079B8 (hr)
HU (1) HU227673B1 (hr)
ME (1) ME00440B (hr)
MX (1) MXPA02012921A (hr)
NO (1) NO323446B1 (hr)
NZ (1) NZ523234A (hr)
OA (1) OA12305A (hr)
PL (1) PL348493A1 (hr)
PT (1) PT1294689E (hr)
RS (1) RS51717B (hr)
SI (1) SI1294689T1 (hr)
SK (1) SK286918B6 (hr)
UA (1) UA57189C2 (hr)
WO (1) WO2001087836A1 (hr)
ZA (1) ZA200300024B (hr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
GB2395195A (en) 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
DK1636185T3 (da) * 2003-06-24 2012-05-07 Servier Lab Nye krystalformer af Perindopril erbumin
PT1675827E (pt) * 2003-10-21 2010-02-15 Servier Lab Novo processo para preparação de perindopril erbumina cristalina
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
PT1729739T (pt) * 2004-03-29 2016-12-01 Servier Lab Processo para a preparação de uma composição farmacêutica sólida
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
AU2006281684B2 (en) * 2005-08-12 2012-08-02 Lek Pharmaceuticals D.D. A process for the preparation of perindopril erbumine
CN101227902A (zh) * 2005-08-12 2008-07-23 桑多斯股份公司 培哚普利特丁胺的新结晶形式
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
WO2008050185A2 (en) * 2006-10-26 2008-05-02 Glenmark Pharmaceuticals Limited Novel polymorphs of perindopril erbumine
WO2008120241A2 (en) * 2007-03-29 2008-10-09 Ipca Laboratories Limited Novel alcohol solvates of perindopril erbumine
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
AU2009263737B2 (en) * 2008-06-24 2013-10-24 Mylan Laboratories Ltd. Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
CN106432042A (zh) * 2015-08-13 2017-02-22 南京华威医药科技开发有限公司 尼达尼布乙磺酸水合物的药物新晶型
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2771010B1 (fr) * 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
BR0112244A (pt) 2003-06-24
BG107533A (bg) 2003-11-28
EP1676839A2 (fr) 2006-07-05
PT1294689E (pt) 2006-07-31
NO20030050D0 (no) 2003-01-06
KR20030016368A (ko) 2003-02-26
AP1407A (en) 2005-05-30
CZ2003356A3 (cs) 2003-05-14
HRP20060361A2 (hr) 2008-06-30
JP2003533508A (ja) 2003-11-11
CN1328260C (zh) 2007-07-25
US20050203165A1 (en) 2005-09-15
CA2415442C (fr) 2009-01-27
EP1294689A1 (fr) 2003-03-26
EP1676839A3 (fr) 2006-11-08
BG66131B1 (bg) 2011-06-30
ES2262666T3 (es) 2006-12-01
SK286918B6 (sk) 2009-07-06
CN1440388A (zh) 2003-09-03
DE60119107T2 (de) 2006-12-07
AR029571A1 (es) 2003-07-02
HU227673B1 (hu) 2011-11-28
OA12305A (en) 2003-12-29
US7259181B2 (en) 2007-08-21
EE05285B1 (et) 2010-04-15
YU100502A (sh) 2003-08-29
UA57189C2 (uk) 2003-06-16
FR2811319B1 (fr) 2002-08-23
AU2001276419B2 (en) 2006-11-16
GEP20043360B (en) 2004-06-10
WO2001087836A1 (fr) 2001-11-22
NO20030050L (no) 2003-01-06
EE200300002A (et) 2004-08-16
FR2811319A1 (fr) 2002-01-11
ATE324367T1 (de) 2006-05-15
HUP0102813A3 (en) 2003-12-29
HRP20030079B8 (hr) 2008-09-30
AU7641901A (en) 2001-11-26
JP2005002121A (ja) 2005-01-06
ZA200300024B (en) 2004-02-05
DK1294689T3 (da) 2006-08-28
HU0102813D0 (en) 2001-09-28
RS51717B (sr) 2011-10-31
HUP0102813A2 (hu) 2002-03-28
SK1482003A3 (en) 2003-06-03
US20040029813A1 (en) 2004-02-12
NO323446B1 (no) 2007-05-07
NZ523234A (en) 2005-01-28
EA004874B1 (ru) 2004-08-26
HRP20030079A2 (en) 2003-04-30
EA200300103A1 (ru) 2003-06-26
KR100513571B1 (ko) 2005-09-09
MXPA02012921A (es) 2004-07-30
SI1294689T1 (sl) 2006-08-31
HRP20060361A8 (hr) 2008-07-31
DE60119107D1 (de) 2006-06-01
CA2415442A1 (fr) 2001-11-22
ME00440B (me) 2011-10-10
CZ301765B6 (cs) 2010-06-16
JP3592297B2 (ja) 2004-11-24
EP1294689B1 (fr) 2006-04-26
PL348493A1 (en) 2002-01-14
HK1058200A1 (en) 2004-05-07
AP2002002710A0 (en) 2002-12-31

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