DK1636185T3 - Nye krystalformer af Perindopril erbumin - Google Patents
Nye krystalformer af Perindopril erbuminInfo
- Publication number
- DK1636185T3 DK1636185T3 DK04737029.1T DK04737029T DK1636185T3 DK 1636185 T3 DK1636185 T3 DK 1636185T3 DK 04737029 T DK04737029 T DK 04737029T DK 1636185 T3 DK1636185 T3 DK 1636185T3
- Authority
- DK
- Denmark
- Prior art keywords
- crystalline form
- stirring
- water
- tert
- methyl ether
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH11092003 | 2003-06-24 | ||
| PCT/CH2004/000374 WO2004113293A1 (de) | 2003-06-24 | 2004-06-18 | Neue kristalline formen von perindopril erbumine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1636185T3 true DK1636185T3 (da) | 2012-05-07 |
Family
ID=33520350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04737029.1T DK1636185T3 (da) | 2003-06-24 | 2004-06-18 | Nye krystalformer af Perindopril erbumin |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7705046B2 (da) |
| EP (1) | EP1636185B1 (da) |
| JP (1) | JP2007507418A (da) |
| KR (1) | KR20060035636A (da) |
| CN (2) | CN101333181A (da) |
| AT (1) | ATE540924T1 (da) |
| AU (1) | AU2004249345B8 (da) |
| BR (1) | BRPI0411966A (da) |
| CA (1) | CA2530550C (da) |
| CY (1) | CY1112597T1 (da) |
| DK (1) | DK1636185T3 (da) |
| EA (1) | EA008603B1 (da) |
| ES (1) | ES2382171T3 (da) |
| HK (1) | HK1093984A1 (da) |
| MX (1) | MXPA05013811A (da) |
| NO (1) | NO333128B1 (da) |
| NZ (1) | NZ544160A (da) |
| PL (1) | PL1636185T3 (da) |
| PT (1) | PT1636185E (da) |
| SI (1) | SI1636185T1 (da) |
| WO (1) | WO2004113293A1 (da) |
| ZA (1) | ZA200600655B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG125976A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
| SG125975A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
| WO2007017893A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | Preparation of novel crystalline form of perindopril erbumine monohydrate |
| WO2007017894A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE |
| JP2009505970A (ja) * | 2005-08-12 | 2009-02-12 | サンド・アクチエンゲゼルシヤフト | ペリンドプリルエルブミンの新規結晶形 |
| UA92613C2 (ru) * | 2005-08-12 | 2010-11-25 | Лек Фармасьютиклз Д.Д. | Способ получения кристаллической формы d эрбумина периндоприла |
| EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
| WO2007092758A2 (en) * | 2006-02-03 | 2007-08-16 | Dr. Reddy's Laboratories Ltd. | Crystalline forms of perindopril erbumine |
| EA200600630A1 (ru) * | 2006-04-20 | 2007-02-27 | ИСМАГИЛОВ, Искандар Халиуллович | ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА |
| WO2008050185A2 (en) * | 2006-10-26 | 2008-05-02 | Glenmark Pharmaceuticals Limited | Novel polymorphs of perindopril erbumine |
| WO2008114270A1 (en) * | 2007-03-22 | 2008-09-25 | Aarti Healthcare Limited | Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof |
| SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
| PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4508729A (en) * | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
| FR2620709B1 (fr) | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| WO1994015957A1 (en) * | 1993-01-08 | 1994-07-21 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Method of crystallizing n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoroacetyl-l-lysyl-l-proline |
| FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2827860B1 (fr) | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| GB2395195A (en) * | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
| EP1973523A2 (en) * | 2005-12-15 | 2008-10-01 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
-
2004
- 2004-06-18 DK DK04737029.1T patent/DK1636185T3/da active
- 2004-06-18 EP EP04737029A patent/EP1636185B1/de active Active
- 2004-06-18 AU AU2004249345A patent/AU2004249345B8/en not_active Ceased
- 2004-06-18 ES ES04737029T patent/ES2382171T3/es active Active
- 2004-06-18 CA CA2530550A patent/CA2530550C/en not_active Expired - Fee Related
- 2004-06-18 EA EA200501859A patent/EA008603B1/ru not_active IP Right Cessation
- 2004-06-18 AT AT04737029T patent/ATE540924T1/de active
- 2004-06-18 PL PL04737029T patent/PL1636185T3/pl unknown
- 2004-06-18 KR KR1020057024852A patent/KR20060035636A/ko not_active Application Discontinuation
- 2004-06-18 SI SI200431851T patent/SI1636185T1/sl unknown
- 2004-06-18 US US10/560,464 patent/US7705046B2/en not_active Expired - Fee Related
- 2004-06-18 WO PCT/CH2004/000374 patent/WO2004113293A1/de active Application Filing
- 2004-06-18 BR BRPI0411966-5A patent/BRPI0411966A/pt not_active Application Discontinuation
- 2004-06-18 CN CNA2008100912488A patent/CN101333181A/zh active Pending
- 2004-06-18 CN CNB2004800178672A patent/CN100395235C/zh not_active Expired - Fee Related
- 2004-06-18 MX MXPA05013811A patent/MXPA05013811A/es active IP Right Grant
- 2004-06-18 PT PT04737029T patent/PT1636185E/pt unknown
- 2004-06-18 NZ NZ544160A patent/NZ544160A/en not_active IP Right Cessation
- 2004-06-18 JP JP2006515624A patent/JP2007507418A/ja active Pending
-
2006
- 2006-01-18 NO NO20060256A patent/NO333128B1/no not_active IP Right Cessation
- 2006-01-23 ZA ZA200600655A patent/ZA200600655B/en unknown
-
2007
- 2007-01-10 HK HK07100333A patent/HK1093984A1/xx not_active IP Right Cessation
-
2010
- 2010-03-09 US US12/720,250 patent/US7981921B2/en not_active Expired - Fee Related
-
2012
- 2012-04-04 CY CY20121100334T patent/CY1112597T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200600655B (en) | 2007-05-30 |
| US7705046B2 (en) | 2010-04-27 |
| AU2004249345B8 (en) | 2009-06-25 |
| NO20060256L (no) | 2006-01-18 |
| KR20060035636A (ko) | 2006-04-26 |
| JP2007507418A (ja) | 2007-03-29 |
| ES2382171T3 (es) | 2012-06-06 |
| EP1636185A1 (de) | 2006-03-22 |
| AU2004249345B2 (en) | 2009-02-26 |
| US7981921B2 (en) | 2011-07-19 |
| HK1093984A1 (en) | 2007-03-16 |
| NO333128B1 (no) | 2013-03-11 |
| SI1636185T1 (sl) | 2012-06-29 |
| EA008603B1 (ru) | 2007-06-29 |
| MXPA05013811A (es) | 2006-06-27 |
| PL1636185T3 (pl) | 2012-12-31 |
| WO2004113293A1 (de) | 2004-12-29 |
| EP1636185B1 (de) | 2012-01-11 |
| CN101333181A (zh) | 2008-12-31 |
| NZ544160A (en) | 2008-07-31 |
| EA200501859A1 (ru) | 2006-06-30 |
| CY1112597T1 (el) | 2016-02-10 |
| AU2004249345A1 (en) | 2004-12-29 |
| PT1636185E (pt) | 2012-04-16 |
| US20070135512A1 (en) | 2007-06-14 |
| CN100395235C (zh) | 2008-06-18 |
| US20100160404A1 (en) | 2010-06-24 |
| CA2530550C (en) | 2017-04-04 |
| CA2530550A1 (en) | 2004-12-08 |
| ATE540924T1 (de) | 2012-01-15 |
| CN1812971A (zh) | 2006-08-02 |
| BRPI0411966A (pt) | 2006-08-29 |
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