HK1093984A1 - Novel crystalline forms of perindopril erbumine - Google Patents

Novel crystalline forms of perindopril erbumine

Info

Publication number
HK1093984A1
HK1093984A1 HK07100333A HK07100333A HK1093984A1 HK 1093984 A1 HK1093984 A1 HK 1093984A1 HK 07100333 A HK07100333 A HK 07100333A HK 07100333 A HK07100333 A HK 07100333A HK 1093984 A1 HK1093984 A1 HK 1093984A1
Authority
HK
Hong Kong
Prior art keywords
crystalline form
stirring
water
perindopril erbumine
tert
Prior art date
Application number
HK07100333A
Other languages
English (en)
Inventor
Straessler Christoph
Lellek Vit
Faessler Roger
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1093984A1 publication Critical patent/HK1093984A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HK07100333A 2003-06-24 2007-01-10 Novel crystalline forms of perindopril erbumine HK1093984A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH11092003 2003-06-24
PCT/CH2004/000374 WO2004113293A1 (de) 2003-06-24 2004-06-18 Neue kristalline formen von perindopril erbumine

Publications (1)

Publication Number Publication Date
HK1093984A1 true HK1093984A1 (en) 2007-03-16

Family

ID=33520350

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07100333A HK1093984A1 (en) 2003-06-24 2007-01-10 Novel crystalline forms of perindopril erbumine

Country Status (22)

Country Link
US (2) US7705046B2 (xx)
EP (1) EP1636185B1 (xx)
JP (1) JP2007507418A (xx)
KR (1) KR20060035636A (xx)
CN (2) CN100395235C (xx)
AT (1) ATE540924T1 (xx)
AU (1) AU2004249345B8 (xx)
BR (1) BRPI0411966A (xx)
CA (1) CA2530550C (xx)
CY (1) CY1112597T1 (xx)
DK (1) DK1636185T3 (xx)
EA (1) EA008603B1 (xx)
ES (1) ES2382171T3 (xx)
HK (1) HK1093984A1 (xx)
MX (1) MXPA05013811A (xx)
NO (1) NO333128B1 (xx)
NZ (1) NZ544160A (xx)
PL (1) PL1636185T3 (xx)
PT (1) PT1636185E (xx)
SI (1) SI1636185T1 (xx)
WO (1) WO2004113293A1 (xx)
ZA (1) ZA200600655B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
WO2007017893A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited Preparation of novel crystalline form of perindopril erbumine monohydrate
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
EA014773B1 (ru) * 2005-08-12 2011-02-28 Лек Фармасьютиклз Д.Д. Способ получения эрбумина периндоприла
US20090099370A1 (en) * 2005-08-12 2009-04-16 Sandoz Ag Crystalline Form of Perindopril Erbumine
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
EA007988B1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ξ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
WO2008050185A2 (en) * 2006-10-26 2008-05-02 Glenmark Pharmaceuticals Limited Novel polymorphs of perindopril erbumine
EP2137148A1 (en) * 2007-03-22 2009-12-30 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
WO1994015957A1 (en) * 1993-01-08 1994-07-21 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Method of crystallizing n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoroacetyl-l-lysyl-l-proline
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
WO2007070851A2 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration

Also Published As

Publication number Publication date
PT1636185E (pt) 2012-04-16
ZA200600655B (en) 2007-05-30
NO333128B1 (no) 2013-03-11
BRPI0411966A (pt) 2006-08-29
ES2382171T3 (es) 2012-06-06
AU2004249345B2 (en) 2009-02-26
MXPA05013811A (es) 2006-06-27
WO2004113293A1 (de) 2004-12-29
KR20060035636A (ko) 2006-04-26
CY1112597T1 (el) 2016-02-10
SI1636185T1 (sl) 2012-06-29
NZ544160A (en) 2008-07-31
US7705046B2 (en) 2010-04-27
AU2004249345A1 (en) 2004-12-29
CN101333181A (zh) 2008-12-31
DK1636185T3 (da) 2012-05-07
JP2007507418A (ja) 2007-03-29
EA200501859A1 (ru) 2006-06-30
AU2004249345B8 (en) 2009-06-25
CN100395235C (zh) 2008-06-18
CA2530550A1 (en) 2004-12-08
US20070135512A1 (en) 2007-06-14
US7981921B2 (en) 2011-07-19
PL1636185T3 (pl) 2012-12-31
NO20060256L (no) 2006-01-18
CA2530550C (en) 2017-04-04
EA008603B1 (ru) 2007-06-29
US20100160404A1 (en) 2010-06-24
EP1636185B1 (de) 2012-01-11
EP1636185A1 (de) 2006-03-22
ATE540924T1 (de) 2012-01-15
CN1812971A (zh) 2006-08-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190618