HRP20060361A8 - NOVI ß-KRISTALNI OBLIK TERC-BUTILAMINSKE SOLI PERINDOPRILA, POSTUPAK ZA NJEGOVU PRIPRAVU I FARMACEUTSKI PRIPRAVCI KOJI GA SADRŽE - Google Patents
NOVI ß-KRISTALNI OBLIK TERC-BUTILAMINSKE SOLI PERINDOPRILA, POSTUPAK ZA NJEGOVU PRIPRAVU I FARMACEUTSKI PRIPRAVCI KOJI GA SADRŽEInfo
- Publication number
- HRP20060361A8 HRP20060361A8 HR20060361A HRP20060361A HRP20060361A8 HR P20060361 A8 HRP20060361 A8 HR P20060361A8 HR 20060361 A HR20060361 A HR 20060361A HR P20060361 A HRP20060361 A HR P20060361A HR P20060361 A8 HRP20060361 A8 HR P20060361A8
- Authority
- HR
- Croatia
- Prior art keywords
- crystalline form
- novel
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical class CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ß kristalni oblik spoja formule (I): karakteriziran svojim dijagramom difrakcije X-zraka u prašku. Lijekovi.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0008792A FR2811319B1 (fr) | 2000-07-06 | 2000-07-06 | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
PCT/FR2001/002168 WO2001087836A1 (fr) | 2000-07-06 | 2001-07-06 | Nouvelle forme cristalline $g(b) du sel de tert-butylamine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20060361A2 HRP20060361A2 (hr) | 2008-06-30 |
HRP20060361A8 true HRP20060361A8 (hr) | 2008-07-31 |
Family
ID=8852171
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20030079A HRP20030079B8 (hr) | 2000-07-06 | 2003-02-06 | POSTUPAK PRIPRAVE NOVOG β-KRISTALNOG OBLIKA TERC-BUTILAMINSKE SOLI PERINDOPRILA |
HR20060361A HRP20060361A8 (hr) | 2000-07-06 | 2006-10-20 | NOVI ß-KRISTALNI OBLIK TERC-BUTILAMINSKE SOLI PERINDOPRILA, POSTUPAK ZA NJEGOVU PRIPRAVU I FARMACEUTSKI PRIPRAVCI KOJI GA SADRŽE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20030079A HRP20030079B8 (hr) | 2000-07-06 | 2003-02-06 | POSTUPAK PRIPRAVE NOVOG β-KRISTALNOG OBLIKA TERC-BUTILAMINSKE SOLI PERINDOPRILA |
Country Status (36)
Country | Link |
---|---|
US (2) | US20040029813A1 (hr) |
EP (2) | EP1676839A3 (hr) |
JP (2) | JP3592297B2 (hr) |
KR (1) | KR100513571B1 (hr) |
CN (1) | CN1328260C (hr) |
AP (1) | AP1407A (hr) |
AR (1) | AR029571A1 (hr) |
AT (1) | ATE324367T1 (hr) |
AU (2) | AU2001276419B2 (hr) |
BG (1) | BG66131B1 (hr) |
BR (1) | BR0112244A (hr) |
CA (1) | CA2415442C (hr) |
CZ (1) | CZ301765B6 (hr) |
DE (1) | DE60119107T2 (hr) |
DK (1) | DK1294689T3 (hr) |
EA (1) | EA004874B1 (hr) |
EE (1) | EE05285B1 (hr) |
ES (1) | ES2262666T3 (hr) |
FR (1) | FR2811319B1 (hr) |
GE (1) | GEP20043360B (hr) |
HK (1) | HK1058200A1 (hr) |
HR (2) | HRP20030079B8 (hr) |
HU (1) | HU227673B1 (hr) |
ME (1) | ME00440B (hr) |
MX (1) | MXPA02012921A (hr) |
NO (1) | NO323446B1 (hr) |
NZ (1) | NZ523234A (hr) |
OA (1) | OA12305A (hr) |
PL (1) | PL348493A1 (hr) |
PT (1) | PT1294689E (hr) |
RS (1) | RS51717B (hr) |
SI (1) | SI1294689T1 (hr) |
SK (1) | SK286918B6 (hr) |
UA (1) | UA57189C2 (hr) |
WO (1) | WO2001087836A1 (hr) |
ZA (1) | ZA200300024B (hr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
GB2395195A (en) | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
SI1636185T1 (sl) * | 2003-06-24 | 2012-06-29 | Servier Lab | Nove kristaliniäśne oblike perindopril erbumina |
ES2336554T3 (es) | 2003-10-21 | 2010-04-14 | Les Laboratoires Servier | Nuevo metodo para la preparacion de perindopril erbumina cristalina. |
SI21703A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
ES2603856T3 (es) | 2004-03-29 | 2017-03-01 | Les Laboratoires Servier | Procedimiento para preparar una composición farmacéutica sólida |
SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
SG125975A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
SG125976A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
JP2006290825A (ja) * | 2005-04-13 | 2006-10-26 | Shiono Chemical Co Ltd | アルファ型ペリンドプリルエルブミンの製造法 |
WO2007017894A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE |
MX2008002066A (es) * | 2005-08-12 | 2008-04-16 | Sandoz Ag | Neuva forma cristalina de perindopril-erbumina. |
US20100016614A1 (en) * | 2005-08-12 | 2010-01-21 | Lek Pharmaceuticals D.D | Process for the preparation of perindopril erbumine |
EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
WO2007092758A2 (en) * | 2006-02-03 | 2007-08-16 | Dr. Reddy's Laboratories Ltd. | Crystalline forms of perindopril erbumine |
FR2897866B1 (fr) * | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2897865B1 (fr) | 2006-02-28 | 2008-04-18 | Servier Lab | Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
WO2008050185A2 (en) * | 2006-10-26 | 2008-05-02 | Glenmark Pharmaceuticals Limited | Novel polymorphs of perindopril erbumine |
WO2008120241A2 (en) * | 2007-03-29 | 2008-10-09 | Ipca Laboratories Limited | Novel alcohol solvates of perindopril erbumine |
SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
ES2552653T3 (es) * | 2008-06-24 | 2015-12-01 | Mylan Laboratories Limited | Formas polimórficas novedosas de (l)-arginina de perindoprilo y proceso para la preparación de las mismas |
SI23149A (sl) | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
CN106432042A (zh) * | 2015-08-13 | 2017-02-22 | 南京华威医药科技开发有限公司 | 尼达尼布乙磺酸水合物的药物新晶型 |
EP3842035A1 (en) | 2019-12-23 | 2021-06-30 | KRKA, d.d., Novo mesto | Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
FR2771010B1 (fr) * | 1997-11-19 | 2003-08-15 | Adir | Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires |
FR2811318B1 (fr) | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
-
2000
- 2000-07-06 FR FR0008792A patent/FR2811319B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-07 UA UA2003021021A patent/UA57189C2/uk unknown
- 2001-07-05 HU HU0102813A patent/HU227673B1/hu not_active IP Right Cessation
- 2001-07-06 US US10/312,902 patent/US20040029813A1/en not_active Abandoned
- 2001-07-06 PL PL01348493A patent/PL348493A1/xx not_active Application Discontinuation
- 2001-07-06 BR BR0112244-4A patent/BR0112244A/pt not_active Application Discontinuation
- 2001-07-06 GE GE5076A patent/GEP20043360B/en unknown
- 2001-07-06 NZ NZ523234A patent/NZ523234A/en not_active IP Right Cessation
- 2001-07-06 MX MXPA02012921A patent/MXPA02012921A/es active IP Right Grant
- 2001-07-06 ES ES01954059T patent/ES2262666T3/es not_active Expired - Lifetime
- 2001-07-06 PT PT01954059T patent/PT1294689E/pt unknown
- 2001-07-06 EA EA200300103A patent/EA004874B1/ru not_active IP Right Cessation
- 2001-07-06 AU AU2001276419A patent/AU2001276419B2/en not_active Ceased
- 2001-07-06 AR ARP010103225A patent/AR029571A1/es unknown
- 2001-07-06 AT AT01954059T patent/ATE324367T1/de active
- 2001-07-06 WO PCT/FR2001/002168 patent/WO2001087836A1/fr active Application Filing
- 2001-07-06 EE EEP200300002A patent/EE05285B1/xx not_active IP Right Cessation
- 2001-07-06 AP APAP/P/2002/002710A patent/AP1407A/en active
- 2001-07-06 JP JP2001584233A patent/JP3592297B2/ja not_active Expired - Fee Related
- 2001-07-06 SK SK148-2003A patent/SK286918B6/sk not_active IP Right Cessation
- 2001-07-06 CN CNB018123554A patent/CN1328260C/zh not_active Expired - Fee Related
- 2001-07-06 KR KR10-2003-7000116A patent/KR100513571B1/ko not_active IP Right Cessation
- 2001-07-06 ME MEP-2008-669A patent/ME00440B/me unknown
- 2001-07-06 DK DK01954059T patent/DK1294689T3/da active
- 2001-07-06 RS YU100502A patent/RS51717B/sr unknown
- 2001-07-06 EP EP06075789A patent/EP1676839A3/fr not_active Withdrawn
- 2001-07-06 OA OA1200200398A patent/OA12305A/en unknown
- 2001-07-06 CA CA002415442A patent/CA2415442C/fr not_active Expired - Fee Related
- 2001-07-06 DE DE60119107T patent/DE60119107T2/de not_active Expired - Lifetime
- 2001-07-06 EP EP01954059A patent/EP1294689B1/fr not_active Expired - Lifetime
- 2001-07-06 CZ CZ20030356A patent/CZ301765B6/cs not_active IP Right Cessation
- 2001-07-06 AU AU7641901A patent/AU7641901A/xx active Pending
- 2001-07-06 SI SI200130535T patent/SI1294689T1/sl unknown
-
2003
- 2003-01-02 ZA ZA200300024A patent/ZA200300024B/en unknown
- 2003-01-06 NO NO20030050A patent/NO323446B1/no not_active IP Right Cessation
- 2003-02-05 BG BG107533A patent/BG66131B1/bg unknown
- 2003-02-06 HR HR20030079A patent/HRP20030079B8/hr not_active IP Right Cessation
-
2004
- 2004-02-12 HK HK04100953A patent/HK1058200A1/xx not_active IP Right Cessation
- 2004-07-13 JP JP2004206159A patent/JP2005002121A/ja active Pending
-
2005
- 2005-02-04 US US11/052,489 patent/US7259181B2/en not_active Expired - Fee Related
-
2006
- 2006-10-20 HR HR20060361A patent/HRP20060361A8/hr not_active Application Discontinuation
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