HK1253727A1 - 使用丙酮酸激酶激活劑的方法 - Google Patents

使用丙酮酸激酶激活劑的方法

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Publication number
HK1253727A1
HK1253727A1 HK18112875.5A HK18112875A HK1253727A1 HK 1253727 A1 HK1253727 A1 HK 1253727A1 HK 18112875 A HK18112875 A HK 18112875A HK 1253727 A1 HK1253727 A1 HK 1253727A1
Authority
HK
Hong Kong
Prior art keywords
methods
pyruvate kinase
kinase activators
activators
pyruvate
Prior art date
Application number
HK18112875.5A
Other languages
English (en)
Inventor
Samuel V Agresta
Yue Chen
Marvin Barry Cohen
Leonard Luan C Dang
Charles Kung
Elizabeth A Merica
Bruce Alan Silver
Hua Yang
Original Assignee
安吉奧斯醫藥品有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 安吉奧斯醫藥品有限公司 filed Critical 安吉奧斯醫藥品有限公司
Publication of HK1253727A1 publication Critical patent/HK1253727A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
HK18112875.5A 2015-06-11 2018-10-10 使用丙酮酸激酶激活劑的方法 HK1253727A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562174216P 2015-06-11 2015-06-11

Publications (1)

Publication Number Publication Date
HK1253727A1 true HK1253727A1 (zh) 2019-06-28

Family

ID=57504271

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18112875.5A HK1253727A1 (zh) 2015-06-11 2018-10-10 使用丙酮酸激酶激活劑的方法

Country Status (20)

Country Link
US (2) US11234976B2 (zh)
EP (2) EP4344703A1 (zh)
JP (3) JP7320339B2 (zh)
AU (2) AU2016276951B2 (zh)
CA (1) CA2989111C (zh)
DK (1) DK3307271T3 (zh)
ES (1) ES2959690T3 (zh)
FI (1) FI3307271T3 (zh)
HK (1) HK1253727A1 (zh)
HR (1) HRP20231247T1 (zh)
HU (1) HUE063541T2 (zh)
LT (1) LT3307271T (zh)
MA (1) MA44392B1 (zh)
MD (1) MD3307271T2 (zh)
MX (1) MX2017016041A (zh)
PL (1) PL3307271T3 (zh)
PT (1) PT3307271T (zh)
RS (1) RS64777B1 (zh)
SI (1) SI3307271T1 (zh)
WO (1) WO2016201227A1 (zh)

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PT2704721T (pt) 2011-05-03 2018-06-14 Agios Pharmaceuticals Inc Ativadores da piruvato-cinase para utilização em terapia
MD3448859T2 (ro) * 2017-03-20 2020-03-31 Forma Therapeutics Inc Compoziții de pirolopirol în calitate de activatori ai piruvatkinazei (PKR)
WO2019099651A1 (en) * 2017-11-16 2019-05-23 Agios Pharmaceuticals, Inc. Methods of using deuterated pyruvate kinase activators
IL305343A (en) 2017-11-22 2023-10-01 Agios Pharmaceuticals Inc Crystal forms of N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
CN108169370B (zh) * 2017-12-19 2020-09-04 万舒（北京）医药科技有限公司 测定生物样品中丙酮酸乙酯及其代谢物丙酮酸的方法
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r
JP7450610B2 (ja) 2018-09-19 2024-03-15 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ピルビン酸キナーゼｒの活性化
MX2021014228A (es) 2019-05-22 2022-02-21 Agios Pharmaceuticals Inc Formas cristalinas de sal de n-(4-(4 (ciclopropilmetil)piperazin 1- carbonil)fenil)quinolin-8-sulfonamida.
US11878049B1 (en) 2019-06-14 2024-01-23 Agios Pharmaceuticals, Inc. Mitapivat therapy and modulators of cytochrome P450
AU2021347349A1 (en) 2020-09-25 2023-06-08 Agios Pharmaceuticals, Inc. Pharmaceutical formulation
WO2023154036A1 (en) 2022-02-08 2023-08-17 Agios Pharmaceuticals, Inc. Methods for titrating mitapivat
WO2022231627A1 (en) 2021-04-30 2022-11-03 Agios Pharmaceuticals, Inc. Methods for titrating mitapivat for use in treating thalassemia
KR20240004620A (ko) 2021-04-30 2024-01-11 아지오스 파마슈티컬스 아이엔씨. 미타피바트를 적정하는 방법
CA3236880A1 (en) 2021-11-16 2023-05-25 Agios Pharmaceuticals, Inc. Compounds for treating mds-associated anemias and other conditions

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