HK1218257A1 - 用於使腫瘤靶向成像的化合物綴合的氨基酸連接基的製備和合成方法 - Google Patents

用於使腫瘤靶向成像的化合物綴合的氨基酸連接基的製備和合成方法

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Publication number
HK1218257A1
HK1218257A1 HK16106296.0A HK16106296A HK1218257A1 HK 1218257 A1 HK1218257 A1 HK 1218257A1 HK 16106296 A HK16106296 A HK 16106296A HK 1218257 A1 HK1218257 A1 HK 1218257A1
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Hong Kong
Prior art keywords
tumors
synthesis
manufacture
amino acid
methods
Prior art date
Application number
HK16106296.0A
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English (en)
Inventor
‧庫拉拉特尼
‧嘉嘉裡
‧諾施
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On Target Laboratories Llc
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Publication of HK1218257A1 publication Critical patent/HK1218257A1/zh

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
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    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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HK16106296.0A 2013-03-15 2016-06-02 用於使腫瘤靶向成像的化合物綴合的氨基酸連接基的製備和合成方法 HK1218257A1 (zh)

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Application Number Priority Date Filing Date Title
US201361791921P 2013-03-15 2013-03-15
PCT/US2013/056629 WO2014149069A1 (en) 2013-03-15 2013-08-26 Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
PCT/US2013/063593 WO2014149073A1 (en) 2013-03-15 2013-10-04 Methods of manufacture and synthesis of amino acid linking groups conjugated to compounds used for targeted imaging of tumors

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US (7) US9333270B2 (zh)
EP (3) EP2968335B1 (zh)
JP (5) JP6192799B2 (zh)
CN (3) CN105228628B (zh)
AU (4) AU2013383382B2 (zh)
BR (1) BR112015022810B1 (zh)
CA (3) CA2903994C (zh)
EA (1) EA029738B1 (zh)
ES (1) ES2765896T3 (zh)
HK (1) HK1218257A1 (zh)
IL (3) IL240509B (zh)
MX (3) MX358184B (zh)
WO (3) WO2014149069A1 (zh)

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