EP2812451A4 - Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer - Google Patents

Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer

Info

Publication number
EP2812451A4
EP2812451A4 EP13746869.0A EP13746869A EP2812451A4 EP 2812451 A4 EP2812451 A4 EP 2812451A4 EP 13746869 A EP13746869 A EP 13746869A EP 2812451 A4 EP2812451 A4 EP 2812451A4
Authority
EP
European Patent Office
Prior art keywords
ros1
fusions
diagnosing
methods
treating cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13746869.0A
Other languages
German (de)
French (fr)
Other versions
EP2812451A2 (en
Inventor
David Hout
John Handshoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Genetics Inc
Original Assignee
Insight Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Genetics Inc filed Critical Insight Genetics Inc
Publication of EP2812451A2 publication Critical patent/EP2812451A2/en
Publication of EP2812451A4 publication Critical patent/EP2812451A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
EP13746869.0A 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer Withdrawn EP2812451A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596720P 2012-02-08 2012-02-08
PCT/US2013/025345 WO2013119950A2 (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer

Publications (2)

Publication Number Publication Date
EP2812451A2 EP2812451A2 (en) 2014-12-17
EP2812451A4 true EP2812451A4 (en) 2016-01-06

Family

ID=48948165

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13746869.0A Withdrawn EP2812451A4 (en) 2012-02-08 2013-02-08 Methods and compositions relating to fusions of ros1 for diagnosing and treating cancer

Country Status (5)

Country Link
EP (1) EP2812451A4 (en)
JP (1) JP2015508644A (en)
CN (1) CN104364391A (en)
AU (1) AU2013216904A1 (en)
WO (1) WO2013119950A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016003082A (en) 2013-09-10 2016-09-13 Univ Texas Therapeutics targeting truncated adenomatous polyposis coli (apc) proteins.
US10231965B2 (en) * 2014-02-20 2019-03-19 Ignyta, Inc. Molecules for administration to ROS1 mutant cancer cells
EP3825421B1 (en) * 2014-03-25 2022-06-22 Quest Diagnostics Investments Incorporated Detection of gene fusions by intragenic differential expression (ide) using average cycle thresholds
US10082496B2 (en) * 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
KR102595599B1 (en) 2014-12-02 2023-11-02 이그니타, 인코포레이티드 Combinations for the treatment of neuroblastoma
CN104830989A (en) * 2015-05-25 2015-08-12 上海允英医疗科技有限公司 Detection kit for fusion mutation of ROS1 and various genes
CN108138230B (en) * 2015-07-21 2023-03-10 夸登特健康公司 Locked nucleic acids for capturing fusion genes
CN108697661A (en) 2015-12-18 2018-10-23 亚尼塔公司 Combination for treating cancer
EP3654952A1 (en) 2017-07-19 2020-05-27 Ignyta, Inc. Pharmaceutical compositions comprising entrectinib
EP3697390A1 (en) 2017-10-17 2020-08-26 Ignyta, Inc. Pharmaceutical compositions and dosage forms
WO2020076723A1 (en) * 2018-10-08 2020-04-16 Revolution Medicines, Inc. Shp2 inhibitor compositions for use in treating cancer
WO2024072805A1 (en) * 2022-09-26 2024-04-04 Lau, Johnson Yiu-Nam Compositions, systems, and methods for detection of ovarian cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (en) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
WO2011146945A2 (en) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Alk and ros kinase in cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1454994A1 (en) * 2003-03-07 2004-09-08 Université de la Méditerranée Standardized and optimized real-time quantitative reverse transcriptase polymerase chain reaction method for detection of MRD in leukemia
US20100143918A1 (en) * 2007-01-19 2010-06-10 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
HUE035769T2 (en) * 2009-02-12 2018-05-28 Cell Signaling Technology Inc Mutant ROS expression in human liver cancer
EP2432900A4 (en) * 2009-05-15 2012-11-21 Insight Genetics Inc Methods and compositions relating to fusions of alk for diagnosing and treating cancer
US9109259B2 (en) * 2010-06-22 2015-08-18 Japanese Foundation For Cancer Research Detection method for novel ROS1 fusions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084631A2 (en) * 2006-01-20 2007-07-26 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
WO2011146945A2 (en) * 2010-05-21 2011-11-24 Cell Signaling Technology, Inc. Alk and ros kinase in cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHENGUANG LI ET AL: "Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers", PLOS ONE, vol. 6, no. 11, 30 November 2011 (2011-11-30), pages e28204, XP055209333, DOI: 10.1371/journal.pone.0028204 *

Also Published As

Publication number Publication date
JP2015508644A (en) 2015-03-23
WO2013119950A2 (en) 2013-08-15
AU2013216904A1 (en) 2014-08-28
WO2013119950A3 (en) 2014-11-13
CN104364391A (en) 2015-02-18
EP2812451A2 (en) 2014-12-17

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Legal Events

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

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