HK1203079A1 - Single-chain antibodies and other heteromultimers - Google Patents

Single-chain antibodies and other heteromultimers

Info

Publication number
HK1203079A1
HK1203079A1 HK15103581.2A HK15103581A HK1203079A1 HK 1203079 A1 HK1203079 A1 HK 1203079A1 HK 15103581 A HK15103581 A HK 15103581A HK 1203079 A1 HK1203079 A1 HK 1203079A1
Authority
HK
Hong Kong
Prior art keywords
heteromultimers
chain antibodies
antibodies
chain
Prior art date
Application number
HK15103581.2A
Other languages
English (en)
Chinese (zh)
Inventor
Bernd Wranik
Dan L Eaton
Erin H Christensen
Jiansheng Wu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1203079A1 publication Critical patent/HK1203079A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK15103581.2A 2012-02-10 2015-04-13 Single-chain antibodies and other heteromultimers HK1203079A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261597486P 2012-02-10 2012-02-10
PCT/US2013/025365 WO2013119966A2 (fr) 2012-02-10 2013-02-08 Anticorps et autres hétéromultimères monocaténaires

Publications (1)

Publication Number Publication Date
HK1203079A1 true HK1203079A1 (en) 2015-10-16

Family

ID=47891913

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103581.2A HK1203079A1 (en) 2012-02-10 2015-04-13 Single-chain antibodies and other heteromultimers

Country Status (11)

Country Link
US (1) US9688758B2 (fr)
EP (1) EP2812357B1 (fr)
JP (2) JP6486686B2 (fr)
KR (1) KR20140127854A (fr)
CN (1) CN104105711B (fr)
BR (1) BR112014019579A2 (fr)
CA (1) CA2861124A1 (fr)
HK (1) HK1203079A1 (fr)
MX (1) MX2014009565A (fr)
RU (1) RU2644341C2 (fr)
WO (1) WO2013119966A2 (fr)

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WO2012085111A1 (fr) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée
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EP2867253B1 (fr) 2012-06-27 2016-09-14 F. Hoffmann-La Roche AG Méthode de sélection et de production d'entités de ciblage personnalisées fortement sélectives et multi-spécifiques renfermant au moins deux entités de liaison différentes et leurs utilisations
BR112014028368A2 (pt) 2012-06-27 2017-11-14 Hoffmann La Roche método de produção de conjugado de região fc de anticorpo, conjugado de região fc de anticorpo e formulação farmacêutica
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JP2022522662A (ja) 2019-02-21 2022-04-20 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用
CA3130508A1 (fr) 2019-02-21 2020-08-27 Marengo Therapeutics, Inc. Molecules d'anticorps se liant a nkp30 et utilisations associees
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MX2014009565A (es) 2014-11-10
CN104105711A (zh) 2014-10-15
RU2644341C2 (ru) 2018-02-08
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US9688758B2 (en) 2017-06-27
WO2013119966A2 (fr) 2013-08-15
BR112014019579A2 (pt) 2019-10-15
JP2018070634A (ja) 2018-05-10
EP2812357A2 (fr) 2014-12-17
EP2812357B1 (fr) 2020-11-04
KR20140127854A (ko) 2014-11-04
RU2014136702A (ru) 2016-03-27
US20150133638A1 (en) 2015-05-14
JP2015508077A (ja) 2015-03-16

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