CA2156924A1 - Agents de reticulation a base de polyamides non immunogene hydrosoluble - Google Patents

Agents de reticulation a base de polyamides non immunogene hydrosoluble

Info

Publication number
CA2156924A1
CA2156924A1 CA 2156924 CA2156924A CA2156924A1 CA 2156924 A1 CA2156924 A1 CA 2156924A1 CA 2156924 CA2156924 CA 2156924 CA 2156924 A CA2156924 A CA 2156924A CA 2156924 A1 CA2156924 A1 CA 2156924A1
Authority
CA
Canada
Prior art keywords
polyamide
group
soluble
water
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2156924
Other languages
English (en)
Inventor
Ton That Hai
Deanna J. Nelson
David Eugene Pereira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2156924A1 publication Critical patent/CA2156924A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)

Abstract

La présente invention concerne des agents de réticulation à base de polyamides non immunogène hydrosoluble et leur emploi pour réticuler, polymériser, décorer et conjuguer des protéines, des polynucléotides et autres substrats biologiques afin de constituer des produits hydrosolubles non immunogènes. La présente invention concerne des protéines, des polynucléotides et autres substrats biologiques qu'il est possible de réticuler, conjuguer, polymériser ou décorer au moyen de polyamides hydrosolubles, pour constituer des produits essentiellement non immunogènes.
CA 2156924 1993-12-27 1994-12-20 Agents de reticulation a base de polyamides non immunogene hydrosoluble Abandoned CA2156924A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17388293A 1993-12-27 1993-12-27
US08/173,882 1993-12-27

Publications (1)

Publication Number Publication Date
CA2156924A1 true CA2156924A1 (fr) 1995-07-06

Family

ID=22633907

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2156924 Abandoned CA2156924A1 (fr) 1993-12-27 1994-12-20 Agents de reticulation a base de polyamides non immunogene hydrosoluble

Country Status (5)

Country Link
EP (1) EP0702553A1 (fr)
JP (1) JPH08507549A (fr)
AU (1) AU1444095A (fr)
CA (1) CA2156924A1 (fr)
WO (1) WO1995017886A1 (fr)

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EP1400551B1 (fr) * 1998-08-28 2007-06-13 Amylin Pharmaceuticals, Inc. Procédé de fabrication de chaines polyamides de longueur définie et leur conjugués avec des protéines
AU764144B2 (en) 1998-08-28 2003-08-14 Gryphon Therapeutics, Inc. Polyamide chains of precise length, methods to manufacture them and their conjugates
WO2011034605A2 (fr) 2009-09-16 2011-03-24 Genentech, Inc. Complexes protéiques contenant une super-hélice et/ou une attache et leurs utilisations
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
WO2012085111A1 (fr) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Complexe polypeptide-polynucléotide et son utilisation dans l'administration d'une fraction effectrice ciblée
BR112013032235A2 (pt) 2011-06-15 2016-11-22 Hoffmann La Roche anticorpos do receptor de epo anti-humano e métodos de uso
RU2644341C2 (ru) 2012-02-10 2018-02-08 Дженентек, Инк. Одноцепочечные антитела и другие гетеромультимеры
CA2871882A1 (fr) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag Methode de fabrication de conjugues d'anticorps a region fc comprenant au moins une entite de liaison qui se lie specifiquement a une cible et leurs utilisations
EP2867253B1 (fr) 2012-06-27 2016-09-14 F. Hoffmann-La Roche AG Méthode de sélection et de production d'entités de ciblage personnalisées fortement sélectives et multi-spécifiques renfermant au moins deux entités de liaison différentes et leurs utilisations
JP6445429B2 (ja) 2012-06-27 2018-12-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 少なくとも２つの異なる標的化実体を含むテーラーメイドで選択的かつ多重特異性治療用分子を選択および作製するための方法およびその使用
SI3151921T1 (sl) 2014-06-06 2019-12-31 Bristol-Myers Squibb Company Protitelesa proti z glukortikoidom induciranim receptorjem za faktor nekroze tumorja(GITR) in njihova uporaba
HUE050596T2 (hu) 2014-11-21 2020-12-28 Bristol Myers Squibb Co Antitestek CD73 ellen és azok felhasználásai
EP3224277B1 (fr) 2014-11-25 2020-08-26 Bristol-Myers Squibb Company Nouveaux polypeptides fixant pd-l1 pour l'imagerie
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
JP6738348B2 (ja) 2014-12-19 2020-08-12 リジェネサンス ベスローテン フェンノートシャップ ヒトｃ６に結合する抗体およびその使用
WO2016127052A1 (fr) 2015-02-05 2016-08-11 Bristol-Myers Squibb Company Cxcl11 et smica comme biomarqueurs prédictifs de l'efficacité de l'immunothérapie anti-ctla-4
HRP20230060T1 (hr) 2015-05-29 2023-03-17 Bristol-Myers Squibb Company Antitijela protiv ox40 i njihova primjena
MX2018006072A (es) 2015-11-19 2018-08-01 Squibb Bristol Myers Co Anticuerpos contra receptor de factor de necrosis de tumor inducido por glucocorticoides (gitr) y usos de los mismos.
US20190284293A1 (en) 2016-03-04 2019-09-19 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
KR102397783B1 (ko) 2016-06-01 2022-05-12 브리스톨-마이어스 스큅 컴퍼니 Pd-l1 결합 폴리펩티드에 의한 pet 영상화
TWI780057B (zh) 2016-07-14 2022-10-11 美商必治妥美雅史谷比公司 針對tim3之抗體及其用途
JP7045724B2 (ja) 2016-11-07 2022-04-01 ニューラクル サイエンス カンパニー リミテッド 配列類似性を持つ抗ファミリー１９、メンバーａ５抗体及びその用途
SG11201906947SA (en) 2017-02-17 2019-08-27 Bristol Myers Squibb Co Antibodies to alpha-synuclein and uses thereof
WO2019075090A1 (fr) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. Anticorps anti-lap et leurs utilisations
KR20200108870A (ko) 2018-01-12 2020-09-21 브리스톨-마이어스 스큅 컴퍼니 Tim3에 대한 항체 및 그의 용도
MX2020009861A (es) 2018-03-23 2020-10-08 Bristol Myers Squibb Co Anticuerpos contra el complejo principal de histocompatibilidad relacionado con las cadenas a y b clase i (mica) y/o (micb) y sus usos.
MA52190A (fr) 2018-04-02 2021-02-17 Bristol Myers Squibb Co Anticorps anti-trem-1 et utilisations associées
KR102661891B1 (ko) 2018-05-10 2024-05-23 주식회사 뉴라클사이언스 서열 유사성 19, 멤버 a5 항체를 갖는 항-패밀리 및 그의 사용 방법
EP3841124A4 (fr) 2018-06-29 2022-03-23 ApitBio, Inc. Anticorps anti-l1cam et leurs utilisations
EP3863722A2 (fr) 2018-10-10 2021-08-18 Tilos Theapeutics, Inc. Variants d'anticorps anti-lap et leurs utilisations
US20210403602A1 (en) 2018-12-03 2021-12-30 Bristol-Myers Squibb Company Anti-ido antibody and uses thereof
PE20212305A1 (es) 2019-01-22 2021-12-10 Bristol Myers Squibb Co Anticuerpos contra subunidad alfa il-7r y usos de estos
CN114144435B (zh) 2019-07-15 2024-06-25 百时美施贵宝公司 针对人trem-1的抗体及其用途
CN114174536A (zh) 2019-07-15 2022-03-11 百时美施贵宝公司 抗trem-1抗体及其用途
WO2021207449A1 (fr) 2020-04-09 2021-10-14 Merck Sharp & Dohme Corp. Anticorps anti-lap à maturation d'affinité et leurs utilisations
JP2024514530A (ja) 2021-04-02 2024-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 切断型ｃｄｃｐ１に対する抗体およびその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168602A (en) * 1975-03-11 1979-09-25 Sun Ventures, Inc. Block copolymer of poly (dioxaarylamide) and polyamide and fibers and fibrous material produced therefrom
US5053520A (en) * 1988-09-22 1991-10-01 Abbott Laboratories Heterobifunctional maleimido containing coupling agents

Also Published As

Publication number Publication date
WO1995017886A1 (fr) 1995-07-06
EP0702553A4 (fr) 1996-01-19
EP0702553A1 (fr) 1996-03-27
JPH08507549A (ja) 1996-08-13
AU1444095A (en) 1995-07-17

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