HK1199470A1 - Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof egfr - Google Patents
Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof egfrInfo
- Publication number
- HK1199470A1 HK1199470A1 HK14112920.4A HK14112920A HK1199470A1 HK 1199470 A1 HK1199470 A1 HK 1199470A1 HK 14112920 A HK14112920 A HK 14112920A HK 1199470 A1 HK1199470 A1 HK 1199470A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- egfr
- antigen binding
- binding molecules
- vectors encoding
- encoding same
- Prior art date
Links
- 108060006698 EGF receptor Proteins 0.000 title 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65011505P | 2005-02-07 | 2005-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1199470A1 true HK1199470A1 (en) | 2015-07-03 |
Family
ID=36777599
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14112920.4A HK1199470A1 (en) | 2005-02-07 | 2008-05-13 | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof egfr |
HK08105244.5A HK1110873A1 (en) | 2005-02-07 | 2008-05-13 | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof egfr |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08105244.5A HK1110873A1 (en) | 2005-02-07 | 2008-05-13 | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof egfr |
Country Status (28)
Country | Link |
---|---|
US (8) | US7722867B2 (pl) |
EP (4) | EP1871805B1 (pl) |
JP (2) | JP5336089B2 (pl) |
KR (2) | KR101569300B1 (pl) |
CN (2) | CN103981190A (pl) |
AR (1) | AR052285A1 (pl) |
AU (1) | AU2006211037B2 (pl) |
BR (1) | BRPI0607315B1 (pl) |
CA (1) | CA2596835C (pl) |
CR (2) | CR9236A (pl) |
DK (1) | DK1871805T3 (pl) |
ES (1) | ES2755976T3 (pl) |
HK (2) | HK1199470A1 (pl) |
HR (1) | HRP20192134T1 (pl) |
IL (1) | IL184498A (pl) |
LT (1) | LT1871805T (pl) |
MA (1) | MA29279B1 (pl) |
MX (1) | MX2007008619A (pl) |
NO (1) | NO20073662L (pl) |
NZ (1) | NZ556286A (pl) |
PL (1) | PL1871805T3 (pl) |
PT (1) | PT1871805T (pl) |
RS (1) | RS59761B1 (pl) |
RU (2) | RU2488597C2 (pl) |
SI (1) | SI1871805T1 (pl) |
TW (1) | TWI387602B (pl) |
UA (1) | UA95068C2 (pl) |
WO (1) | WO2006082515A2 (pl) |
Families Citing this family (164)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2261229A3 (en) | 1998-04-20 | 2011-03-23 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
EP1423510A4 (en) | 2001-08-03 | 2005-06-01 | Glycart Biotechnology Ag | ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED CELL CYTOTOXICITY DEPENDENT OF ANTIBODIES |
WO2006082515A2 (en) | 2005-02-07 | 2006-08-10 | Glycart Biotechnology Ag | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
MX2009012838A (es) | 2007-06-06 | 2009-12-11 | Hoffmann La Roche | Composicion de un primer anticuerpo monoclonal no marcado que se aglutina a un antigeno tumoral y a un segundo anticuerpo monoclonal de reaccion no cruzada marcado con un marcador fluorescsente del infrarrojo proximo. |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
RU2011116112A (ru) * | 2008-09-26 | 2012-11-10 | Роше Гликарт Аг (Ch) | Биспецифические анти-egfr/анти-igf-1r антитела |
AR075982A1 (es) * | 2009-03-31 | 2011-05-11 | Roche Glycart Ag | Terapia de combinacion de un anticuerpo afucosilado y una o mas de las citoquinas seleccionadas de gm- csf humano, m -csf humano y/o il-3 humano y composicion |
CA2754646A1 (en) * | 2009-03-31 | 2010-10-07 | Roche Glycart Ag | Treatment of cancer with a humanized anti-egfr igg1 antibody and irinotecan |
PE20120591A1 (es) | 2009-04-02 | 2012-05-23 | Roche Glycart Ag | Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla |
WO2010112194A1 (en) | 2009-04-02 | 2010-10-07 | F. Hoffmann-La Roche Ag | Antigen-binding polypeptides and multispecific antibodies comprising them |
US20100256340A1 (en) | 2009-04-07 | 2010-10-07 | Ulrich Brinkmann | Trivalent, bispecific antibodies |
AU2010233993A1 (en) | 2009-04-07 | 2011-09-08 | Roche Glycart Ag | Bispecific anti-ErbB-1/anti-c-Met antibodies |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
US20120302737A1 (en) | 2009-09-16 | 2012-11-29 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
US20110158987A1 (en) | 2009-12-29 | 2011-06-30 | F. Hoffmann-Laroche Ag | Novel antibody formulation |
CN102906115A (zh) * | 2010-01-11 | 2013-01-30 | 阿雷克森制药公司 | 在经抗cd200抗体治疗的人体内的免疫调节效应的生物标记 |
WO2011101328A2 (en) * | 2010-02-18 | 2011-08-25 | Roche Glycart Ag | Treatment with a humanized igg class anti egfr antibody and an antibody against insulin like growth factor 1 receptor |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
CN101875697B (zh) * | 2010-04-15 | 2014-04-30 | 北京天广实生物技术股份有限公司 | 新型抗egfr人源抗体tgm10的设计及其应用 |
KR101586128B1 (ko) | 2010-08-24 | 2016-01-15 | 에프. 호프만-라 로슈 아게 | 디술피드 안정화 ― Fv 단편을 포함하는 이중특이적 항체 |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
CN102153647B (zh) * | 2011-01-27 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗egfr人源化抗体l3-h3及其编码基因与应用 |
RU2013139267A (ru) | 2011-02-10 | 2015-03-20 | Рош Гликарт Аг | Улучшенная иммунотерапия |
EP2681240B1 (en) | 2011-02-28 | 2017-08-16 | F. Hoffmann-La Roche AG | Monovalent antigen binding proteins |
RU2607038C2 (ru) | 2011-02-28 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Антигенсвязывающие белки |
WO2012121167A1 (ja) * | 2011-03-04 | 2012-09-13 | 日本電気株式会社 | 個体識別システム、個体識別方法及びそれらに用いられる装置、プログラム |
CA2844540C (en) | 2011-08-23 | 2018-10-16 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
CA2837975C (en) | 2011-08-23 | 2022-04-05 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
WO2013026837A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
PL2748202T3 (pl) | 2011-08-23 | 2018-12-31 | Roche Glycart Ag | Dwuswoiste cząsteczki wiążące antygen |
AU2012300279A1 (en) | 2011-08-26 | 2014-04-03 | Merrimack Pharmaceuticals, Inc. | Tandem Fc bispecific antibodies |
BR112014006537A2 (pt) | 2011-09-23 | 2017-11-28 | Roche Glycart Ag | anticorpos biespecíficos, formulação farmacêutica, usos de um anticorpo biespecífico, método de tratamento, ácido nucleico, vetores de expressão, célula hospedeira e método para a produção de um anticorpo biespecífico |
WO2013113641A1 (en) | 2012-01-31 | 2013-08-08 | Roche Glycart Ag | Use of nkp46 as a predictive biomarker for cancer treatment with adcc- enhanced antibodies |
CN104105711B (zh) | 2012-02-10 | 2018-11-30 | 弗·哈夫曼-拉罗切有限公司 | 单链抗体及其他异多聚体 |
RU2014138586A (ru) | 2012-03-02 | 2016-04-20 | Рош Гликарт Аг | Прогностический биомаркер для лечения рака антителами с повышенной антителозависимой клеточной цитотоксичностью |
CN110317259A (zh) * | 2012-03-27 | 2019-10-11 | 株式会社绿十字 | 表皮生长因子受体表面抗原的表位及其用途 |
WO2013173255A2 (en) * | 2012-05-17 | 2013-11-21 | Sorrento Therapeutics Inc. | Antigen binding proteins that bind egfr |
CN104411718B (zh) | 2012-06-27 | 2018-04-24 | 弗·哈夫曼-拉罗切有限公司 | 用于制备包含特异性结合靶的至少一种结合实体的抗体Fc区缀合物的方法及其用途 |
CN104395339A (zh) | 2012-06-27 | 2015-03-04 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制高度选择性和多特异性靶向实体的方法及其用途 |
PL3434695T3 (pl) | 2012-08-07 | 2021-05-17 | Roche Glycart Ag | Ulepszona immunoterapia |
KR20150064068A (ko) | 2012-10-08 | 2015-06-10 | 로슈 글리카트 아게 | 2개의 Fab 단편을 포함하는 FC-부재 항체 및 이용 방법 |
AR094403A1 (es) | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
WO2014114595A1 (en) | 2013-01-23 | 2014-07-31 | Roche Glycart Ag | Predictive biomarker for cancer treatment with adcc-enhanced antibodies |
EP3708584A1 (en) | 2013-02-26 | 2020-09-16 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
CA2896370A1 (en) * | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
EP2961770A1 (en) | 2013-02-26 | 2016-01-06 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
BR112015021462A2 (pt) | 2013-03-06 | 2017-10-10 | Adimab Llc | anticorpos biespecíficos anti-c-met tandem fc |
SG11201507743XA (en) * | 2013-04-22 | 2015-11-27 | Glycotope Gmbh | Anti-cancer treatments with anti-egfr antibodies having a low fucosylation |
CN105612182B (zh) | 2013-10-11 | 2019-12-10 | 豪夫迈·罗氏有限公司 | 多特异性结构域交换共有可变轻链抗体 |
MX2016006301A (es) | 2013-11-13 | 2016-12-16 | Zymeworks Inc | Construcciones de unión a antígeno monovalente que se dirigen a egfr y/o her2, y sus usos. |
EP3662928A1 (en) * | 2014-04-10 | 2020-06-10 | OBI Pharma Inc. | Antibodies binding to tumour associated carbohydrate antigens, pharmaceutical compositions and uses thereof |
BR112016030462A2 (pt) | 2014-08-04 | 2018-01-16 | F. Hoffmann-La Roche Ag | moléculas de ligação, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método de produção de uma molécula de ligação, composição farmacêutica, uso da molécula de ligação, método de tratamento de doenças e de indução da lise de células alvo |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3659625A1 (en) | 2014-10-23 | 2020-06-03 | Innate Pharma | Treatment of cancers using anti-nkg2a agents |
WO2016079050A1 (en) | 2014-11-20 | 2016-05-26 | F. Hoffmann-La Roche Ag | Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists |
LT3221357T (lt) | 2014-11-20 | 2020-08-25 | F. Hoffmann-La Roche Ag | Bendros lengvosios grandinės ir naudojimo būdai |
EP3227332B1 (en) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
WO2017055392A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules |
AR106365A1 (es) | 2015-10-02 | 2018-01-10 | Hoffmann La Roche | Moléculas biespecíficas de unión a antígeno activadoras de células t |
CN108026177B (zh) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | 双特异性抗cd19xcd3 t细胞活化性抗原结合分子 |
WO2017055385A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xgd2 bispecific t cell activating antigen binding molecules |
US20180282410A1 (en) | 2015-10-02 | 2018-10-04 | Hoffmann-La Roche Inc. | Anti-cd3xrob04 bispecific t cell activating antigen binding molecules |
CA2990755A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffman-La Roche Ag | Bispecific anti-ceaxcd3 t cell activating antigen binding molecules |
EP3356409A2 (en) | 2015-10-02 | 2018-08-08 | H. Hoffnabb-La Roche Ag | Bispecific t cell activating antigen binding molecules |
WO2017055393A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xtim-3 bispecific t cell activating antigen binding molecules |
CA2997406C (en) | 2015-12-09 | 2024-05-28 | F. Hoffmann-La Roche Ag | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release |
AU2017205089B2 (en) | 2016-01-08 | 2023-10-05 | F. Hoffmann-La Roche Ag | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
KR102444614B1 (ko) | 2016-03-22 | 2022-09-21 | 에프. 호프만-라 로슈 아게 | 프로테아제-활성화된 t 세포 이중특이적 분자 |
PE20231511A1 (es) | 2016-03-22 | 2023-09-26 | Hoffmann La Roche | Moleculas biespecificas de celulas t activadas por proteasas que se unen especificamente al receptor 1 de folato (folr1) y cd3 |
WO2018060301A1 (en) | 2016-09-30 | 2018-04-05 | F. Hoffmann-La Roche Ag | Bispecific antibodies against cd3 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
PE20191703A1 (es) | 2017-03-27 | 2019-11-27 | Hoffmann La Roche | Formatos mejorados de receptor de union a antigeno |
CA3056837A1 (en) | 2017-03-27 | 2018-10-04 | F. Hoffmann-La Roche Ag | Improved antigen binding receptors |
MA49033B1 (fr) | 2017-04-03 | 2022-10-31 | Hoffmann La Roche | Immunoconjugué d'un anticorps contre pd-1 avec il-2 mutée ou avec il-15 |
SG11201909218RA (en) | 2017-04-03 | 2019-11-28 | Hoffmann La Roche | Antibodies binding to steap-1 |
EP3606947B1 (en) | 2017-04-03 | 2022-12-21 | F. Hoffmann-La Roche AG | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
TWI707871B (zh) | 2017-04-05 | 2020-10-21 | 瑞士商赫孚孟拉羅股份公司 | 抗lag3抗體 |
CN110505883A (zh) | 2017-04-13 | 2019-11-26 | 豪夫迈·罗氏有限公司 | 供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂 |
GB201710836D0 (en) * | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
CN107881160A (zh) * | 2017-08-11 | 2018-04-06 | 百奥泰生物科技(广州)有限公司 | 一种由基因组被编辑的cho宿主细胞产生的具有独特糖谱的重组抗体及其制备方法 |
US11802154B2 (en) | 2017-12-20 | 2023-10-31 | Alexion Pharmaceuticals, Inc. | Humanized anti-CD200 antibodies and uses thereof |
EP3729080B1 (en) | 2017-12-21 | 2023-04-19 | F. Hoffmann-La Roche AG | Universal reporter cell assay for specificity test of novel antigen binding moieties |
KR102575787B1 (ko) | 2017-12-21 | 2023-09-08 | 에프. 호프만-라 로슈 아게 | Hla-a2/wt1에 결합하는 항체 |
EP3731865A1 (en) | 2017-12-29 | 2020-11-04 | F. Hoffmann-La Roche AG | Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody |
CR20200391A (es) | 2018-02-08 | 2020-10-19 | Genentech Inc | Moléculas biespecíficas de unión al antígeno y métodos de uso |
TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
AU2019245243A1 (en) | 2018-03-29 | 2020-09-03 | Genentech, Inc | Modulating lactogenic activity in mammalian cells |
EP3802624A4 (en) * | 2018-06-01 | 2022-03-23 | Musc Foundation for Research Development | GLYCAN ANALYSIS OF PROTEINS AND CELLS |
TW202030204A (zh) | 2018-12-21 | 2020-08-16 | 瑞士商赫孚孟拉羅股份公司 | 靶向腫瘤之超促效cd28抗原結合分子 |
WO2020127619A1 (en) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 |
AR117468A1 (es) | 2018-12-21 | 2021-08-11 | Hoffmann La Roche | ANTICUERPO QUE SE UNE A VEGF Y A IL-1b Y MÉTODOS DE UTILIZACIÓN |
JP2022514343A (ja) | 2018-12-21 | 2022-02-10 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 腫瘍標的化アゴニストcd28抗原結合分子 |
US20220025056A1 (en) | 2018-12-26 | 2022-01-27 | Innate Pharma | Leucocyte immunoglobulin-like receptor neutralizing antibodies |
WO2020260329A1 (en) | 2019-06-26 | 2020-12-30 | F. Hoffmann-La Roche Ag | Fusion of an antibody binding cea and 4-1bbl |
JP2022538139A (ja) | 2019-07-02 | 2022-08-31 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 変異体インターロイキン-2及び抗cd8抗体を含む免疫複合体 |
AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
EP4004045A1 (en) | 2019-07-31 | 2022-06-01 | F. Hoffmann-La Roche AG | Antibodies binding to gprc5d |
CR20220019A (es) | 2019-07-31 | 2022-02-11 | Hoffmann La Roche | Anticuerpos que se fijan a gprc5d |
US20210130492A1 (en) | 2019-09-18 | 2021-05-06 | Genentech, Inc. | Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use |
CR20220256A (es) | 2019-12-18 | 2022-08-31 | Hoffmann La Roche | Anticuerpos que se unen a hla-a2/mage-a4 |
CN111018990A (zh) * | 2020-02-10 | 2020-04-17 | 张喜田 | 一种新型的重组抗表皮生长因子受体单克隆抗体及其应用 |
CA3169908A1 (en) | 2020-03-26 | 2021-09-30 | Genentech, Inc. | Modified mammalian cells having reduced host cell proteins |
MX2022012541A (es) | 2020-04-15 | 2022-11-07 | Hoffmann La Roche | Inmunoconjugados. |
IL298038A (en) | 2020-05-11 | 2023-01-01 | Hoffmann La Roche | Combined treatment with modified pbmcs and an immune couple |
BR112022024996A2 (pt) | 2020-06-08 | 2022-12-27 | Hoffmann La Roche | Anticorpos, ácido nucleico, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, agente terapêutico, uso do anticorpo e método para tratar um indivíduo com hepatite b |
WO2021255146A1 (en) | 2020-06-19 | 2021-12-23 | F. Hoffmann-La Roche Ag | Antibodies binding to cd3 and cea |
KR20230025783A (ko) | 2020-06-19 | 2023-02-23 | 에프. 호프만-라 로슈 아게 | 면역 활성화 Fc 도메인 결합 분자 |
AR122659A1 (es) | 2020-06-19 | 2022-09-28 | Hoffmann La Roche | Anticuerpos biespecíficos para linfocitos t activados por proteasa |
TWI811703B (zh) | 2020-06-19 | 2023-08-11 | 瑞士商赫孚孟拉羅股份公司 | 與cd3及cd19結合之抗體 |
JP2023530961A (ja) | 2020-06-19 | 2023-07-20 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Cd3に結合する抗体 |
TW202216767A (zh) | 2020-06-19 | 2022-05-01 | 瑞士商赫孚孟拉羅股份公司 | 與CD3及FolR1結合之抗體 |
BR112022025989A2 (pt) | 2020-06-23 | 2023-01-17 | Hoffmann La Roche | Moléculas, um ou mais polinucleotídeos, um ou mais vetores, célula hospedeira, método para produzir uma molécula, composição farmacêutica, uso da molécula e método para tratar uma doença |
MX2022016453A (es) | 2020-06-24 | 2023-02-01 | Genentech Inc | Lineas celulares resistentes a la apoptosis. |
EP4172203A1 (en) | 2020-06-25 | 2023-05-03 | F. Hoffmann-La Roche AG | Anti-cd3/anti-cd28 bispecific antigen binding molecules |
CA3187277A1 (en) | 2020-07-10 | 2022-01-13 | F. Hoffmann-La Roche Ag | Antibodies which bind to cancer cells and target radionuclides to said cells |
AU2021308653A1 (en) | 2020-07-17 | 2023-02-16 | Genentech, Inc. | Anti-Notch2 antibodies and methods of use |
CN116234831A (zh) | 2020-08-03 | 2023-06-06 | 豪夫迈·罗氏有限公司 | 改善的抗原结合受体 |
WO2022047222A2 (en) | 2020-08-28 | 2022-03-03 | Genentech, Inc. | Crispr/cas9 multiplex knockout of host cell proteins |
WO2022049165A1 (en) | 2020-09-04 | 2022-03-10 | F. Hoffmann-La Roche Ag | Antibody that binds to vegf-a and ang2 and methods of use |
AR123855A1 (es) | 2020-10-20 | 2023-01-18 | Genentech Inc | Anticuerpos anti-mertk conjugados con peg y métodos de uso |
JP2023547447A (ja) | 2020-10-28 | 2023-11-10 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 改良型抗原結合受容体 |
WO2022148853A1 (en) | 2021-01-11 | 2022-07-14 | F. Hoffmann-La Roche Ag | Immunoconjugates |
WO2022152656A1 (en) | 2021-01-12 | 2022-07-21 | F. Hoffmann-La Roche Ag | Split antibodies which bind to cancer cells and target radionuclides to said cells |
KR20230131205A (ko) | 2021-01-13 | 2023-09-12 | 에프. 호프만-라 로슈 아게 | 병용 요법 |
JP2024509695A (ja) | 2021-02-03 | 2024-03-05 | ジェネンテック, インコーポレイテッド | 多重特異性結合タンパク質分解プラットフォームおよび使用方法 |
AR125074A1 (es) | 2021-03-12 | 2023-06-07 | Genentech Inc | Anticuerpos anti-klk7, anticuerpos anti-klk5, anticuerpos multiespecíficos anti-klk5 / klk7 y métodos de uso |
EP4314032A1 (en) | 2021-03-30 | 2024-02-07 | F. Hoffmann-La Roche AG | Protease-activated polypeptides |
EP4326855A1 (en) | 2021-04-19 | 2024-02-28 | Genentech, Inc. | Modified mammalian cells |
KR20240010469A (ko) | 2021-05-21 | 2024-01-23 | 제넨테크, 인크. | 관심 재조합 생성물의 생성을 위한 변형된 세포 |
AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
EP4370545A1 (en) | 2021-07-12 | 2024-05-22 | Genentech, Inc. | Structures for reducing antibody-lipase binding |
KR20240032889A (ko) | 2021-07-14 | 2024-03-12 | 제넨테크, 인크. | 항-c-c 모티프 케모카인 수용체 8(ccr8) 항체 및 사용 방법 |
EP4373859A1 (en) | 2021-07-22 | 2024-05-29 | F. Hoffmann-La Roche AG | Heterodimeric fc domain antibodies |
CN117794953A (zh) | 2021-08-03 | 2024-03-29 | 豪夫迈·罗氏有限公司 | 双特异性抗体及使用方法 |
EP4416174A1 (en) | 2021-10-14 | 2024-08-21 | F. Hoffmann-La Roche AG | New interleukin-7 immunoconjugates |
WO2023062048A1 (en) | 2021-10-14 | 2023-04-20 | F. Hoffmann-La Roche Ag | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
CN118302443A (zh) | 2021-11-25 | 2024-07-05 | 豪夫迈·罗氏有限公司 | 改善的抗原结合受体 |
CN118284625A (zh) | 2021-11-26 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 抗tyrp1/抗cd3双特异性抗体与tyrp1特异性抗体的组合疗法 |
AR127887A1 (es) | 2021-12-10 | 2024-03-06 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y plap |
CN116333117B (zh) * | 2021-12-16 | 2024-04-26 | 徕特康(苏州)生物制药有限公司 | 抗表皮生长因子受体抗体及其制备方法和用途 |
CN116333116B (zh) * | 2021-12-16 | 2024-03-05 | 徕特康(苏州)生物制药有限公司 | 抗表皮生长因子受体抗体及其制备方法和用途 |
WO2023141445A1 (en) | 2022-01-19 | 2023-07-27 | Genentech, Inc. | Anti-notch2 antibodies and conjugates and methods of use |
WO2023180511A1 (en) | 2022-03-25 | 2023-09-28 | F. Hoffmann-La Roche Ag | Improved chimeric receptors |
TW202402810A (zh) | 2022-05-11 | 2024-01-16 | 瑞士商赫孚孟拉羅股份公司 | 與vegf—a及il6結合之抗體及其使用方法 |
WO2024030856A2 (en) | 2022-08-01 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory proteins and related methods |
WO2024068705A1 (en) | 2022-09-29 | 2024-04-04 | F. Hoffmann-La Roche Ag | Protease-activated polypeptides |
WO2024077118A2 (en) | 2022-10-06 | 2024-04-11 | Bicara Therapeutics Inc. | Multispecific proteins and related methods |
WO2024077239A1 (en) | 2022-10-07 | 2024-04-11 | Genentech, Inc. | Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies |
WO2024079009A1 (en) | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and proteasome inhibitors |
WO2024079015A1 (en) | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and imids |
WO2024079010A1 (en) | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and cd38 antibodies |
WO2024094741A1 (en) | 2022-11-03 | 2024-05-10 | F. Hoffmann-La Roche Ag | Combination therapy with anti-cd19/anti-cd28 bispecific antibody |
WO2024100170A1 (en) | 2022-11-11 | 2024-05-16 | F. Hoffmann-La Roche Ag | Antibodies binding to hla-a*02/foxp3 |
WO2024104933A1 (en) | 2022-11-15 | 2024-05-23 | F. Hoffmann-La Roche Ag | Antigen binding molecules |
WO2024155807A1 (en) | 2023-01-18 | 2024-07-25 | Genentech, Inc. | Multispecific antibodies and uses thereof |
WO2024153725A1 (en) | 2023-01-20 | 2024-07-25 | F. Hoffmann-La Roche Ag | Recombinant fc domain - il2 variant polypeptides and combination therapy with membrane-anchored antigen binding polypeptides |
WO2024156672A1 (en) | 2023-01-25 | 2024-08-02 | F. Hoffmann-La Roche Ag | Antibodies binding to csf1r and cd3 |
US20240269263A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2820404A (en) | 1954-11-23 | 1958-01-21 | Kwei Chung Shu | Photoprinting apparatus |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
DK0531472T3 (da) | 1991-03-06 | 2003-12-01 | Merck Patent Gmbh | Humaniserede monoklonale antistoffer |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
GB9401182D0 (en) * | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
CN102416176A (zh) | 1995-07-27 | 2012-04-18 | 基因技术股份有限公司 | 稳定等渗的冻干蛋白质制剂 |
US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
DE19746874A1 (de) | 1997-10-23 | 1999-04-29 | Qiagen Gmbh | Verfahren zur Isolierung und Reinigung von Nukleinsäuren an hydrophoben Oberflächen - insbesondere unter Verwendung hydrophober Membranen |
EP2261229A3 (en) | 1998-04-20 | 2011-03-23 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
US6322980B1 (en) | 1999-04-30 | 2001-11-27 | Aclara Biosciences, Inc. | Single nucleotide detection using degradation of a fluorescent sequence |
ES2568899T3 (es) | 1999-04-09 | 2016-05-05 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
IL145941A (en) * | 1999-04-28 | 2007-08-19 | Univ Texas | Preparations and methods for the treatment of cancer by selective inhibition of VEGF |
AU8822601A (en) | 2000-07-31 | 2002-02-13 | Biolex Inc | Expression of biologically active polypeptides in duckweed |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US20020128448A1 (en) | 2000-10-20 | 2002-09-12 | Idec Pharmaceuticals Corporation | Variant IgG3 Rituxan and therapeutic use thereof |
DK2163256T3 (en) * | 2001-05-11 | 2015-12-07 | Ludwig Inst For Cancer Res Ltd | Specific binding proteins and use thereof |
US7247301B2 (en) * | 2001-06-13 | 2007-07-24 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
US6881557B2 (en) | 2001-07-12 | 2005-04-19 | Arrowsmith Technologies Llp | Super humanized antibodies |
EP1423510A4 (en) | 2001-08-03 | 2005-06-01 | Glycart Biotechnology Ag | ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED CELL CYTOTOXICITY DEPENDENT OF ANTIBODIES |
US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
US20030157108A1 (en) | 2001-10-25 | 2003-08-21 | Genentech, Inc. | Glycoprotein compositions |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
US8932825B2 (en) | 2001-12-27 | 2015-01-13 | Glycofi Inc. | Method to engineer mammalian-type carbohydrate structures |
US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
US7657380B2 (en) * | 2003-12-04 | 2010-02-02 | Xencor, Inc. | Methods of generating variant antibodies with increased host string content |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
AU2003219402B2 (en) | 2002-03-19 | 2008-05-08 | Stichting Dienst Landbouwkundig Onderzoek | GnTIII (UDP-n-acethylglucosamine:beta-D mannoside beta (1,4)-N-acethylglucosaminy ltransferase III) expression in plants |
WO2003080672A1 (en) | 2002-03-22 | 2003-10-02 | Aprogen, Inc. | Humanized antibody and process for preparing same |
WO2003084119A1 (en) | 2002-03-28 | 2003-10-09 | Advanced Micro Devices, Inc. | Synchronization data detection unit and method |
US20030190689A1 (en) | 2002-04-05 | 2003-10-09 | Cell Signaling Technology,Inc. | Molecular profiling of disease and therapeutic response using phospho-specific antibodies |
CA2481837A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Production process for antibody composition |
EP1502603A4 (en) | 2002-04-09 | 2006-12-13 | Kyowa Hakko Kogyo Kk | AN ANTIBODY COMPOSITION CONTAINING MEDICAMENT FOR PATIENTS WITH Fc gamma RIIIa POLYMORPHISM |
US20040259150A1 (en) | 2002-04-09 | 2004-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa |
ATE503829T1 (de) | 2002-04-09 | 2011-04-15 | Kyowa Hakko Kirin Co Ltd | Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins |
US20040110704A1 (en) | 2002-04-09 | 2004-06-10 | Kyowa Hakko Kogyo Co., Ltd. | Cells of which genome is modified |
WO2005056606A2 (en) | 2003-12-03 | 2005-06-23 | Xencor, Inc | Optimized antibodies that target the epidermal growth factor receptor |
AU2003251597A1 (en) | 2002-06-19 | 2004-01-06 | Abgenix, Inc. | Method for predicting response to epidermal growth factor receptor-directed therapy |
EP1539966B1 (en) | 2002-09-12 | 2010-06-30 | Greenovation Biotech GmbH | Protein production method |
RU2390527C2 (ru) * | 2002-09-27 | 2010-05-27 | Ксенкор, Инк. | АНТИТЕЛО, СОДЕРЖАЩЕЕ Fc-ВАРИАНТНУЮ ЧАСТЬ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АНТИТЕЛО, И СПОСОБ ЛЕЧЕНИЯ МЛЕКОПИТАЮЩЕГО |
US6938692B2 (en) | 2002-12-17 | 2005-09-06 | Halliburton Energy Services, Inc. | Permeable cement composition and method for preparing the same |
WO2004057002A2 (en) | 2002-12-20 | 2004-07-08 | Greenovation Biotech Gmbh | Production of heterologous glycosylated proteins in bryophyte cells |
AU2004204494B2 (en) | 2003-01-09 | 2011-09-29 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
EP1587921B1 (en) | 2003-01-22 | 2010-07-28 | GlycArt Biotechnology AG | Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function |
EA202091901A1 (ru) | 2003-11-05 | 2020-11-24 | Роше Гликарт Аг | АНТИТЕЛА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ АФФИННОСТЬЮ К СВЯЗЫВАНИЮ С Fc-РЕЦЕПТОРОМ И ЭФФЕКТОРНОЙ ФУНКЦИЕЙ |
WO2006082515A2 (en) * | 2005-02-07 | 2006-08-10 | Glycart Biotechnology Ag | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof |
WO2007031872A2 (en) * | 2005-07-13 | 2007-03-22 | L'oréal | Keratin fibre coating composition comprising a liquid fatty phase and a tackifying resin |
CN101291954B (zh) | 2005-08-26 | 2013-03-27 | 罗氏格黎卡特股份公司 | 具有改变的细胞信号传导活性的修饰的抗原结合分子 |
AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
US20090017050A1 (en) * | 2007-07-13 | 2009-01-15 | Ventana Medical Systems, Inc. | Egfr antigen-binding molecules and uses thereof |
RU2011116112A (ru) * | 2008-09-26 | 2012-11-10 | Роше Гликарт Аг (Ch) | Биспецифические анти-egfr/анти-igf-1r антитела |
-
2006
- 2006-02-07 WO PCT/IB2006/000238 patent/WO2006082515A2/en active Application Filing
- 2006-02-07 EP EP06710336.6A patent/EP1871805B1/en active Active
- 2006-02-07 EP EP11176829A patent/EP2404937A1/en not_active Withdrawn
- 2006-02-07 TW TW095104103A patent/TWI387602B/zh not_active IP Right Cessation
- 2006-02-07 EP EP19198853.4A patent/EP3660049A1/en not_active Withdrawn
- 2006-02-07 DK DK06710336T patent/DK1871805T3/da active
- 2006-02-07 KR KR1020147002356A patent/KR101569300B1/ko active IP Right Grant
- 2006-02-07 LT LT06710336T patent/LT1871805T/lt unknown
- 2006-02-07 RS RS20191498A patent/RS59761B1/sr unknown
- 2006-02-07 CN CN201410056372.6A patent/CN103981190A/zh active Pending
- 2006-02-07 ES ES06710336T patent/ES2755976T3/es active Active
- 2006-02-07 JP JP2007553735A patent/JP5336089B2/ja active Active
- 2006-02-07 EP EP11176828A patent/EP2402374A1/en not_active Withdrawn
- 2006-02-07 AU AU2006211037A patent/AU2006211037B2/en not_active Ceased
- 2006-02-07 MX MX2007008619A patent/MX2007008619A/es active IP Right Grant
- 2006-02-07 CN CN200680004310.4A patent/CN101115773B/zh active Active
- 2006-02-07 SI SI200632361T patent/SI1871805T1/sl unknown
- 2006-02-07 CA CA2596835A patent/CA2596835C/en active Active
- 2006-02-07 UA UAA200710028A patent/UA95068C2/uk unknown
- 2006-02-07 NZ NZ556286A patent/NZ556286A/en not_active IP Right Cessation
- 2006-02-07 US US11/348,526 patent/US7722867B2/en active Active
- 2006-02-07 AR ARP060100439A patent/AR052285A1/es unknown
- 2006-02-07 PT PT67103366T patent/PT1871805T/pt unknown
- 2006-02-07 BR BRPI0607315-8A patent/BRPI0607315B1/pt active IP Right Grant
- 2006-02-07 RU RU2007133439/10A patent/RU2488597C2/ru not_active Application Discontinuation
- 2006-02-07 PL PL06710336T patent/PL1871805T3/pl unknown
-
2007
- 2007-07-09 IL IL184498A patent/IL184498A/en active IP Right Grant
- 2007-07-09 CR CR9236A patent/CR9236A/es unknown
- 2007-07-17 NO NO20073662A patent/NO20073662L/no not_active Application Discontinuation
- 2007-08-17 US US11/889,981 patent/US7846432B2/en active Active
- 2007-08-31 MA MA30180A patent/MA29279B1/fr unknown
- 2007-09-07 KR KR1020077020499A patent/KR101467566B1/ko active IP Right Grant
-
2008
- 2008-05-13 HK HK14112920.4A patent/HK1199470A1/xx unknown
- 2008-05-13 HK HK08105244.5A patent/HK1110873A1/xx unknown
-
2010
- 2010-11-02 US US12/938,180 patent/US8097436B2/en active Active
-
2011
- 2011-12-09 US US13/315,989 patent/US8614065B2/en active Active
-
2012
- 2012-11-19 CR CR20120587A patent/CR20120587A/es unknown
-
2013
- 2013-02-28 JP JP2013038450A patent/JP5763695B2/ja active Active
- 2013-04-26 RU RU2013119417A patent/RU2610688C2/ru active
- 2013-11-19 US US14/084,303 patent/US9309317B2/en active Active
-
2016
- 2016-02-23 US US15/050,821 patent/US9957326B2/en active Active
-
2018
- 2018-04-27 US US15/965,143 patent/US20190106497A1/en not_active Abandoned
-
2019
- 2019-11-27 HR HRP20192134TT patent/HRP20192134T1/hr unknown
- 2019-12-02 US US16/700,217 patent/US20200332012A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL184498A0 (en) | Antigen binding molecules that bind egfr, vectors encoding same , and uses thereof | |
HK1131163A1 (en) | Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof | |
HRP20190312T1 (hr) | Vežući proteini, uključujući protutijela, derivate protutijela i fragmente protutijela, koji se specifično vežu na cd154 i njihova upotreba | |
HK1253391A1 (zh) | 與161p2f10b蛋白結合的抗體和相關分子 | |
HRP20150074T1 (hr) | Humana antitijela koja se vežu za mezotelin i njihove uporabe | |
IL188345A (en) | A binding protein specific to cd37 | |
IL211132A0 (en) | Anti-il-6 antibodies, compositions, methods and uses | |
EP1846032A4 (en) | LUCA2 AND ANTIBODY BINDING | |
HK1107402A1 (en) | Kid31 and antibodies that bind thereto kid31 | |
IL202259A0 (en) | Antigen binding proteins that bind par-2 | |
PL1871804T3 (pl) | Przeciwciała wiążące CCX-CKR2 | |
ZA200709303B (en) | Antibodies and related molecules that bind to 161P2F210B proteins | |
ZA201000706B (en) | Antigen binding proteins that bind par-2 | |
GB0511881D0 (en) | Binding molecules |