HK1164319A1 - Preparation and therapeutic applications of (2s,3r)-n-2-((3- pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide (2s3r)-n-2-((3-))-1-[222]-3-)-35- - Google Patents

Preparation and therapeutic applications of (2s,3r)-n-2-((3- pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide (2s3r)-n-2-((3-))-1-[222]-3-)-35-

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Publication number
HK1164319A1
HK1164319A1 HK12105193A HK12105193A HK1164319A1 HK 1164319 A1 HK1164319 A1 HK 1164319A1 HK 12105193 A HK12105193 A HK 12105193A HK 12105193 A HK12105193 A HK 12105193A HK 1164319 A1 HK1164319 A1 HK 1164319A1
Authority
HK
Hong Kong
Prior art keywords
difluorobenzamide
azabicyclo
pyridinyl
oct
methyl
Prior art date
Application number
HK12105193A
Other languages
English (en)
Chinese (zh)
Inventor
Merouane Bencherif
Nikolai Fedorov
Terry Hauser
Kristen Jordan
Sharon Rae Letchworth
Anatoly Mazurov
Julio A Munoz
Jason Speake
Daniel Yohannes
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41719329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1164319(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of HK1164319A1 publication Critical patent/HK1164319A1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
HK12105193A 2009-01-26 2012-05-28 Preparation and therapeutic applications of (2s,3r)-n-2-((3- pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide (2s3r)-n-2-((3-))-1-[222]-3-)-35- HK1164319A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14726009P 2009-01-26 2009-01-26
PCT/US2010/021926 WO2010085724A1 (en) 2009-01-26 2010-01-25 Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Publications (1)

Publication Number Publication Date
HK1164319A1 true HK1164319A1 (en) 2012-09-21

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HK12105193A HK1164319A1 (en) 2009-01-26 2012-05-28 Preparation and therapeutic applications of (2s,3r)-n-2-((3- pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide (2s3r)-n-2-((3-))-1-[222]-3-)-35-

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US (4) US8476296B2 (ko)
EP (1) EP2389378B1 (ko)
JP (1) JP5600122B2 (ko)
KR (1) KR101737924B1 (ko)
CN (1) CN102292335B (ko)
AR (1) AR075152A1 (ko)
AU (1) AU2010206638B2 (ko)
BR (1) BRPI1006053A2 (ko)
CA (1) CA2749123C (ko)
CL (1) CL2010000059A1 (ko)
CO (1) CO6501143A2 (ko)
DK (1) DK2389378T3 (ko)
EA (1) EA201170976A1 (ko)
EC (1) ECSP11011220A (ko)
ES (1) ES2503465T3 (ko)
HK (1) HK1164319A1 (ko)
HR (1) HRP20140756T1 (ko)
IL (1) IL213620A0 (ko)
MX (1) MX2011007791A (ko)
MY (1) MY152387A (ko)
NZ (1) NZ593484A (ko)
PE (1) PE20120005A1 (ko)
PL (1) PL2389378T3 (ko)
PT (1) PT2389378E (ko)
RS (1) RS53521B1 (ko)
SG (1) SG172156A1 (ko)
SI (1) SI2389378T1 (ko)
SM (1) SMT201400152B (ko)
TW (1) TW201031664A (ko)
UA (1) UA105204C2 (ko)
WO (1) WO2010085724A1 (ko)
ZA (1) ZA201105126B (ko)

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