SI2389378T1 - Priprava in terapevtske uporabe (2s,3r)-n-2-((3-piridinil)metil)-1- azabiciklo(2.2.2)okt-3-il)-3,5-difluorobenzamida - Google Patents

Priprava in terapevtske uporabe (2s,3r)-n-2-((3-piridinil)metil)-1- azabiciklo(2.2.2)okt-3-il)-3,5-difluorobenzamida

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Publication number
SI2389378T1
SI2389378T1 SI201030720T SI201030720T SI2389378T1 SI 2389378 T1 SI2389378 T1 SI 2389378T1 SI 201030720 T SI201030720 T SI 201030720T SI 201030720 T SI201030720 T SI 201030720T SI 2389378 T1 SI2389378 T1 SI 2389378T1
Authority
SI
Slovenia
Prior art keywords
difluorobenzamide
pyridinyl
methyl
preparation
therapeutic applications
Prior art date
Application number
SI201030720T
Other languages
English (en)
Inventor
Merouane Bencherif
Nikolai Fedorov
Terry Hauser
Kristen Jordan
Sharon Rae Letchworth
Anatoly Mazurov
Julio A. Munoz
Jason Speake
Daniel Yohannes
Original Assignee
Targacept, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41719329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2389378(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept, Inc. filed Critical Targacept, Inc.
Publication of SI2389378T1 publication Critical patent/SI2389378T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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SI201030720T 2009-01-26 2010-01-25 Priprava in terapevtske uporabe (2s,3r)-n-2-((3-piridinil)metil)-1- azabiciklo(2.2.2)okt-3-il)-3,5-difluorobenzamida SI2389378T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14726009P 2009-01-26 2009-01-26
PCT/US2010/021926 WO2010085724A1 (en) 2009-01-26 2010-01-25 Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
EP20100701307 EP2389378B1 (en) 2009-01-26 2010-01-25 Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Publications (1)

Publication Number Publication Date
SI2389378T1 true SI2389378T1 (sl) 2014-10-30

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SI201030720T SI2389378T1 (sl) 2009-01-26 2010-01-25 Priprava in terapevtske uporabe (2s,3r)-n-2-((3-piridinil)metil)-1- azabiciklo(2.2.2)okt-3-il)-3,5-difluorobenzamida

Country Status (32)

Country Link
US (4) US8476296B2 (sl)
EP (1) EP2389378B1 (sl)
JP (1) JP5600122B2 (sl)
KR (1) KR101737924B1 (sl)
CN (1) CN102292335B (sl)
AR (1) AR075152A1 (sl)
AU (1) AU2010206638B2 (sl)
BR (1) BRPI1006053A2 (sl)
CA (1) CA2749123C (sl)
CL (1) CL2010000059A1 (sl)
CO (1) CO6501143A2 (sl)
DK (1) DK2389378T3 (sl)
EA (1) EA201170976A1 (sl)
EC (1) ECSP11011220A (sl)
ES (1) ES2503465T3 (sl)
HK (1) HK1164319A1 (sl)
HR (1) HRP20140756T1 (sl)
IL (1) IL213620A0 (sl)
MX (1) MX2011007791A (sl)
MY (1) MY152387A (sl)
NZ (1) NZ593484A (sl)
PE (1) PE20120005A1 (sl)
PL (1) PL2389378T3 (sl)
PT (1) PT2389378E (sl)
RS (1) RS53521B1 (sl)
SG (1) SG172156A1 (sl)
SI (1) SI2389378T1 (sl)
SM (1) SMT201400152B (sl)
TW (1) TW201031664A (sl)
UA (1) UA105204C2 (sl)
WO (1) WO2010085724A1 (sl)
ZA (1) ZA201105126B (sl)

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TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
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JO3766B1 (ar) * 2011-10-20 2021-01-31 Novartis Ag منشط مستقبل أسيتيل كولين الفا - 7 النيكوتيني
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BR112015016995B8 (pt) 2013-01-15 2022-07-26 Novartis Ag Uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
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DK2389378T3 (da) 2014-07-07
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