SMT201400152B - Preparazione ed applicazioni terapeutiche di (2S,3R)-N-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]ott-3-il)-3,5-difluorobenzammide - Google Patents

Preparazione ed applicazioni terapeutiche di (2S,3R)-N-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]ott-3-il)-3,5-difluorobenzammide

Info

Publication number
SMT201400152B
SMT201400152B SM201400152T SM201400152T SMT201400152B SM T201400152 B SMT201400152 B SM T201400152B SM 201400152 T SM201400152 T SM 201400152T SM 201400152 T SM201400152 T SM 201400152T SM T201400152 B SMT201400152 B SM T201400152B
Authority
SM
San Marino
Prior art keywords
difluorobenzamide
azabicyclo
pyridinyl
oct
methyl
Prior art date
Application number
SM201400152T
Other languages
English (en)
Inventor
Merouane Bencherif
Nikolai Fedorov
Terry Hauser
Kristen Jordan
Sharon Rae Letchworth
Anatoly Mazurov
Julio A Munoz
Jason Speake
Daniel Yohannes
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41719329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201400152(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of SMT201400152B publication Critical patent/SMT201400152B/it

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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SM201400152T 2009-01-26 2014-10-17 Preparazione ed applicazioni terapeutiche di (2S,3R)-N-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]ott-3-il)-3,5-difluorobenzammide SMT201400152B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14726009P 2009-01-26 2009-01-26
PCT/US2010/021926 WO2010085724A1 (en) 2009-01-26 2010-01-25 Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Publications (1)

Publication Number Publication Date
SMT201400152B true SMT201400152B (it) 2015-01-15

Family

ID=41719329

Family Applications (1)

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SM201400152T SMT201400152B (it) 2009-01-26 2014-10-17 Preparazione ed applicazioni terapeutiche di (2S,3R)-N-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]ott-3-il)-3,5-difluorobenzammide

Country Status (32)

Country Link
US (4) US8476296B2 (it)
EP (1) EP2389378B1 (it)
JP (1) JP5600122B2 (it)
KR (1) KR101737924B1 (it)
CN (1) CN102292335B (it)
AR (1) AR075152A1 (it)
AU (1) AU2010206638B2 (it)
BR (1) BRPI1006053A2 (it)
CA (1) CA2749123C (it)
CL (1) CL2010000059A1 (it)
CO (1) CO6501143A2 (it)
DK (1) DK2389378T3 (it)
EA (1) EA201170976A1 (it)
EC (1) ECSP11011220A (it)
ES (1) ES2503465T3 (it)
HK (1) HK1164319A1 (it)
HR (1) HRP20140756T1 (it)
IL (1) IL213620A0 (it)
MX (1) MX2011007791A (it)
MY (1) MY152387A (it)
NZ (1) NZ593484A (it)
PE (1) PE20120005A1 (it)
PL (1) PL2389378T3 (it)
PT (1) PT2389378E (it)
RS (1) RS53521B1 (it)
SG (1) SG172156A1 (it)
SI (1) SI2389378T1 (it)
SM (1) SMT201400152B (it)
TW (1) TW201031664A (it)
UA (1) UA105204C2 (it)
WO (1) WO2010085724A1 (it)
ZA (1) ZA201105126B (it)

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CA3083244C (en) 2011-10-20 2023-01-03 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
AU2013356914B2 (en) 2012-12-11 2017-01-05 Novartis Ag Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
CA2898045C (en) 2013-01-15 2018-08-28 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
BR112015016994A8 (pt) 2013-01-15 2018-01-23 Novartis Ag uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
KR101879920B1 (ko) 2013-01-15 2018-07-18 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
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