FR2941953B1 - Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique - Google Patents

Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique

Info

Publication number
FR2941953B1
FR2941953B1 FR0900578A FR0900578A FR2941953B1 FR 2941953 B1 FR2941953 B1 FR 2941953B1 FR 0900578 A FR0900578 A FR 0900578A FR 0900578 A FR0900578 A FR 0900578A FR 2941953 B1 FR2941953 B1 FR 2941953B1
Authority
FR
France
Prior art keywords
aza
benzamide
bicyclo
hex
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0900578A
Other languages
English (en)
Other versions
FR2941953A1 (fr
Inventor
Gihad Dargazanli
Bouhtou Genevieve Estenne
Abel Kader Mafroud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0900578A priority Critical patent/FR2941953B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to AU2010212702A priority patent/AU2010212702A1/en
Priority to CN2010800150193A priority patent/CN102388049A/zh
Priority to BRPI1008660A priority patent/BRPI1008660A2/pt
Priority to SG2011057205A priority patent/SG173606A1/en
Priority to KR1020117021203A priority patent/KR20110118812A/ko
Priority to US13/148,583 priority patent/US20120071536A1/en
Priority to PCT/FR2010/050203 priority patent/WO2010092286A1/fr
Priority to MX2011008447A priority patent/MX2011008447A/es
Priority to RU2011137463/04A priority patent/RU2011137463A/ru
Priority to ARP100100344A priority patent/AR075379A1/es
Priority to JP2011548758A priority patent/JP2012517411A/ja
Priority to CA2751863A priority patent/CA2751863A1/fr
Priority to TW099104005A priority patent/TW201036979A/zh
Priority to EP10708303A priority patent/EP2396334A1/fr
Priority to UY0001032428A priority patent/UY32428A/es
Publication of FR2941953A1 publication Critical patent/FR2941953A1/fr
Application granted granted Critical
Publication of FR2941953B1 publication Critical patent/FR2941953B1/fr
Priority to IL214490A priority patent/IL214490A0/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
FR0900578A 2009-02-10 2009-02-10 Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique Expired - Fee Related FR2941953B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR0900578A FR2941953B1 (fr) 2009-02-10 2009-02-10 Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
CA2751863A CA2751863A1 (fr) 2009-02-10 2010-02-09 Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl]-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
BRPI1008660A BRPI1008660A2 (pt) 2009-02-10 2010-02-09 derivados de n-[(2-aza-biciclo[2.1.1] hex-1-il)-aril-metil]benzamida, sua preparação e sua aplicação em teraêutica
SG2011057205A SG173606A1 (en) 2009-02-10 2010-02-09 N-[(2-azabicyclo[2.1.1]hex-1-yl]-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
KR1020117021203A KR20110118812A (ko) 2009-02-10 2010-02-09 Ｎ-〔（２-아자비시클로〔２.１.１〕헥스-１-일）-아릴-메틸〕-벤즈아미드 유도체, 그의 제조 방법, 및 그의 치료 용도
US13/148,583 US20120071536A1 (en) 2009-02-10 2010-02-09 N-[(2-azabicyclo[2.1.1]hex-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
PCT/FR2010/050203 WO2010092286A1 (fr) 2009-02-10 2010-02-09 Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl]-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
MX2011008447A MX2011008447A (es) 2009-02-10 2010-02-09 Derivados de n-[(2-aza-biciclo[2.1.1]hex-1-il)-abril-metil]-benzam ida, su prepracion y su uso en terapeutica.
AU2010212702A AU2010212702A1 (en) 2009-02-10 2010-02-09 N-[(2-azabicyclo[2.1.1]hex-1-yl]-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof
ARP100100344A AR075379A1 (es) 2009-02-10 2010-02-09 Derivados de n-(2-aza-biciclo(2.1.1) hex-1-il)-aril-metil)-benzamida, su preparacion y su aplicacion en terapeutica.
JP2011548758A JP2012517411A (ja) 2009-02-10 2010-02-09 Ｎ−［（２−アザビシクロ［２．１．１］ヘキス−１−イル）−アリール−メチル］−ベンズアミド誘導体類、これらの製造およびこれらの治療使用
CN2010800150193A CN102388049A (zh) 2009-02-10 2010-02-09 N-[(2-氮杂双环[2.1.1]己-1-基)-芳基-甲基]-苯甲酰胺衍生物、其制备及其治疗用途
TW099104005A TW201036979A (en) 2009-02-10 2010-02-09 N-[(2-azabicyclo[2.1.1]hex-1-yl)(aryl)methyl]benzamide derivatives, their preparation and their therapeutic application
EP10708303A EP2396334A1 (fr) 2009-02-10 2010-02-09 Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl]-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
RU2011137463/04A RU2011137463A (ru) 2009-02-10 2010-02-09 Производные n-[([2.1.1]гекс-1-ил)арилметил] бензамида, их получение и применение в терапии
UY0001032428A UY32428A (es) 2009-02-10 2010-02-10 Derivados de n-[(2-aza-biciclo[2.1.1]hex-1-il)-aril-metil]-benzamida, su preparacion y su aplicacion en terapeutica
IL214490A IL214490A0 (en) 2009-02-10 2011-08-07 N-[(2-azabicyclo[2.1.1]hex-1-yl)-aryl-methyl]-benzamide derivatives, preparation thereof, and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0900578A FR2941953B1 (fr) 2009-02-10 2009-02-10 Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2941953A1 FR2941953A1 (fr) 2010-08-13
FR2941953B1 true FR2941953B1 (fr) 2011-04-08

Family

ID=40935627

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0900578A Expired - Fee Related FR2941953B1 (fr) 2009-02-10 2009-02-10 Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique

Country Status (17)

Country Link
US (1) US20120071536A1 (fr)
EP (1) EP2396334A1 (fr)
JP (1) JP2012517411A (fr)
KR (1) KR20110118812A (fr)
CN (1) CN102388049A (fr)
AR (1) AR075379A1 (fr)
AU (1) AU2010212702A1 (fr)
BR (1) BRPI1008660A2 (fr)
CA (1) CA2751863A1 (fr)
FR (1) FR2941953B1 (fr)
IL (1) IL214490A0 (fr)
MX (1) MX2011008447A (fr)
RU (1) RU2011137463A (fr)
SG (1) SG173606A1 (fr)
TW (1) TW201036979A (fr)
UY (1) UY32428A (fr)
WO (1) WO2010092286A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2005058317A1 (fr) * 2003-12-18 2005-06-30 Glaxo Group Limited Inhibiteurs du transporteur-1 de la glycine
AU2006309050B2 (en) * 2005-10-28 2012-08-16 Merck Sharp & Dohme Corp. Piperidine glycine transporter inhibitors
WO2009013535A1 (fr) * 2007-07-23 2009-01-29 Astrazeneca Ab Dérivés de 2-azabicyclo(2,2,2)octane en tant que modulateurs du récepteur transporteur de type i de la glycine

Also Published As

Publication number Publication date
IL214490A0 (en) 2011-09-27
RU2011137463A (ru) 2013-03-20
FR2941953A1 (fr) 2010-08-13
MX2011008447A (es) 2011-11-29
CN102388049A (zh) 2012-03-21
UY32428A (es) 2010-09-30
BRPI1008660A2 (pt) 2016-03-08
CA2751863A1 (fr) 2010-08-19
AU2010212702A1 (en) 2011-09-01
SG173606A1 (en) 2011-09-29
JP2012517411A (ja) 2012-08-02
EP2396334A1 (fr) 2011-12-21
KR20110118812A (ko) 2011-11-01
AR075379A1 (es) 2011-03-30
TW201036979A (en) 2010-10-16
US20120071536A1 (en) 2012-03-22
WO2010092286A1 (fr) 2010-08-19

Similar Documents

Publication Publication Date Title
FR2911604B1 (fr) Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2910473B1 (fr) Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
FR2904316B1 (fr) Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique.
FR2903985B1 (fr) Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2915198B1 (fr) Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
FR2926556B1 (fr) Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2933700B1 (fr) Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2915199B1 (fr) Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
FR2880625B1 (fr) Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2891828B1 (fr) Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
FR2953520B1 (fr) Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
FR2915197B1 (fr) Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2934265B1 (fr) Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
FR2952934B1 (fr) Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2888848B1 (fr) Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2920023B1 (fr) Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique
FR2917413B1 (fr) Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
FR2927625B1 (fr) Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
FR2938537B1 (fr) Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
FR2930249B1 (fr) Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique.
FR2892416B1 (fr) Derives de 6-heteroarylpyridoindolone, leur preparation et leur application en therapeutique
FR2940284B1 (fr) Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
FR2925901B1 (fr) DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2932481B1 (fr) Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20121031