WO2005058317A1 - Inhibiteurs du transporteur-1 de la glycine - Google Patents

Inhibiteurs du transporteur-1 de la glycine Download PDF

Info

Publication number
WO2005058317A1
WO2005058317A1 PCT/EP2004/014472 EP2004014472W WO2005058317A1 WO 2005058317 A1 WO2005058317 A1 WO 2005058317A1 EP 2004014472 W EP2004014472 W EP 2004014472W WO 2005058317 A1 WO2005058317 A1 WO 2005058317A1
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
alkyl
compound
phenyl
4alkyl
Prior art date
Application number
PCT/EP2004/014472
Other languages
English (en)
Inventor
Andrea Bozzoli
Clive Leslie Branch
Howard Marshall
David John Nash
Roderick Alan Porter
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329360A external-priority patent/GB0329360D0/en
Priority claimed from GB0413107A external-priority patent/GB0413107D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of WO2005058317A1 publication Critical patent/WO2005058317A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Abstract

La présente invention se rapporte à un composé représenté par la formule (I) ou à un sel ou solvate de ce composé. Dans la formule (I), R1, R3 et R10, X et Ar sont tels que définis dans la description. L'invention se rapporte également aux utilisations de ces composés. Ces composés inhibent les transporteurs GlyT1 et sont utiles pour le traitement de certains troubles neurologiques et neuropsychiatriques, et notamment pour le traitement de la schizophrénie.
PCT/EP2004/014472 2003-12-18 2004-12-16 Inhibiteurs du transporteur-1 de la glycine WO2005058317A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0329360A GB0329360D0 (en) 2003-12-18 2003-12-18 Compounds
GB0329360.2 2003-12-18
GB0413107A GB0413107D0 (en) 2004-06-11 2004-06-11 Compounds
GB0413107.4 2004-06-11

Publications (1)

Publication Number Publication Date
WO2005058317A1 true WO2005058317A1 (fr) 2005-06-30

Family

ID=34702517

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/014472 WO2005058317A1 (fr) 2003-12-18 2004-12-16 Inhibiteurs du transporteur-1 de la glycine

Country Status (1)

Country Link
WO (1) WO2005058317A1 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066121A2 (fr) * 2004-12-16 2006-06-22 Janssen Pharmaceutica N.V. Combinaison d'un inhibiteur de transporteur glycine (glyt1) et d'un antipsychotique destinee au traitement de symptomes de la schizophrenie ainsi que la preparation et l'utilisation de ce compose
EP1871165A2 (fr) * 2005-04-11 2008-01-02 Yale University Corporation Methode de traitement d'un prodrome schizophrenique
FR2941954A1 (fr) * 2009-02-10 2010-08-13 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
FR2941953A1 (fr) * 2009-02-10 2010-08-13 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
US8420670B2 (en) 2007-08-22 2013-04-16 Abbott Laboratories 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8563617B2 (en) 2009-02-16 2013-10-22 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8642587B2 (en) 2009-02-16 2014-02-04 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
US8653100B2 (en) 2008-04-01 2014-02-18 Abbvie Inc. Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846741B2 (en) 2011-11-18 2014-09-30 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2014154488A1 (fr) 2013-03-28 2014-10-02 Syngenta Participations Ag Procédés de lutte contre des organismes nuisibles résistant aux néonicotinoïdes
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045011A1 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine
WO2003053942A1 (fr) * 2001-12-20 2003-07-03 H. Lundbeck A/S Derives d'aryloxyphenyle et d'arylsulfanylphenyle

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045011A1 (fr) * 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Inhibiteurs du transport de la glycine
WO2003053942A1 (fr) * 2001-12-20 2003-07-03 H. Lundbeck A/S Derives d'aryloxyphenyle et d'arylsulfanylphenyle

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066121A3 (fr) * 2004-12-16 2006-08-10 Janssen Pharmaceutica Nv Combinaison d'un inhibiteur de transporteur glycine (glyt1) et d'un antipsychotique destinee au traitement de symptomes de la schizophrenie ainsi que la preparation et l'utilisation de ce compose
WO2006066121A2 (fr) * 2004-12-16 2006-06-22 Janssen Pharmaceutica N.V. Combinaison d'un inhibiteur de transporteur glycine (glyt1) et d'un antipsychotique destinee au traitement de symptomes de la schizophrenie ainsi que la preparation et l'utilisation de ce compose
EP1871165A2 (fr) * 2005-04-11 2008-01-02 Yale University Corporation Methode de traitement d'un prodrome schizophrenique
EP1871165A4 (fr) * 2005-04-11 2009-10-21 Yale University Corp Methode de traitement d'un prodrome schizophrenique
US8492418B2 (en) 2005-04-11 2013-07-23 Yale University Method of treating schizophrenia prodrome
US8420670B2 (en) 2007-08-22 2013-04-16 Abbott Laboratories 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8653100B2 (en) 2008-04-01 2014-02-18 Abbvie Inc. Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8957089B2 (en) 2008-04-01 2015-02-17 AbbVie Deutschland GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
WO2010092286A1 (fr) * 2009-02-10 2010-08-19 Sanofi-Aventis Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl]-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
WO2010092287A1 (fr) * 2009-02-10 2010-08-19 Sanofi-Aventis Derives de n-[(6-aza-bicyclo[3.2.1]oct-1-yl)-aryl-methyl]-benzamide, leur preparation et leur application en therapeutique
FR2941953A1 (fr) * 2009-02-10 2010-08-13 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
FR2941954A1 (fr) * 2009-02-10 2010-08-13 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
US8563617B2 (en) 2009-02-16 2013-10-22 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8642587B2 (en) 2009-02-16 2014-02-04 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
US9096619B2 (en) 2009-02-16 2015-08-04 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9067871B2 (en) 2009-02-16 2015-06-30 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9227930B2 (en) 2010-08-13 2016-01-05 Abbvie Inc. Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9238619B2 (en) 2010-08-13 2016-01-19 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846741B2 (en) 2011-11-18 2014-09-30 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2014154488A1 (fr) 2013-03-28 2014-10-02 Syngenta Participations Ag Procédés de lutte contre des organismes nuisibles résistant aux néonicotinoïdes
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy

Similar Documents

Publication Publication Date Title
WO2005058317A1 (fr) Inhibiteurs du transporteur-1 de la glycine
WO2005058882A1 (fr) Composes comprenant des groupes mopholinyle et piperidinyle utilises comme inhibiteurs de glyt1 et de glyt2
WO2005058885A2 (fr) Composes
EP1833811B1 (fr) Hétérocycles oxygénés en tant que composés inhibiteurs de transporteurs de glycine
US20100216837A1 (en) Glycine transport inhibitors
WO2005049023A1 (fr) Inhibiteurs du transporteur glyt1
EP1838663B1 (fr) Inhibiteurs du transport de la glycine
US20090221577A1 (en) Compounds having morpholinyl and piperidinyl groups for use as glyt1 inhibitors
EP1858869A1 (fr) Pipéridines acylées en tant qu&#39;inhibiteurs de transporteurs de glycine
US20090286828A1 (en) 2-amino-1-phenylethylcarboxamide derivatives
US20090253700A1 (en) N-&#39;4-4(4-morpholinyl) phenyl!- &#39;(4-piperidinyl) methyl! carboxamide derivatives and their use as glycine transporter inhibitors
EP2041082B1 (fr) Composés ayant une activité au niveau du transporteur glyt1
US20100016374A1 (en) Compounds Which Inhibit the Glycine Transporter and Uses Thereof
US20090227629A1 (en) Compounds having activity at the glycine transporter glyt1 and uses thereof
WO2007147836A1 (fr) Composés inhibant le transporteur de la glycine et utilisations en médecine
US20090318447A1 (en) N-[6-(4-morpholinyl)-3-pyridinyl]-2-(tetrahydro-2h-pyran-4-yl)-n-[(1--4-piperidinyl) methyl] acetamide derivatives and related compounds as glyt1 transport inhibitors for the treatment of neurological disorders such as schizophrenia
WO2006094840A1 (fr) Composés
WO2006002956A1 (fr) Derives de piperidine et utilisation associee en tant qu&#39;inhibiteurs du transporteur de glycine
WO2007147839A1 (fr) Composés inhibant le transporteur de la glycine et utilisations de ceux-ci en médecine
WO2007147834A1 (fr) Composés inhibant le transporteur de la glycine et utilisations de ceux-ci en médecine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase