WO2005058882A1 - Composes comprenant des groupes mopholinyle et piperidinyle utilises comme inhibiteurs de glyt1 et de glyt2 - Google Patents

Composes comprenant des groupes mopholinyle et piperidinyle utilises comme inhibiteurs de glyt1 et de glyt2 Download PDF

Info

Publication number
WO2005058882A1
WO2005058882A1 PCT/EP2004/014469 EP2004014469W WO2005058882A1 WO 2005058882 A1 WO2005058882 A1 WO 2005058882A1 EP 2004014469 W EP2004014469 W EP 2004014469W WO 2005058882 A1 WO2005058882 A1 WO 2005058882A1
Authority
WO
WIPO (PCT)
Prior art keywords
optionally substituted
alkyl
compound
4alkyl
group
Prior art date
Application number
PCT/EP2004/014469
Other languages
English (en)
Inventor
Clive Leslie Branch
Howard Marshall
David John Nash
Roderick Alan Porter
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of WO2005058882A1 publication Critical patent/WO2005058882A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

L'invention concerne un composé représenté par la formule (I), ou un sel ou un solvate de celui-ci : (I) R1, R3 et R4, Het, X et Ar sont tels que définis dans le descriptif. L'invention concerne également les utilisations de ces composés. Ces composés inhibent les transporteurs de GlyT1 est servent au traitement de certains troubles neurologiques et neuropsychiatriques, notamment de la schizophrénie.
PCT/EP2004/014469 2003-12-18 2004-12-16 Composes comprenant des groupes mopholinyle et piperidinyle utilises comme inhibiteurs de glyt1 et de glyt2 WO2005058882A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0329362.8A GB0329362D0 (en) 2003-12-18 2003-12-18 Compounds
GB0329362.8 2003-12-18

Publications (1)

Publication Number Publication Date
WO2005058882A1 true WO2005058882A1 (fr) 2005-06-30

Family

ID=30471322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/014469 WO2005058882A1 (fr) 2003-12-18 2004-12-16 Composes comprenant des groupes mopholinyle et piperidinyle utilises comme inhibiteurs de glyt1 et de glyt2

Country Status (2)

Country Link
GB (1) GB0329362D0 (fr)
WO (1) WO2005058882A1 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077026A1 (fr) * 2005-01-18 2006-07-27 F.Hoffmann-La Roche Ag Derives de phenylmethanone disubstitues en 2, 5 en tant qu'inhibiteurs du transporteur 1 de la glycine (glyt-i) pour le traitement de troubles neurologiques et neuropsychiatriques
EP1871165A2 (fr) * 2005-04-11 2008-01-02 Yale University Corporation Methode de traitement d'un prodrome schizophrenique
US7442710B2 (en) 2005-01-26 2008-10-28 Hoffman-La Roche Inc. Substituted phenyl methanones
US7557114B2 (en) 2005-02-07 2009-07-07 Hoffman-La Roche Inc. Heterocyclic-substituted phenyl methanones
US8420670B2 (en) 2007-08-22 2013-04-16 Abbott Laboratories 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
CN103209964A (zh) * 2010-08-13 2013-07-17 Abbvie德国有限责任两合公司 苯烷基胺衍生物、含其的药物组合物及其在治疗中的用途
US8519026B2 (en) 2006-12-28 2013-08-27 Nuplex Resins B.V. Waterborne polymeric dispersions
US8563617B2 (en) 2009-02-16 2013-10-22 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8642587B2 (en) 2009-02-16 2014-02-04 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
US8653100B2 (en) 2008-04-01 2014-02-18 Abbvie Inc. Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846741B2 (en) 2011-11-18 2014-09-30 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055478A1 (fr) * 2001-12-21 2003-07-10 Smithkline Beecham P.L.C. Inhibiteurs de transporteurs glyt1 et utilisatons de ceux-ci dans le traitement de troubles neurologiques et neuropsychiatriques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055478A1 (fr) * 2001-12-21 2003-07-10 Smithkline Beecham P.L.C. Inhibiteurs de transporteurs glyt1 et utilisatons de ceux-ci dans le traitement de troubles neurologiques et neuropsychiatriques

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790763B2 (en) 2005-01-18 2010-09-07 Hoffmann-La Roche Inc. Substituted phenyl methanone derivatives
WO2006077026A1 (fr) * 2005-01-18 2006-07-27 F.Hoffmann-La Roche Ag Derives de phenylmethanone disubstitues en 2, 5 en tant qu'inhibiteurs du transporteur 1 de la glycine (glyt-i) pour le traitement de troubles neurologiques et neuropsychiatriques
US7442710B2 (en) 2005-01-26 2008-10-28 Hoffman-La Roche Inc. Substituted phenyl methanones
US7557114B2 (en) 2005-02-07 2009-07-07 Hoffman-La Roche Inc. Heterocyclic-substituted phenyl methanones
US8188139B2 (en) 2005-02-07 2012-05-29 Hoffman-La Roche Inc. Heterocyclic-substituted phenyl methanones
EP1871165A4 (fr) * 2005-04-11 2009-10-21 Yale University Corp Methode de traitement d'un prodrome schizophrenique
EP1871165A2 (fr) * 2005-04-11 2008-01-02 Yale University Corporation Methode de traitement d'un prodrome schizophrenique
US8492418B2 (en) 2005-04-11 2013-07-23 Yale University Method of treating schizophrenia prodrome
US8519026B2 (en) 2006-12-28 2013-08-27 Nuplex Resins B.V. Waterborne polymeric dispersions
US8420670B2 (en) 2007-08-22 2013-04-16 Abbott Laboratories 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8957089B2 (en) 2008-04-01 2015-02-17 AbbVie Deutschland GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8653100B2 (en) 2008-04-01 2014-02-18 Abbvie Inc. Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US8563617B2 (en) 2009-02-16 2013-10-22 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8642587B2 (en) 2009-02-16 2014-02-04 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
US9096619B2 (en) 2009-02-16 2015-08-04 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9067871B2 (en) 2009-02-16 2015-06-30 AbbVie Deutschland GmbH & Co. KG Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9227930B2 (en) 2010-08-13 2016-01-05 Abbvie Inc. Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9238619B2 (en) 2010-08-13 2016-01-19 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
CN103209964A (zh) * 2010-08-13 2013-07-17 Abbvie德国有限责任两合公司 苯烷基胺衍生物、含其的药物组合物及其在治疗中的用途
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846741B2 (en) 2011-11-18 2014-09-30 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586942B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9586945B2 (en) 2013-10-17 2017-03-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy

Also Published As

Publication number Publication date
GB0329362D0 (en) 2004-01-21

Similar Documents

Publication Publication Date Title
WO2005058882A1 (fr) Composes comprenant des groupes mopholinyle et piperidinyle utilises comme inhibiteurs de glyt1 et de glyt2
WO2005058317A1 (fr) Inhibiteurs du transporteur-1 de la glycine
WO2005058885A2 (fr) Composes
US20090326027A1 (en) N-Phenyl-2-0X0-1,4-Diazaspiro [4.5] Dec-3-EN-1-YL Acetamide Derivatives And Their Use As Glycine Transporter Inhibitors
EP1833811B1 (fr) Hétérocycles oxygénés en tant que composés inhibiteurs de transporteurs de glycine
US20100216837A1 (en) Glycine transport inhibitors
WO2005049023A1 (fr) Inhibiteurs du transporteur glyt1
US20080255144A1 (en) Acylated Piperidines as Glycine Transporter Inhibitors
US20090221577A1 (en) Compounds having morpholinyl and piperidinyl groups for use as glyt1 inhibitors
US20090286828A1 (en) 2-amino-1-phenylethylcarboxamide derivatives
US20080090822A1 (en) Piperazine Derivatives As Glyt 1 Inhibitors
US20090253700A1 (en) N-'4-4(4-morpholinyl) phenyl!- '(4-piperidinyl) methyl! carboxamide derivatives and their use as glycine transporter inhibitors
US20080070973A1 (en) Compounds having activity at the GlyT1 transporter
US20100113545A1 (en) Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
US20100016374A1 (en) Compounds Which Inhibit the Glycine Transporter and Uses Thereof
US20090227629A1 (en) Compounds having activity at the glycine transporter glyt1 and uses thereof
US20090318447A1 (en) N-[6-(4-morpholinyl)-3-pyridinyl]-2-(tetrahydro-2h-pyran-4-yl)-n-[(1--4-piperidinyl) methyl] acetamide derivatives and related compounds as glyt1 transport inhibitors for the treatment of neurological disorders such as schizophrenia
EP1858868A1 (fr) Composes
WO2010010133A1 (fr) Phénylacétamides à substitution 2-thia-1,3-diazaspirocyclique utilisés comme médiateurs glt1 dans les maladies neurologiques
WO2006002956A1 (fr) Derives de piperidine et utilisation associee en tant qu'inhibiteurs du transporteur de glycine
US20110009440A1 (en) Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase