HK1075199A1 - Process for the preparation of crystalline nano-particle dispersions - Google Patents

Process for the preparation of crystalline nano-particle dispersions

Info

Publication number
HK1075199A1
HK1075199A1 HK05107482.5A HK05107482A HK1075199A1 HK 1075199 A1 HK1075199 A1 HK 1075199A1 HK 05107482 A HK05107482 A HK 05107482A HK 1075199 A1 HK1075199 A1 HK 1075199A1
Authority
HK
Hong Kong
Prior art keywords
preparation
dispersion
water
particle dispersions
insoluble substance
Prior art date
Application number
HK05107482.5A
Other languages
English (en)
Inventor
Tommy Urban Skantze
Per Lennart Lindfors
Sara Forssen
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1075199A1 publication Critical patent/HK1075199A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
HK05107482.5A 2002-07-18 2005-08-25 Process for the preparation of crystalline nano-particle dispersions HK1075199A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0216700.5A GB0216700D0 (en) 2002-07-18 2002-07-18 Process
PCT/GB2003/003044 WO2004009057A1 (fr) 2002-07-18 2003-07-14 Procede de preparation de dispersions de nanoparticules cristallines

Publications (1)

Publication Number Publication Date
HK1075199A1 true HK1075199A1 (en) 2005-12-09

Family

ID=9940704

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107482.5A HK1075199A1 (en) 2002-07-18 2005-08-25 Process for the preparation of crystalline nano-particle dispersions

Country Status (18)

Country Link
US (1) US7780989B2 (fr)
EP (1) EP1524964B1 (fr)
JP (1) JP2006504511A (fr)
KR (1) KR101061309B1 (fr)
CN (1) CN100594885C (fr)
AT (1) ATE489939T1 (fr)
BR (1) BR0312631A (fr)
CA (1) CA2492709C (fr)
DE (1) DE60335189D1 (fr)
ES (1) ES2355137T3 (fr)
GB (1) GB0216700D0 (fr)
HK (1) HK1075199A1 (fr)
IL (1) IL165930A0 (fr)
MX (1) MXPA05000595A (fr)
NO (1) NO20050860L (fr)
NZ (1) NZ537654A (fr)
WO (1) WO2004009057A1 (fr)
ZA (1) ZA200410343B (fr)

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GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
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GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
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CN102048702B (zh) * 2010-12-03 2012-05-23 山东大学 一种联苯双酯纳米结晶制剂及其制备方法
JP2014511867A (ja) * 2011-04-18 2014-05-19 合肥貝霓医薬科技有限公司 ジヒドロピリジン系カルシウムチャネルブロッカーの精製、及びそのナノ粒子の調製方法
CN102746215A (zh) * 2011-04-18 2012-10-24 张兆勇 一种制备高纯度盐酸贝尼地平的方法
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CN102846554B (zh) * 2012-09-28 2014-11-26 山东大学 一种h2纳米结晶制剂及其制备方法
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Also Published As

Publication number Publication date
DE60335189D1 (de) 2011-01-13
CN100594885C (zh) 2010-03-24
EP1524964B1 (fr) 2010-12-01
US7780989B2 (en) 2010-08-24
CN1668280A (zh) 2005-09-14
KR101061309B1 (ko) 2011-08-31
JP2006504511A (ja) 2006-02-09
NO20050860L (no) 2005-04-18
ES2355137T3 (es) 2011-03-23
CA2492709A1 (fr) 2004-01-29
BR0312631A (pt) 2005-04-19
US20050202092A1 (en) 2005-09-15
ATE489939T1 (de) 2010-12-15
CA2492709C (fr) 2012-01-24
IL165930A0 (en) 2006-01-15
KR20050023432A (ko) 2005-03-09
GB0216700D0 (en) 2002-08-28
WO2004009057A1 (fr) 2004-01-29
EP1524964A1 (fr) 2005-04-27
ZA200410343B (en) 2005-10-17
NZ537654A (en) 2006-08-31
MXPA05000595A (es) 2005-04-19
AU2003244871A1 (en) 2004-02-09

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