DE60220923D1 - Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct) - Google Patents

Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct)

Info

Publication number
DE60220923D1
DE60220923D1 DE60220923T DE60220923T DE60220923D1 DE 60220923 D1 DE60220923 D1 DE 60220923D1 DE 60220923 T DE60220923 T DE 60220923T DE 60220923 T DE60220923 T DE 60220923T DE 60220923 D1 DE60220923 D1 DE 60220923D1
Authority
DE
Germany
Prior art keywords
water
medium
charactered
mct
triglyceride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60220923T
Other languages
English (en)
Other versions
DE60220923T2 (de
Inventor
Pia Margaretha Skantze
Tommy Urban Skantze
Corswant Lars Christian Von
Schantz Anna Elisa Zzackrisson
Per Lennart Lindfors
Ulf Olsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0119081A external-priority patent/GB0119081D0/en
Priority claimed from GB0212463A external-priority patent/GB0212463D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60220923D1 publication Critical patent/DE60220923D1/de
Application granted granted Critical
Publication of DE60220923T2 publication Critical patent/DE60220923T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Dental Preparations (AREA)
DE60220923T 2001-08-06 2002-08-01 Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct) Expired - Lifetime DE60220923T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0119081A GB0119081D0 (en) 2001-08-06 2001-08-06 Process
GB0119081 2001-08-06
GB0212463A GB0212463D0 (en) 2002-05-30 2002-05-30 Process
GB0212463 2002-05-30
PCT/GB2002/003583 WO2003013472A1 (en) 2001-08-06 2002-08-01 Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)

Publications (2)

Publication Number Publication Date
DE60220923D1 true DE60220923D1 (de) 2007-08-09
DE60220923T2 DE60220923T2 (de) 2008-03-06

Family

ID=26246405

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60220923T Expired - Lifetime DE60220923T2 (de) 2001-08-06 2002-08-01 Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct)

Country Status (20)

Country Link
US (1) US20050009908A1 (de)
EP (1) EP1416917B1 (de)
JP (1) JP4714412B2 (de)
KR (1) KR100914113B1 (de)
CN (1) CN1254233C (de)
AT (1) ATE365537T1 (de)
AU (1) AU2002317409B2 (de)
BR (1) BR0211705A (de)
CA (1) CA2456180C (de)
CY (1) CY1107059T1 (de)
DE (1) DE60220923T2 (de)
DK (1) DK1416917T3 (de)
ES (1) ES2287293T3 (de)
HK (1) HK1064048A1 (de)
IL (2) IL160103A0 (de)
MX (1) MXPA04001071A (de)
NO (1) NO20040484L (de)
NZ (1) NZ530916A (de)
PT (1) PT1416917E (de)
WO (1) WO2003013472A1 (de)

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GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
AU2004247615B2 (en) * 2003-06-18 2008-02-21 Astrazeneca Ab 2-substituted 5,6-diaryl-pyrazine derivatives as CB1 modulators
GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314261D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
WO2006069098A1 (en) * 2004-12-22 2006-06-29 Elan Pharma International Ltd. Nanoparticulate bicalutamide formulations
BRPI0614904A2 (pt) * 2005-08-12 2012-12-25 Astrazeneca Ab processo para a preparaÇço de uma dispersço estÁvel de partÍculas submÍcron amorfas sàlidas em um meio aquoso, dispersço de partÍculas submÍcron amorfas, e , composiÇço farmacÊutica
WO2008013785A2 (en) * 2006-07-24 2008-01-31 Singh-Broemer And Company, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
US20100260691A1 (en) * 2006-07-31 2010-10-14 Narayanan Kolazi S Aqueous compositions containing a hydrophobic material
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
CN101605533B (zh) * 2007-02-09 2012-04-18 阿斯利康(瑞典)有限公司 制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
TW200920347A (en) * 2007-07-16 2009-05-16 Poniard Pharmaceuticals Inc Oral formulations for picoplatin
EP2249644A4 (de) * 2008-02-08 2012-05-30 Poniard Pharmaceuticals Inc Picoplatin und amrubicin zur behandlung von lungenkrebs
BRPI1004808B1 (pt) * 2010-10-27 2020-09-29 Embrapa - Empresa Brasileira De Pesquisa Agropecuária Composições baseadas em nanopartículas de própolis, processos de obtenção e uso
CN104487075A (zh) 2012-02-29 2015-04-01 普马特里克斯公司 可吸入干粉剂
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
PT106738B (pt) * 2013-01-09 2015-06-08 Hovione Farmaciencia Sa Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico
JP2016507542A (ja) * 2013-02-08 2016-03-10 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 反応型噴霧乾燥による無機／有機複合材料の製造
WO2019055525A1 (en) * 2017-09-12 2019-03-21 Raj Selvaraj FORMULATION OF SOLID NANOPARTICLES OF WATER-INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD CURING
JP2024530045A (ja) 2021-11-05 2024-08-14 シンクルス・ファーマ・ホールディング・アクチエボラグ リナプラザングルレート塩酸塩の多形

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Also Published As

Publication number Publication date
IL160103A (en) 2008-11-26
JP4714412B2 (ja) 2011-06-29
CN1564677A (zh) 2005-01-12
JP2005500362A (ja) 2005-01-06
PT1416917E (pt) 2007-08-16
DK1416917T3 (da) 2007-09-17
ES2287293T3 (es) 2007-12-16
CA2456180C (en) 2011-10-11
MXPA04001071A (es) 2004-05-20
EP1416917A1 (de) 2004-05-12
ATE365537T1 (de) 2007-07-15
NO20040484L (no) 2004-03-31
WO2003013472A1 (en) 2003-02-20
KR100914113B1 (ko) 2009-08-27
KR20040025739A (ko) 2004-03-25
DE60220923T2 (de) 2008-03-06
HK1064048A1 (en) 2005-01-21
CA2456180A1 (en) 2003-02-20
CN1254233C (zh) 2006-05-03
AU2002317409B2 (en) 2007-06-21
CY1107059T1 (el) 2012-10-24
US20050009908A1 (en) 2005-01-13
BR0211705A (pt) 2004-09-28
EP1416917B1 (de) 2007-06-27
NZ530916A (en) 2005-07-29
IL160103A0 (en) 2004-06-20

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