ATE365537T1 - Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct) - Google Patents

Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct)

Info

Publication number
ATE365537T1
ATE365537T1 AT02745697T AT02745697T ATE365537T1 AT E365537 T1 ATE365537 T1 AT E365537T1 AT 02745697 T AT02745697 T AT 02745697T AT 02745697 T AT02745697 T AT 02745697T AT E365537 T1 ATE365537 T1 AT E365537T1
Authority
AT
Austria
Prior art keywords
water
medium
mct
excipient
active substance
Prior art date
Application number
AT02745697T
Other languages
English (en)
Inventor
Pia Skantze
Tommy Skantze
Corswant Lars Von
Schantz Anna Zzackrisson
Per Lindfors
Ulf Olsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0119081A external-priority patent/GB0119081D0/en
Priority claimed from GB0212463A external-priority patent/GB0212463D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE365537T1 publication Critical patent/ATE365537T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02745697T 2001-08-06 2002-08-01 Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct) ATE365537T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0119081A GB0119081D0 (en) 2001-08-06 2001-08-06 Process
GB0212463A GB0212463D0 (en) 2002-05-30 2002-05-30 Process

Publications (1)

Publication Number Publication Date
ATE365537T1 true ATE365537T1 (de) 2007-07-15

Family

ID=26246405

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02745697T ATE365537T1 (de) 2001-08-06 2002-08-01 Wässrige dispersion stabiler nanopartikel eines wasserunlöslichen wirkstoffs und ein hilfsstoff wie mittelkettige triglyceride (mct)

Country Status (20)

Country Link
US (1) US20050009908A1 (de)
EP (1) EP1416917B1 (de)
JP (1) JP4714412B2 (de)
KR (1) KR100914113B1 (de)
CN (1) CN1254233C (de)
AT (1) ATE365537T1 (de)
AU (1) AU2002317409B2 (de)
BR (1) BR0211705A (de)
CA (1) CA2456180C (de)
CY (1) CY1107059T1 (de)
DE (1) DE60220923T2 (de)
DK (1) DK1416917T3 (de)
ES (1) ES2287293T3 (de)
HK (1) HK1064048A1 (de)
IL (2) IL160103A0 (de)
MX (1) MXPA04001071A (de)
NO (1) NO20040484L (de)
NZ (1) NZ530916A (de)
PT (1) PT1416917E (de)
WO (1) WO2003013472A1 (de)

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GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0230087D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
US20060135523A1 (en) * 2003-06-18 2006-06-22 Astrazeneca Ab 2-substituted 5,6-diaryl-pyrazine derivatives as cb1 modulator
GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314261D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
US20060159767A1 (en) * 2004-12-22 2006-07-20 Elan Pharma International Limited Nanoparticulate bicalutamide formulations
EP1915131A4 (de) * 2005-08-12 2012-07-25 Astrazeneca Ab Verfahren
WO2008013785A2 (en) 2006-07-24 2008-01-31 Singh-Broemer And Company, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
US20100260691A1 (en) * 2006-07-31 2010-10-14 Narayanan Kolazi S Aqueous compositions containing a hydrophobic material
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
JP2010517759A (ja) * 2007-02-09 2010-05-27 アストラゼネカ・アクチエボラーグ 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
JP2010533714A (ja) * 2007-07-16 2010-10-28 ポニアード ファーマシューティカルズ， インコーポレイテッド ピコプラチンのための経口製剤
CN102014624A (zh) * 2008-02-08 2011-04-13 帕纳德制药公司 治疗肺癌的吡铂和氨柔比星
BRPI1004808B1 (pt) * 2010-10-27 2020-09-29 Embrapa - Empresa Brasileira De Pesquisa Agropecuária Composições baseadas em nanopartículas de própolis, processos de obtenção e uso
NZ629722A (en) 2012-02-29 2017-03-31 Pulmatrix Operating Co Inc Inhalable dry powders
KR102045732B1 (ko) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 온도감응형 계면활성제를 이용한 수용성 나노입자의 제조방법
PT106738B (pt) 2013-01-09 2015-06-08 Hovione Farmaciencia Sa Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico
WO2014122077A1 (de) * 2013-02-08 2014-08-14 Basf Se Herstellung von anorganisch-organischen kompositmaterialien durch reaktive sprühtrocknung
WO2019055525A1 (en) * 2017-09-12 2019-03-21 Raj Selvaraj FORMULATION OF SOLID NANOPARTICLES OF WATER-INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD CURING
JP2024530045A (ja) 2021-11-05 2024-08-14 シンクルス・ファーマ・ホールディング・アクチエボラグ リナプラザングルレート塩酸塩の多形

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GB0216700D0 (en) * 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations

Also Published As

Publication number Publication date
CY1107059T1 (el) 2012-10-24
JP2005500362A (ja) 2005-01-06
DE60220923T2 (de) 2008-03-06
HK1064048A1 (en) 2005-01-21
KR100914113B1 (ko) 2009-08-27
PT1416917E (pt) 2007-08-16
CA2456180C (en) 2011-10-11
IL160103A0 (en) 2004-06-20
ES2287293T3 (es) 2007-12-16
CN1254233C (zh) 2006-05-03
NZ530916A (en) 2005-07-29
DE60220923D1 (de) 2007-08-09
US20050009908A1 (en) 2005-01-13
WO2003013472A1 (en) 2003-02-20
BR0211705A (pt) 2004-09-28
MXPA04001071A (es) 2004-05-20
EP1416917B1 (de) 2007-06-27
JP4714412B2 (ja) 2011-06-29
DK1416917T3 (da) 2007-09-17
KR20040025739A (ko) 2004-03-25
NO20040484L (no) 2004-03-31
EP1416917A1 (de) 2004-05-12
AU2002317409B2 (en) 2007-06-21
CN1564677A (zh) 2005-01-12
IL160103A (en) 2008-11-26
CA2456180A1 (en) 2003-02-20

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