HK1057373A1 - Substituted triazole diamine derivatives as kinaseinhibitors - Google Patents
Substituted triazole diamine derivatives as kinaseinhibitorsInfo
- Publication number
- HK1057373A1 HK1057373A1 HK04100258A HK04100258A HK1057373A1 HK 1057373 A1 HK1057373 A1 HK 1057373A1 HK 04100258 A HK04100258 A HK 04100258A HK 04100258 A HK04100258 A HK 04100258A HK 1057373 A1 HK1057373 A1 HK 1057373A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kinaseinhibitors
- substituted triazole
- diamine derivatives
- kinase
- triazole diamine
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- -1 triazole diamine Chemical class 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 229940127263 dual kinase inhibitor Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25770300P | 2000-12-22 | 2000-12-22 | |
| PCT/US2001/050559 WO2002057240A1 (en) | 2000-12-22 | 2001-12-21 | Substituted triazole diamine derivatives as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1057373A1 true HK1057373A1 (en) | 2004-04-02 |
Family
ID=22977396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK04100258A HK1057373A1 (en) | 2000-12-22 | 2004-01-14 | Substituted triazole diamine derivatives as kinaseinhibitors |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6924302B2 (sk) |
| EP (1) | EP1355889B1 (sk) |
| CN (1) | CN100357278C (sk) |
| AT (1) | ATE328874T1 (sk) |
| BG (2) | BG107959A (sk) |
| BR (1) | BR0116792A (sk) |
| CA (1) | CA2432870A1 (sk) |
| CZ (1) | CZ20031941A3 (sk) |
| DE (1) | DE60120494T2 (sk) |
| DK (1) | DK1355889T3 (sk) |
| ES (1) | ES2266313T3 (sk) |
| HK (1) | HK1057373A1 (sk) |
| HU (1) | HUP0303868A3 (sk) |
| IL (1) | IL156584A0 (sk) |
| MX (1) | MXPA03005777A (sk) |
| NO (1) | NO20032848L (sk) |
| NZ (1) | NZ526624A (sk) |
| PL (1) | PL363316A1 (sk) |
| PT (1) | PT1355889E (sk) |
| RU (1) | RU2274639C2 (sk) |
| SK (1) | SK9062003A3 (sk) |
| WO (1) | WO2002057240A1 (sk) |
| YU (1) | YU51803A (sk) |
| ZA (1) | ZA200305619B (sk) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4483581B2 (ja) * | 2002-08-06 | 2010-06-16 | 東レ株式会社 | 腎疾患治療又は予防剤及び腎疾患の診断方法 |
| CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
| US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
| MXPA05012275A (es) | 2003-05-13 | 2006-02-10 | Depuy Spine Inc | Un metodo para tratar enfermedad degenerativa del disco. |
| US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
| US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
| US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| US8361467B2 (en) | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
| EP1663211B1 (en) | 2003-08-06 | 2010-01-20 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| DE10356579A1 (de) * | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
| US20090270456A1 (en) * | 2004-01-09 | 2009-10-29 | Masaichi Hasegawa | Novel chemical compounds |
| AU2005209231B8 (en) | 2004-01-21 | 2011-07-28 | Emory University | Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection |
| EA200601441A1 (ru) * | 2004-02-11 | 2007-02-27 | Янссен Фармацевтика Н.В. | Способ получения соединений замещённого триазола |
| EA200700818A1 (ru) * | 2004-10-08 | 2007-08-31 | Янссен Фармацевтика, Н.В. | Производные 1,2,4-триазолиламиноарил(гетероарил)сульфонамидов |
| ES2352453T3 (es) * | 2004-10-21 | 2011-02-18 | Vertex Pharmaceuticals Incorporated | Triazoles útiles como inhibidores de proteínas quinasas. |
| DE102004055998A1 (de) | 2004-11-19 | 2006-05-24 | Rheinische Friedrich-Wilhelms-Universität Bonn | Niedermolekulare Inhibitoren von Guaninnucleotid-Austauschfaktoren der Cytohesin-Familie |
| JP5475235B2 (ja) | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| CA2621503C (en) * | 2005-09-07 | 2014-05-20 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| EP2045253A4 (en) | 2006-06-29 | 2013-01-23 | Nissan Chemical Ind Ltd | alpha-amino acid derivative and pharmaceutical agent containing it as an active ingredient |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| DE102006054205A1 (de) * | 2006-11-15 | 2008-05-29 | Rheinische Friedrich-Wilhelms Universität | Verwendung von Cytohesin-Inhibitoren zur chemischen Induktion von Langlebigkeit |
| CA2695613A1 (en) | 2006-12-19 | 2008-06-26 | Pharmos Corporation | Sulfonamide derivatives with therapeutic indications |
| WO2008083356A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| ES2672172T3 (es) * | 2006-12-29 | 2018-06-12 | Rigel Pharmaceuticals, Inc. | Triazoles N3-heteroarilsustituidos y triazoles N5-heteroarilsustituidos útiles como inhibidores de Axl |
| ES2460894T3 (es) | 2006-12-29 | 2014-05-14 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con heteroarilo policíclico útiles como inhibidores de Axl |
| ES2404668T3 (es) | 2006-12-29 | 2013-05-28 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl |
| CA2710043C (en) | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| MX2010004177A (es) | 2007-10-18 | 2010-05-03 | Janssen Pharmaceutica Nv | 1,2,4-triazoles trisustituidos. |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| SI2205592T1 (sl) * | 2007-10-26 | 2013-09-30 | Rigel Pharmaceuticals, Inc. | Triazoli substituirani s policikličnim arilom in triazoli substituirani s policikličnim heteroarilom uporabni kot Axl inhibitorji |
| US8986696B2 (en) | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
| MX2010008700A (es) | 2008-02-22 | 2010-08-30 | Hoffmann La Roche | Moduladores de beta-amiloide. |
| AR070936A1 (es) | 2008-03-19 | 2010-05-12 | Janssen Pharmaceutica Nv | 1,2,4 -triazoles trisustituidos |
| AR071763A1 (es) | 2008-05-09 | 2010-07-14 | Janssen Pharmaceutica Nv | Pirazoles trisustituidos, composiciones farmaceuticas que los contienen, y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos |
| WO2010005876A2 (en) | 2008-07-09 | 2010-01-14 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| PT2328888E (pt) | 2008-07-09 | 2013-01-29 | Rigel Pharmaceuticals Inc | Triazóis bicíclicos em ponte substituídos com heteroarilos úteis como inibidores axl |
| AU2009301210B2 (en) | 2008-10-09 | 2014-05-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| MX2011004954A (es) * | 2008-11-10 | 2011-05-30 | Hoffmann La Roche | Moduladores heterociclicos de gamma-secretasa. |
| CA2749843C (en) | 2009-01-16 | 2017-09-05 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| US20140010783A1 (en) * | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
| KR20150105302A (ko) | 2012-11-05 | 2015-09-16 | 난트 홀딩스 아이피, 엘엘씨 | 헤지 호그 신호 경로의 억제제로서 환상 술폰아미드 함유 유도체 |
| BR112015021432A2 (pt) * | 2013-03-05 | 2017-07-18 | Hoffmann La Roche | compostos antivirais |
| RU2015137966A (ru) * | 2013-03-06 | 2017-04-06 | Ф. Хоффманн-Ля Рош Аг | Противовирусные соединения |
| US11040947B2 (en) | 2017-03-22 | 2021-06-22 | The Research Foundation For The State University Of New York | Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors |
| US12110278B2 (en) * | 2020-10-13 | 2024-10-08 | Yale University | Selective JAK2 pseudokinase ligands and methods of use |
| KR20240093844A (ko) * | 2021-10-26 | 2024-06-24 | 바소카데아, 인코포레이티드 | Gpr39 단백질의 길항제 |
| CN114292243B (zh) * | 2022-01-12 | 2023-11-21 | 中山大学 | 一种三唑类衍生物或其药学上可接受的盐及其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2352944A (en) * | 1942-07-04 | 1944-07-04 | Gen Electric | Triazole derivatives |
| NL301383A (sk) | 1962-12-06 | |||
| US4727022A (en) * | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| US5196351A (en) * | 1987-09-30 | 1993-03-23 | Beckman Instruments, Inc. | Bidentate conjugate and method of use thereof |
| US5683867A (en) * | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| ES2315612T3 (es) * | 1991-04-10 | 2009-04-01 | The Scripps Research Institute | Genotecas de receptores heterodimericos usando fagemidos. |
| UA41295C2 (uk) * | 1991-09-02 | 2001-09-17 | Яманугі Фармасетікл Ко., Лтд | Триазолілзаміщені третинні амінні сполуки або їх солі як інгібітор ароматази та фармацевтична композиція на їх основі |
| US5543507A (en) * | 1992-03-05 | 1996-08-06 | Isis Pharmaceuticals, Inc. | Covalently cross-linked oligonucleotides |
| US5362859A (en) * | 1992-07-27 | 1994-11-08 | Sepracor, Inc. | High-capacity affinity supports and methods for the preparation and use of same |
| US5512435A (en) * | 1993-02-05 | 1996-04-30 | Renschler; Markus F. | Receptor-binding antiproliferative peptides |
| WO1995003286A1 (fr) | 1993-07-23 | 1995-02-02 | The Green Cross Corporation | Derive de triazole et son utilisation pharmaceutique |
| US5698401A (en) * | 1995-11-14 | 1997-12-16 | Abbott Laboratories | Use of nuclear magnetic resonance to identify ligands to target biomolecules |
| SK5212000A3 (en) * | 1997-10-27 | 2001-04-09 | Agouron Pharmaceuticals Inc Ag | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
| GB9918180D0 (en) * | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
-
2001
- 2001-12-21 BR BR0116792-8A patent/BR0116792A/pt not_active IP Right Cessation
- 2001-12-21 NZ NZ526624A patent/NZ526624A/en not_active IP Right Cessation
- 2001-12-21 DE DE60120494T patent/DE60120494T2/de not_active Expired - Lifetime
- 2001-12-21 CA CA002432870A patent/CA2432870A1/en not_active Abandoned
- 2001-12-21 ES ES01998116T patent/ES2266313T3/es not_active Expired - Lifetime
- 2001-12-21 EP EP01998116A patent/EP1355889B1/en not_active Expired - Lifetime
- 2001-12-21 HU HU0303868A patent/HUP0303868A3/hu unknown
- 2001-12-21 CN CNB018226450A patent/CN100357278C/zh not_active Expired - Fee Related
- 2001-12-21 WO PCT/US2001/050559 patent/WO2002057240A1/en active IP Right Grant
- 2001-12-21 MX MXPA03005777A patent/MXPA03005777A/es active IP Right Grant
- 2001-12-21 PT PT01998116T patent/PT1355889E/pt unknown
- 2001-12-21 SK SK906-2003A patent/SK9062003A3/sk not_active Application Discontinuation
- 2001-12-21 AT AT01998116T patent/ATE328874T1/de active
- 2001-12-21 US US10/029,750 patent/US6924302B2/en not_active Expired - Lifetime
- 2001-12-21 DK DK01998116T patent/DK1355889T3/da active
- 2001-12-21 RU RU2003118448/04A patent/RU2274639C2/ru not_active IP Right Cessation
- 2001-12-21 YU YU51803A patent/YU51803A/sh unknown
- 2001-12-21 IL IL15658401A patent/IL156584A0/xx unknown
- 2001-12-21 PL PL01363316A patent/PL363316A1/xx not_active Application Discontinuation
- 2001-12-21 CZ CZ20031941A patent/CZ20031941A3/cs unknown
-
2003
- 2003-06-20 NO NO20032848A patent/NO20032848L/no not_active Application Discontinuation
- 2003-07-01 BG BG107959A patent/BG107959A/bg unknown
- 2003-07-08 BG BG107985A patent/BG107985A/bg unknown
- 2003-07-21 ZA ZA200305619A patent/ZA200305619B/en unknown
-
2004
- 2004-01-14 HK HK04100258A patent/HK1057373A1/xx not_active IP Right Cessation
-
2005
- 2005-02-01 US US11/047,800 patent/US7317031B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT1355889E (pt) | 2006-09-29 |
| ES2266313T3 (es) | 2007-03-01 |
| DK1355889T3 (da) | 2006-10-09 |
| CA2432870A1 (en) | 2002-07-25 |
| NO20032848D0 (no) | 2003-06-20 |
| BG107985A (bg) | 2004-11-30 |
| DE60120494T2 (de) | 2006-12-21 |
| HUP0303868A3 (en) | 2008-03-28 |
| NO20032848L (no) | 2003-08-20 |
| DE60120494D1 (de) | 2006-07-20 |
| YU51803A (sh) | 2006-05-25 |
| US6924302B2 (en) | 2005-08-02 |
| CZ20031941A3 (cs) | 2004-08-18 |
| US20050182116A1 (en) | 2005-08-18 |
| US20040077699A1 (en) | 2004-04-22 |
| RU2274639C2 (ru) | 2006-04-20 |
| SK9062003A3 (en) | 2004-04-06 |
| CN1575284A (zh) | 2005-02-02 |
| BR0116792A (pt) | 2004-02-17 |
| US7317031B2 (en) | 2008-01-08 |
| WO2002057240A1 (en) | 2002-07-25 |
| EP1355889B1 (en) | 2006-06-07 |
| RU2003118448A (ru) | 2005-01-27 |
| MXPA03005777A (es) | 2005-02-14 |
| HUP0303868A2 (hu) | 2004-03-01 |
| NZ526624A (en) | 2005-07-29 |
| IL156584A0 (en) | 2004-01-04 |
| EP1355889A1 (en) | 2003-10-29 |
| ATE328874T1 (de) | 2006-06-15 |
| ZA200305619B (en) | 2004-10-21 |
| CN100357278C (zh) | 2007-12-26 |
| PL363316A1 (en) | 2004-11-15 |
| BG107959A (bg) | 2004-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1057373A1 (en) | Substituted triazole diamine derivatives as kinaseinhibitors | |
| IL147618A0 (en) | Method for treating chronic pain using mek inhibitors | |
| HK1055956A1 (en) | Macroheterocylic compounds useful as kinase inhibitors | |
| WO2001005391A3 (en) | Method for treating chronic pain using mek inhibitors | |
| ZA200202985B (en) | Tyrosine kinase inhibitors. | |
| CY1117951T1 (el) | Αναστολεiς κινασης υποκατεστημενης τριαζινης | |
| HK1040705A1 (en) | Substituted pyrazoles as p38 kinase inhibitors. | |
| IL141388A0 (en) | 4-amino substituted-2- substituted 1,2,3,4- tetrahydroquinolines as cetp inhibitors | |
| HK1035183A1 (en) | New hydroxyindoles, their use as phosphodiesterase4 inhibitors and method for producing same. | |
| MXPA03008690A (es) | Inhibidores novedosos de tirosina cinasa. | |
| IL139080A0 (en) | Btx inhibitors and methods for their indentification and use | |
| MXPA03009847A (es) | Inhibidores de cinasa derivados de pirazol. | |
| WO2001005392A3 (en) | Method for treating chronic pain using mek inhibitors | |
| MXPA03008853A (es) | Antagonistas de ccr5 utiles para el tratamiento del sida. | |
| GB0011358D0 (en) | Novel use | |
| HUP0303034A3 (en) | Novel 7-azaindole-derivatives, use thereof as phosphodiesterase 4 inhibitors and method for producing the same | |
| MXPA03001717A (es) | METODO PARA EL TRATAMIENTO DE LA MIGRAnA. | |
| NO20015062L (no) | Substituerte 3-cyano-[1.7],[1.5]og[1.8]-naftyridin- inhibitorer for tyrosin-kinaser | |
| IL152097A0 (en) | Use of pyrazole derivatives for treating infertility | |
| ZA200307306B (en) | Indolines, substituted in portion 6, and their use as kinase inhibitors. | |
| MXPA02012907A (es) | Procedimiento para encontrar compuestos que son adecuados para el tratamiento y/o la profilaxia de la obesidad. | |
| MXPA03001962A (es) | Metodo para tratar alergias utilizando pirazoles sustituidos. | |
| MXPA03006607A (es) | Metodo combinado para tratar trastornos dependientes de hormonas. | |
| MXPA03001484A (es) | Quinazolinas, medicamentos que contienen estos compuestos, y son efectivos como inhbidores de tirosina quinasa, su utilizacion y metodos para su produccion. | |
| AU5576601A (en) | Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20091221 |