HK1039938A1 - 用作cetp抑制剂的4-氨基取代的-2-取代的-1，2，3，4-四氢喹啉 - Google Patents

用作cetp抑制剂的4-氨基取代的-2-取代的-1，2，3，4-四氢喹啉 Download PDF

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Publication number
HK1039938A1
HK1039938A1 HK02101447.5A HK02101447A HK1039938A1 HK 1039938 A1 HK1039938 A1 HK 1039938A1 HK 02101447 A HK02101447 A HK 02101447A HK 1039938 A1 HK1039938 A1 HK 1039938A1
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Hong Kong
Prior art keywords
optionally
substituted
alkyl
mono
trifluoromethyl
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HK02101447.5A
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English (en)
Chinese (zh)
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M‧P‧德尼诺
M‧P‧德尼諾
G‧T‧马格努斯-阿伊特
R‧B‧鲁格里
G‧T‧馬格努斯-阿伊特
R‧T‧韦斯特
R‧B‧魯格裏
R‧T‧韋斯特
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辉瑞产品公司
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Publication of HK1039938A1 publication Critical patent/HK1039938A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK02101447.5A 1998-09-17 1999-09-10 用作cetp抑制剂的4-氨基取代的-2-取代的-1，2，3，4-四氢喹啉 HK1039938A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10092798P 1998-09-17 1998-09-17
US60/100,927 1998-09-17
PCT/IB1999/001534 WO2000017165A1 (en) 1998-09-17 1999-09-10 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors

Publications (1)

Publication Number Publication Date
HK1039938A1 true HK1039938A1 (zh) 2002-05-17

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HK02101447.5A HK1039938A1 (zh) 1998-09-17 1999-09-10 用作cetp抑制剂的4-氨基取代的-2-取代的-1，2，3，4-四氢喹啉

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US (2) US6140343A (enExample)
EP (1) EP1114032B1 (enExample)
JP (1) JP3561474B2 (enExample)
KR (1) KR100422286B1 (enExample)
CN (2) CN1318057A (enExample)
AP (1) AP1345A (enExample)
AR (1) AR030523A1 (enExample)
AT (1) ATE268324T1 (enExample)
AU (1) AU747715B2 (enExample)
BG (1) BG65101B1 (enExample)
BR (1) BR9913855A (enExample)
CA (1) CA2344248C (enExample)
CO (1) CO5290250A1 (enExample)
CR (1) CR6306A (enExample)
CU (1) CU23053A3 (enExample)
CZ (1) CZ2001954A3 (enExample)
DE (1) DE69917790T2 (enExample)
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EA (1) EA005761B1 (enExample)
EE (1) EE200100167A (enExample)
ES (1) ES2221420T3 (enExample)
GC (1) GC0000108A (enExample)
GE (1) GEP20032973B (enExample)
GT (1) GT199900147A (enExample)
HK (1) HK1039938A1 (enExample)
HR (1) HRP20010200B1 (enExample)
HU (1) HUP0103512A3 (enExample)
ID (1) ID27838A (enExample)
IL (1) IL141388A0 (enExample)
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MA (1) MA26689A1 (enExample)
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PE (1) PE20001054A1 (enExample)
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PT (1) PT1114032E (enExample)
SI (1) SI1114032T1 (enExample)
SK (1) SK3532001A3 (enExample)
SV (1) SV1999000150A (enExample)
TN (1) TNSN99170A1 (enExample)
TR (1) TR200100780T2 (enExample)
TW (1) TW502022B (enExample)
UA (1) UA70960C2 (enExample)
WO (1) WO2000017165A1 (enExample)
YU (1) YU18101A (enExample)
ZA (1) ZA200101745B (enExample)

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