HK1025517A1 - The use of quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of helicobacter pylori infections and the associated gastroduodenal diseases - Google Patents

The use of quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of helicobacter pylori infections and the associated gastroduodenal diseases

Info

Publication number
HK1025517A1
HK1025517A1 HK00104882A HK00104882A HK1025517A1 HK 1025517 A1 HK1025517 A1 HK 1025517A1 HK 00104882 A HK00104882 A HK 00104882A HK 00104882 A HK00104882 A HK 00104882A HK 1025517 A1 HK1025517 A1 HK 1025517A1
Authority
HK
Hong Kong
Prior art keywords
carboxylic acid
helicobacter pylori
treatment
pct
pylori infections
Prior art date
Application number
HK00104882A
Other languages
English (en)
Inventor
Michael Matzke
Petersen Uwe
Jaetsch Thomas
Bartel Stephan
Schenke Thomas
Himmler Thomas
Baasner Bernd
Werling Hans-Otto
Schaller Klaus
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of HK1025517A1 publication Critical patent/HK1025517A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK00104882A 1996-12-16 2000-08-04 The use of quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of helicobacter pylori infections and the associated gastroduodenal diseases HK1025517A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19652239A DE19652239A1 (de) 1996-12-16 1996-12-16 Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
PCT/EP1997/006781 WO1998026779A1 (de) 1996-12-16 1997-12-04 Verwendung von 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen

Publications (1)

Publication Number Publication Date
HK1025517A1 true HK1025517A1 (en) 2000-11-17

Family

ID=7814837

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00104882A HK1025517A1 (en) 1996-12-16 2000-08-04 The use of quinolone carboxylic acid and naphthyridon carboxylic acid derivatives for the treatment of helicobacter pylori infections and the associated gastroduodenal diseases

Country Status (28)

Country Link
US (2) US6133260A (ko)
EP (1) EP0946176B1 (ko)
JP (3) JP3463939B2 (ko)
KR (1) KR100536153B1 (ko)
CN (1) CN100335054C (ko)
AT (1) ATE214929T1 (ko)
AU (1) AU717751B2 (ko)
BG (1) BG64615B1 (ko)
BR (1) BR9714032A (ko)
CA (1) CA2274894C (ko)
CZ (2) CZ297364B6 (ko)
DE (2) DE19652239A1 (ko)
DK (1) DK0946176T3 (ko)
EA (1) EA002477B1 (ko)
EE (1) EE04090B1 (ko)
ES (1) ES2175519T3 (ko)
HK (1) HK1025517A1 (ko)
HU (1) HU226523B1 (ko)
IL (1) IL130311A (ko)
NO (1) NO325617B1 (ko)
NZ (2) NZ336228A (ko)
PL (1) PL191193B1 (ko)
PT (1) PT946176E (ko)
RS (1) RS49684B (ko)
SK (2) SK283223B6 (ko)
TR (1) TR199901754T2 (ko)
UA (1) UA57055C2 (ko)
WO (1) WO1998026779A1 (ko)

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DE19633805A1 (de) * 1996-02-23 1997-08-28 Bayer Ag Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
ES2203254T3 (es) * 1998-11-18 2004-04-01 Asahi Glass Company Ltd. Derivados de acido aminoacrilico y procedimiento de produccion correspondiente.
DE19917617A1 (de) * 1999-04-19 2000-10-26 Bayer Ag -(-)Enantiomeres des 2-[2-(1-Chlor-cyclopropyl)-3-(2-chlorphenyl) 2-hydroxy-propyl]-2,4-dihydro-[1,2,4]-triazol-3-thions
US6858625B1 (en) * 1999-07-01 2005-02-22 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or salts thereof
JP4803935B2 (ja) * 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
EP1560584B1 (en) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab i inhibitors
DK1575951T3 (da) * 2002-12-06 2014-09-15 Debiopharm Int Sa Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
JP4880448B2 (ja) 2003-03-17 2012-02-22 アフィナム ファーマシューティカルズ，インコーポレーテッド 複数の抗生物質を含む組成物、及びそれを用いる方法
ES2402420T3 (es) 2003-09-29 2013-05-03 Daiichi Sankyo Company, Limited Derivado del ácido 8-cianoquinolonacarboxílico
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
WO2007053131A2 (en) 2004-06-04 2007-05-10 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as antibiotic agents
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
CA2658506C (en) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
AU2010266120B2 (en) * 2009-07-02 2014-02-06 Curofin Pharma Gmbh Compositions comprising finafloxacin and methods for treating ophthalmic, otic, or nasal infections
RU2449805C1 (ru) 2011-01-27 2012-05-10 Общество С Ограниченной Ответственностью "Гармония" Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования
KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
US20150045739A1 (en) 2013-08-12 2015-02-12 Novartis Ag Method for treating otic infections after tympanostomy tube placement
DE102014115951A1 (de) 2014-11-03 2016-05-04 Merlion Pharmaceuticals Pte Ltd. Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de) 2015-01-06 2016-07-07 Merlion Pharmaceuticals Pte Ltd. Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
CN107987074B (zh) * 2017-10-27 2020-12-29 浙江美诺华药物化学有限公司 一种普拉沙星的合成方法
CN111989314B (zh) 2018-04-25 2024-04-30 拜耳动物保健有限责任公司 喹诺酮甲酸酯水解的方法

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Also Published As

Publication number Publication date
IL130311A (en) 2004-01-04
HUP0000450A3 (en) 2001-02-28
ATE214929T1 (de) 2002-04-15
ES2175519T3 (es) 2002-11-16
JP2009235106A (ja) 2009-10-15
JP2000514825A (ja) 2000-11-07
EA002477B1 (ru) 2002-06-27
HU226523B1 (en) 2009-03-30
JP2000351781A (ja) 2000-12-19
PL191193B1 (pl) 2006-03-31
SK14962000A3 (sk) 2003-01-09
NO992903L (no) 1999-06-14
NO992903D0 (no) 1999-06-14
CA2274894A1 (en) 1998-06-25
BG64615B1 (bg) 2005-09-30
RS49684B (sr) 2007-11-15
TR199901754T2 (xx) 1999-09-21
BR9714032A (pt) 2000-05-09
KR20000069483A (ko) 2000-11-25
IL130311A0 (en) 2000-06-01
CN1245428A (zh) 2000-02-23
CN100335054C (zh) 2007-09-05
JP5112395B2 (ja) 2013-01-09
DE19652239A1 (de) 1998-06-18
AU717751B2 (en) 2000-03-30
PL333928A1 (en) 2000-01-31
HUP0000450A2 (hu) 2000-10-28
JP4463380B2 (ja) 2010-05-19
EP0946176B1 (de) 2002-03-27
CZ297363B6 (cs) 2006-11-15
SK283224B6 (sk) 2003-03-04
NZ506162A (en) 2001-06-29
CZ216899A3 (cs) 2000-02-16
CZ297364B6 (cs) 2006-11-15
US6432948B1 (en) 2002-08-13
AU5854198A (en) 1998-07-15
DK0946176T3 (da) 2002-06-10
WO1998026779A1 (de) 1998-06-25
EE9900248A (et) 1999-12-15
NZ336228A (en) 2000-12-22
JP3463939B2 (ja) 2003-11-05
SK79599A3 (en) 2001-01-18
UA57055C2 (uk) 2003-06-16
EP0946176A1 (de) 1999-10-06
YU27499A (sh) 2002-10-18
KR100536153B1 (ko) 2005-12-14
PT946176E (pt) 2002-08-30
SK283223B6 (sk) 2003-03-04
US6133260A (en) 2000-10-17
BG103474A (en) 2000-01-31
EE04090B1 (et) 2003-08-15
DE59706808D1 (de) 2002-05-02
EA199900526A1 (ru) 2000-08-28
CA2274894C (en) 2009-04-07
NO325617B1 (no) 2008-06-30

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Effective date: 20171203