GT201500293A - Composiciones de arni contra el componente c5 del complemento y métodos para su uso - Google Patents

Composiciones de arni contra el componente c5 del complemento y métodos para su uso

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Publication number
GT201500293A
GT201500293A GT201500293A GT201500293A GT201500293A GT 201500293 A GT201500293 A GT 201500293A GT 201500293 A GT201500293 A GT 201500293A GT 201500293 A GT201500293 A GT 201500293A GT 201500293 A GT201500293 A GT 201500293A
Authority
GT
Guatemala
Prior art keywords
arni
complement
methods
component
compositions against
Prior art date
Application number
GT201500293A
Other languages
English (en)
Spanish (es)
Inventor
Kevin Fitzgerald
James Butler
Brian Bettencourt
Anna Borodovsky
Satyanarayana Kuchimanchi
Klaus Charisse
Muthiah Manoharan
Martin Maier
Kallanthottathil G Rajeev
Donald Foster
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of GT201500293A publication Critical patent/GT201500293A/es

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N2310/00Structure or type of the nucleic acid
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GT201500293A 2013-03-14 2015-09-14 Composiciones de arni contra el componente c5 del complemento y métodos para su uso GT201500293A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361782531P 2013-03-14 2013-03-14
US201361837399P 2013-06-20 2013-06-20
US201361904579P 2013-11-15 2013-11-15
US201361912777P 2013-12-06 2013-12-06
US201461942367P 2014-02-20 2014-02-20

Publications (1)

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GT201500293A true GT201500293A (es) 2018-12-18

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EP (3) EP3312281A3 (enExample)
JP (5) JP6524060B2 (enExample)
KR (4) KR102342916B1 (enExample)
CN (3) CN105324485B (enExample)
AU (4) AU2014244116B9 (enExample)
BR (1) BR112015022876B1 (enExample)
CA (2) CA2904654C (enExample)
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DO (1) DOP2015000234A (enExample)
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US9879266B2 (en) 2002-11-14 2018-01-30 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
US9228186B2 (en) 2002-11-14 2016-01-05 Thermo Fisher Scientific Inc. Methods and compositions for selecting siRNA of improved functionality
SI3366775T2 (sl) 2011-11-18 2025-12-31 Alnylam Pharmaceuticals, Inc. Modificirana sredstva RNAI
CN105324485B (zh) 2013-03-14 2021-11-23 阿尔尼拉姆医药品有限公司 补体组分C5 iRNA组合物及其使用方法
JP6505079B2 (ja) 2013-03-29 2019-04-24 アレクシオン ファーマシューティカルズ, インコーポレイテッド 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法
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