GT199900056A - Nuevas dihidropirimidinas - Google Patents

Nuevas dihidropirimidinas

Info

Publication number
GT199900056A
GT199900056A GT199900056A GT199900056A GT199900056A GT 199900056 A GT199900056 A GT 199900056A GT 199900056 A GT199900056 A GT 199900056A GT 199900056 A GT199900056 A GT 199900056A GT 199900056 A GT199900056 A GT 199900056A
Authority
GT
Guatemala
Prior art keywords
dihydropyrimidines
new
new dihydropyrimidines
irmulas
precisely
Prior art date
Application number
GT199900056A
Other languages
English (en)
Spanish (es)
Inventor
Joern Stoelting
Juergen Stoltefub
Siegfried Goldmann
Thomas Dr Kraemer
Karl-Heinz Dr Schlemer
Ulrich Niewhoener
Arnold Dr Paebens
Erwin Dr Graef
Stefan Dr Lottmann
Olaf Weber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199900056A publication Critical patent/GT199900056A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
GT199900056A 1998-04-18 1999-04-16 Nuevas dihidropirimidinas GT199900056A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19817264A DE19817264A1 (de) 1998-04-18 1998-04-18 Neue Dihydropyrimidine

Publications (1)

Publication Number Publication Date
GT199900056A true GT199900056A (es) 2000-10-07

Family

ID=7864972

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199900056A GT199900056A (es) 1998-04-18 1999-04-16 Nuevas dihidropirimidinas

Country Status (37)

Country Link
US (3) US6696451B1 (US07714131-20100511-C00006.png)
EP (1) EP1080086B1 (US07714131-20100511-C00006.png)
JP (2) JP4590097B2 (US07714131-20100511-C00006.png)
KR (1) KR100636771B1 (US07714131-20100511-C00006.png)
CN (1) CN1159311C (US07714131-20100511-C00006.png)
AR (1) AR018187A1 (US07714131-20100511-C00006.png)
AT (1) ATE223401T1 (US07714131-20100511-C00006.png)
AU (1) AU740318B2 (US07714131-20100511-C00006.png)
BG (1) BG64649B1 (US07714131-20100511-C00006.png)
BR (2) BR9909730B1 (US07714131-20100511-C00006.png)
CA (1) CA2328780C (US07714131-20100511-C00006.png)
CO (1) CO5021127A1 (US07714131-20100511-C00006.png)
CU (1) CU23049A3 (US07714131-20100511-C00006.png)
CZ (1) CZ293482B6 (US07714131-20100511-C00006.png)
DE (2) DE19817264A1 (US07714131-20100511-C00006.png)
DK (1) DK1080086T3 (US07714131-20100511-C00006.png)
ES (1) ES2183548T3 (US07714131-20100511-C00006.png)
GT (1) GT199900056A (US07714131-20100511-C00006.png)
HK (1) HK1039119A1 (US07714131-20100511-C00006.png)
HU (1) HUP0102372A3 (US07714131-20100511-C00006.png)
ID (1) ID27263A (US07714131-20100511-C00006.png)
IL (2) IL138584A0 (US07714131-20100511-C00006.png)
MY (1) MY126527A (US07714131-20100511-C00006.png)
NO (2) NO321985B1 (US07714131-20100511-C00006.png)
NZ (1) NZ507569A (US07714131-20100511-C00006.png)
PE (1) PE20000427A1 (US07714131-20100511-C00006.png)
PL (1) PL193898B1 (US07714131-20100511-C00006.png)
PT (1) PT1080086E (US07714131-20100511-C00006.png)
RU (1) RU2245881C9 (US07714131-20100511-C00006.png)
SI (1) SI1080086T1 (US07714131-20100511-C00006.png)
SK (1) SK286407B6 (US07714131-20100511-C00006.png)
SV (1) SV1999000047A (US07714131-20100511-C00006.png)
TR (1) TR200003011T2 (US07714131-20100511-C00006.png)
TW (1) TW548274B (US07714131-20100511-C00006.png)
UA (1) UA63998C2 (US07714131-20100511-C00006.png)
WO (1) WO1999054326A1 (US07714131-20100511-C00006.png)
ZA (1) ZA200005136B (US07714131-20100511-C00006.png)

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AU4289100A (en) * 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
AU5568400A (en) 1999-06-23 2001-01-09 Ajinomoto Co., Inc. Novel dihydropyrimidine derivatives
AU3009801A (en) * 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
DE10012823A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013125A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10125131A1 (de) * 2001-05-23 2002-12-05 Bayer Ag Verfahren zur Spaltung des Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrmidincarboxylat-Racemats
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
CN101104617B (zh) 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101104604B (zh) * 2006-07-10 2011-03-02 北京摩力克科技有限公司 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
RU2452733C2 (ru) * 2007-04-27 2012-06-10 Пэдью Фарма Л.П. Антагонисты trpv1 и их применение
EP2514750B1 (en) * 2007-06-18 2013-11-20 Sunshine Lake Pharma Co., Ltd Bromo-phenyl substituted thiazolyl dihydropyrimidines
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US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
ES2640049T3 (es) 2012-08-24 2017-10-31 Sunshine Lake Pharma Co., Ltd. Derivados de 3,6-dihidropirimidina 2,4,5,6-sustituidos como inhibidores de la polimerasa del virus de la hepatitis B (VHB) para el tratamiento de, por ejemplo, la hepatitis crónica
MA37942B1 (fr) 2012-09-10 2020-01-31 Hoffmann La Roche Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
AU2013342164A1 (en) * 2012-11-09 2015-06-04 Assembly Biosciences, Inc. Alternative uses for HBV assembly effectors
CN117180582A (zh) 2013-03-15 2023-12-08 费雪派克医疗保健有限公司 用于医疗回路的组件
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MY172391A (en) 2013-11-27 2019-11-22 Sunshine Lake Pharma Co Ltd Processes for preparing dihydropyrimidine derivatives and intermediates thereof
MY196243A (en) 2014-03-28 2023-03-24 Sunshine Lake Pharma Co Ltd Dihydropyrimidine Compounds and Their Application In Pharmaceuticals
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BR112016028000B1 (pt) * 2014-05-30 2022-05-17 Qilu Pharmaceutical Co., Ltd Derivado de alça de di-hidropirimido como um inibidor de hbv
CN105859708B (zh) 2015-02-07 2020-01-21 广东东阳光药业有限公司 二氢嘧啶衍生物的盐及其在药物中的应用
AU2018291688B2 (en) * 2017-06-27 2022-02-03 Janssen Pharmaceutica Nv Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections
US10759774B2 (en) 2017-09-28 2020-09-01 The Curators Of The University Of Missouri Inhibitors of hepatitis B virus targeting capsid assembly
KR20200083552A (ko) 2017-11-02 2020-07-08 아이쿠리스 게엠베하 운트 코. 카게 B형 간염 바이러스 (hbv)에 활성인 신규 고활성 피라졸로-피페리딘 치환된 인돌-2-카르복스아미드
JP2021501764A (ja) 2017-11-02 2021-01-21 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト B型肝炎ウイルス(hbv)に対して有効な新規高活性アミノチアゾール置換インドール−2−カルボキサミド
KR20210006412A (ko) * 2018-05-08 2021-01-18 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 디히드로피리미딘 유도체 및 hbv 감염 또는 hbv-유도성 질환의 치료에 있어서의 이의 용도
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
UY38435A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb)
AR116946A1 (es) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
AR117189A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
CA3118339A1 (en) 2018-11-02 2020-05-07 Aicuris Gmbh & Co. Kg Novel urea 6,7-dihydro-4h-thiazolo[5,4-c]pyridines active against the hepatitis b virus (hbv)
AR117188A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb)
UY38436A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
CN113227090A (zh) 2018-12-20 2021-08-06 詹森药业有限公司 杂芳基二氢嘧啶衍生物和治疗乙型肝炎感染的方法
AU2020265392A1 (en) 2019-04-30 2021-12-23 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis B virus (HBV)
SG11202111333UA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
SG11202111236UA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
JP2022533008A (ja) 2019-04-30 2022-07-21 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト B型肝炎ウイルス(hbv)に対し活性な新規のオキサリルピペラジン
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators

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ZA200005136B (en) 2001-03-02
MY126527A (en) 2006-10-31
CZ293482B6 (cs) 2004-05-12
RU2245881C9 (ru) 2006-02-10
RU2245881C2 (ru) 2005-02-10
TW548274B (en) 2003-08-21
US20070117812A1 (en) 2007-05-24
KR100636771B1 (ko) 2006-10-23
WO1999054326A1 (de) 1999-10-28
HUP0102372A3 (en) 2003-01-28
DE59902573D1 (en) 2002-10-10
NO20005215D0 (no) 2000-10-17
CU23049A3 (es) 2005-06-24
UA63998C2 (uk) 2004-02-16
PT1080086E (pt) 2002-12-31
PL343481A1 (en) 2001-08-27
EP1080086B1 (de) 2002-09-04
US6696451B1 (en) 2004-02-24
SK286407B6 (sk) 2008-09-05
AU740318B2 (en) 2001-11-01
NO20045259L (no) 2000-12-13
ES2183548T3 (es) 2003-03-16
AU3813399A (en) 1999-11-08
SK15652000A3 (sk) 2001-04-09
KR20010042788A (ko) 2001-05-25
BG64649B1 (bg) 2005-10-31
JP2010241837A (ja) 2010-10-28
IL138584A0 (en) 2001-10-31
HUP0102372A2 (hu) 2001-12-28
IL138584A (en) 2006-09-05
CZ20003871A3 (cs) 2001-01-17
TR200003011T2 (tr) 2001-01-22
CN1159311C (zh) 2004-07-28
WO1999054326A8 (de) 1999-12-29
BR9909730B1 (pt) 2012-09-04
SI1080086T1 (en) 2003-02-28
BRPI9917862A2 (US07714131-20100511-C00006.png) 2010-12-07
NO321985B1 (no) 2006-07-31
EP1080086A1 (de) 2001-03-07
CA2328780A1 (en) 1999-10-28
DK1080086T3 (da) 2002-12-23
US7514565B2 (en) 2009-04-07
PE20000427A1 (es) 2000-06-25
BRPI9917862B1 (pt) 2013-05-07
JP5237332B2 (ja) 2013-07-17
ATE223401T1 (de) 2002-09-15
US20040167135A1 (en) 2004-08-26
JP2002512243A (ja) 2002-04-23
BRPI9917862B8 (pt) 2021-05-25
AR018187A1 (es) 2001-10-31
BG104812A (en) 2001-06-29
CO5021127A1 (es) 2001-03-27
NZ507569A (en) 2002-04-26
BR9909730A (pt) 2000-12-19
PL193898B1 (pl) 2007-03-30
DE19817264A1 (de) 1999-10-21
NO329020B1 (no) 2010-07-26
SV1999000047A (es) 2000-06-23
NO20005215L (no) 2000-12-13
HK1039119A1 (en) 2002-04-12
ID27263A (id) 2001-03-22
JP4590097B2 (ja) 2010-12-01
CA2328780C (en) 2008-09-23
CN1305471A (zh) 2001-07-25

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