FR2558837B1
(fr)
*
|
1984-01-26 |
1986-06-27 |
Sanofi Sa |
Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
|
IL77243A
(en)
*
|
1984-12-21 |
1996-11-14 |
Procter & Gamble |
Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
|
PH27078A
(en)
*
|
1984-12-21 |
1993-02-01 |
Procter & Gamble |
Pharmaceutical compositions containing geminal diphosphonates
|
US5641762A
(en)
*
|
1985-05-02 |
1997-06-24 |
Research Corporation Technologies, Inc. |
Bone targeted inhibitors of carbonic anhydrase
|
US4761406A
(en)
*
|
1985-06-06 |
1988-08-02 |
The Procter & Gamble Company |
Regimen for treating osteoporosis
|
US4902679A
(en)
*
|
1985-12-13 |
1990-02-20 |
Norwich Eaton Pharmaceuticals, Inc. |
Methods of treating diseases with certain geminal diphosphonates
|
ES2039237T3
(es)
*
|
1986-04-24 |
1993-09-16 |
Fujisawa Pharmaceutical Co., Ltd. |
Procedimiento para preparar nuevos compuestos de acido difosfonico.
|
IL84731A0
(en)
*
|
1986-12-19 |
1988-05-31 |
Norwich Eaton Pharma |
Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
|
KR880011136A
(ko)
*
|
1987-03-11 |
1988-10-26 |
모리오까 시게오 |
아졸- 아미노메틸렌 비스포스폰산 유도체
|
IL86951A
(en)
*
|
1987-07-06 |
1996-07-23 |
Procter & Gamble Pharma |
Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
|
DE3805663A1
(de)
*
|
1988-02-24 |
1989-09-07 |
Henkel Kgaa |
Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
|
CH675422A5
(GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
*
|
1988-03-31 |
1990-09-28 |
Symphar Sa |
|
FR2629716B1
(fr)
*
|
1988-04-07 |
1991-07-19 |
Sanofi Sa |
Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
|
DE3822650A1
(de)
*
|
1988-07-05 |
1990-02-01 |
Boehringer Mannheim Gmbh |
Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
|
RU2091311C1
(ru)
*
|
1988-11-01 |
1997-09-27 |
Арч Дивелопмент Корпорейшн |
Способ извлечения ионов металла
|
US5154843A
(en)
*
|
1989-02-08 |
1992-10-13 |
The Lubrizol Corporation |
Hydroxyalkane phosphonic acids and derivatives thereof and lubricants containing the same
|
PH26923A
(en)
*
|
1989-03-08 |
1992-12-03 |
Ciba Geigy |
N-substituted amino alkanediphosphonic acids
|
US5220021A
(en)
*
|
1989-04-03 |
1993-06-15 |
The Upjohn Company |
Geminal bisphosphonic acids and derivatives as anti-arthritic agents
|
JPH0377894A
(ja)
*
|
1989-08-18 |
1991-04-03 |
Toray Ind Inc |
メチレンジホスホン酸化合物
|
EP0416689B1
(en)
*
|
1989-09-06 |
1995-11-29 |
Merck & Co. Inc. |
Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
|
EP0438375B1
(de)
*
|
1990-01-18 |
1995-12-27 |
Ciba-Geigy Ag |
Phoshponsäure- und Thionophosphonsäure-Derivate
|
IE912115A1
(en)
*
|
1990-06-25 |
1992-01-01 |
Takeda Chemical Industries Ltd |
Bisphosphonic acid derivatives, their production and use
|
WO1992003451A1
(en)
*
|
1990-08-21 |
1992-03-05 |
The Upjohn Company |
Bisphosphonic acid derivatives as anti-arthritic agents
|
WO1992010504A2
(en)
*
|
1990-12-07 |
1992-06-25 |
The Upjohn Company |
Phosphonic acid derivatives useful as antiinflammatory agents
|
EP0491374B1
(en)
*
|
1990-12-19 |
1996-01-31 |
Takeda Chemical Industries, Ltd. |
Bisphosphonic acid derivatives, their production and use
|
IT1244698B
(it)
*
|
1991-02-01 |
1994-08-08 |
Gentili Ist Spa |
Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
|
EP0590009B1
(en)
*
|
1991-06-19 |
1998-03-18 |
PHARMACIA & UPJOHN COMPANY |
Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents
|
EP0521622B1
(en)
*
|
1991-07-03 |
1997-08-13 |
PHARMACIA & UPJOHN COMPANY |
Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories
|
DK0594857T3
(da)
*
|
1991-09-05 |
1998-10-07 |
Toray Industries |
Methandiphosphonsyrederivat, fremstilling deraf ogmedicinsk anvendelse deraf
|
EP0541037A3
(en)
*
|
1991-11-06 |
1997-02-26 |
Takeda Chemical Industries Ltd |
Squalene synthetase inhibitory composition and use thereof
|
JPH06172372A
(ja)
*
|
1991-11-06 |
1994-06-21 |
Takeda Chem Ind Ltd |
スクアレン合成酵素阻害剤およびその用途
|
EP0642521A1
(en)
*
|
1992-05-29 |
1995-03-15 |
Procter & Gamble Pharmaceuticals |
Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
|
EP0646119B1
(en)
*
|
1992-05-29 |
1998-07-15 |
PROCTER & GAMBLE PHARMACEUTICALS, INC. |
Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque
|
US5391743A
(en)
*
|
1992-05-29 |
1995-02-21 |
Procter & Gamble Pharmaceuticals, Inc. |
Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
|
US5753634A
(en)
*
|
1992-05-29 |
1998-05-19 |
The Procter & Gamble Company |
Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
|
US5763611A
(en)
*
|
1992-05-29 |
1998-06-09 |
The Procter & Gamble Company |
Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
|
SG50518A1
(en)
*
|
1992-05-29 |
1998-07-20 |
Procter & Gamble Pharma |
Sulfur-containing phosponate compounds for treating abnormal calcium and phosphate metabolism
|
ES2133402T3
(es)
*
|
1992-06-30 |
1999-09-16 |
Procter & Gamble Pharma |
Composiciones, para el tratamiento de la artritis, que contienen fosfonatos y farmacos anti-inflamatorios no esteroideos.
|
CA2111670A1
(en)
*
|
1992-07-10 |
1994-01-20 |
Norio Kawabe |
A methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals
|
GB9215433D0
(en)
*
|
1992-07-21 |
1992-09-02 |
Cmb Foodcan Plc |
Apparatus for stripping a drawn article from a punch
|
FR2694558B1
(fr)
*
|
1992-08-05 |
1994-10-28 |
Sanofi Elf |
Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
|
ATE157097T1
(de)
*
|
1992-08-07 |
1997-09-15 |
Upjohn Co |
Phosphonoessigsäure und ester als antientzündungsmittel
|
EP0663919A1
(en)
*
|
1992-10-09 |
1995-07-26 |
PHARMACIA & UPJOHN COMPANY |
Pyrimidine bisphosphonate esters as anti-inflamatories
|
JPH06135976A
(ja)
*
|
1992-10-30 |
1994-05-17 |
Toray Ind Inc |
メタンジホスホン酸誘導体、その製造方法およびその医薬用途
|
US5332728A
(en)
*
|
1992-11-23 |
1994-07-26 |
Bristol-Myers Squibb Company |
Method for treating a fungal infection
|
AU670337B2
(en)
|
1992-11-30 |
1996-07-11 |
Novartis Ag |
Use of certain methanebisphosphonic acid derivatives in fracture healing
|
US6399592B1
(en)
|
1992-12-23 |
2002-06-04 |
Merck & Co., Inc. |
Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
|
FI944998L
(fi)
*
|
1993-02-25 |
1994-10-24 |
Toray Industries |
Menetelmä metaanidifosfonihappoyhdisteen valmistamiseksi
|
FR2703590B1
(fr)
*
|
1993-04-05 |
1995-06-30 |
Sanofi Elf |
Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
|
US5854227A
(en)
*
|
1994-03-04 |
1998-12-29 |
Hartmann; John F. |
Therapeutic derivatives of diphosphonates
|
US20010007863A1
(en)
*
|
1998-06-18 |
2001-07-12 |
Merck & Co., Inc. |
Wet granulation formulation for bisphosphonic acids
|
FI961749A0
(fi)
*
|
1994-08-24 |
1996-04-23 |
Toray Industries |
Menetelmä metaanidifosfonihappoyhdisteen valmistamiseksi
|
JPH11511041A
(ja)
|
1995-06-06 |
1999-09-28 |
メルク エンド カンパニー インコーポレーテッド |
整形外科的埋め込み装置の無菌性動揺を防止するビスホスホネートセメント組成物
|
US5880111A
(en)
*
|
1995-06-07 |
1999-03-09 |
Farcasiu; Dan |
Therapeutic derivations of diphosphonates
|
WO1997012619A1
(en)
*
|
1995-09-29 |
1997-04-10 |
Novartis Ag |
Method of treating the navicular disease in horses
|
CA2267984A1
(en)
*
|
1996-10-09 |
1998-04-16 |
Elizanor Biopharmaceuticals, Inc. |
Diphosphonate therapeutic compounds
|
US8586781B2
(en)
|
1998-04-02 |
2013-11-19 |
Mbc Pharma, Inc. |
Bone targeted therapeutics and methods of making and using the same
|
SK286080B6
(sk)
|
1998-09-09 |
2008-03-05 |
Metabasis Therapeutics, Inc. |
Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny
|
FR2784031B1
(fr)
*
|
1998-10-02 |
2002-02-01 |
Sanofi Elf |
Utilisation de derives de l'acide bisphosphonique pour la preparation d'un medicament destine au traitement des boiteries
|
WO2000038693A1
(fr)
*
|
1998-12-25 |
2000-07-06 |
Toray Industries, Inc. |
Inhibiteurs de la production d'interleukine-6
|
US6900282B2
(en)
*
|
1999-07-23 |
2005-05-31 |
The Children's Hospital Of Philadelphia |
Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
|
ATE426628T1
(de)
|
1999-07-23 |
2009-04-15 |
Philadelphia Children Hospital |
Polyurethanderivatzusammensetzungen und verfahren zu ihrer herstellung
|
AR021347A1
(es)
|
1999-10-20 |
2002-07-17 |
Cipla Ltd |
Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
|
AU2583901A
(en)
*
|
1999-12-17 |
2001-06-25 |
Ariad Pharmaceuticals, Inc. |
Proton pump inhibitors
|
IL149887A0
(en)
*
|
1999-12-22 |
2002-11-10 |
Metabasis Therapeutics Inc |
Novel bisamidate phosphonate prodrugs
|
US6677320B2
(en)
|
2000-01-20 |
2004-01-13 |
Hoffmann-La Roches Inc. |
Parenteral bisphosphonate composition with improved local tolerance
|
US7563774B2
(en)
|
2000-06-29 |
2009-07-21 |
Metabasis Therapeutics, Inc. |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
|
CA2443857C
(en)
*
|
2001-04-10 |
2012-06-26 |
Mbc Research, Inc. |
Bisphosphonate conjugates and methods of making and using the same
|
US20060269602A1
(en)
*
|
2001-04-13 |
2006-11-30 |
Dasch James R |
Method of modifying the release profile of sustained release compositions
|
US6558702B2
(en)
|
2001-04-13 |
2003-05-06 |
Alkermes Controlled Therapeutics, Inc. |
Method of modifying the release profile of sustained release compositions
|
TWI315982B
(en)
*
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
TWI349553B
(en)
*
|
2001-12-21 |
2011-10-01 |
Procter & Gamble |
Kit and use of bisphosphonate for treating high bone turnover
|
US20050070504A1
(en)
*
|
2001-12-21 |
2005-03-31 |
The Procter & Gamble Co. |
Risedronate compositions and their methods of use
|
EP1469860A4
(en)
*
|
2002-01-24 |
2005-09-07 |
Yissum Res Dev Co |
ANTICANCER COMBINATION AND USE THEREOF
|
CA2480814A1
(en)
*
|
2002-04-05 |
2003-10-23 |
Merck & Co., Inc. |
Method for inhibiting bone resorption with an alendronate and vitamin d formulation
|
PT1506041E
(pt)
*
|
2002-05-10 |
2007-12-28 |
Hoffmann La Roche |
Ácido ibandrónico para o tratamento e a prevenção da osteoporose
|
AU2003233731A1
(en)
*
|
2002-06-06 |
2003-12-22 |
Xavier Billot |
1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
|
US20040138180A1
(en)
*
|
2002-10-03 |
2004-07-15 |
Barr Laboratories, Inc. |
Bisphosphonate composition and process for the preparation thereof
|
PT1596870E
(pt)
|
2002-12-20 |
2007-10-15 |
Hoffmann La Roche |
Formulação com uma dose elevada de ibandronato
|
US7408014B2
(en)
|
2003-07-08 |
2008-08-05 |
The Children's Hospital Of Philadelphia |
Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
|
CN1839114A
(zh)
|
2003-08-21 |
2006-09-27 |
默克弗罗斯特加拿大有限公司 |
组织蛋白酶半胱氨酸蛋白酶抑制剂
|
AU2004273672A1
(en)
*
|
2003-09-19 |
2005-03-31 |
Wisconsin Alumni Research Foundation |
Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and a bisphosphonate
|
US20050261250A1
(en)
*
|
2004-05-19 |
2005-11-24 |
Merck & Co., Inc., |
Compositions and methods for inhibiting bone resorption
|
CA2566798A1
(en)
|
2004-05-24 |
2005-12-08 |
The Procter & Gamble Company |
Enteric solid oral dosage form of bisphosphonate containing a chelating agent
|
UA87854C2
(en)
|
2004-06-07 |
2009-08-25 |
Мерк Энд Ко., Инк. |
N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
|
WO2006023515A2
(en)
*
|
2004-08-18 |
2006-03-02 |
Metabasis Therapeutics, Inc. |
Novel thiazole inhibitors of fructose 1,6-bisphosphatase
|
US8697139B2
(en)
|
2004-09-21 |
2014-04-15 |
Frank M. Phillips |
Method of intervertebral disc treatment using articular chondrocyte cells
|
AU2006302797B2
(en)
|
2005-03-02 |
2012-02-02 |
Merck Canada Inc. |
Composition for inhibition of cathepsin K
|
WO2006102117A1
(en)
*
|
2005-03-17 |
2006-09-28 |
Elan Pharma International Limited |
Nanoparticulate biphosphonate compositions
|
US7538163B2
(en)
*
|
2005-03-24 |
2009-05-26 |
Medtronic, Inc. |
Modification of thermoplastic polymers
|
BRPI0821090B8
(pt)
|
2007-12-21 |
2021-05-25 |
Ligand Pharm Inc |
moduladores seletivos de receptores de androgênio (sarms) e uso do mesmo
|
EP2324041A4
(en)
|
2008-08-13 |
2012-06-13 |
Targanta Therapeutics Corp |
PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
|
US20120100206A1
(en)
|
2009-06-11 |
2012-04-26 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Targeted liposomes comprising n-containing bisphosphonates and uses thereof
|
FR2954320B1
(fr)
|
2009-12-17 |
2012-06-15 |
Cll Pharma |
Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels
|
US8791162B2
(en)
|
2011-02-14 |
2014-07-29 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
WO2013008240A2
(en)
|
2011-07-13 |
2013-01-17 |
Yissum Research Development Company Of The Hebrew University Ofjerusalem Ltd. |
Liposomes co-encapsulating a bisphosphonate and an amphipathic agent
|
WO2013019874A1
(en)
|
2011-08-01 |
2013-02-07 |
Mbc Pharma, Inc. |
Vitamin b6 derivatives of nucleotides, acyclonucleotides and acyclonucleoside phosphonates
|
GB201200868D0
(en)
|
2012-01-19 |
2012-02-29 |
Depuy Int Ltd |
Bone filler composition
|
WO2015051479A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
CN105593230B
(zh)
|
2013-10-08 |
2018-07-06 |
默沙东公司 |
组织蛋白酶半胱氨酸蛋白酶抑制剂
|
WO2015120580A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Cathepsin cysteine protease inhibitors
|
PL407922A1
(pl)
|
2014-04-16 |
2015-10-26 |
Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością |
Nowe bisfosfoniany i ich zastosowanie
|
BR112016027778A2
(pt)
|
2014-05-30 |
2017-08-15 |
Pfizer |
Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica
|
BR112021020864A2
(pt)
|
2019-04-19 |
2021-12-14 |
Ligand Pharm Inc |
Formas cristalinas e métodos de produção de formas cristalinas de um composto
|
WO2023275715A1
(en)
|
2021-06-30 |
2023-01-05 |
Pfizer Inc. |
Metabolites of selective androgen receptor modulators
|