GEP201706659B - Novel bicyclic pyridinones - Google Patents

Novel bicyclic pyridinones

Info

Publication number
GEP201706659B
GEP201706659B GEAP201313766A GEAP2013013766A GEP201706659B GE P201706659 B GEP201706659 B GE P201706659B GE AP201313766 A GEAP201313766 A GE AP201313766A GE AP2013013766 A GEAP2013013766 A GE AP2013013766A GE P201706659 B GEP201706659 B GE P201706659B
Authority
GE
Georgia
Prior art keywords
novel bicyclic
pyridinones
bicyclic pyridinones
novel
compounds
Prior art date
Application number
GEAP201313766A
Other languages
English (en)
Inventor
Ende Christopher William Am
Michael Eric Green
Scott Johnson Douglas
Gregory Wayne Kauffman
Christopher John O'donnell
Nandini Chaturbhai Patel
Martin Youngjin Pettersson
Antonia Friederike Stepan
Cory Michael Stiff
Chakrapani Subramanyam
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of GEP201706659B publication Critical patent/GEP201706659B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
GEAP201313766A 2012-09-21 2013-09-06 Novel bicyclic pyridinones GEP201706659B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261703969P 2012-09-21 2012-09-21

Publications (1)

Publication Number Publication Date
GEP201706659B true GEP201706659B (en) 2017-04-25

Family

ID=49585452

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201313766A GEP201706659B (en) 2012-09-21 2013-09-06 Novel bicyclic pyridinones

Country Status (46)

Country Link
US (3) US8916564B2 (instruction)
EP (1) EP2897956B1 (instruction)
JP (1) JP5844018B2 (instruction)
KR (1) KR101725696B1 (instruction)
CN (1) CN104662021B (instruction)
AP (1) AP2015008277A0 (instruction)
AR (1) AR092628A1 (instruction)
AU (1) AU2013319845B2 (instruction)
BR (1) BR112015006436A2 (instruction)
CA (1) CA2882386C (instruction)
CL (1) CL2015000717A1 (instruction)
CR (1) CR20150053A (instruction)
CU (1) CU20150021A7 (instruction)
CY (1) CY1118662T1 (instruction)
DK (1) DK2897956T3 (instruction)
DO (1) DOP2015000069A (instruction)
EA (1) EA026668B1 (instruction)
EC (1) ECSP15015594A (instruction)
ES (1) ES2609987T3 (instruction)
GE (1) GEP201706659B (instruction)
GT (1) GT201500069A (instruction)
HR (1) HRP20161558T1 (instruction)
HU (1) HUE031248T2 (instruction)
IL (1) IL237163A (instruction)
IN (1) IN2015DN01119A (instruction)
LT (1) LT2897956T (instruction)
MA (1) MA37886B1 (instruction)
MD (1) MD4583B1 (instruction)
ME (1) ME02571B (instruction)
MX (1) MX360599B (instruction)
MY (1) MY181891A (instruction)
NI (1) NI201500038A (instruction)
NZ (1) NZ704863A (instruction)
PE (1) PE20150686A1 (instruction)
PH (1) PH12015500376B1 (instruction)
PL (1) PL2897956T3 (instruction)
PT (1) PT2897956T (instruction)
RS (1) RS55426B1 (instruction)
SG (1) SG11201501074WA (instruction)
SI (1) SI2897956T1 (instruction)
TN (1) TN2015000084A1 (instruction)
TW (1) TWI500616B (instruction)
UA (1) UA110688C2 (instruction)
UY (1) UY35039A (instruction)
WO (1) WO2014045156A1 (instruction)
ZA (1) ZA201501195B (instruction)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
JP6275161B2 (ja) 2012-12-20 2018-02-07 ヤンセン ファーマシューティカ エヌ．ベー． γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
WO2014111457A1 (en) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
ES2742078T3 (es) * 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
US10562897B2 (en) 2014-01-16 2020-02-18 Janssen Pharmaceutica Nv Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
MX369074B (es) * 2014-04-01 2019-10-28 Pfizer Cromeno y 1,1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de la gamma secretasa.
EA033423B1 (ru) * 2015-02-03 2019-10-31 Pfizer Циклопропанбензофуранилпиридопиразиндионы
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
CN109311876B (zh) 2016-06-16 2022-05-03 豪夫迈·罗氏有限公司 杂芳基雌激素受体调节剂及其用途
US10925872B2 (en) * 2016-12-16 2021-02-23 Pipeline Therapeutics, Inc. Methods of treating cochlear synaptopathy
JP2022504265A (ja) 2018-10-02 2022-01-13 フリークエンシー セラピューティクス インコーポレイテッド 耳治療薬に関する医薬組成物及び方法
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
KR20220007050A (ko) 2019-04-08 2022-01-18 프리퀀시 테라퓨틱스, 인크. 난청을 치료하기 위한 chir99021과 발프로산의 조합
AR120680A1 (es) 2019-12-06 2022-03-09 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
CN113402490B (zh) * 2021-03-29 2023-01-03 白银京宇新药业有限公司 一种1，2，6，7-四氢-8H-茚并[5，4-b]呋喃-8-酮的制备方法
AR126073A1 (es) 2021-06-04 2023-09-06 Vertex Pharma N-(hidroxialquil(hetero)aril)tetrahidrofuran carboxamidas como moduladores de canales de sodio
CN114034792B (zh) * 2021-11-09 2024-06-25 山东新华制药股份有限公司 检测氯酮含量的液相色谱分析方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419789A (en) 1972-08-02 1975-12-31 Pfizer 2-trifluoromethyl-4-quinolinols
WO1992000075A1 (en) 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
NO179904C (no) 1992-09-04 1997-01-08 Takeda Chemical Industries Ltd Kondenserte heterocykliske forbindelser og deres anvendelse
EP0683234B2 (en) 1993-01-25 2007-06-06 Takeda Chemical Industries, Ltd. Antibody against beta-amyloid or their derivative and use thereof
TW394773B (en) 1995-03-24 2000-06-21 Takeda Chemical Industries Ltd Cyclic compounds for antagonizing tachykinin receptor, substance p receptor and neurokinin a receptor, their production and pharmaceutical composition
DE19709877A1 (de) 1997-03-11 1998-09-17 Bayer Ag 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
US8173127B2 (en) 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
EP0994728B1 (en) 1997-04-09 2008-07-30 Intellect Neurosciences, Inc. Recombinant antibodies specific for beta-amyloid ends, dna encoding and methods of use thereof
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
US6743427B1 (en) 1997-12-02 2004-06-01 Neuralab Limited Prevention and treatment of amyloidogenic disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
JP3537394B2 (ja) 1998-03-03 2004-06-14 ピーピージー インダストリーズ オハイオ， インコーポレイテッド 含浸ガラス繊維ストランドおよびそれを含む製品
US20020132817A1 (en) 1998-03-19 2002-09-19 Hideaki Natsugari Heterocyclic compounds, their production and use
CA2352612A1 (en) 1998-11-27 2000-06-08 Hideo Fukui Pharmaceuticals
IL151378A0 (en) 2000-02-24 2003-04-10 Univ Washington Humanized antibodies that sequester amyloid beta peptide
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
CA2427661C (en) 2000-11-03 2013-05-28 Proteotech, Inc. Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants
CA2451998A1 (en) 2001-08-17 2003-02-27 Eli Lilly And Company Anti-a.beta. antibodies
US20030195205A1 (en) 2001-11-02 2003-10-16 Pfizer Inc. PDE9 inhibitors for treating cardiovascular disorders
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
CA2498111A1 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
EP1551809A1 (en) 2002-10-09 2005-07-13 Pfizer Products Inc. Pyrazole compounds for treatment of neurodegenerative disorders
MXPA05003621A (es) 2002-10-09 2005-10-19 Rinat Neuroscience Corp Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos.
WO2004035577A2 (en) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US20040220186A1 (en) 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
JP2006527756A (ja) 2003-06-19 2006-12-07 ファイザー・プロダクツ・インク Ｎｋ１拮抗薬
CA2534532A1 (en) 2003-08-21 2005-03-10 Pfizer Products, Inc. Compounds for the treatment of neurodegenerative disorders
US20070031416A1 (en) 2003-09-09 2007-02-08 Takeda Pharmaceutical Company Limited Use of antibody
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
JP2007519734A (ja) 2004-01-28 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド アミノシクロペンチルピリドピラジノン系ケモカイン受容体活性調節剤
WO2005080361A1 (en) 2004-02-02 2005-09-01 Pfizer Products Inc. Histamine-3 receptor modulators
CN1929737A (zh) 2004-03-09 2007-03-14 默克公司 Hiv整合酶抑制剂
DE602005007717D1 (de) 2004-03-23 2008-08-07 Pfizer Prod Inc Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen
ATE411030T1 (de) 2004-04-14 2008-10-15 Gilead Sciences Inc Phosphonatanaloga von hiv- integrasehemmerverbindungen
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
AP2007003890A0 (en) 2004-07-30 2007-02-28 Rinat Neuroscience Corp Antibodies directed against amy-loid-beta peptide and methods using same
FR2877015B1 (fr) 2004-10-21 2007-10-26 Commissariat Energie Atomique Revetement nanostructure et procede de revetement.
GB0423356D0 (en) 2004-10-21 2004-11-24 Merck Sharp & Dohme Therapeutic agents
WO2006069081A2 (en) 2004-12-22 2006-06-29 Washington University In St. Louis USE OF ANTI-Aβ ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY
PE20061323A1 (es) 2005-04-29 2007-02-09 Rinat Neuroscience Corp Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
WO2006121831A2 (en) 2005-05-10 2006-11-16 Merck & Co., Inc. Hiv integrase inhibitors
NZ564187A (en) 2005-05-12 2010-03-26 Pfizer Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
WO2006126083A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
CA2603830A1 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Co Llc PYRIDINE [2,3-B] PYRAZINONES
WO2006126082A2 (en) 2005-05-24 2006-11-30 Pharmacia & Upjohn Company Llc Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
JP2008543923A (ja) 2005-06-22 2008-12-04 ファイザー・プロダクツ・インク ヒスタミン−３受容体アンタゴニスト
US20070060534A1 (en) 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
US8158673B2 (en) 2005-10-27 2012-04-17 Pfizer Inc. Histamine-3 receptor antagonists
EP1945639A1 (en) 2005-11-04 2008-07-23 Pfizer Limited Tetrahydronaphthyridine derivative
WO2007061923A2 (en) 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
EP1957465A4 (en) 2005-11-18 2009-04-08 Glaxo Group Ltd NEW INTERMEDIATE PRODUCTS AND THEIR USE
US20070117839A1 (en) 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
BRPI0618814A2 (pt) 2005-11-24 2014-04-29 Eisai R&D Man Co Ltd Composto ou um sal farmacologicamente aceitável do mesmo, e, agente farmacêutico
WO2007063385A2 (en) 2005-12-01 2007-06-07 Pfizer Products Inc. Spirocyclic amine histamine-3 receptor antagonists
WO2007069053A1 (en) 2005-12-14 2007-06-21 Pfizer Products Inc. Benzimidazole antagonists of the h-3 receptor
AR059075A1 (es) * 2006-01-20 2008-03-12 Schering Corp Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
WO2007088450A2 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor
WO2007088462A1 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Spirochromane antagonists of the h-3 receptor
WO2007099423A1 (en) 2006-03-02 2007-09-07 Pfizer Products Inc. 1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
WO2007105053A2 (en) 2006-03-13 2007-09-20 Pfizer Products Inc. Tetralines antagonists of the h-3 receptor
KR101061328B1 (ko) 2006-04-21 2011-08-31 화이자 프로덕츠 인크. 피리딘[3,4-ｂ]피라지논
WO2007136572A2 (en) 2006-05-15 2007-11-29 Merck & Co., Inc. Antidiabetic bicyclic compounds
WO2007136714A2 (en) 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
JPWO2007135969A1 (ja) 2006-05-19 2009-10-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア系−シンナミド誘導体
WO2007138431A2 (en) 2006-05-30 2007-12-06 Pfizer Products Inc. Azabicyclic ether histamine-3 antagonists
SI2124933T1 (sl) 2007-01-22 2012-12-31 Pfizer Products Inc. Tosilatna sol terapevtske spojine in farmacevtski sestavi tega
JP2010518083A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション ピペリジン誘導体
WO2008099210A2 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
TW200848054A (en) 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
WO2008137102A2 (en) 2007-05-04 2008-11-13 Torreypines Therapeutics, Inc. Methods of modulating amyloid beta and compounds useful therefor
US8357682B2 (en) 2007-05-07 2013-01-22 Zhaoning Zhu Gamma secretase modulators
KR101138045B1 (ko) 2007-05-11 2012-04-24 에프. 호프만-라 로슈 아게 아밀로이드 베타에 대한 조절제로서의 헤트아릴아닐린
TW200908968A (en) 2007-05-29 2009-03-01 Sgx Pharmaceuticals Inc Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
WO2008153793A2 (en) 2007-06-01 2008-12-18 Schering Corporation Gamma secretase modulators
US8580956B2 (en) 2007-06-01 2013-11-12 Merck Sharp & Dohme Corp. Gamma secretase modulators
EP2166854A4 (en) 2007-06-13 2012-05-16 Merck Sharp & Dohme TRIAZONE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER AND RELATED SUFFERINGS
CN101772493A (zh) 2007-06-29 2010-07-07 先灵公司 γ分泌酶调节剂
EP2185522A1 (en) 2007-08-06 2010-05-19 Schering Corporation Gamma secretase modulators
EP2181992B8 (en) 2007-08-31 2013-06-26 Eisai R&D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
MX2010002674A (es) 2007-09-06 2010-03-25 Schering Corp Moduladores de gamma secretasa.
MX2010003397A (es) 2007-09-28 2010-04-09 Schering Corp Moduladores de la gamma secretasa.
GB0720444D0 (en) 2007-10-18 2007-11-28 Glaxo Group Ltd Novel compounds
WO2009061699A1 (en) 2007-11-05 2009-05-14 Schering Corporation Gamma secretase modulators
JP2011506336A (ja) * 2007-12-06 2011-03-03 シェーリング コーポレイション γ−セクレターゼ調節剤
EP2227471A1 (en) 2007-12-11 2010-09-15 Schering Corporation Gamma secretase modulators
EP2268636A1 (en) 2007-12-11 2011-01-05 Schering Corporation Gamma secretase modulators
CA2707492A1 (en) 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
KR101244517B1 (ko) 2008-01-11 2013-03-18 에프. 호프만-라 로슈 아게 아밀로이드 베타에 대한 조절제
EP2257541B1 (en) 2008-02-22 2013-08-14 F. Hoffmann-La Roche AG Modulators for amyloid beta
US20110027264A1 (en) 2008-02-29 2011-02-03 Xianhai Huang Gamma secretase modulators for the treatment of alzheimer's disease
US20100137320A1 (en) 2008-02-29 2010-06-03 Schering Corporation Gamma secretase modulators
CA2722606A1 (en) 2008-05-05 2009-11-12 Amgen Inc. Urea compounds as gamma secretase modulators
FR2933700B1 (fr) * 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
TW201006801A (en) 2008-07-18 2010-02-16 Lilly Co Eli Imidazole carboxamides
WO2010019392A1 (en) 2008-08-13 2010-02-18 Merck Sharp & Dohme Corp. Purine derivatives for treatment of alzheimer's disease
EP2312946A4 (en) 2008-08-13 2012-10-24 Merck Sharp & Dohme PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
US20110172427A1 (en) 2008-08-27 2011-07-14 Eisai R&D Management Co., Ltd. Process for preparing certain cinnamide compounds
JP5502089B2 (ja) 2008-10-09 2014-05-28 エフ．ホフマン−ラ ロシュ アーゲー アミロイドβのモジュレーター
JP2012508181A (ja) 2008-11-06 2012-04-05 シェーリング コーポレイション γ−セクレターゼ調節剤
MX2011004680A (es) 2008-11-06 2011-05-25 Astrazeneca Ab Moduladores de beta amiloide.
CA2742500A1 (en) 2008-11-06 2010-05-14 Schering Corporation Gamma secretase modulators
KR101293421B1 (ko) 2008-11-10 2013-08-05 에프. 호프만-라 로슈 아게 헤테로사이클릭 감마 분비효소 조절제
EP2378879A4 (en) 2008-12-16 2012-06-06 Merck Sharp & Dohme TRIAZONE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
EP2379075A4 (en) 2008-12-16 2012-05-30 Merck Sharp & Dohme TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
HUE025547T2 (en) 2008-12-19 2016-02-29 Boehringer Ingelheim Int Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
TW201034666A (en) 2008-12-22 2010-10-01 Schering Corp Gamma secretase modulators
EP2379566A2 (en) 2008-12-22 2011-10-26 Schering Corporation Gamma secretase modulators
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
AU2010211109B2 (en) 2009-02-06 2014-11-27 Cellzome Limited Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
TWI461425B (zh) 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
JP2012121809A (ja) 2009-02-26 2012-06-28 Eisai R & D Management Co Ltd 多環式化合物の製造法およびその中間体
MX2011006782A (es) 2009-02-26 2011-07-20 Eisai R&D Man Co Ltd Sal de derivado de tetrahidrotriazolopiridina y un cristal de la misma.
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
JP2012051805A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd テトラヒドロトリアゾロピリジン誘導体の製造方法
JP2012051806A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
US20120053165A1 (en) 2009-03-03 2012-03-01 Pfizer Inc. Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
AU2010279377B2 (en) 2009-08-07 2014-07-03 Dow Agrosciences Llc Pesticidal compositions
WO2011048525A1 (en) * 2009-10-20 2011-04-28 Pfizer Inc. Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
SG10201502073PA (en) * 2009-12-22 2015-05-28 Vertex Pharma Isoindolinone inhibitors of phosphatidylinositol 3-kinase
CA2830027C (en) 2011-03-31 2016-04-26 Pfizer Inc. Novel bicyclic pyridinones
EP2850083B1 (en) 2012-05-16 2016-04-27 Janssen Pharmaceuticals, Inc. Substituted 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives useful for the treatment of (inter alia) alzheimer's disease
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
TWI614238B (zh) 2012-09-21 2018-02-11 必治妥美雅史谷比公司 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
JP6275161B2 (ja) 2012-12-20 2018-02-07 ヤンセン ファーマシューティカ エヌ．ベー． γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
WO2014111457A1 (en) 2013-01-17 2014-07-24 Janssen Pharmaceutica Nv Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators
ES2742078T3 (es) 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
EP3119347B1 (en) 2014-03-21 2023-06-07 Align Technology, Inc. Segmented orthodontic appliance with elastics
MX369074B (es) 2014-04-01 2019-10-28 Pfizer Cromeno y 1,1a,2,7b-tetrahidrociclopropa[c]cromeno piridopirazinadionas como moduladores de la gamma secretasa.

Also Published As

Publication number Publication date
LT2897956T (lt) 2017-01-10
MA37886A1 (fr) 2016-02-29
AR092628A1 (es) 2015-04-29
DOP2015000069A (es) 2015-05-15
WO2014045156A1 (en) 2014-03-27
HUE031248T2 (en) 2017-06-28
MD4583B1 (ro) 2018-07-31
CR20150053A (es) 2015-03-25
IN2015DN01119A (instruction) 2015-06-26
UA110688C2 (uk) 2016-01-25
US8916564B2 (en) 2014-12-23
EP2897956B1 (en) 2016-11-09
ME02571B (me) 2017-06-20
IL237163A0 (en) 2015-04-30
CL2015000717A1 (es) 2015-06-19
CN104662021A (zh) 2015-05-27
TN2015000084A1 (fr) 2016-06-29
EA201590319A1 (ru) 2015-09-30
NZ704863A (en) 2017-03-31
US9751877B2 (en) 2017-09-05
CA2882386A1 (en) 2014-03-27
PT2897956T (pt) 2017-01-13
US20150072990A1 (en) 2015-03-12
US9193726B2 (en) 2015-11-24
HK1206013A1 (zh) 2015-12-31
CA2882386C (en) 2017-11-28
GT201500069A (es) 2016-03-01
CY1118662T1 (el) 2017-07-12
EP2897956A1 (en) 2015-07-29
PE20150686A1 (es) 2015-05-23
JP2015529238A (ja) 2015-10-05
MA37886B1 (fr) 2016-09-30
KR20150044948A (ko) 2015-04-27
SG11201501074WA (en) 2015-05-28
CU20150021A7 (es) 2015-08-27
UY35039A (es) 2014-04-30
IL237163A (en) 2016-12-29
NI201500038A (es) 2015-06-05
ES2609987T3 (es) 2017-04-25
EA026668B1 (ru) 2017-05-31
JP5844018B2 (ja) 2016-01-13
MD20150023A2 (ro) 2015-07-31
TWI500616B (zh) 2015-09-21
ECSP15015594A (es) 2017-08-31
AU2013319845A1 (en) 2015-02-26
SI2897956T1 (sl) 2017-02-28
TW201425311A (zh) 2014-07-01
MX360599B (es) 2018-11-08
CN104662021B (zh) 2016-08-24
BR112015006436A2 (pt) 2017-07-04
PH12015500376A1 (en) 2015-04-20
RS55426B1 (sr) 2017-04-28
KR101725696B1 (ko) 2017-04-10
MX2015003637A (es) 2015-06-05
MY181891A (en) 2021-01-12
AP2015008277A0 (en) 2015-02-28
DK2897956T3 (en) 2017-01-16
US20160024088A1 (en) 2016-01-28
PH12015500376B1 (en) 2015-04-20
AU2013319845B2 (en) 2017-09-14
ZA201501195B (en) 2016-01-27
HRP20161558T1 (hr) 2016-12-30
US20140088111A1 (en) 2014-03-27
PL2897956T3 (pl) 2017-05-31

Similar Documents

Publication Publication Date Title
GEP201706659B (en) Novel bicyclic pyridinones
MX347917B (es) Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
NZ703950A (en) Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds
IN2014DN07384A (instruction)
AU2014270524A8 (en) 2-phenylimidazo [1,2-a]pyrimidines as imaging agents
UA115887C2 (uk) АМІНОЗАМІЩЕНІ ІМІДАЗО[1,2-а]ПІРИДИНКАРБОКСАМІДИ І ЇХ ЗАСТОСУВАННЯ
MX2015007097A (es) Nuevas fenil-piridinas/pirazinas bi-anulares para el tratamiento de cancer.
GEP201706695B (en) Substituted 4-phenyl-pyridi-nes for the treatment of nk-1 receptor related diseases
EA024842B9 (ru) Соединения в качестве модуляторов протеинкиназы pi3k
MX352928B (es) Compuestos de piridazina-amida.
GEP20207172B (en) 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors
NZ629499A (en) Novel 3,5-disubstituted-3h-imidazo[4,5-b]pyridine and 3,5- disubstituted -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
IN2014MN00697A (instruction)
MX340574B (es) Imidazo pirazinas.
MX2014000964A (es) Derivados aza heterociclicos sustituidos.
WO2012104823A3 (en) Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
WO2014035846A3 (en) Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use
WO2014086453A8 (en) Azaheterobicyclic compounds
IN2014DN09826A (instruction)
NZ707773A (en) Methods of treating liver diseases
IN2015DN00950A (instruction)
GB201209015D0 (en) Novel compounds
MX2013006670A (es) Derivado de 2-carboxamida-4-piperazinil-benzofurano.
MX2015005312A (es) Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12.
PH12016500173A1 (en) Derivatives of 1 h-pyrazolo[3,4-b]pyridine and pharmaceutical compositions thereof for the treatment of proliferative disorders