GB1516793A - 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative several processes for its preparation and its use as a coronary therapeutic agent - Google Patents

1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative several processes for its preparation and its use as a coronary therapeutic agent

Info

Publication number
GB1516793A
GB1516793A GB45501/76A GB4550176A GB1516793A GB 1516793 A GB1516793 A GB 1516793A GB 45501/76 A GB45501/76 A GB 45501/76A GB 4550176 A GB4550176 A GB 4550176A GB 1516793 A GB1516793 A GB 1516793A
Authority
GB
United Kingdom
Prior art keywords
dihydropyridine
preparation
therapeutic agent
dicarboxylic acid
acid diester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45501/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1516793A publication Critical patent/GB1516793A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB45501/76A 1975-11-05 1976-11-02 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative several processes for its preparation and its use as a coronary therapeutic agent Expired GB1516793A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2549568A DE2549568C3 (de) 1975-11-05 1975-11-05 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
GB1516793A true GB1516793A (en) 1978-07-05

Family

ID=5960951

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45501/76A Expired GB1516793A (en) 1975-11-05 1976-11-02 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative several processes for its preparation and its use as a coronary therapeutic agent

Country Status (27)

Country Link
JP (1) JPS5259161A (no)
AT (1) AT352129B (no)
AU (1) AU498964B2 (no)
BE (1) BE847968A (no)
BG (6) BG25078A3 (no)
CA (1) CA1085406A (no)
CH (2) CH623038A5 (no)
CS (1) CS200499B2 (no)
DE (1) DE2549568C3 (no)
DK (1) DK146762C (no)
ES (2) ES452986A1 (no)
FI (1) FI60704C (no)
FR (1) FR2330395A1 (no)
GB (1) GB1516793A (no)
GR (1) GR61241B (no)
HK (1) HK12681A (no)
IE (1) IE43984B1 (no)
IL (1) IL50817A (no)
LU (2) LU76133A1 (no)
NL (2) NL175915C (no)
NO (1) NO145574C (no)
NZ (1) NZ182502A (no)
PL (2) PL105940B1 (no)
PT (1) PT65797B (no)
RO (1) RO70295A (no)
SE (1) SE423542B (no)
ZA (1) ZA766622B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
JPS5982192U (ja) * 1982-11-27 1984-06-02 エムケ−精工株式会社 扉
DE3312216A1 (de) * 1983-04-05 1984-10-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers

Also Published As

Publication number Publication date
DE2549568A1 (de) 1977-05-18
IE43984L (en) 1977-05-05
PT65797B (de) 1978-05-12
AU1935876A (en) 1978-05-11
BG24805A3 (en) 1978-05-12
DE2549568C3 (de) 1981-10-29
AT352129B (de) 1979-09-10
ATA814276A (de) 1979-02-15
HK12681A (en) 1981-04-10
FI60704C (fi) 1982-03-10
SE7612308L (sv) 1977-05-06
NO145574B (no) 1982-01-11
DK146762B (da) 1983-12-27
BG24804A3 (en) 1978-05-12
NO145574C (no) 1982-04-21
FI60704B (fi) 1981-11-30
FI763160A (no) 1977-05-06
LU76133A1 (no) 1977-06-02
BE847968A (fr) 1977-05-04
SE423542B (sv) 1982-05-10
BG24668A3 (en) 1978-04-12
IL50817A (en) 1979-07-25
JPS5647185B2 (no) 1981-11-07
NL930035I1 (nl) 1993-08-02
PL106084B1 (pl) 1979-11-30
CH623038A5 (en) 1981-05-15
PT65797A (de) 1976-12-01
NO763608L (no) 1977-05-06
GR61241B (en) 1978-10-12
NL175915C (nl) 1985-01-16
FR2330395B1 (no) 1978-12-22
JPS5259161A (en) 1977-05-16
BG24803A3 (en) 1978-05-12
CA1085406A (en) 1980-09-09
ZA766622B (en) 1977-10-26
IE43984B1 (en) 1981-07-15
BG25078A3 (en) 1978-07-12
NZ182502A (en) 1978-07-28
CS200499B2 (en) 1980-09-15
IL50817A0 (en) 1977-01-31
PL105940B1 (pl) 1979-11-30
DE2549568B2 (de) 1980-08-21
BG25079A3 (en) 1978-07-12
ES452986A1 (es) 1977-12-16
DK146762C (da) 1984-06-12
NL7612198A (nl) 1977-05-09
AU498964B2 (en) 1979-03-29
FR2330395A1 (fr) 1977-06-03
DK498476A (da) 1977-05-06
NL930035I2 (nl) 1993-10-01
RO70295A (ro) 1981-08-17
ES463166A1 (es) 1978-07-16
LU88275I2 (no) 1994-02-03
CH622779A5 (en) 1981-04-30

Similar Documents

Publication Publication Date Title
GR69233B (no)
SE7714374L (sv) 1,4-dihydropyridinforbindelser
DE3665711D1 (de) Novel guanidinomethylbenzoic acid derivatives
GB1516793A (en) 1,4-dihydropyridine-3,5-dicarboxylic acid diester derivative several processes for its preparation and its use as a coronary therapeutic agent
ES8705411A1 (es) Procedimiento para preparar derivados de 1-piperazinacarboxamida
DE3879258D1 (de) Praeparat gegen ulcus.
JPS5543076A (en) Preparation of 1,3-dithiolan-2-ylidenemalonate derivative
SE7702130L (sv) Forfarande for framstellning av n-(merkaptoacyl)-histidiner
ATE3769T1 (de) 1-imidazol-2-yliden-3-thienyl-harnstoffderivate verfahren zu deren herstellung und pharmazeutische zusammensetzungen.
JPS5212141A (en) Novel amino benzoic acid derivatives, their preparation, and pharmaceu tical compositions therefrom
ES461785A1 (es) Un metodo para la preparacion de un ester de acido behenico.
DE68905406D1 (de) Chinolin-verbindung.
JPS5225740A (en) Preparation of o-acyl-amidinophenols or acid addition salts thereof
SE7903336L (sv) N-alkenylmoranolin-derivat
JPS5253897A (en) Process for preparing, n6-etheno-2-subtituted-thio-adenosine-2', 5'pho sphates
DE3675291D1 (de) 1-alkyl-ergolinyl-thioharnstoffderivate.
JPS5239674A (en) Imidazole derivatives and agricultural bactericides therefrom
SE412907B (sv) Forfarande for framstellning av nya n-2'-karboxifenyl-4-klorantranilsyror
JPS5461185A (en) Nucleic acid base derivatives
IL50467A (en) Derivatives of 3-(3,5-dichlorophenyl)-ureidoaceti acid,process for the preparation thereof and fungicidal compositions containing the same
ATE63544T1 (de) 4-cyanopiperidine-derivate, herstellung und anwendung.
JPS51123823A (en) A barbituric acid insecticide and tickicide
JPS5218830A (en) Homoisotwistylamines antiviral agents for animals
JPS5283393A (en) Synthesis of novel penicillin derivatives
FR2315932A1 (fr) Derives d'acides quinoleine-carboxyliques et medicaments qui en contiennent

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
CTFF Supplementary protection certificate filed

Free format text: SPC/GB96/042, 960913

CTFF Supplementary protection certificate filed

Free format text: SPC/GB96/042, 960913

PE20 Patent expired after termination of 20 years

Effective date: 19961101

CTFG Supplementary protection certificate granted

Free format text: SPC/GB96/042, 970422, EXPIRES:20011101

CTFE Supplementary protection certificate entered into force

Free format text: SPC/GB96/042, 961102, EXPIRES:20011101

SPCE Supplementary protection certificate expired

Free format text: SPC/GB96/042, 20011101