CS200499B2 - Process for preparing isobutylestere of 2,6-dimethyl-3-methoxycarbonyl-4-/2-nitrophenyl/1,4-dihydropyridin-5-carboxylic acid - Google Patents

Process for preparing isobutylestere of 2,6-dimethyl-3-methoxycarbonyl-4-/2-nitrophenyl/1,4-dihydropyridin-5-carboxylic acid Download PDF

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Publication number
CS200499B2
CS200499B2 CS767068A CS706876A CS200499B2 CS 200499 B2 CS200499 B2 CS 200499B2 CS 767068 A CS767068 A CS 767068A CS 706876 A CS706876 A CS 706876A CS 200499 B2 CS200499 B2 CS 200499B2
Authority
CS
Czechoslovakia
Prior art keywords
dimethyl
compound
methoxycarbonyl
nitrophenyl
carboxylic acid
Prior art date
Application number
CS767068A
Other languages
Czech (cs)
English (en)
Inventor
Egbert Wehinger
Friedrich Bossert
Arend Heise
Stanislav Kazda
Kurt Stoepel
Wulf Vater
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Priority to CS776535A priority Critical patent/CS200500B2/cs
Publication of CS200499B2 publication Critical patent/CS200499B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS767068A 1975-11-05 1976-11-02 Process for preparing isobutylestere of 2,6-dimethyl-3-methoxycarbonyl-4-/2-nitrophenyl/1,4-dihydropyridin-5-carboxylic acid CS200499B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS776535A CS200500B2 (cs) 1975-11-05 1977-10-07 Způsob výroby isobutylesteru 2,6-dimethyl-3-methoxykarbonyl-4- -(2'-nitrofenyl)-1,4-dihydropyridin-5-karboxylové kyseliny

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2549568A DE2549568C3 (de) 1975-11-05 1975-11-05 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
CS200499B2 true CS200499B2 (en) 1980-09-15

Family

ID=5960951

Family Applications (1)

Application Number Title Priority Date Filing Date
CS767068A CS200499B2 (en) 1975-11-05 1976-11-02 Process for preparing isobutylestere of 2,6-dimethyl-3-methoxycarbonyl-4-/2-nitrophenyl/1,4-dihydropyridin-5-carboxylic acid

Country Status (27)

Country Link
JP (1) JPS5259161A (no)
AT (1) AT352129B (no)
AU (1) AU498964B2 (no)
BE (1) BE847968A (no)
BG (6) BG25078A3 (no)
CA (1) CA1085406A (no)
CH (2) CH623038A5 (no)
CS (1) CS200499B2 (no)
DE (1) DE2549568C3 (no)
DK (1) DK146762C (no)
ES (2) ES452986A1 (no)
FI (1) FI60704C (no)
FR (1) FR2330395A1 (no)
GB (1) GB1516793A (no)
GR (1) GR61241B (no)
HK (1) HK12681A (no)
IE (1) IE43984B1 (no)
IL (1) IL50817A (no)
LU (2) LU88275I2 (no)
NL (2) NL175915C (no)
NO (1) NO145574C (no)
NZ (1) NZ182502A (no)
PL (2) PL106084B1 (no)
PT (1) PT65797B (no)
RO (1) RO70295A (no)
SE (1) SE423542B (no)
ZA (1) ZA766622B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
JPS55301A (en) * 1978-02-14 1980-01-05 Yamanouchi Pharmaceut Co Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
JPS5982192U (ja) * 1982-11-27 1984-06-02 エムケ−精工株式会社 扉
DE3312216A1 (de) * 1983-04-05 1984-10-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
US4794111A (en) * 1984-05-23 1988-12-27 Bayer Aktiengesellschaft Dihydropyridine preparations containing β-blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
DE2549568A1 (de) 1977-05-18
DK146762C (da) 1984-06-12
CH623038A5 (en) 1981-05-15
NL930035I2 (nl) 1993-10-01
SE423542B (sv) 1982-05-10
DE2549568B2 (de) 1980-08-21
BG25078A3 (en) 1978-07-12
BG24805A3 (en) 1978-05-12
AU498964B2 (en) 1979-03-29
ES452986A1 (es) 1977-12-16
FI60704B (fi) 1981-11-30
GB1516793A (en) 1978-07-05
SE7612308L (sv) 1977-05-06
BG25079A3 (en) 1978-07-12
LU76133A1 (no) 1977-06-02
CH622779A5 (en) 1981-04-30
JPS5259161A (en) 1977-05-16
BG24804A3 (en) 1978-05-12
PT65797B (de) 1978-05-12
BG24803A3 (en) 1978-05-12
PL105940B1 (pl) 1979-11-30
AU1935876A (en) 1978-05-11
NO145574C (no) 1982-04-21
NZ182502A (en) 1978-07-28
DK146762B (da) 1983-12-27
BG24668A3 (en) 1978-04-12
IE43984B1 (en) 1981-07-15
LU88275I2 (no) 1994-02-03
CA1085406A (en) 1980-09-09
GR61241B (en) 1978-10-12
NL930035I1 (nl) 1993-08-02
DK498476A (da) 1977-05-06
NL7612198A (nl) 1977-05-09
ZA766622B (en) 1977-10-26
PL106084B1 (pl) 1979-11-30
FR2330395B1 (no) 1978-12-22
PT65797A (de) 1976-12-01
NO763608L (no) 1977-05-06
DE2549568C3 (de) 1981-10-29
AT352129B (de) 1979-09-10
ES463166A1 (es) 1978-07-16
NO145574B (no) 1982-01-11
HK12681A (en) 1981-04-10
BE847968A (fr) 1977-05-04
IL50817A0 (en) 1977-01-31
ATA814276A (de) 1979-02-15
IE43984L (en) 1977-05-05
NL175915C (nl) 1985-01-16
IL50817A (en) 1979-07-25
FR2330395A1 (fr) 1977-06-03
JPS5647185B2 (no) 1981-11-07
RO70295A (ro) 1981-08-17
FI60704C (fi) 1982-03-10
FI763160A (no) 1977-05-06

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