GB1468497A - Esters of 1-acylpiperazine-4-carboxylic acids - Google Patents

Esters of 1-acylpiperazine-4-carboxylic acids

Info

Publication number
GB1468497A
GB1468497A GB4610375A GB4610375A GB1468497A GB 1468497 A GB1468497 A GB 1468497A GB 4610375 A GB4610375 A GB 4610375A GB 4610375 A GB4610375 A GB 4610375A GB 1468497 A GB1468497 A GB 1468497A
Authority
GB
United Kingdom
Prior art keywords
acylpiperazine
give
bicyclic
tetrahydro
nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4610375A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7436963A external-priority patent/FR2313060A1/fr
Priority claimed from FR7527162A external-priority patent/FR2322602A1/fr
Priority claimed from FR7527161A external-priority patent/FR2322601A1/fr
Priority claimed from FR7527160A external-priority patent/FR2322600A1/fr
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of GB1468497A publication Critical patent/GB1468497A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB4610375A 1974-11-07 1975-11-06 Esters of 1-acylpiperazine-4-carboxylic acids Expired GB1468497A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR7436963A FR2313060A1 (fr) 1974-11-07 1974-11-07 Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
FR7527162A FR2322602A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de l'oxathiinno- et du dithiinnopyrrole, leur preparation et les compositions qui les contiennent
FR7527161A FR2322601A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
FR7527160A FR2322600A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de la pyrrolo (3,4-b) pyrazine, leur preparation et les compositions qui les contiennent

Publications (1)

Publication Number Publication Date
GB1468497A true GB1468497A (en) 1977-03-30

Family

ID=27446274

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4610375A Expired GB1468497A (en) 1974-11-07 1975-11-06 Esters of 1-acylpiperazine-4-carboxylic acids

Country Status (27)

Country Link
US (1) US4220646A (OSRAM)
JP (2) JPS5422996B2 (OSRAM)
AR (2) AR208414A1 (OSRAM)
AT (2) AT343123B (OSRAM)
AU (1) AU503200B2 (OSRAM)
BE (1) BE835325A (OSRAM)
CA (1) CA1057755A (OSRAM)
CH (1) CH609057A5 (OSRAM)
CS (2) CS231957B2 (OSRAM)
CY (1) CY1045A (OSRAM)
DD (1) DD122684A5 (OSRAM)
DE (1) DE2550111C2 (OSRAM)
DK (1) DK141098B (OSRAM)
FI (1) FI60707C (OSRAM)
GB (1) GB1468497A (OSRAM)
HK (1) HK19380A (OSRAM)
HU (1) HU173108B (OSRAM)
IE (1) IE41928B1 (OSRAM)
IL (1) IL48423A (OSRAM)
LU (1) LU73738A1 (OSRAM)
NL (1) NL177405C (OSRAM)
NO (1) NO143576C (OSRAM)
OA (1) OA05162A (OSRAM)
PL (1) PL101248B1 (OSRAM)
SE (1) SE407063B (OSRAM)
SU (2) SU673173A3 (OSRAM)
YU (2) YU39583B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274929A1 (fr) * 1986-12-02 1988-07-20 Rhone-Poulenc Sante Nouveaux dérivés du pyrrole, leur préparation et les compositions pharmaceutiques qui les contiennent
EP0271404B1 (fr) * 1986-12-02 1991-08-14 Rhone-Poulenc Sante Nouveaux dérivés du pyrrole, leur préparation et les compositions pharmaceutiques qui les contiennent
US5380724A (en) * 1992-06-17 1995-01-10 Gyogyszerkutato Intezet Kft Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing same

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2371198A2 (fr) * 1976-11-22 1978-06-16 Rhone Poulenc Ind Nouveaux derives du dithiepinno (1,4)(2,3-c) pyrrole, leur preparation et les compositions qui les contiennent
US4533751A (en) * 1981-10-09 1985-08-06 Scm Corporation Preparation of 1,3-dienamines from myrcene and substituted myrcene
FR2525606A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Sante Nouveaux derives du dithiino (1,4) (2,3-c) pyrrole, leur preparation et les medicaments qui les contiennent
FR2671800B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
TW279864B (OSRAM) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
US5565567A (en) * 1993-06-04 1996-10-15 Henkel Corporation. Polymerizable N,N'-substituted piperazine acrylamide compounds
US5922820A (en) * 1993-06-04 1999-07-13 Henkel Corporation Polymerizable compounds
CN1126474A (zh) * 1993-06-04 1996-07-10 亨凯尔公司 聚合的化合物
NZ294392A (en) 1994-09-23 1999-05-28 Axys Pharm Inc Asthma drugs and compounds
US5663357A (en) * 1995-11-22 1997-09-02 Allergan Substituted heteroarylamides having retinoid-like biological activity
US5756742A (en) * 1995-12-22 1998-05-26 Henkel Corporation Polymerizable compounds
US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
EP1396493A4 (en) * 2001-04-26 2005-08-03 Ajinomoto Kk HETEROCYCLIC COMPOUNDS
RU2318823C2 (ru) 2002-03-29 2008-03-10 Индивус Фармасьютикалз, Инк. Способы получения 2-(7-хлор-1,8-нафтиридин-2-ил)-3-(5-метил-2-оксогексил)-1-изоиндолинона
WO2004037212A2 (en) * 2002-10-24 2004-05-06 Sepracor, Inc. Compositions comprising zopiclone derivatives and methods of making and using the same
UA79518C2 (en) * 2002-11-22 2007-06-25 Merck & Co Inc Process for preparation of phosphodiesterase-4 inhibitors
AR042194A1 (es) * 2002-11-22 2005-06-15 Merck & Co Inc Metodo para preparar inhibidores de fosfodiesterasa - 4
US6909002B2 (en) * 2002-11-22 2005-06-21 Merck & Co., Inc. Method of preparing inhibitors of phosphodiesterase-4
JP5646126B2 (ja) 2003-12-11 2014-12-24 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 鎮静剤と神経伝達物質調節剤の併用、および睡眠の質の向上方法および鬱の治療方法
US20050232983A1 (en) * 2004-04-14 2005-10-20 Indevus Pharmaceuticals, Inc. Transdermal patch
WO2007005961A2 (en) * 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
CN100569775C (zh) * 2007-12-19 2009-12-16 齐鲁天和惠世制药有限公司 佐匹克隆的晶型转换的方法
WO2010088385A1 (en) 2009-01-30 2010-08-05 Sepracor Inc. Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrol o [3,4-b] pyrazine and methods for measuring effectiveness of coating
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN110678497B (zh) * 2017-05-25 2022-09-16 信越化学工业株式会社 含有氟聚醚基的聚合物改性有机硅化合物、表面处理剂和物品
CN108129476A (zh) * 2017-11-27 2018-06-08 华中农业大学 一种杂环内酰胺衍生物及其用于作物病原菌杀菌剂的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR2101081B1 (OSRAM) * 1970-08-19 1974-01-11 Rhone Poulenc Sa
BE790408A (fr) * 1971-10-22 1973-04-20 Rhone Poulenc Sa Nouveaux derives de la pyrrolo (3,4-b) pyridine, leur preparation et les compositions medicinales qui les
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
BE793851A (fr) * 1972-01-10 1973-07-10 Rhone Poulenc Sa Nouveaux derives de l'isoindoline, leur preparation et les compositions medicinales qui les contiennent
AR207555A1 (es) * 1972-12-04 1976-10-15 Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles
OA04700A (fr) * 1973-05-15 1980-07-31 Rhone Poulenc Sa Nouveaux dérivés de la naphtyridine et leur procédé de préparation.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274929A1 (fr) * 1986-12-02 1988-07-20 Rhone-Poulenc Sante Nouveaux dérivés du pyrrole, leur préparation et les compositions pharmaceutiques qui les contiennent
AU594538B2 (en) * 1986-12-02 1990-03-08 Rhone-Poulenc Sante New pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
EP0271404B1 (fr) * 1986-12-02 1991-08-14 Rhone-Poulenc Sante Nouveaux dérivés du pyrrole, leur préparation et les compositions pharmaceutiques qui les contiennent
US5380724A (en) * 1992-06-17 1995-01-10 Gyogyszerkutato Intezet Kft Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing same

Also Published As

Publication number Publication date
CS231958B2 (en) 1985-01-16
FI60707B (fi) 1981-11-30
YU192182A (en) 1983-01-21
DK499275A (OSRAM) 1976-05-08
CS751075A2 (en) 1984-01-16
CS598377A2 (en) 1984-01-16
BE835325A (fr) 1976-05-06
NO143576C (no) 1981-03-11
NO143576B (no) 1980-12-01
IL48423A0 (en) 1976-01-30
DE2550111C2 (de) 1983-09-15
JPS5422996B2 (OSRAM) 1979-08-10
SU604496A3 (ru) 1978-04-25
YU40087B (en) 1985-06-30
PL101248B1 (pl) 1978-12-30
SE407063B (sv) 1979-03-12
AU8633175A (en) 1977-05-12
IL48423A (en) 1979-03-12
IE41928L (en) 1976-05-07
JPS5170776A (OSRAM) 1976-06-18
AT343123B (de) 1978-05-10
FI753127A7 (OSRAM) 1976-05-08
CA1057755A (fr) 1979-07-03
AT343666B (de) 1978-06-12
ATA848675A (de) 1977-09-15
YU281575A (en) 1983-01-21
NO753713L (OSRAM) 1976-05-10
LU73738A1 (OSRAM) 1976-09-06
IE41928B1 (en) 1980-04-23
FI60707C (fi) 1982-03-10
AR208800A1 (es) 1977-02-28
SU673173A3 (ru) 1979-07-05
OA05162A (fr) 1981-01-31
NL7512732A (nl) 1976-05-11
DK141098C (OSRAM) 1980-07-07
AR208414A1 (es) 1976-12-27
CY1045A (en) 1980-08-01
NL177405C (nl) 1985-09-16
NL177405B (nl) 1985-04-16
ATA401977A (de) 1977-10-15
CH609057A5 (OSRAM) 1979-02-15
YU39583B (en) 1985-03-20
CS231957B2 (en) 1985-01-16
HU173108B (hu) 1979-02-28
DK141098B (da) 1980-01-14
HK19380A (en) 1980-04-18
DE2550111A1 (de) 1976-05-13
JPS5498790A (en) 1979-08-03
DD122684A5 (OSRAM) 1976-10-20
JPS558508B2 (OSRAM) 1980-03-04
AU503200B2 (en) 1979-08-30
SE7512477L (sv) 1976-05-10
US4220646A (en) 1980-09-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee