FR2462908A1 - Comprime secable permettant une liberation controlee et retardee de la substance active - Google Patents

Comprime secable permettant une liberation controlee et retardee de la substance active Download PDF

Info

Publication number
FR2462908A1
FR2462908A1 FR8017858A FR8017858A FR2462908A1 FR 2462908 A1 FR2462908 A1 FR 2462908A1 FR 8017858 A FR8017858 A FR 8017858A FR 8017858 A FR8017858 A FR 8017858A FR 2462908 A1 FR2462908 A1 FR 2462908A1
Authority
FR
France
Prior art keywords
active substance
release
tablet
delayed
height
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8017858A
Other languages
English (en)
French (fr)
Other versions
FR2462908B1 (nl
Inventor
Hans Hess
Carlo Voellmy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH7514/79A external-priority patent/CH648754A5/de
Priority claimed from CH395980A external-priority patent/CH646330A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2462908A1 publication Critical patent/FR2462908A1/fr
Application granted granted Critical
Publication of FR2462908B1 publication Critical patent/FR2462908B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8017858A 1979-08-16 1980-08-13 Comprime secable permettant une liberation controlee et retardee de la substance active Granted FR2462908A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH7514/79A CH648754A5 (en) 1979-08-16 1979-08-16 Pharmaceutical slow release tablet
CH395980A CH646330A5 (en) 1980-05-21 1980-05-21 Divisible slow-release pharmaceutical tablets

Publications (2)

Publication Number Publication Date
FR2462908A1 true FR2462908A1 (fr) 1981-02-20
FR2462908B1 FR2462908B1 (nl) 1983-07-08

Family

ID=25694276

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8017858A Granted FR2462908A1 (fr) 1979-08-16 1980-08-13 Comprime secable permettant une liberation controlee et retardee de la substance active

Country Status (20)

Country Link
US (1) US4353887A (nl)
AU (1) AU531058B2 (nl)
CA (1) CA1158555A (nl)
DE (1) DE3030622C2 (nl)
DK (1) DK153772C (nl)
ES (1) ES494274A0 (nl)
FI (1) FI76691C (nl)
FR (1) FR2462908A1 (nl)
GB (1) GB2057878B (nl)
GR (1) GR69943B (nl)
IE (1) IE50108B1 (nl)
IL (1) IL60839A (nl)
IT (1) IT1145285B (nl)
LU (1) LU82718A1 (nl)
MY (1) MY8700198A (nl)
NL (1) NL8004616A (nl)
NO (1) NO156274C (nl)
NZ (1) NZ194681A (nl)
PT (1) PT71706B (nl)
SE (1) SE445802B (nl)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023264A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Plc Product
EP2103302A1 (fr) 2008-03-21 2009-09-23 Les Laboratoires Servier Forme galénique sécable permettant une libération modifiée du principe actif
US10501523B2 (en) 2014-07-18 2019-12-10 Sanofi IL-8 level based method of predicting the outcome of colon cancer treatment
US11033606B2 (en) 2011-04-26 2021-06-15 Sanofi Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-FU) and irinotecan (FOLFIRI)

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IN158328B (nl) * 1981-03-09 1986-10-18 Ici Plc
JPS5839618A (ja) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd 持続性積層錠剤
JPS58152813A (ja) * 1982-03-08 1983-09-10 Sumitomo Chem Co Ltd 鮮明な刻印を有する錠剤およびその製法
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
DK152744C (da) * 1982-08-13 1988-10-31 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat
US4503031A (en) * 1982-12-17 1985-03-05 Glassman Jacob A Super-fast-starting-sustained release tablet
DE3314003A1 (de) * 1983-04-18 1984-10-18 Boehringer Ingelheim KG, 6507 Ingelheim Teilbare tablette mit verzoegerter wirkstofffreigabe und verfahren zu deren herstellung
US4591500A (en) * 1983-04-25 1986-05-27 Microencapsulation S.A. Tablet having the shape of a capsule, process and device for its preparation
JPS604120A (ja) * 1983-06-22 1985-01-10 Shionogi & Co Ltd 作用持続型ピナシジル製剤
DE3505433A1 (de) * 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
US4631305A (en) * 1985-03-22 1986-12-23 The Upjohn Company Polymeric material as a disintegrant in a compressed tablet
DE3869337D1 (de) * 1987-11-20 1992-04-23 Greither Peter Kapsel und verfahren zu ihrer herstellung.
US5051261A (en) * 1987-11-24 1991-09-24 Fmc Corporation Method for preparing a solid sustained release form of a functionally active composition
ATE84963T1 (de) * 1987-12-17 1993-02-15 Upjohn Co Dreifach gekerbte arzneimitteltablette.
IL95423A (en) * 1989-09-21 1994-11-11 American Cyanamid Co Pulse system for delivery of minocycline once daily
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5009896A (en) * 1989-10-04 1991-04-23 Akzo N.V. Multi-fractionable tablet structure
US5213738A (en) * 1990-05-15 1993-05-25 L. Perrigo Company Method for making a capsule-shaped tablet
US5061494A (en) * 1990-06-14 1991-10-29 The Upjohn Comany Tri-scored drug tablet
DE4100920A1 (de) * 1991-01-15 1992-07-16 Degussa Wirkstoffzubereitung zur oralen verabreichung an wiederkaeuer
GB9101502D0 (en) * 1991-01-23 1991-03-06 Controlled Therapeutics Sct Controlled release compositions
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
US5398850A (en) * 1993-08-06 1995-03-21 River Medical, Inc. Gas delivery apparatus for infusion
US5398851A (en) * 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5571261A (en) * 1993-08-06 1996-11-05 River Medical, Inc Liquid delivery device
FR2709420B1 (fr) * 1993-09-01 1995-11-17 Sogeval Comprimé vétérinaire plus spécialement destiné aux chats.
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
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WO1999051207A1 (fr) * 1998-04-03 1999-10-14 Kyowa Hakko Kogyo Co., Ltd. Comprime secable et conditionnement au travers duquel appliquer une force de pression
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
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DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
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FR2859632B1 (fr) * 2003-09-15 2005-11-18 Arrow Generiques Comprime multisecable a observance amelioree.
DE202004002700U1 (de) * 2004-02-20 2004-04-29 Desitin Arzneimittel Gmbh Viertelbare Tablette
US7838031B2 (en) * 2004-05-21 2010-11-23 Lawrence Solomon Method of administering a partial dose using a segmented pharmaceutical tablet
CA2566310C (en) * 2004-05-21 2014-05-13 Lawrence Solomon Scored pharmaceutical tablets comprising a plurality of segments
CN1960713A (zh) * 2004-05-21 2007-05-09 阿库-伯雷克技术公司 含有两个或多个单元片段的药片
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
GB0423964D0 (en) * 2004-10-28 2004-12-01 Jagotec Ag Dosage form
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
EP1712224A1 (en) * 2005-04-12 2006-10-18 Alexander von Mérey Divisible rectangular flat tablet
CA2616204C (en) 2005-09-09 2015-12-01 Labopharm Inc. Sustained drug release composition
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US20070160960A1 (en) * 2005-10-21 2007-07-12 Laser Shot, Inc. System and method for calculating a projectile impact coordinates
US7985419B1 (en) 2006-12-22 2011-07-26 Watson Laboratories, Inc. Divisible tablet and associated methods
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
US20080286344A1 (en) * 2007-05-16 2008-11-20 Olivia Darmuzey Solid form
US20080311162A1 (en) * 2007-05-16 2008-12-18 Olivia Darmuzey Solid form
US20080286343A1 (en) * 2007-05-16 2008-11-20 Dzenana Cengic Solid form
WO2008140459A1 (en) * 2007-05-16 2008-11-20 Fmc Corporation Solid form
WO2008140460A1 (en) * 2007-05-16 2008-11-20 Fmc Corporation Solid form
WO2008140461A1 (en) * 2007-05-16 2008-11-20 Fmc Corporation Solid form
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PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
TW201006473A (en) * 2008-08-13 2010-02-16 Orient Pharma Co Ltd Bi-layer medicine tablet containing Zaleplon
US20100104687A1 (en) * 2008-10-24 2010-04-29 Kaplan Allan S Segmented confectionery products
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
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CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
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US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
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FR1603314A (en) * 1965-02-23 1971-04-05 Pharmaceutical tablets - having a core and a matrix material
GB1368574A (en) * 1971-02-12 1974-10-02 Ives Lab Inc Divisible tablet
GB1387643A (en) * 1971-03-16 1975-03-19 Ives Lab Inc Divisible tablet

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023264A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Plc Product
US6161260A (en) * 1996-11-27 2000-12-19 Flewitt; Harry Pharmaceutical tablet designed for easier breaking
EP2103302A1 (fr) 2008-03-21 2009-09-23 Les Laboratoires Servier Forme galénique sécable permettant une libération modifiée du principe actif
FR2928836A1 (fr) * 2008-03-21 2009-09-25 Servier Lab Forme galenique secable permettant une liberation modifiee du principe actif
WO2009125087A1 (fr) * 2008-03-21 2009-10-15 Les Laboratoires Servier Forme galenique secable permettant une liberation modifiee du principe actif
AP2729A (en) * 2008-03-21 2013-08-31 Servier Lab Dividable galenical form allowing modified releaseof the active ingredient
EP3025706A1 (fr) * 2008-03-21 2016-06-01 Les Laboratoires Servier Forme galénique sécable permettant une libération modifiée du principe actif
US11033606B2 (en) 2011-04-26 2021-06-15 Sanofi Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-FU) and irinotecan (FOLFIRI)
US10501523B2 (en) 2014-07-18 2019-12-10 Sanofi IL-8 level based method of predicting the outcome of colon cancer treatment
US11208461B2 (en) 2014-07-18 2021-12-28 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer

Also Published As

Publication number Publication date
DK153772C (da) 1989-01-23
NL8004616A (nl) 1981-02-18
CA1158555A (en) 1983-12-13
LU82718A1 (de) 1981-03-24
FR2462908B1 (nl) 1983-07-08
IT8049501A0 (it) 1980-08-14
ES8106231A1 (es) 1981-08-01
AU6148180A (en) 1981-02-19
AU531058B2 (en) 1983-08-11
SE8005759L (sv) 1981-02-17
DE3030622A1 (de) 1981-03-26
GB2057878B (en) 1983-07-20
IE50108B1 (en) 1986-02-19
IL60839A (en) 1983-11-30
DE3030622C2 (de) 1996-05-30
FI802542A (fi) 1981-02-17
NO156274C (no) 1987-08-26
GB2057878A (en) 1981-04-08
GR69943B (nl) 1982-07-21
ES494274A0 (es) 1981-08-01
FI76691C (fi) 1988-12-12
DK153772B (da) 1988-09-05
FI76691B (fi) 1988-08-31
PT71706A (en) 1980-09-01
IL60839A0 (en) 1980-10-26
MY8700198A (en) 1987-12-31
NZ194681A (en) 1983-06-17
IT1145285B (it) 1986-11-05
NO802447L (no) 1981-02-17
US4353887A (en) 1982-10-12
NO156274B (no) 1987-05-18
SE445802B (sv) 1986-07-21
PT71706B (en) 1981-06-17
DK354580A (da) 1981-02-17
IE801727L (en) 1981-02-16

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