|
US1003489A
(en)
|
1911-04-10 |
1911-09-19 |
Minnie Moritz |
Barber's reversible hair-cloth.
|
|
US3361306A
(en)
|
1966-03-31 |
1968-01-02 |
Merck & Co Inc |
Aerosol unit dispensing uniform amounts of a medically active ingredient
|
|
US3565070A
(en)
|
1969-02-28 |
1971-02-23 |
Riker Laboratories Inc |
Inhalation actuable aerosol dispenser
|
|
FR2224175B1
(OSRAM)
|
1973-04-04 |
1978-04-14 |
Isf Spa |
|
|
US4069819A
(en)
|
1973-04-13 |
1978-01-24 |
Societa Farmaceutici S.P.A. |
Inhalation device
|
|
IT1017153B
(it)
|
1974-07-15 |
1977-07-20 |
Isf Spa |
Apparecchio per inalazioni
|
|
SE438261B
(sv)
|
1981-07-08 |
1985-04-15 |
Draco Ab |
Anvendning i dosinhalator av ett perforerat membran
|
|
US4816570A
(en)
|
1982-11-30 |
1989-03-28 |
The Board Of Regents Of The University Of Texas System |
Biologically reversible phosphate and phosphonate protective groups
|
|
US4805811A
(en)
|
1985-03-29 |
1989-02-21 |
Aktiebolaget Draco |
Dosage device
|
|
SE448277B
(sv)
|
1985-04-12 |
1987-02-09 |
Draco Ab |
Indikeringsanordning vid en doseringsanordning for lekemedel
|
|
US4968788A
(en)
|
1986-04-04 |
1990-11-06 |
Board Of Regents, The University Of Texas System |
Biologically reversible phosphate and phosphonate protective gruops
|
|
US4894376A
(en)
|
1988-02-26 |
1990-01-16 |
Trustees Of The University Of Pennsylvania |
Methods of treating diseases characterized by hyperexcitability of neurons
|
|
IT1228459B
(it)
|
1989-02-23 |
1991-06-19 |
Phidea S R L |
Inalatore con svuotamento regolare e completo della capsula.
|
|
US4955371A
(en)
|
1989-05-08 |
1990-09-11 |
Transtech Scientific, Inc. |
Disposable inhalation activated, aerosol device for pulmonary medicine
|
|
AU651835B2
(en)
|
1990-06-13 |
1994-08-04 |
Arnold Glazier |
Phosphorous prodrugs
|
|
EP0481214B1
(en)
|
1990-09-14 |
1998-06-24 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Prodrugs of phosphonates
|
|
WO1993000951A1
(en)
|
1991-07-02 |
1993-01-21 |
Inhale, Inc. |
Method and device for delivering aerosolized medicaments
|
|
US5261538A
(en)
|
1992-04-21 |
1993-11-16 |
Glaxo Inc. |
Aerosol testing method
|
|
US5785049A
(en)
|
1994-09-21 |
1998-07-28 |
Inhale Therapeutic Systems |
Method and apparatus for dispersion of dry powder medicaments
|
|
US5388572A
(en)
|
1993-10-26 |
1995-02-14 |
Tenax Corporation (A Connecticut Corp.) |
Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
|
|
US5522385A
(en)
|
1994-09-27 |
1996-06-04 |
Aradigm Corporation |
Dynamic particle size control for aerosolized drug delivery
|
|
US5622163A
(en)
|
1994-11-29 |
1997-04-22 |
Iep Group, Inc. |
Counter for fluid dispensers
|
|
US5544647A
(en)
|
1994-11-29 |
1996-08-13 |
Iep Group, Inc. |
Metered dose inhalator
|
|
US6887707B2
(en)
|
1996-10-28 |
2005-05-03 |
University Of Washington |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
|
|
EP1060190B1
(en)
|
1998-03-03 |
2003-11-19 |
Novo Nordisk A/S |
New salt forms of (2e)- 5-amino-5- methylhex-2- enoic acid n-methyl-n-((1r)-1-(n- methyl-n-((1r)-1-(methylcarbamoyl)-2- phenylethyl)carbamoyl)-2- (2-naphtyl)ethyl)amide
|
|
US6312662B1
(en)
|
1998-03-06 |
2001-11-06 |
Metabasis Therapeutics, Inc. |
Prodrugs phosphorus-containing compounds
|
|
AU3363499A
(en)
|
1998-03-27 |
1999-10-18 |
George W. Griesgraber |
Nucleosides with antiviral and anticancer activity
|
|
AU760688B2
(en)
|
1998-10-16 |
2003-05-22 |
Merck Sharp & Dohme Limited |
Pyrazolo-triazine derivatives as ligands for GABA receptors
|
|
US6116234A
(en)
|
1999-02-01 |
2000-09-12 |
Iep Pharmaceutical Devices Inc. |
Metered dose inhaler agitator
|
|
DE19912636A1
(de)
|
1999-03-20 |
2000-09-21 |
Aventis Cropscience Gmbh |
Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel
|
|
DK1163250T3
(da)
|
1999-03-24 |
2006-11-13 |
Exiqon As |
Forbedret syntese af [2.2.1]bicyclonukleosider
|
|
JP2003514766A
(ja)
|
1999-06-03 |
2003-04-22 |
アボット・ラボラトリーズ |
活性剤としてルイス酸を用いるオリゴヌクレオチド合成
|
|
AUPQ105499A0
(en)
|
1999-06-18 |
1999-07-08 |
Biota Scientific Management Pty Ltd |
Antiviral agents
|
|
US6656915B1
(en)
|
1999-09-15 |
2003-12-02 |
Biocryst Pharmaceuticals, Inc. |
Inhibiting T-cell proliferation
|
|
AU1262001A
(en)
|
1999-11-04 |
2001-05-14 |
Biochem Pharma Inc. |
Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
|
|
CN1427722A
(zh)
|
2000-02-18 |
2003-07-02 |
希拉生物化学股份有限公司 |
用核苷类似物治疗或预防黄病毒感染的方法
|
|
PY0111577A
(es)
|
2000-05-23 |
2017-01-02 |
Idenix Cayman Ltd |
Métodos y composiciones para el tratamiento del virus de la hepatitis c
|
|
AP2006003708A0
(en)
|
2000-05-26 |
2006-08-31 |
Idenix Cayman Ltd |
Methods and compositions for treating flavivirusesand pestiviruses
|
|
US6596700B2
(en)
|
2000-05-26 |
2003-07-22 |
Idenix Pharmaceuticals Inc. |
Methods of treating hepatitis delta virus infection with β-L-2'-deoxy-nucleosides
|
|
CN1291994C
(zh)
|
2000-07-21 |
2006-12-27 |
吉里德科学公司 |
核苷酸膦酸酯类似物前药及其筛选和制备方法
|
|
US20030008841A1
(en)
|
2000-08-30 |
2003-01-09 |
Rene Devos |
Anti-HCV nucleoside derivatives
|
|
JP2004533406A
(ja)
|
2000-10-18 |
2004-11-04 |
フアーマセツト・リミテツド |
ウイルス感染症および異常細胞増殖を治療するための修飾ヌクレオシド
|
|
AUPR213700A0
(en)
|
2000-12-18 |
2001-01-25 |
Biota Scientific Management Pty Ltd |
Antiviral agents
|
|
SI1355916T1
(sl)
|
2001-01-22 |
2007-04-30 |
Merck & Co Inc |
Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
|
|
DE10145223A1
(de)
|
2001-09-13 |
2003-04-03 |
Basf Ag |
Verfahren zur Herstellung von meso-Zeaxanthin
|
|
EP1438054A4
(en)
|
2001-09-28 |
2006-07-26 |
Idenix Cayman Ltd |
METHODS AND COMPOSITIONS FOR TREATING FLAVIVIRUS AND PESTIVIRUS USING MODIFIED NUCLEOSIDE AT 4 'POSITION
|
|
AT410792B
(de)
|
2001-12-28 |
2003-07-25 |
Dsm Fine Chem Austria Gmbh |
Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung
|
|
WO2003073989A2
(en)
|
2002-02-28 |
2003-09-12 |
Biota, Inc. |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
|
US7285658B2
(en)
|
2002-02-28 |
2007-10-23 |
Biota, Inc. |
Nucleotide mimics and their prodrugs
|
|
US20040138170A1
(en)
|
2002-03-06 |
2004-07-15 |
Montgomery John A. |
Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
|
|
GB0210124D0
(en)
|
2002-05-02 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0210127D0
(en)
|
2002-05-02 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
KR20050006221A
(ko)
|
2002-05-06 |
2005-01-15 |
제네랩스 테크놀로지스, 인코포레이티드 |
C형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
|
|
US20050250728A1
(en)
|
2002-05-23 |
2005-11-10 |
Shanta Bantia |
Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
|
|
RU2005118421A
(ru)
|
2002-11-15 |
2006-01-20 |
Айденикс (Кайман) Лимитед (Ky) |
2'-разветвленные нуклеозиды и мутация flaviviridae
|
|
TWI332507B
(en)
|
2002-11-19 |
2010-11-01 |
Hoffmann La Roche |
Antiviral nucleoside derivatives
|
|
PL1628685T3
(pl)
|
2003-04-25 |
2011-05-31 |
Gilead Sciences Inc |
Przeciwwirusowe analogi fosfonianowe
|
|
BRPI0411900B8
(pt)
|
2003-06-26 |
2021-05-25 |
Biotron Ltd |
compostos e composições farmacêuticas compreendendo os mesmos
|
|
GB0317009D0
(en)
|
2003-07-21 |
2003-08-27 |
Univ Cardiff |
Chemical compounds
|
|
DK1658302T3
(da)
|
2003-07-25 |
2010-11-22 |
Idenix Pharmaceuticals Inc |
Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C
|
|
KR20060123707A
(ko)
|
2003-08-27 |
2006-12-04 |
바이오타, 인코포레이티드 |
치료제로서의 신규 트리시클릭 뉴클레오시드 또는뉴클레오티드
|
|
US20050129764A1
(en)
|
2003-12-11 |
2005-06-16 |
Vergez Juan A. |
Osmotic device containing licofelone
|
|
JP2005187428A
(ja)
|
2003-12-26 |
2005-07-14 |
Univ Of Tokyo |
抗mgl抗体によるフィロウイルス治療薬
|
|
JP2005185235A
(ja)
|
2003-12-26 |
2005-07-14 |
Univ Of Tokyo |
ウイルス感染に対する感受性診断のための方法およびキット。
|
|
US20070020299A1
(en)
|
2003-12-31 |
2007-01-25 |
Pipkin James D |
Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
|
|
EP2360165A3
(de)
|
2004-03-16 |
2012-01-04 |
Boehringer Ingelheim International GmbH |
Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
US7534767B2
(en)
|
2004-06-15 |
2009-05-19 |
Merck & Co., Inc. |
C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
|
|
WO2006002231A1
(en)
|
2004-06-22 |
2006-01-05 |
Biocryst Pharmaceuticals, Inc. |
Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
|
|
MX2007003085A
(es)
|
2004-09-14 |
2007-08-02 |
Pharmasset Inc |
Preparacion de 2'-fluoro-2'-alquilo sustituido u otras ribofuranosil pirimidinas y purinas opcionalmente sustituidas y sus derivados.
|
|
AU2005317081A1
(en)
|
2004-10-21 |
2006-06-22 |
Merck & Co., Inc. |
Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection
|
|
CN101043893A
(zh)
|
2004-10-21 |
2007-09-26 |
默克公司 |
治疗RNA-依赖性RNA病毒感染的氟化吡咯并[2,3-d]嘧啶核苷
|
|
US8133870B2
(en)
|
2004-10-29 |
2012-03-13 |
Biocryst Pharmaceuticals, Inc. |
Therapeutic furopyrimidines and thienopyrimidines
|
|
WO2006064033A2
(en)
|
2004-12-16 |
2006-06-22 |
Boehringer Ingelheim International Gmbh |
Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
|
|
EP1858889A1
(en)
|
2005-03-08 |
2007-11-28 |
Biota Scientific Management Pty. Ltd. |
Bicyclic nucleosides and nucleotides as therapeutic agents
|
|
EP2537520A1
(en)
|
2005-03-29 |
2012-12-26 |
Biocryst Pharmaceuticals, Inc. |
Hepatics C therapies
|
|
TW200720285A
(en)
|
2005-04-25 |
2007-06-01 |
Genelabs Tech Inc |
Nucleoside compounds for treating viral infections
|
|
WO2006121820A1
(en)
|
2005-05-05 |
2006-11-16 |
Valeant Research & Development |
Phosphoramidate prodrugs for treatment of viral infection
|
|
WO2007027248A2
(en)
|
2005-05-16 |
2007-03-08 |
Valeant Research & Development |
3', 5' - cyclic nucleoside analogues for treatment of hcv
|
|
PT2826770T
(pt)
|
2005-06-24 |
2018-12-18 |
Biotron Ltd |
Compostos acilguanidinas com atividade antiviral
|
|
US20100087388A1
(en)
|
2005-10-03 |
2010-04-08 |
Kotra Lakshmi P |
Odcase inhibitors as anti-virals and antibiotics
|
|
JP5116687B2
(ja)
|
2005-11-02 |
2013-01-09 |
バイエル・ファルマ・アクチェンゲゼルシャフト |
がんおよび他の過剰増殖性疾患の処置のためのピロロ[2,1−f][1,2,4]トリアジン−4−イルアミンIGF−1Rキナーゼ阻害剤
|
|
NO20055456L
(no)
|
2005-11-17 |
2007-05-18 |
Fluens Synthesis As |
Kontinuerlig stromningsreaktor
|
|
PT1954264E
(pt)
|
2005-12-01 |
2009-12-23 |
Basilea Pharmaceutica Ag |
Processo para a preparação de intermediários de epoxibutanol
|
|
PE20070855A1
(es)
|
2005-12-02 |
2007-10-14 |
Bayer Pharmaceuticals Corp |
Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
|
|
KR101461680B1
(ko)
|
2005-12-02 |
2014-11-19 |
바이엘 헬스케어 엘엘씨 |
과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체
|
|
WO2007065289A2
(en)
|
2005-12-09 |
2007-06-14 |
Basilea Pharmaceutica Ag |
4-oxo-(iso)tretinoin for the topical treatment of severe dermatological disorders
|
|
AU2006324098C1
(en)
|
2005-12-09 |
2011-12-08 |
F. Hoffmann-La Roche Ag |
Antiviral nucleosides
|
|
US7879815B2
(en)
|
2006-02-14 |
2011-02-01 |
Merck Sharp & Dohme Corp. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
WO2007097991A2
(en)
|
2006-02-16 |
2007-08-30 |
Pharmasset, Inc. |
Methods and kits for dosing of antiviral agents
|
|
DE102006015378A1
(de)
|
2006-04-03 |
2007-10-04 |
Ludwig-Maximilians-Universität München |
Verfahren zur Synthese von Organoelementverbindungen
|
|
CL2007001427A1
(es)
|
2006-05-22 |
2008-05-16 |
Novartis Ag |
Sal de maleato de 5-amino-3-(2',3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d]pirimidin-2-ona; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una infeccion po
|
|
WO2008005542A2
(en)
|
2006-07-07 |
2008-01-10 |
Gilead Sciences, Inc., |
Antiviral phosphinate compounds
|
|
JP5225991B2
(ja)
|
2006-07-18 |
2013-07-03 |
アナディス ファーマシューティカルズ インク |
チアゾロ[4,5−d]ピリミジンのカーボネート及びカルバメートプロドラッグ
|
|
US20080161324A1
(en)
*
|
2006-09-14 |
2008-07-03 |
Johansen Lisa M |
Compositions and methods for treatment of viral diseases
|
|
US7879806B2
(en)
|
2006-11-06 |
2011-02-01 |
Boehringer Ingelheim International Gmbh |
Glucopyranosyl-substituted benzyl-benzonitrile derivates, medicaments containing such compounds, their use and process for their manufacture
|
|
US8148349B2
(en)
|
2006-12-20 |
2012-04-03 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
|
US8071568B2
(en)
|
2007-01-05 |
2011-12-06 |
Merck Sharp & Dohme Corp. |
Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
|
|
SI2114980T1
(sl)
*
|
2007-01-12 |
2012-11-30 |
Biocryst Pharm Inc |
Protivirusni nukleozidni analogi
|
|
JP2010522241A
(ja)
|
2007-03-21 |
2010-07-01 |
ブリストル−マイヤーズ スクイブ カンパニー |
増殖性疾患、アレルギー性疾患、自己免疫疾患または炎症性疾患として有用な縮合ヘテロ環化合物
|
|
SI2308514T1
(sl)
|
2007-03-23 |
2013-09-30 |
To-Bbb Holding B.V. |
Konjugati za prenos zdravila preko krvno-moĹľganske pregrade
|
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
|
AU2008251555B2
(en)
*
|
2007-05-10 |
2012-08-30 |
Biocryst Pharmaceuticals, Inc. |
Tetrahydrofuro [3 4-D] dioxolane compounds for use in the treatment of viral infections and cancer
|
|
CN100532388C
(zh)
|
2007-07-16 |
2009-08-26 |
郑州大学 |
2’-氟-4’-取代-核苷类似物、其制备方法及应用
|
|
WO2009018609A1
(en)
|
2007-08-03 |
2009-02-12 |
Biotrom Limited |
Hepatitis c antiviral compositions and methods
|
|
KR101502533B1
(ko)
|
2007-11-22 |
2015-03-13 |
에스케이케미칼주식회사 |
우수한 안정성을 갖는 택산 유도체 함유 주사제용동결건조 조성물 및 이의 제조방법
|
|
US20090176732A1
(en)
*
|
2007-12-21 |
2009-07-09 |
Alios Biopharma Inc. |
Protected nucleotide analogs
|
|
TW200942243A
(en)
|
2008-03-05 |
2009-10-16 |
Biocryst Pharm Inc |
Antiviral therapeutic agents
|
|
US8227431B2
(en)
|
2008-03-17 |
2012-07-24 |
Hetero Drugs Limited |
Nucleoside derivatives
|
|
HRP20130048T1
(hr)
|
2008-04-23 |
2013-02-28 |
Gilead Sciences, Inc. |
Karba-nukleozidni analozi za antivirusnu terapiju
|
|
US7863291B2
(en)
|
2008-04-23 |
2011-01-04 |
Bristol-Myers Squibb Company |
Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
|
|
WO2010036407A2
(en)
|
2008-05-15 |
2010-04-01 |
Biocryst Pharmaceuticals, Inc. |
Antiviral nucleoside analogs
|
|
EP2313102A2
(en)
*
|
2008-07-03 |
2011-04-27 |
Biota Scientific Management |
Bycyclic nucleosides and nucleotides as therapeutic agents
|
|
EP2342616A2
(en)
|
2008-09-23 |
2011-07-13 |
Alnylam Pharmaceuticals Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
|
CA2751277C
(en)
|
2009-02-10 |
2018-10-30 |
Gilead Sciences, Inc. |
Carba-nucleoside analogs for antiviral treatment
|
|
AR075584A1
(es)
|
2009-02-27 |
2011-04-20 |
Intermune Inc |
COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
|
|
AU2010226466A1
(en)
*
|
2009-03-20 |
2011-10-20 |
Alios Biopharma, Inc. |
Substituted nucleoside and nucleotide analogs
|
|
PL2411394T3
(pl)
|
2009-03-24 |
2015-01-30 |
Biocryst Pharm Inc |
Użyteczne sole farmaceutyczne 7-[(3r, 4r)-3-hydroksy-4-hydroksymetylopirolidyn-1-ylometylo]-3,5-dihydropirolo[3,2-d]pirymidyno-4-nu
|
|
TWI583692B
(zh)
|
2009-05-20 |
2017-05-21 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
|
TW201116525A
(en)
|
2009-07-21 |
2011-05-16 |
Gilead Sciences Inc |
Inhibitors of flaviviridae viruses
|
|
US7973013B2
(en)
|
2009-09-21 |
2011-07-05 |
Gilead Sciences, Inc. |
2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
|
|
AU2010295373B2
(en)
|
2009-09-21 |
2016-09-29 |
Gilead Sciences, Inc. |
2' -fluoro substituted carba-nucleoside analogs for antiviral treatment
|
|
US8455451B2
(en)
|
2009-09-21 |
2013-06-04 |
Gilead Sciences, Inc. |
2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
|
|
WO2011035250A1
(en)
|
2009-09-21 |
2011-03-24 |
Gilead Sciences, Inc. |
Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs
|
|
US20120288492A1
(en)
|
2009-12-28 |
2012-11-15 |
Dcb-Usa Llc |
NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS
|
|
WO2011100131A2
(en)
|
2010-01-28 |
2011-08-18 |
Alnylam Pharmacuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
|
UY33312A
(es)
|
2010-03-31 |
2011-10-31 |
Pharmasset Inc |
Fosforamidato de nucleosido de purina
|
|
CL2011000716A1
(es)
|
2010-03-31 |
2012-04-20 |
Gilead Pharmasset Llc |
Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
|
|
TW201201815A
(en)
|
2010-05-28 |
2012-01-16 |
Gilead Sciences Inc |
1'-substituted-carba-nucleoside prodrugs for antiviral treatment
|
|
EA025311B1
(ru)
|
2010-07-19 |
2016-12-30 |
Гайлид Сайэнсиз, Инк. |
Способы получения диастереомерно чистых фосфорамидатных пролекарств
|
|
ES2524356T3
(es)
|
2010-07-22 |
2014-12-05 |
Gilead Sciences, Inc. |
Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae
|
|
TW201305185A
(zh)
|
2010-09-13 |
2013-02-01 |
吉李德科學股份有限公司 |
用於抗病毒治療之2’-氟取代之碳-核苷類似物
|
|
PE20131165A1
(es)
|
2010-09-20 |
2013-10-14 |
Gilead Sciences Inc |
Analogos de carba-nucleosidos sustituidos con 2'-fluoro para tratamiento antiviral
|
|
GEP20156313B
(en)
|
2010-09-22 |
2015-07-10 |
Alios Biopharma Inc |
Substituted nucleotide analogs
|
|
MX348759B
(es)
|
2010-10-15 |
2017-06-28 |
Biocryst Pharm Inc |
Metodos y composiciones para inhibicion de polimerasa.
|
|
AU2011349844B2
(en)
|
2010-12-20 |
2017-06-01 |
Gilead Sciences, Inc. |
Combinations for treating HCV
|
|
ES2744587T3
(es)
|
2011-04-13 |
2020-02-25 |
Gilead Sciences Inc |
Análogos de N-nucleósido de pirimidina 1-sustituidos para un tratamiento antiviral
|
|
ES2639122T3
(es)
|
2011-05-13 |
2017-10-25 |
Zoetis Services Llc |
Composiciones inmunogénicas de glucoproteína G de virus Hendra y Nipah
|
|
WO2013039861A2
(en)
|
2011-09-12 |
2013-03-21 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof
|
|
SI2709613T2
(sl)
|
2011-09-16 |
2020-12-31 |
Gilead Pharmasset LLC c/o Gilead Sciences, Inc. |
Postopki za zdravljenje HCV
|
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
|
WO2013084165A1
(en)
|
2011-12-05 |
2013-06-13 |
Medivir Ab |
Hcv polymerase inhibitors
|
|
US20130143835A1
(en)
|
2011-12-05 |
2013-06-06 |
Medivir Ab |
HCV Polymerase Inhibitors
|
|
US8980865B2
(en)
|
2011-12-22 |
2015-03-17 |
Alios Biopharma, Inc. |
Substituted nucleotide analogs
|
|
AP3913A
(en)
|
2012-05-22 |
2016-11-26 |
Idenix Pharamaceuticals Inc |
D-amino acid compounds for liver disease
|
|
US9556216B2
(en)
|
2012-08-31 |
2017-01-31 |
Novartis Ag |
2′-Ethynyl nucleoside derivatives for treatment of viral infections
|
|
MX2015002954A
(es)
|
2012-09-10 |
2015-06-05 |
Hoffmann La Roche |
Nuevas 6-aminoacido-heteroarilhidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b.
|
|
WO2014042433A2
(en)
|
2012-09-14 |
2014-03-20 |
Kainos Medicine, Inc. |
Compounds and compositions for modulating adenosine a3 receptor activity
|
|
WO2014078778A2
(en)
|
2012-11-16 |
2014-05-22 |
Biocryst Pharmaceuticals, Inc. |
Antiviral azasugar-containing nucleosides
|
|
WO2014078463A1
(en)
|
2012-11-19 |
2014-05-22 |
Merck Sharp & Dohme Corp. |
2 -alkynyl substituted nucleoside derivatives for treating viral diseases
|
|
GEP201706757B
(en)
|
2012-12-21 |
2017-10-25 |
Alios Biopharma Inc |
Substituted nucleosides, nucleotides and analogs thereof
|
|
US9283242B2
(en)
|
2013-01-22 |
2016-03-15 |
Massachusetts Institute Of Technology |
Uses of dihydro bases
|
|
US10034893B2
(en)
|
2013-02-01 |
2018-07-31 |
Enanta Pharmaceuticals, Inc. |
5, 6-D2 uridine nucleoside/tide derivatives
|
|
BR112015025766A2
(pt)
|
2013-04-12 |
2017-10-17 |
Achillion Pharmaceuticals Inc |
derivado de nucleosídeo altamente ativo para o tratamento de hcv
|
|
HK1224229A1
(zh)
|
2013-06-26 |
2017-08-18 |
Alios Biopharma, Inc. |
取代的核苷,核苷酸及其类似物
|
|
UA117375C2
(uk)
|
2013-09-04 |
2018-07-25 |
Медівір Аб |
Інгібітори полімерази hcv
|
|
PL3043865T3
(pl)
|
2013-09-11 |
2021-07-05 |
Institut National De La Santé Et De La Recherche Médicale (Inserm) |
SPOSOBY I KOMPOZYCjE FARMACEUTYCZNE W LECZENIU ZAKAŻENIA WIRUSEM ZAPALENIA WĄTROBY TYPU B
|
|
JP6562908B2
(ja)
|
2013-10-11 |
2019-08-21 |
ヤンセン バイオファーマ インク. |
置換ヌクレオシド、置換ヌクレオチドおよびその類似体
|
|
UA119050C2
(uk)
|
2013-11-11 |
2019-04-25 |
Ґілеад Саєнсиз, Інк. |
ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ
|
|
JP2017504633A
(ja)
|
2014-01-30 |
2017-02-09 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
B型肝炎ウイルス感染の治療及び予防のための新規なジヒドロキノリジノン
|
|
ES2714110T3
(es)
|
2014-03-07 |
2019-05-27 |
Hoffmann La Roche |
Heteroarildihidropirimidinas 6-fusionadas novedosas para el tratamiento y profilaxis de la infección por el virus de la hepatitis B
|
|
WO2015143712A1
(en)
|
2014-03-28 |
2015-10-01 |
Merck Sharp & Dohme Corp. |
4'-substituted nucleoside reverse transcriptase inhibitors
|
|
CA2948080A1
(en)
|
2014-05-13 |
2015-11-19 |
F. Hoffmann-La Roche Ag |
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
|
|
US9616076B2
(en)
|
2014-06-02 |
2017-04-11 |
The Board Of Regents Of The University Of Texas Systems |
Methods for treating viral infections using hydrogen sulfide donors
|
|
US9504701B2
(en)
|
2014-06-02 |
2016-11-29 |
The Board Of Regents Of The University Of Texas System |
Methods for treating viral infections using hydrogen sulfide donors
|
|
HUE051986T2
(hu)
|
2014-06-24 |
2021-04-28 |
Janssen Biopharma Inc |
Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
|
|
TN2016000566A1
(en)
|
2014-06-24 |
2018-04-04 |
Alios Biopharma Inc |
Substituted nucleosides, nucleotides and analogs thereof
|
|
WO2016012470A1
(en)
|
2014-07-25 |
2016-01-28 |
F. Hoffmann-La Roche Ag |
New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
|
|
TWI678369B
(zh)
|
2014-07-28 |
2019-12-01 |
美商基利科學股份有限公司 |
用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類
|
|
CN106573898B
(zh)
|
2014-08-14 |
2018-11-09 |
豪夫迈·罗氏有限公司 |
治疗和预防乙型肝炎病毒感染的新的哒嗪酮和三嗪酮
|
|
TWI740546B
(zh)
|
2014-10-29 |
2021-09-21 |
美商基利科學股份有限公司 |
製備核糖苷的方法
|
|
US9637485B2
(en)
|
2014-11-03 |
2017-05-02 |
Hoffmann-La Roche Inc. |
6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
|
|
AR103222A1
(es)
|
2014-12-23 |
2017-04-26 |
Hoffmann La Roche |
Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
|
|
US9676793B2
(en)
|
2014-12-23 |
2017-06-13 |
Hoffmann-Laroche Inc. |
Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
|
|
CN107108610B
(zh)
|
2014-12-30 |
2019-06-04 |
豪夫迈·罗氏有限公司 |
用于治疗和预防肝炎b病毒感染的新的四氢吡啶并嘧啶和四氢吡啶并吡啶化合物
|
|
CN107109497A
(zh)
|
2014-12-31 |
2017-08-29 |
豪夫迈·罗氏有限公司 |
通过实时PCR从细胞裂解物定量HBV cccDNA的高通量新方法
|
|
MA41338B1
(fr)
|
2015-01-16 |
2019-07-31 |
Hoffmann La Roche |
Composés de pyrazine pour le traitement de maladies infectieuses
|
|
WO2016120186A1
(en)
|
2015-01-27 |
2016-08-04 |
F. Hoffmann-La Roche Ag |
Recombinant hbv cccdna, the method to generate thereof and the use thereof
|
|
EP3256471B1
(en)
|
2015-02-11 |
2018-12-12 |
F. Hoffmann-La Roche AG |
Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
|
|
GB201503578D0
(en)
|
2015-03-03 |
2015-04-15 |
Ge Healthcare Bio Sciences Ab |
Sanitization method for affinity chromatography matrices
|
|
HRP20220355T1
(hr)
|
2015-09-16 |
2022-05-13 |
Gilead Sciences, Inc. |
Postupci za liječenje infekcija coronaviridae
|
|
US11963972B2
(en)
|
2016-03-23 |
2024-04-23 |
Emory University |
Antiviral agents and nucleoside analogs for treatment of Zika virus
|
|
WO2017184668A1
(en)
|
2016-04-20 |
2017-10-26 |
Gilead Sciences, Inc. |
Methods for treating flaviviridae virus infections
|
|
AU2018218179B2
(en)
|
2017-02-08 |
2023-05-04 |
Biotron Limited |
Methods of treating influenza
|
|
CN116036112A
(zh)
|
2017-03-14 |
2023-05-02 |
吉利德科学公司 |
治疗猫冠状病毒感染的方法
|
|
WO2018204198A1
(en)
|
2017-05-01 |
2018-11-08 |
Gilead Sciences, Inc. |
Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
|
|
EP4512475A3
(en)
|
2017-07-11 |
2025-05-14 |
Gilead Sciences, Inc. |
Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
|
|
CN109748944B
(zh)
|
2017-11-03 |
2021-12-10 |
中国科学院上海药物研究所 |
5’-脱氧-5’-异丙基取代氨基核苷类化合物、其制备方法和用途
|
|
CN111265532A
(zh)
|
2020-01-21 |
2020-06-12 |
中国人民解放军军事科学院军事医学研究院 |
取代氨基丙酸酯类化合物在治疗2019-nCoV感染中的应用
|
|
AU2021214911A1
(en)
|
2020-01-27 |
2022-07-21 |
Gilead Sciences, Inc. |
Methods for treating SARS CoV-2 infections
|
|
CN113214334A
(zh)
|
2020-02-05 |
2021-08-06 |
华创合成制药股份有限公司 |
用于治疗病毒感染的化合物及其制备方法和用途
|
|
TWI791193B
(zh)
|
2020-02-18 |
2023-02-01 |
美商基利科學股份有限公司 |
抗病毒化合物
|
|
WO2021168930A1
(zh)
|
2020-02-25 |
2021-09-02 |
顾世海 |
一种瑞德西韦的片剂及其制备方法
|
|
CN111233929B
(zh)
|
2020-02-28 |
2023-02-28 |
成都阿奇生物医药科技有限公司 |
一种核苷类似物的氘代物及其制备方法和用途
|
|
CN118994170A
(zh)
|
2020-03-12 |
2024-11-22 |
吉利德科学公司 |
制备1'-氰基核苷的方法
|
|
EP4132651B1
(en)
|
2020-04-06 |
2026-03-18 |
Gilead Sciences, Inc. |
Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
|
|
ES3041698T3
(en)
|
2020-05-29 |
2025-11-13 |
Gilead Sciences Inc |
Remdesivir for the treatment of viral infections
|
|
EP4171653A2
(en)
|
2020-06-24 |
2023-05-03 |
Regeneron Pharmaceuticals, Inc. |
Tubulysins and protein-tubulysin conjugates
|
|
CA3187821A1
(en)
|
2020-06-24 |
2021-12-30 |
Gilead Sciences, Inc. |
1'-cyano nucleoside analogs and uses thereof
|
|
WO2022047065A2
(en)
|
2020-08-27 |
2022-03-03 |
Gilead Sciences, Inc. |
Compounds and methods for treatment of viral infections
|
|
KR20230170948A
(ko)
|
2021-04-16 |
2023-12-19 |
길리애드 사이언시즈, 인코포레이티드 |
아미드를 사용한 카르바뉴클레오시드를 제조하는 방법
|
|
TW202317144A
(zh)
|
2021-06-14 |
2023-05-01 |
美商維納拓爾斯製藥公司 |
口服生物可利用的核苷類似物
|
|
WO2023102472A1
(en)
|
2021-12-01 |
2023-06-08 |
The Scripps Research Institute |
Antiviral prodrugs and formulations thereof
|
|
EP4486746A1
(en)
|
2022-03-02 |
2025-01-08 |
Gilead Sciences, Inc. |
Compounds and methods for treatment of viral infections
|
|
TW202525810A
(zh)
|
2022-03-02 |
2025-07-01 |
美商基利科學股份有限公司 |
用於治療病毒感染的化合物及方法
|
|
CN119604286A
(zh)
|
2022-06-06 |
2025-03-11 |
吉利德科学公司 |
用于治疗包括sars-cov-2的病毒感染的方法
|
|
WO2024006376A1
(en)
|
2022-06-29 |
2024-01-04 |
Gilead Sciences, Inc. |
Solid forms of a nucleoside analogue and uses thereof
|
|
WO2024006461A1
(en)
|
2022-06-30 |
2024-01-04 |
Gilead Sciences, Inc. |
Solid forms of a nucleoside analogue and uses thereof
|
|
WO2024054618A1
(en)
|
2022-09-09 |
2024-03-14 |
Gilead Sciences, Inc. |
Methods for treatment of viral infections
|
|
WO2024076951A2
(en)
|
2022-10-04 |
2024-04-11 |
The Scripps Research Institute |
Antiviral prodrugs and formulations thereof
|
|
TWI883612B
(zh)
|
2022-10-27 |
2025-05-11 |
美商基利科學股份有限公司 |
醫藥配方及其用途
|
|
JP2025540572A
(ja)
|
2022-11-18 |
2025-12-16 |
ギリアード サイエンシーズ, インコーポレイテッド |
ポックスウイルス感染を治療する方法
|
|
TW202545959A
(zh)
|
2023-04-28 |
2025-12-01 |
美商基利科學股份有限公司 |
用於治療病毒感染的化合物及方法
|
|
WO2025054278A1
(en)
|
2023-09-06 |
2025-03-13 |
Gilead Sciences, Inc. |
Solid forms of a nucleoside analogue and uses thereof
|
|
CN121843949A
(zh)
|
2023-09-15 |
2026-04-10 |
吉利德科学公司 |
用于治疗病毒感染的化合物和方法
|
|
US20250109157A1
(en)
|
2023-09-28 |
2025-04-03 |
Gilead Sciences, Inc. |
Compounds and methods for treatment of viral infections
|