FR15C0003I2 - Production de muteines recombinantes du facteur de coagulation sanguine viii dans des lignees de cellules humaines - Google Patents

Production de muteines recombinantes du facteur de coagulation sanguine viii dans des lignees de cellules humaines

Info

Publication number
FR15C0003I2
FR15C0003I2 FR15C0003C FR15C0003C FR15C0003I2 FR 15C0003 I2 FR15C0003 I2 FR 15C0003I2 FR 15C0003 C FR15C0003 C FR 15C0003C FR 15C0003 C FR15C0003 C FR 15C0003C FR 15C0003 I2 FR15C0003 I2 FR 15C0003I2
Authority
FR
France
Prior art keywords
factor viii
human cell
production
muteins
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR15C0003C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma Biopharmaceuticals GmbH
Original Assignee
Octapharma Biopharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00106225A external-priority patent/EP1136553A1/en
Application filed by Octapharma Biopharmaceuticals GmbH filed Critical Octapharma Biopharmaceuticals GmbH
Publication of FR15C0003I1 publication Critical patent/FR15C0003I1/fr
Application granted granted Critical
Publication of FR15C0003I2 publication Critical patent/FR15C0003I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
FR15C0003C 2000-03-22 2015-01-20 Production de muteines recombinantes du facteur de coagulation sanguine viii dans des lignees de cellules humaines Active FR15C0003I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00106225A EP1136553A1 (en) 2000-03-22 2000-03-22 Production of recombinant blood clotting factors in human cell lines
US20324900P 2000-05-08 2000-05-08
PCT/EP2001/003220 WO2001070968A2 (en) 2000-03-22 2001-03-21 Production of recombinant blood clotting factors in human cell lines
EP01927769A EP1266006B1 (en) 2000-03-22 2001-03-21 Production of recombinant muteins of blood clotting factor viii in human cell lines

Publications (2)

Publication Number Publication Date
FR15C0003I1 FR15C0003I1 (fr) 2015-02-27
FR15C0003I2 true FR15C0003I2 (fr) 2015-11-20

Family

ID=26070708

Family Applications (1)

Application Number Title Priority Date Filing Date
FR15C0003C Active FR15C0003I2 (fr) 2000-03-22 2015-01-20 Production de muteines recombinantes du facteur de coagulation sanguine viii dans des lignees de cellules humaines

Country Status (28)

Country Link
US (1) US7572619B2 (es)
EP (2) EP1460131A3 (es)
JP (1) JP3894795B2 (es)
KR (1) KR100581574B1 (es)
CN (1) CN1454257B (es)
AT (1) ATE312176T1 (es)
AU (3) AU2001254715B2 (es)
BE (1) BE2014C077I2 (es)
BG (1) BG65930B1 (es)
BR (1) BRPI0109494B8 (es)
CA (1) CA2404163C (es)
CZ (1) CZ303929B6 (es)
DE (1) DE60115613T2 (es)
DK (1) DK1266006T3 (es)
EA (1) EA004317B1 (es)
EE (1) EE200200538A (es)
ES (1) ES2254403T3 (es)
FR (1) FR15C0003I2 (es)
HR (1) HRP20020767B1 (es)
HU (1) HU228091B1 (es)
IL (2) IL151857A0 (es)
MX (1) MXPA02009221A (es)
NO (1) NO330910B1 (es)
NZ (1) NZ521732A (es)
RS (1) RS50743B (es)
SI (1) SI1266006T1 (es)
SK (1) SK287706B6 (es)
WO (1) WO2001070968A2 (es)

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Also Published As

Publication number Publication date
AU2001254715B2 (en) 2006-02-02
DK1266006T3 (da) 2006-01-16
US7572619B2 (en) 2009-08-11
CZ303929B6 (cs) 2013-07-03
ES2254403T3 (es) 2006-06-16
EE200200538A (et) 2004-04-15
HU228091B1 (en) 2012-10-29
AU5471501A (en) 2001-10-03
CZ20023166A3 (cs) 2003-02-12
SK15042002A3 (sk) 2003-09-11
NO330910B1 (no) 2011-08-15
US20040023333A1 (en) 2004-02-05
BG107152A (bg) 2003-06-30
MXPA02009221A (es) 2005-07-25
HUP0300588A3 (en) 2005-09-28
EP1460131A2 (en) 2004-09-22
IL151857A (en) 2010-05-31
NO20024475D0 (no) 2002-09-19
NZ521732A (en) 2004-05-28
EA004317B1 (ru) 2004-02-26
HRP20020767B1 (en) 2011-09-30
KR100581574B1 (ko) 2006-05-22
BE2014C077I2 (es) 2020-01-30
SI1266006T1 (sl) 2006-06-30
EP1266006A2 (en) 2002-12-18
FR15C0003I1 (fr) 2015-02-27
AU2006201848A1 (en) 2006-05-25
WO2001070968A3 (en) 2001-12-13
RS50743B (sr) 2010-08-31
JP2003530093A (ja) 2003-10-14
DE60115613T2 (de) 2006-08-24
NO20024475L (no) 2002-11-20
CA2404163A1 (en) 2001-09-27
HUP0300588A2 (hu) 2003-06-28
CN1454257A (zh) 2003-11-05
JP3894795B2 (ja) 2007-03-22
EP1266006B1 (en) 2005-12-07
BR0109494A (pt) 2002-12-10
YU71002A (sh) 2005-11-28
IL151857A0 (en) 2003-04-10
BRPI0109494B8 (pt) 2021-05-25
SK287706B6 (en) 2011-07-06
CN1454257B (zh) 2013-01-16
WO2001070968A2 (en) 2001-09-27
BRPI0109494B1 (pt) 2021-05-11
DE60115613D1 (de) 2006-01-12
CA2404163C (en) 2009-09-29
BG65930B1 (bg) 2010-05-31
HRP20020767A2 (en) 2005-02-28
EA200201008A1 (ru) 2003-02-27
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EP1460131A3 (en) 2005-06-01
ATE312176T1 (de) 2005-12-15

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