BE2014C077I2 - - Google Patents

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Publication number
BE2014C077I2
BE2014C077I2 BE2014C077C BE2014C077C BE2014C077I2 BE 2014C077 I2 BE2014C077 I2 BE 2014C077I2 BE 2014C077 C BE2014C077 C BE 2014C077C BE 2014C077 C BE2014C077 C BE 2014C077C BE 2014C077 I2 BE2014C077 I2 BE 2014C077I2
Authority
BE
Belgium
Prior art keywords
factor viii
factor
promoter
vector
cell line
Prior art date
Application number
BE2014C077C
Other languages
English (en)
French (fr)
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00106225A external-priority patent/EP1136553A1/en
Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of BE2014C077I2 publication Critical patent/BE2014C077I2/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
BE2014C077C 2000-03-22 2014-12-29 BE2014C077I2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00106225A EP1136553A1 (en) 2000-03-22 2000-03-22 Production of recombinant blood clotting factors in human cell lines
US20324900P 2000-05-08 2000-05-08
EP01927769A EP1266006B1 (en) 2000-03-22 2001-03-21 Production of recombinant muteins of blood clotting factor viii in human cell lines
PCT/EP2001/003220 WO2001070968A2 (en) 2000-03-22 2001-03-21 Production of recombinant blood clotting factors in human cell lines

Publications (1)

Publication Number Publication Date
BE2014C077I2 true BE2014C077I2 (es) 2020-01-30

Family

ID=26070708

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2014C077C BE2014C077I2 (es) 2000-03-22 2014-12-29

Country Status (28)

Country Link
US (1) US7572619B2 (es)
EP (2) EP1460131A3 (es)
JP (1) JP3894795B2 (es)
KR (1) KR100581574B1 (es)
CN (1) CN1454257B (es)
AT (1) ATE312176T1 (es)
AU (3) AU2001254715B2 (es)
BE (1) BE2014C077I2 (es)
BG (1) BG65930B1 (es)
BR (1) BRPI0109494B8 (es)
CA (1) CA2404163C (es)
CZ (1) CZ303929B6 (es)
DE (1) DE60115613T2 (es)
DK (1) DK1266006T3 (es)
EA (1) EA004317B1 (es)
EE (1) EE200200538A (es)
ES (1) ES2254403T3 (es)
FR (1) FR15C0003I2 (es)
HR (1) HRP20020767B1 (es)
HU (1) HU228091B1 (es)
IL (2) IL151857A0 (es)
MX (1) MXPA02009221A (es)
NO (1) NO330910B1 (es)
NZ (1) NZ521732A (es)
RS (1) RS50743B (es)
SI (1) SI1266006T1 (es)
SK (1) SK287706B6 (es)
WO (1) WO2001070968A2 (es)

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EP1319016A4 (en) * 2000-09-19 2006-05-10 Univ Emory MODIFIED FACTOR VIII
EP1469064A1 (en) 2003-04-15 2004-10-20 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Expression of proteins in endothelial cells derived from precursor cells from cord blood
EP1755652B1 (en) * 2004-03-19 2010-11-24 Baxter International Inc. Factor ixa for the treatment of bleeding disorders
KR100624013B1 (ko) * 2004-06-25 2006-09-19 주식회사 녹십자홀딩스 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
DK1804839T3 (da) 2004-09-22 2012-04-10 St Jude Childrens Res Hospital Forbedret ekspression af faktor ix i genterapivektorer
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
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CA2835053C (en) 2011-05-13 2020-07-07 Octapharma Ag A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii
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MX358220B (es) 2011-11-30 2018-08-10 Chugai Pharmaceutical Co Ltd Portador que contiene fármaco en la célula para formar el inmunocomplejo.
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Also Published As

Publication number Publication date
US7572619B2 (en) 2009-08-11
FR15C0003I2 (fr) 2015-11-20
IL151857A0 (en) 2003-04-10
MXPA02009221A (es) 2005-07-25
AU2006201848A1 (en) 2006-05-25
IL151857A (en) 2010-05-31
HU228091B1 (en) 2012-10-29
US20040023333A1 (en) 2004-02-05
NO20024475D0 (no) 2002-09-19
CZ20023166A3 (cs) 2003-02-12
EP1460131A3 (en) 2005-06-01
ES2254403T3 (es) 2006-06-16
WO2001070968A3 (en) 2001-12-13
EE200200538A (et) 2004-04-15
DE60115613D1 (de) 2006-01-12
EA004317B1 (ru) 2004-02-26
SK15042002A3 (sk) 2003-09-11
DE60115613T2 (de) 2006-08-24
KR20030011079A (ko) 2003-02-06
RS50743B (sr) 2010-08-31
BG65930B1 (bg) 2010-05-31
ATE312176T1 (de) 2005-12-15
BRPI0109494B1 (pt) 2021-05-11
KR100581574B1 (ko) 2006-05-22
JP2003530093A (ja) 2003-10-14
NO330910B1 (no) 2011-08-15
HRP20020767A2 (en) 2005-02-28
JP3894795B2 (ja) 2007-03-22
CN1454257A (zh) 2003-11-05
CA2404163C (en) 2009-09-29
YU71002A (sh) 2005-11-28
NZ521732A (en) 2004-05-28
HUP0300588A3 (en) 2005-09-28
EP1266006A2 (en) 2002-12-18
AU2001254715B2 (en) 2006-02-02
HUP0300588A2 (hu) 2003-06-28
DK1266006T3 (da) 2006-01-16
HRP20020767B1 (en) 2011-09-30
SK287706B6 (en) 2011-07-06
CN1454257B (zh) 2013-01-16
FR15C0003I1 (fr) 2015-02-27
CZ303929B6 (cs) 2013-07-03
EA200201008A1 (ru) 2003-02-27
CA2404163A1 (en) 2001-09-27
WO2001070968A2 (en) 2001-09-27
EP1266006B1 (en) 2005-12-07
SI1266006T1 (sl) 2006-06-30
EP1460131A2 (en) 2004-09-22
BG107152A (bg) 2003-06-30
AU5471501A (en) 2001-10-03
BR0109494A (pt) 2002-12-10
BRPI0109494B8 (pt) 2021-05-25
NO20024475L (no) 2002-11-20

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