FR11C0023I2 - Derives de benzimidazole a activite antihistaminique - Google Patents
Derives de benzimidazole a activite antihistaminiqueInfo
- Publication number
- FR11C0023I2 FR11C0023I2 FR11C0023C FR11C0023C FR11C0023I2 FR 11C0023 I2 FR11C0023 I2 FR 11C0023I2 FR 11C0023 C FR11C0023 C FR 11C0023C FR 11C0023 C FR11C0023 C FR 11C0023C FR 11C0023 I2 FR11C0023 I2 FR 11C0023I2
- Authority
- FR
- France
- Prior art keywords
- benzimidazole derivatives
- antihistaminic activity
- antihistaminic
- activity
- benzimidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000001387 anti-histamine Effects 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09601236A ES2124167B1 (es) | 1996-06-04 | 1996-06-04 | Nuevos derivados del bencimidazol con actividad antihistaminica. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR11C0023I1 FR11C0023I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2011-08-19 |
| FR11C0023I2 true FR11C0023I2 (fr) | 2012-03-16 |
Family
ID=8295035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR11C0023C Active FR11C0023I2 (fr) | 1996-06-04 | 2011-07-08 | Derives de benzimidazole a activite antihistaminique |
Country Status (27)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL140422A0 (en) | 1998-07-01 | 2002-02-10 | Retinoid Related Receptor Func | Retinoid-related receptor function regulating agent |
| TR200101498T2 (tr) | 1998-11-27 | 2001-11-21 | Basf Aktiengesellschaft | İkameli benzimidazoller ve parp inhibitörleri olarak kullanımları |
| ES2151442B1 (es) * | 1999-01-11 | 2001-07-01 | Espanola Prod Quimicos | Nuevo derivado del bencenoetanol. |
| US6826561B2 (en) | 2000-05-22 | 2004-11-30 | Broadcom Corporation | Method and apparatus for performing a binary search on an expanded tree |
| RU2288917C2 (ru) * | 2002-04-19 | 2006-12-10 | Фаэс Фарма, С.А. | Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение |
| HU230032B1 (hu) * | 2002-04-19 | 2015-05-28 | Faes Farma, S.A | Polimorf 4-{2-[4-[1-(2-etoxietil)-1H-benzimidazol-2-il]-1-piperidinil]etil}-alfa,alfa-dimetil-benzenoecetsav |
| DE60309701T2 (de) * | 2002-06-13 | 2007-09-06 | Vertex Pharmaceuticals Inc., Cambridge | 2-ureido-6-heteroaryl-3h-benzoimidazol-4-carbonsäurederivate und verwandte verbindungen als gyrase und/oder topoisomerase iv inhibitoren zur behandlung von bakteriellen infektionen |
| US20070188330A1 (en) * | 2006-01-24 | 2007-08-16 | Morhard Robert C | System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks |
| US7247623B2 (en) * | 2005-08-19 | 2007-07-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with non-drying antihistamines |
| WO2009102155A2 (en) * | 2008-02-12 | 2009-08-20 | Yuhan Corporation | Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds |
| JP2010013472A (ja) * | 2009-09-09 | 2010-01-21 | Faes Farma Sa | ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体 |
| CN102675101B (zh) * | 2012-05-16 | 2014-01-29 | 王蕾 | 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法 |
| CZ307500B6 (cs) | 2012-08-15 | 2018-10-24 | Zentiva, K.S. | Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty |
| WO2014149019A1 (en) * | 2013-03-15 | 2014-09-25 | Hercules Incorporated | Composition and method of producing personal care compositions with improved deposition properties |
| CN103214455B (zh) * | 2013-03-30 | 2018-08-31 | 北京万全德众医药生物技术有限公司 | 一种比拉斯汀的制备方法 |
| CN103214454A (zh) * | 2013-03-30 | 2013-07-24 | 北京万全德众医药生物技术有限公司 | 一种比拉斯汀晶型及制备方法 |
| WO2014188453A2 (en) * | 2013-05-24 | 2014-11-27 | Msn Laboratories Private Limited | Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid |
| CN103351380B (zh) * | 2013-06-30 | 2019-01-22 | 北京万全德众医药生物技术有限公司 | 一种制备比拉斯汀的方法 |
| CN104447683A (zh) * | 2013-09-12 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 一种稳定的比拉斯汀化合物 |
| CN103896915A (zh) * | 2014-04-01 | 2014-07-02 | 中国药科大学 | 苯并咪唑类衍生物、其制备方法及其在医药上的应用 |
| EP3040334A1 (en) | 2014-12-29 | 2016-07-06 | Faes Farma, S.A. | New benzimidazole derivatives as antihistamine agents |
| CN106349214B (zh) * | 2015-07-13 | 2020-11-03 | 南京长澳医药科技有限公司 | 一种比拉斯汀杂质的制备方法 |
| ES2600827B9 (es) * | 2015-07-24 | 2018-03-28 | Urquima, S.A | Formas cristalinas de bilastina y procedimientos para su preparación |
| CN105272977A (zh) * | 2015-09-19 | 2016-01-27 | 万全万特制药江苏有限公司 | 一种制备比拉斯汀中间体的方法 |
| EP3170817A1 (en) | 2015-11-20 | 2017-05-24 | Faes Farma, S.A. | Co-crystals of benzimidazole compounds |
| EP3170816A1 (en) | 2015-11-20 | 2017-05-24 | Faes Farma, S.A. | Supersaturated compositions of benzimidazole compounds |
| WO2017167949A1 (en) | 2016-04-01 | 2017-10-05 | Krka, D.D., Novo Mesto | Crystalline forms of bilastine |
| EP3452462A4 (en) * | 2016-05-05 | 2019-10-23 | MSN Laboratories Private Limited, R&D Center | Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof |
| CN107365298A (zh) * | 2017-03-14 | 2017-11-21 | 罗欣生物科技（上海）有限公司 | 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法 |
| CN109456316A (zh) * | 2017-09-06 | 2019-03-12 | 万全万特制药江苏有限公司 | 一种比拉斯汀杂质的制备方法 |
| EP3453384B1 (en) | 2017-09-07 | 2020-05-27 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine |
| LT3681475T (lt) | 2017-10-16 | 2021-02-25 | Faes Farma, S.A. | Vandeninės kompozicijos, apimančios bilastiną ir mometazoną |
| EP3470062B1 (en) | 2017-12-18 | 2020-10-28 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate |
| EP3641735B1 (en) | 2017-12-18 | 2021-02-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler |
| CA3088740A1 (en) | 2018-01-18 | 2019-07-25 | Faes Farma, S.A. | Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent |
| CN109081827A (zh) * | 2018-11-06 | 2018-12-25 | 北京天弘天达医药科技股份有限公司 | 一种比拉斯汀的制备方法及应用 |
| EP3725298A1 (en) | 2019-04-16 | 2020-10-21 | Faes Farma, S.A. | Stable and preserved pharmaceutical compositions of bilastine |
| WO2022023463A1 (en) | 2020-07-30 | 2022-02-03 | Faes Farma, S.A. | Decongestant drug delivery system |
| CN112110893A (zh) * | 2020-10-28 | 2020-12-22 | 山东齐环医药科技有限公司 | 一种比拉斯汀的制备方法 |
| WO2022106923A1 (en) | 2020-11-18 | 2022-05-27 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising an antihistamine compound |
| CA3200779A1 (en) | 2020-12-23 | 2022-06-30 | Strusi ORAZIO LUCA | A non-micronized bilastine composition |
| US20250228836A1 (en) | 2022-02-17 | 2025-07-17 | Faes Farma, S.A. | Bilastine composition for once-daily parenteral administration |
| WO2024224308A1 (en) * | 2023-04-27 | 2024-10-31 | Leiutis Pharmaceuticals Llp | Liquid parenteral formulations of bilastine free of cyclodextrins |
| WO2024224326A1 (en) * | 2023-04-27 | 2024-10-31 | Leiutis Pharmaceuticals Llp | Liquid parenteral formulations of bilastine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8904174D0 (en) * | 1989-02-23 | 1989-04-05 | British Bio Technology | Compounds |
| CA2077897A1 (en) * | 1990-04-13 | 1991-10-14 | Robert G. Franz | Substituted benzimidazoles |
| ES2048109B1 (es) * | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
| JP3041954B2 (ja) * | 1992-08-03 | 2000-05-15 | セプラコア インコーポレーテッド | アレルギー疾患治療用のテルフェナジン代謝物及びその光学的に純粋な異性体 |
| EP2261208A1 (en) * | 1993-06-25 | 2010-12-15 | Aventisub II Inc. | Intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives |
-
1996
- 1996-06-04 ES ES09601236A patent/ES2124167B1/es not_active Expired - Fee Related
-
1997
- 1997-06-03 ZA ZA9704893A patent/ZA974893B/xx unknown
- 1997-06-03 DE DE122011000006C patent/DE122011000006I1/de active Pending
- 1997-06-03 DE DE69728608T patent/DE69728608T2/de not_active Expired - Lifetime
- 1997-06-03 CA CA002206754A patent/CA2206754C/en not_active Expired - Lifetime
- 1997-06-03 NO NO19972525A patent/NO313195B1/no not_active IP Right Cessation
- 1997-06-03 AU AU24672/97A patent/AU725700B2/en not_active Expired
- 1997-06-03 EP EP97500099A patent/EP0818454B1/en not_active Expired - Lifetime
- 1997-06-03 SI SI9730652T patent/SI0818454T1/xx unknown
- 1997-06-03 RU RU97108980/04A patent/RU2182150C2/ru active
- 1997-06-03 AT AT97500099T patent/ATE264317T1/de active
- 1997-06-03 DK DK97500099T patent/DK0818454T3/da active
- 1997-06-03 PT PT97500099T patent/PT818454E/pt unknown
- 1997-06-03 HR HR970307A patent/HRP970307B1/xx not_active IP Right Cessation
- 1997-06-04 MX MXPA97004127A patent/MXPA97004127A/es active IP Right Grant
- 1997-06-04 US US08/868,743 patent/US5877187A/en not_active Expired - Lifetime
- 1997-06-04 JP JP16201097A patent/JP4218991B2/ja not_active Expired - Lifetime
- 1997-06-04 HU HU9700997A patent/HU227598B1/hu active Protection Beyond IP Right Term
- 1997-06-04 CZ CZ19971723A patent/CZ289278B6/cs not_active IP Right Cessation
- 1997-06-04 TR TR97/00464A patent/TR199700464A2/xx unknown
- 1997-06-04 IN IN1498DE1997 patent/IN186319B/en unknown
- 1997-06-04 BR BR9703276-0A patent/BR9703276A/pt not_active IP Right Cessation
- 1997-06-04 CN CN97114905A patent/CN1105716C/zh not_active Expired - Lifetime
- 1997-06-04 PL PL97320358A patent/PL188908B1/pl unknown
- 1997-06-05 AR ARP970102441A patent/AR008386A1/es active IP Right Grant
- 1997-07-22 TW TW086110371A patent/TW438794B/zh not_active IP Right Cessation
-
2011
- 2011-03-22 LU LU91798C patent/LU91798I2/fr unknown
- 2011-05-24 NO NO2011008C patent/NO2011008I2/no unknown
- 2011-07-08 FR FR11C0023C patent/FR11C0023I2/fr active Active
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