FI942906A - En stabiliserad farmaceutisk formulering innehållande tillväxthormon och histidin - Google Patents
En stabiliserad farmaceutisk formulering innehållande tillväxthormon och histidin Download PDFInfo
- Publication number
- FI942906A FI942906A FI942906A FI942906A FI942906A FI 942906 A FI942906 A FI 942906A FI 942906 A FI942906 A FI 942906A FI 942906 A FI942906 A FI 942906A FI 942906 A FI942906 A FI 942906A
- Authority
- FI
- Finland
- Prior art keywords
- histidine
- growth hormone
- pharmaceutical formulation
- formulation containing
- containing growth
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 3
- 108010051696 Growth Hormone Proteins 0.000 title abstract 3
- 239000000122 growth hormone Substances 0.000 title abstract 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 150000002411 histidines Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK204691 | 1991-12-20 | ||
| DK204691A DK204691D0 (da) | 1991-12-20 | 1991-12-20 | Hidtil ukendt farmaceutisk praeparat |
| DK136492A DK136492D0 (da) | 1992-11-10 | 1992-11-10 | A pharmaceutical formulation |
| DK136492 | 1992-11-10 | ||
| PCT/DK1992/000379 WO1993012812A1 (en) | 1991-12-20 | 1992-12-16 | A stabilized pharmaceutical formulation comprising growth hormone and histidine |
| DK9200379 | 1992-12-16 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI942906A true FI942906A (sv) | 1994-06-17 |
| FI942906A0 FI942906A0 (sv) | 1994-06-17 |
| FI115116B FI115116B (sv) | 2005-03-15 |
Family
ID=26065653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942906A FI115116B (sv) | 1991-12-20 | 1994-06-17 | Förfarande för framställning av kristaller av tillväxthormon och histidin |
Country Status (24)
| Country | Link |
|---|---|
| EP (2) | EP1197222B1 (sv) |
| JP (2) | JP2950617B2 (sv) |
| KR (1) | KR100266502B1 (sv) |
| AT (2) | ATE368472T1 (sv) |
| AU (1) | AU667503B2 (sv) |
| BG (1) | BG63075B1 (sv) |
| CA (1) | CA2125855C (sv) |
| CZ (1) | CZ283361B6 (sv) |
| DE (3) | DE10399015I1 (sv) |
| DK (1) | DK0618807T3 (sv) |
| ES (2) | ES2185625T3 (sv) |
| FI (1) | FI115116B (sv) |
| HU (1) | HUT69402A (sv) |
| IL (1) | IL104152A (sv) |
| MX (1) | MX9207374A (sv) |
| NL (1) | NL300126I1 (sv) |
| NO (1) | NO942300L (sv) |
| NZ (1) | NZ246556A (sv) |
| PT (1) | PT618807E (sv) |
| RO (1) | RO111990B1 (sv) |
| RU (1) | RU2122426C1 (sv) |
| SK (1) | SK279641B6 (sv) |
| UA (1) | UA41502C2 (sv) |
| WO (1) | WO1993012812A1 (sv) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849700A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
| US5849704A (en) * | 1991-12-20 | 1998-12-15 | Novo Nordisk A/S | Pharmaceutical formulation |
| US6288030B1 (en) * | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| JP3829991B2 (ja) * | 1994-06-17 | 2006-10-04 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ ベノートスハップ | Ｈｇｈ含有医薬組成物 |
| IL114030A (en) * | 1994-06-27 | 2000-08-13 | Hayashibara Biochem Lab | Saccharide composition with a lesser reducibility its preparation and compositions containing it |
| US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| IL115592A (en) * | 1994-10-13 | 2000-07-26 | Novo Nordisk As | Stabilized pharmaceutical formulation comprising a growth hormone and leucine |
| US5547696A (en) * | 1994-10-13 | 1996-08-20 | Novo Nordisk A/S | Pharmaceutical formulation |
| US5654278A (en) * | 1994-10-13 | 1997-08-05 | Novo Nordisk A/S | Composition and method comprising growth hormone and leucine |
| US5705482A (en) * | 1995-01-13 | 1998-01-06 | Novo Nordisk A/S | Pharmaceutical formulation |
| JPH10511964A (ja) * | 1995-01-13 | 1998-11-17 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン及びＸ−Ｌｙｓを含む安定化医薬製剤 |
| ZA96122B (en) * | 1995-01-13 | 1996-07-24 | Novo Nordisk As | A pharmaceutical formulation |
| US5552385A (en) * | 1995-06-05 | 1996-09-03 | Novo Nordisk A/S | Pharmaceutical formulation |
| US6936289B2 (en) | 1995-06-07 | 2005-08-30 | Danisco A/S | Method of improving the properties of a flour dough, a flour dough improving composition and improved food products |
| ZA965367B (en) * | 1995-07-12 | 1997-01-23 | Novo Nordisk As | A pharmaceutical formulation |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| KR100236393B1 (ko) * | 1996-02-02 | 1999-12-15 | 나까니시 히로유끼 | 사람성장호르몬을 함유하는 의약제제 |
| US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| AU1302499A (en) * | 1997-11-12 | 1999-05-31 | Alza Corporation | Buffered drug formulations for transdermal electrotransport delivery |
| WO1999055310A1 (en) * | 1998-04-27 | 1999-11-04 | Altus Biologics Inc. | Stabilized protein crystals, formulations containing them and methods of making them |
| KR20080011353A (ko) | 2000-02-24 | 2008-02-01 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들 |
| MXPA03000073A (es) | 2000-06-26 | 2003-09-25 | Monsanto Technology Llc | Formulaciones que contienen agente tensioactivo no acuoso para la liberacion prolongada de somatrotopina. |
| US6664234B1 (en) | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
| AU8111301A (en) | 2000-08-07 | 2002-02-18 | Inhale Therapeutic Syst | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| ES2644275T3 (es) | 2000-08-11 | 2017-11-28 | Chugai Seiyaku Kabushiki Kaisha | Preparaciones estabilizadas que contienen anticuerpos |
| NZ528260A (en) | 2001-05-18 | 2005-09-30 | Danisco | Method of improving dough and bread quality with the addition of an enzyme that hydrolyses a glycolipid and a phospholipid and incapable of hydrolysing a triglyceride or monoglyceride |
| JP4686361B2 (ja) | 2002-12-31 | 2011-05-25 | アルタス ファーマシューティカルズ インコーポレイテッド | ヒト成長ホルモンの結晶およびその調製方法 |
| WO2004060920A1 (en) * | 2002-12-31 | 2004-07-22 | Altus Pharmaceuticals Inc. | Complexes of protein crystals and ionic polymers |
| EP2264065B1 (en) | 2003-08-05 | 2017-03-08 | Novo Nordisk A/S | Novel insulin derivatives |
| WO2006008508A1 (en) | 2004-07-16 | 2006-01-26 | Danisco A/S | Enzymatic oil-degumming method |
| US8304387B2 (en) * | 2004-12-15 | 2012-11-06 | Swedish Orphan Biovitrum Ab (Publ) | Therapeutic formulations of keratinocyte growth factor |
| CN103520735B (zh) * | 2004-12-22 | 2015-11-25 | Ambrx公司 | 包含非天然编码的氨基酸的人生长激素配方 |
| JP2009506096A (ja) * | 2005-08-30 | 2009-02-12 | ノボ ノルディスク ヘルス ケア アーゲー | ペグ化成長ホルモンの液状調製物 |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| CN101389650B (zh) | 2005-12-28 | 2012-10-10 | 诺沃-诺迪斯克有限公司 | 包含酰化胰岛素和锌的组合物以及制备所述组合物的方法 |
| RU2009103198A (ru) | 2006-07-07 | 2010-08-20 | Ново Нордиск Хелс Кеа Аг (Ch) | Новые белковые конъюгаты и способы их получения |
| JP2010513309A (ja) * | 2006-12-18 | 2010-04-30 | アルタス ファーマシューティカルズ インコーポレイテッド | ヒト成長ホルモン製剤 |
| WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| ES2607003T3 (es) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria |
| CN105879047A (zh) * | 2008-12-16 | 2016-08-24 | 建新公司 | 寡糖-蛋白缀合物 |
| WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| CN107674121A (zh) | 2009-12-21 | 2018-02-09 | Ambrx 公司 | 经过修饰的牛促生长素多肽和其用途 |
| CN107056929A (zh) | 2009-12-21 | 2017-08-18 | Ambrx 公司 | 经过修饰的猪促生长素多肽和其用途 |
| NZ607633A (en) * | 2010-09-21 | 2014-07-25 | Ferring Bv | Improved process for production of recombinant human growth hormone |
| BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
| JP6162606B2 (ja) | 2011-01-14 | 2017-07-12 | レッドウッド バイオサイエンス， インコーポレイテッド | アルデヒド−タグ付き免疫グロブリンポリペプチド及びその使用方法 |
| CN104349768B (zh) | 2012-06-05 | 2017-11-07 | 纽罗德姆有限公司 | 包含阿朴吗啡和有机酸的组合物及其用途 |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
| US11559580B1 (en) * | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| RU2740185C2 (ru) * | 2015-12-10 | 2021-01-12 | Меникон Ко., Лтд. | Пептидная композиция |
| WO2017189432A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| US20210188941A1 (en) * | 2018-05-25 | 2021-06-24 | Dr. Reddy's Laboratories Limited | Stable fusion protein formulation |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| CN112912100A (zh) | 2018-10-26 | 2021-06-04 | 诺和诺德股份有限公司 | 稳定的司美鲁肽组合物及其用途 |
| WO2022197963A1 (en) * | 2021-03-19 | 2022-09-22 | Pfizer Inc. | Long-acting growth hormone compositions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
| EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
| DK168790D0 (sv) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As |
-
1992
- 1992-12-16 UA UA94005308A patent/UA41502C2/uk unknown
- 1992-12-16 EP EP01128974A patent/EP1197222B1/en not_active Expired - Lifetime
- 1992-12-16 CZ CZ941507A patent/CZ283361B6/cs not_active IP Right Cessation
- 1992-12-16 AT AT01128974T patent/ATE368472T1/de not_active IP Right Cessation
- 1992-12-16 WO PCT/DK1992/000379 patent/WO1993012812A1/en active IP Right Grant
- 1992-12-16 JP JP5511361A patent/JP2950617B2/ja not_active Expired - Lifetime
- 1992-12-16 AU AU33446/93A patent/AU667503B2/en not_active Ceased
- 1992-12-16 AT AT93902089T patent/ATE227583T1/de active
- 1992-12-16 ES ES93902089T patent/ES2185625T3/es not_active Expired - Lifetime
- 1992-12-16 EP EP93902089A patent/EP0618807B1/en not_active Expired - Lifetime
- 1992-12-16 PT PT93902089T patent/PT618807E/pt unknown
- 1992-12-16 RU RU94045932A patent/RU2122426C1/ru active
- 1992-12-16 DE DE10399015C patent/DE10399015I1/de active Granted
- 1992-12-16 ES ES01128974T patent/ES2291264T3/es not_active Expired - Lifetime
- 1992-12-16 SK SK754-94A patent/SK279641B6/sk not_active IP Right Cessation
- 1992-12-16 RO RO94-01056A patent/RO111990B1/ro unknown
- 1992-12-16 KR KR1019940702139A patent/KR100266502B1/ko not_active IP Right Cessation
- 1992-12-16 DE DE69233704T patent/DE69233704T2/de not_active Expired - Lifetime
- 1992-12-16 HU HU9401832A patent/HUT69402A/hu unknown
- 1992-12-16 DE DE69232847T patent/DE69232847T2/de not_active Expired - Lifetime
- 1992-12-16 CA CA002125855A patent/CA2125855C/en not_active Expired - Lifetime
- 1992-12-16 DK DK93902089T patent/DK0618807T3/da active
- 1992-12-16 NZ NZ246556A patent/NZ246556A/en unknown
- 1992-12-17 MX MX9207374A patent/MX9207374A/es active IP Right Grant
- 1992-12-18 IL IL104152A patent/IL104152A/en not_active IP Right Cessation
-
1994
- 1994-05-30 BG BG98806A patent/BG63075B1/bg unknown
- 1994-06-17 FI FI942906A patent/FI115116B/sv not_active IP Right Cessation
- 1994-06-17 NO NO942300A patent/NO942300L/no not_active Application Discontinuation
-
1999
- 1999-02-03 JP JP11026405A patent/JPH11315031A/ja active Pending
-
2003
- 2003-05-01 NL NL300126C patent/NL300126I1/nl unknown
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| JPS5936616A (ja) | セフアロスポリン誘導体の安定な医薬組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Ref document number: 115116 Country of ref document: FI |
|
| PC | Transfer of assignment of patent |
Owner name: NOVO NORDISK HEALTH CARE AG Free format text: NOVO NORDISK HEALTH CARE AG |
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| MA | Patent expired |