HUP9802286A2 - Stabilizált gyógyszerkészítmény amely valamely növekedési hormont és legalább egy bázikus aminosavmaradékot és legalább egy savas aminosav maradékot tartalmazó peptidet foglal magában - Google Patents
Stabilizált gyógyszerkészítmény amely valamely növekedési hormont és legalább egy bázikus aminosavmaradékot és legalább egy savas aminosav maradékot tartalmazó peptidet foglal magábanInfo
- Publication number
- HUP9802286A2 HUP9802286A2 HU9802286A HUP9802286A HUP9802286A2 HU P9802286 A2 HUP9802286 A2 HU P9802286A2 HU 9802286 A HU9802286 A HU 9802286A HU P9802286 A HUP9802286 A HU P9802286A HU P9802286 A2 HUP9802286 A2 HU P9802286A2
- Authority
- HU
- Hungary
- Prior art keywords
- amino acid
- acid residue
- peptide
- growth hormone
- pharmaceutical formulation
- Prior art date
Links
- 125000000539 amino acid group Chemical group 0.000 title abstract 4
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgya gyógyszerkészítmény, amely növekedési hőrmőnt éslegalább egy bázikűs aminősav maradékőt és leglaább egy savas aminősavmaradékőt magába főglaló peptidet tartalmaz additívűmként vagypűfferőldóanyagként és nagy stabilitást műtató dezamidálással,őxidációval és a peptikötés bőntásával szemben. A termék stabilitásalehetővé teszi annak raktárőzását és szállítását liőfilizáltállapőtban, őldőtt vagy újraőldőtt főrmában, szőbahőmérsékleten. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88195P | 1995-07-12 | 1995-07-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9802286A2 true HUP9802286A2 (hu) | 1999-02-01 |
HUP9802286A3 HUP9802286A3 (en) | 1999-06-28 |
Family
ID=21693419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802286A HUP9802286A3 (en) | 1995-07-12 | 1996-06-28 | A stabilized pharmaceutical formulation comprising a growth hormone and a peptide comprising at least, one basic amino acid residue and at least one acid amino acid residue |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0837690A1 (hu) |
JP (1) | JPH11510483A (hu) |
KR (1) | KR19990028908A (hu) |
CN (1) | CN1190896A (hu) |
AU (1) | AU699850B2 (hu) |
BR (1) | BR9609573A (hu) |
CA (1) | CA2226553A1 (hu) |
CZ (1) | CZ6198A3 (hu) |
HU (1) | HUP9802286A3 (hu) |
IL (1) | IL122519A0 (hu) |
NO (1) | NO980103D0 (hu) |
PL (1) | PL324386A1 (hu) |
WO (1) | WO1997002833A1 (hu) |
ZA (1) | ZA965367B (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100236393B1 (ko) * | 1996-02-02 | 1999-12-15 | 나까니시 히로유끼 | 사람성장호르몬을 함유하는 의약제제 |
US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
AU8111301A (en) | 2000-08-07 | 2002-02-18 | Inhale Therapeutic Syst | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
AU2003289317A1 (en) * | 2002-12-11 | 2004-06-30 | Santen Pharmaceutical Co., Ltd. | Preservative for ophthalmology |
CN103751769B (zh) * | 2013-12-25 | 2015-08-19 | 楼秀余 | 一种冻干重组人生长激素胶囊及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
HUT69402A (en) * | 1991-12-20 | 1995-09-28 | Novo Nordisk As | Process for producing stabilized pharmaceutical formulations comprising growth hormone and histidine |
DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
EP0805689A1 (en) * | 1995-01-13 | 1997-11-12 | Novo Nordisk A/S | A stabilized pharmaceutical formulation comprising a growth hormone and x-lys |
-
1996
- 1996-06-25 ZA ZA965367A patent/ZA965367B/xx unknown
- 1996-06-28 CN CN96195465A patent/CN1190896A/zh active Pending
- 1996-06-28 HU HU9802286A patent/HUP9802286A3/hu unknown
- 1996-06-28 JP JP9505422A patent/JPH11510483A/ja active Pending
- 1996-06-28 BR BR9609573A patent/BR9609573A/pt not_active Application Discontinuation
- 1996-06-28 WO PCT/DK1996/000290 patent/WO1997002833A1/en not_active Application Discontinuation
- 1996-06-28 CA CA002226553A patent/CA2226553A1/en not_active Abandoned
- 1996-06-28 KR KR1019980700210A patent/KR19990028908A/ko not_active Application Discontinuation
- 1996-06-28 EP EP96922774A patent/EP0837690A1/en not_active Withdrawn
- 1996-06-28 PL PL96324386A patent/PL324386A1/xx unknown
- 1996-06-28 IL IL12251996A patent/IL122519A0/xx unknown
- 1996-06-28 AU AU63533/96A patent/AU699850B2/en not_active Ceased
- 1996-06-28 CZ CZ9861A patent/CZ6198A3/cs unknown
-
1998
- 1998-01-09 NO NO980103A patent/NO980103D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR19990028908A (ko) | 1999-04-15 |
CN1190896A (zh) | 1998-08-19 |
ZA965367B (en) | 1997-01-23 |
IL122519A0 (en) | 1998-06-15 |
NO980103L (no) | 1998-01-09 |
EP0837690A1 (en) | 1998-04-29 |
NO980103D0 (no) | 1998-01-09 |
JPH11510483A (ja) | 1999-09-14 |
CA2226553A1 (en) | 1997-01-30 |
HUP9802286A3 (en) | 1999-06-28 |
MX9800309A (es) | 1998-07-31 |
AU699850B2 (en) | 1998-12-17 |
WO1997002833A1 (en) | 1997-01-30 |
AU6353396A (en) | 1997-02-10 |
CZ6198A3 (cs) | 1998-06-17 |
PL324386A1 (en) | 1998-05-25 |
BR9609573A (pt) | 1999-03-02 |
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