ES2173197T3 - Una formula farmaceutica que contiene hormona de crecimiento e isoleucina. - Google Patents
Una formula farmaceutica que contiene hormona de crecimiento e isoleucina.Info
- Publication number
- ES2173197T3 ES2173197T3 ES95933346T ES95933346T ES2173197T3 ES 2173197 T3 ES2173197 T3 ES 2173197T3 ES 95933346 T ES95933346 T ES 95933346T ES 95933346 T ES95933346 T ES 95933346T ES 2173197 T3 ES2173197 T3 ES 2173197T3
- Authority
- ES
- Spain
- Prior art keywords
- isoleucine
- growth hormone
- formula containing
- containing growth
- pharmaceutical formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 229960000310 isoleucine Drugs 0.000 title abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000006240 deamidation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
FORMULACION FARMACEUTICA QUE INCLUYE UNA HORMONA DE CRECIMIENTO E ISOLEUCINA COMO SUSTANCIA ADITIVA O AMORTIGUANTE QUE MUESTRA UNA ESTABILIDAD MUY ALTA CONTRA LA DEAMIDACION, OXIDACION Y DISOCIACION DE ENLACES PEPTIDOS. LA ESTABILIDAD DEL PRODUCTO PERMITE EL ALMACENAMIENTO Y EMBALAJE DEL MISMO EN UN ESTADO LIOFILIZADO O EN LA FORMA DE UNA FORMULACION DISUELTA O REDISUELTA A TEMPERATURA AMBIENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/322,837 US5631225A (en) | 1994-10-13 | 1994-10-13 | Pharmaceutical formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173197T3 true ES2173197T3 (es) | 2002-10-16 |
Family
ID=23256650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95933346T Expired - Lifetime ES2173197T3 (es) | 1994-10-13 | 1995-10-13 | Una formula farmaceutica que contiene hormona de crecimiento e isoleucina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5631225A (es) |
EP (1) | EP0785796B1 (es) |
JP (1) | JP4064454B2 (es) |
KR (1) | KR970706839A (es) |
AT (1) | ATE214614T1 (es) |
AU (1) | AU699345B2 (es) |
DE (1) | DE69525955T2 (es) |
ES (1) | ES2173197T3 (es) |
IL (1) | IL115590A (es) |
WO (1) | WO1996011703A1 (es) |
ZA (1) | ZA958604B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022858A (en) * | 1991-12-20 | 2000-02-08 | Novo Nordisk A/S | Pharmaceutical formulation of human-growth hormone pretreated with zinc salt |
US6673335B1 (en) | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
NZ257212A (en) * | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
NZ285664A (en) * | 1994-05-18 | 1998-07-28 | Inhale Therapeutic Syst | Dry powder interferon composition adapted for pulmonary delivery |
US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
EP1227832A2 (en) * | 1999-11-09 | 2002-08-07 | Gudrun Rappold-Hoerbrand | Methods of treating short stature disorders related to the short stature homeobox-containing (shox) gene |
WO2001085136A2 (en) | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
WO2002011695A2 (en) | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
EP1458360B1 (en) | 2001-12-19 | 2011-05-11 | Novartis AG | Pulmonary delivery of aminoglycosides |
EP2170268A2 (en) * | 2007-06-25 | 2010-04-07 | Amgen, Inc. | Compositions of specific binding agents to hepatocyte growth factor |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4056520A (en) * | 1972-03-31 | 1977-11-01 | Research Corporation | Clinically active bovine growth hormone fraction |
US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
JPS5967228A (ja) * | 1982-10-07 | 1984-04-16 | Green Cross Corp:The | 寒冷不溶性グロブリンの凍結乾燥方法 |
US4917685A (en) * | 1986-05-16 | 1990-04-17 | International Minerals & Chem. Corp. | Delivery device for the administration of stabilized growth promoting hormones |
EP0303746B2 (en) * | 1987-08-21 | 1998-12-02 | Mallinckrodt Group Inc. | Stabilization of growth promoting hormones |
US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
EP0374120A3 (en) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Comosition for controlled release of polypeptides |
US5137872A (en) * | 1989-09-18 | 1992-08-11 | Pitman-Moore, Inc. | Growth hormone-releasing factor analogs |
DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
RO111990B1 (ro) * | 1991-12-20 | 1997-04-30 | Novo Nordisk As | Preparate farmaceutice, continand un hormon de crestere sau un derivat al acestuia, si procedeu de preparare |
SE9201073D0 (sv) * | 1992-04-03 | 1992-04-03 | Kabi Pharmacia Ab | Protein formulation |
CA2337745C (en) * | 1992-07-31 | 2005-04-12 | Genentech, Inc. | Human growth hormone aqueous formulation |
-
1994
- 1994-10-13 US US08/322,837 patent/US5631225A/en not_active Expired - Lifetime
-
1995
- 1995-10-12 IL IL11559095A patent/IL115590A/xx not_active IP Right Cessation
- 1995-10-12 ZA ZA958604A patent/ZA958604B/xx unknown
- 1995-10-13 DE DE69525955T patent/DE69525955T2/de not_active Expired - Lifetime
- 1995-10-13 KR KR1019970702430A patent/KR970706839A/ko active IP Right Grant
- 1995-10-13 ES ES95933346T patent/ES2173197T3/es not_active Expired - Lifetime
- 1995-10-13 JP JP51286296A patent/JP4064454B2/ja not_active Expired - Fee Related
- 1995-10-13 WO PCT/DK1995/000409 patent/WO1996011703A1/en active IP Right Grant
- 1995-10-13 EP EP95933346A patent/EP0785796B1/en not_active Expired - Lifetime
- 1995-10-13 AT AT95933346T patent/ATE214614T1/de not_active IP Right Cessation
- 1995-10-13 AU AU36053/95A patent/AU699345B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DE69525955D1 (de) | 2002-04-25 |
AU699345B2 (en) | 1998-12-03 |
AU3605395A (en) | 1996-05-06 |
ZA958604B (en) | 1996-05-14 |
DE69525955T2 (de) | 2002-11-07 |
WO1996011703A1 (en) | 1996-04-25 |
JPH10507182A (ja) | 1998-07-14 |
EP0785796A1 (en) | 1997-07-30 |
JP4064454B2 (ja) | 2008-03-19 |
IL115590A (en) | 2000-02-29 |
EP0785796B1 (en) | 2002-03-20 |
KR970706839A (ko) | 1997-12-01 |
ATE214614T1 (de) | 2002-04-15 |
IL115590A0 (en) | 1996-01-19 |
US5631225A (en) | 1997-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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