FI93949C - Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi Download PDF

Info

Publication number
FI93949C
FI93949C FI891144A FI891144A FI93949C FI 93949 C FI93949 C FI 93949C FI 891144 A FI891144 A FI 891144A FI 891144 A FI891144 A FI 891144A FI 93949 C FI93949 C FI 93949C
Authority
FI
Finland
Prior art keywords
lysine
mmol
acid
mixture
preparation
Prior art date
Application number
FI891144A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI891144A (fi
FI891144A0 (fi
FI93949B (fi
Inventor
Jenoe Szilbereky
Miklos Koller
Ti Nagy P Ter Liter
M Ria Boros
Cz Istv N R
Gyoengyv R Soos
R Al N Pint
Meth G Bor N
Original Assignee
Biorex Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kft filed Critical Biorex Kft
Publication of FI891144A0 publication Critical patent/FI891144A0/fi
Publication of FI891144A publication Critical patent/FI891144A/fi
Application granted granted Critical
Publication of FI93949B publication Critical patent/FI93949B/fi
Publication of FI93949C publication Critical patent/FI93949C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI891144A 1988-03-09 1989-03-09 Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi FI93949C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU113188 1988-03-09
HU881131A HU199775B (en) 1988-03-09 1988-03-09 Process for production of formed by fatty acids salts of amin acids and medical compositions containing them

Publications (4)

Publication Number Publication Date
FI891144A0 FI891144A0 (fi) 1989-03-09
FI891144A FI891144A (fi) 1989-09-10
FI93949B FI93949B (fi) 1995-03-15
FI93949C true FI93949C (fi) 1995-06-26

Family

ID=10952971

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891144A FI93949C (fi) 1988-03-09 1989-03-09 Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi

Country Status (16)

Country Link
JP (1) JP2751068B2 (ko)
KR (1) KR0140993B1 (ko)
AT (1) AT398073B (ko)
BE (1) BE1003663A3 (ko)
CA (1) CA1339147C (ko)
CH (1) CH678851A5 (ko)
DE (1) DE3907688C2 (ko)
ES (1) ES2010439A6 (ko)
FI (1) FI93949C (ko)
FR (1) FR2628419B1 (ko)
GB (1) GB2216522B (ko)
HU (1) HU199775B (ko)
IT (1) IT1229563B (ko)
LU (1) LU87470A1 (ko)
NL (1) NL8900573A (ko)
SE (1) SE508603C2 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04279523A (ja) * 1991-01-11 1992-10-05 Nisshin Flour Milling Co Ltd 免疫賦活油脂加工品
DE69231592T2 (de) * 1991-06-24 2001-06-21 Women's And Children's Hospital, North Adelaide Verfahren und zusammensetzungen zur behandlung von malaria und anderen erkrankungen
WO1995009622A1 (en) * 1993-10-06 1995-04-13 Peptide Technology Limited Polyunsaturated fatty acids and uses thereof
NL9401743A (nl) * 1994-10-20 1996-06-03 Prospa Bv Zouten van aminoalcoholen en farmaceutische formuleringen die deze bevatten.
AUPM906594A0 (en) * 1994-10-26 1994-11-17 Peptide Technology Limited Synthetic polyunsaturated fatty acid analogues
US5639858A (en) * 1995-03-22 1997-06-17 Tularik, Inc. Human signal transducer and binding assays
HU227588B1 (hu) * 2004-12-03 2011-09-28 Sinnex Mueszaki Fejlesztoe Es Tanacsado Kft Többszörösen telítetlen zsírsavak észtereit tartalmazó vírusellenes és immunstimuláns gyógyászati készítmény
WO2007079394A2 (en) * 2005-12-30 2007-07-12 Revance Therapeutics, Inc. Arginine heteromers for topical administration
PL3236782T3 (pl) * 2014-12-23 2020-06-29 Evonik Operations Gmbh Sposób zwiększania stabilności kompozycji zawierającej wielonienasycone kwasy tłuszczowe omega-3
EP3248467A1 (de) * 2016-05-25 2017-11-29 Evonik Technochemie GmbH Verfahren zur herstellung einer zusammensetzung enthaltend omega-3-fettsäure-l-lysin-salze
EP3668498A1 (en) * 2017-08-15 2020-06-24 Evonik Operations GmbH Tablets with high active ingredient content of omega-3 fatty acid amino acid salts
US20230065371A1 (en) * 2020-01-30 2023-03-02 Silicycle Inc. Process for manufacturing solid neutral amino acid salts of polyunsaturated fatty acids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4887011A (ko) * 1972-02-04 1973-11-16
US4513008A (en) * 1982-07-30 1985-04-23 The Vinoxen Company, Inc. Virucidal compositions and therapy
GB8327911D0 (en) * 1983-10-19 1983-11-23 Ciba Geigy Ag Salts as corrosion inhibitors
US4537772A (en) * 1984-05-02 1985-08-27 Merck & Co., Inc. Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines
FR2587900B1 (fr) * 1985-10-01 1988-10-07 Morelle Jean Associations acides gras-acides amines basiques, douees de proprietes emollientes, emulsifiantes et antioxydantes, destinees a la cosmetique, la dermatologie et l'alimentation
JPS63230632A (ja) * 1987-03-20 1988-09-27 Nippon Oil & Fats Co Ltd リポキシゲナ−ゼ代謝刺激剤
DE3726299A1 (de) * 1987-06-26 1989-02-23 Dietl Hans Fettemulsion zur intravenoesen anwendung

Also Published As

Publication number Publication date
DE3907688C2 (de) 1996-09-05
IT8919705A0 (it) 1989-03-09
FI891144A (fi) 1989-09-10
SE8900827D0 (sv) 1989-03-09
HUT49564A (en) 1989-10-30
AT398073B (de) 1994-09-26
NL8900573A (nl) 1989-10-02
GB2216522B (en) 1992-01-02
FR2628419A1 (fr) 1989-09-15
ATA50989A (de) 1994-01-15
CA1339147C (en) 1997-07-29
JPH024746A (ja) 1990-01-09
KR890014451A (ko) 1989-10-23
GB8905384D0 (en) 1989-04-19
GB2216522A (en) 1989-10-11
BE1003663A3 (fr) 1992-05-19
FI891144A0 (fi) 1989-03-09
JP2751068B2 (ja) 1998-05-18
HU199775B (en) 1990-03-28
CH678851A5 (ko) 1991-11-15
SE8900827L (sv) 1989-09-10
FR2628419B1 (fr) 1992-02-14
DE3907688A1 (de) 1989-09-21
SE508603C2 (sv) 1998-10-19
LU87470A1 (fr) 1990-10-02
ES2010439A6 (es) 1989-11-01
IT1229563B (it) 1991-09-04
KR0140993B1 (ko) 1998-07-01
FI93949B (fi) 1995-03-15

Similar Documents

Publication Publication Date Title
FI94591C (fi) Menetelmä antiviraalisten ja immunostimuloivien farmaseuttisten koostumusten valmistamiseksi
FI93949C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi
CH634830A5 (de) Verfahren zur herstellung neuer substituierten aminosaeuren.
US5869714A (en) Salts of omega-3-polyunsaturated fatty acids and pharmaceutical formulations containing them
AU662411B2 (en) Novel lipophilic oligopeptides with immunomodulating activity
KR20220128361A (ko) 모발 성장을 촉진하기 위한 화합물의 합성
JP4976307B2 (ja) 新規な抗ウイルス性および免疫刺激性の医薬組成物
DE3243370A1 (de) Benzoylthioverbindungen, ihre herstellung und verwendung als arzneimittel
FR2680508A1 (fr) Nouveaux composes amidiques des 1-(alcoxybenzyl)piperazines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5286715A (en) New adamantyl comprising tripeptides, derivatives and hydrochlorides thereof, their preparation and use
FR2622195A1 (fr) Nouveaux isopolypeptides, procede pour leur preparation et medicaments les contenant
CH637374A5 (en) Substituted amino acids
CA2083507A1 (en) Nicotinylalanine as a therapeutic agent acting on the central nervous system
CA1138776A (en) Process for producing d-penicillamine and preparation containing same
WO2024086777A2 (en) Compounds and methods for treating diseases caused by viruses and bacteria
JPH11130672A (ja) 脂質過酸化抑制剤
WINITZ et al. Chemically Defined Diets
JPH04330095A (ja) 生理活性ポリペプチド、その製造法および抗菌剤
HU208156B (en) Process for producing /n-(gamma-glutamyl)-glycyl/-alanine derivatives and pharmaceutical compositions comprising same

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed

Owner name: BIOREX KFT