PL3236782T3 - Sposób zwiększania stabilności kompozycji zawierającej wielonienasycone kwasy tłuszczowe omega-3 - Google Patents

Sposób zwiększania stabilności kompozycji zawierającej wielonienasycone kwasy tłuszczowe omega-3

Info

Publication number
PL3236782T3
PL3236782T3 PL15810737T PL15810737T PL3236782T3 PL 3236782 T3 PL3236782 T3 PL 3236782T3 PL 15810737 T PL15810737 T PL 15810737T PL 15810737 T PL15810737 T PL 15810737T PL 3236782 T3 PL3236782 T3 PL 3236782T3
Authority
PL
Poland
Prior art keywords
stability
increasing
composition
fatty acids
polyunsaturated omega
Prior art date
Application number
PL15810737T
Other languages
English (en)
Inventor
Günter Knaup
Milan Latinovic
Michael Schwarm
Original Assignee
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52344991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3236782(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evonik Operations Gmbh filed Critical Evonik Operations Gmbh
Publication of PL3236782T3 publication Critical patent/PL3236782T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • A23D9/02—Other edible oils or fats, e.g. shortenings or cooking oils characterised by the production or working-up
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/30—Physical treatment, e.g. electrical or magnetic means, wave energy or irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B5/00—Preserving by using additives, e.g. anti-oxidants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/18—Lipids
    • A23V2250/186—Fatty acids
    • A23V2250/1882—Polyunsaturated fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Botany (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Wood Science & Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL15810737T 2014-12-23 2015-12-17 Sposób zwiększania stabilności kompozycji zawierającej wielonienasycone kwasy tłuszczowe omega-3 PL3236782T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14199989 2014-12-23
PCT/EP2015/080311 WO2016102323A1 (en) 2014-12-23 2015-12-17 Process for increasing the stability of a composition comprising polyunsaturated omega-3 fatty acids
EP15810737.5A EP3236782B1 (en) 2014-12-23 2015-12-17 Process for increasing the stability of a composition comprising polyunsaturated omega-3 fatty acids

Publications (1)

Publication Number Publication Date
PL3236782T3 true PL3236782T3 (pl) 2020-06-29

Family

ID=52344991

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15810737T PL3236782T3 (pl) 2014-12-23 2015-12-17 Sposób zwiększania stabilności kompozycji zawierającej wielonienasycone kwasy tłuszczowe omega-3

Country Status (24)

Country Link
US (2) US10798962B2 (pl)
EP (1) EP3236782B1 (pl)
JP (1) JP6861156B2 (pl)
KR (1) KR102584130B1 (pl)
CN (1) CN107105746B (pl)
AU (1) AU2015371376B2 (pl)
BR (1) BR112017013319B1 (pl)
CL (2) CL2017001614A1 (pl)
CO (1) CO2017005847A2 (pl)
DK (1) DK3236782T3 (pl)
ES (1) ES2781863T3 (pl)
HU (1) HUE048494T2 (pl)
IL (1) IL252481B (pl)
MX (1) MX384154B (pl)
MY (1) MY179033A (pl)
PE (1) PE20171083A1 (pl)
PH (1) PH12017501145A1 (pl)
PL (1) PL3236782T3 (pl)
RU (1) RU2706202C2 (pl)
SA (1) SA517381763B1 (pl)
SG (1) SG11201704396XA (pl)
TW (1) TWI695682B (pl)
WO (1) WO2016102323A1 (pl)
ZA (1) ZA201704820B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3554287B1 (en) * 2016-12-13 2022-01-19 DSM IP Assets B.V. Pufa salt formulations (i)
EP3554282A1 (en) * 2016-12-13 2019-10-23 DSM IP Assets B.V. Pufa salt formulations (ii)
US11622952B2 (en) * 2017-08-15 2023-04-11 Evonik Operations Gmbh Tablets with high active ingredient content of omega-3 fatty acid amino acid salts
EP3586640A1 (en) 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
EP3586642A1 (en) 2018-06-21 2020-01-01 Nuseed Pty Ltd Ala enriched polyunsaturated fatty acid compositions
EP3586643A1 (en) 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
EP3586641A1 (en) 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
WO2020109480A1 (en) 2018-11-30 2020-06-04 Evonik Operations Gmbh Preparation for use to increase the formation of one or more specialized pro-resolving lipid mediators (spm)
ES3038235T3 (en) * 2018-11-30 2025-10-10 Evonik Operations Gmbh Preparation comprising a dispersion of phospholipids and fatty acid salts
CN113395908B (zh) 2018-11-30 2024-06-11 赢创运营有限公司 包含巨大芽孢杆菌属益生菌菌株和多不饱和脂肪酸组分的制剂
US20220233487A1 (en) * 2019-05-06 2022-07-28 Evonik Operations Gmbh Preparation for use in weight management comprising omega-3 fatty acid salts and basic amino acids
US12342842B2 (en) 2019-05-23 2025-07-01 Evonik Operations Gmbh Preparation for use in enhancing formation of short-chain fatty acids (SCFAs)
EP4007500B1 (en) * 2019-08-01 2026-03-25 Evonik Operations GmbH Preparation comprising omega-3 fatty acid salts and extracts of gum resins from boswellia species
EP3804699A1 (en) 2019-10-10 2021-04-14 Evonik Operations GmbH Method of preparing a solid dosage form and a binder
US20220287345A1 (en) 2019-08-08 2022-09-15 Evonik Operations Gmbh Solubility enhancement of poorly soluble actives
WO2021023850A1 (en) 2019-08-08 2021-02-11 Evonik Operations Gmbh Method of preparing a solid dosage form and a binder
EP4009956A1 (en) * 2019-08-08 2022-06-15 Evonik Operations GmbH Down streaming process for the production of polyunsaturated fatty acid salts
US12558320B2 (en) 2019-08-08 2026-02-24 Evonik Operations Gmbh Method of preparing a solid dosage form and a lubricant
WO2021151201A1 (en) * 2020-01-30 2021-08-05 Silicycle Inc. Process for manufacturing solid neutral amino acid salts of polyunsaturated fatty acids
US20230068687A1 (en) * 2020-01-30 2023-03-02 Silicycle Inc. Process for preparing a solid form of basic amino acid salts of polyunsaturated fatty acids
EP4125437A1 (en) 2020-04-01 2023-02-08 Evonik Operations GmbH Preparation for use as vasorelaxant
US20230149336A1 (en) 2020-04-01 2023-05-18 Evonik Operations Gmbh Preparation for use as antioxidant

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US2945049A (en) 1959-05-25 1960-07-12 Gen Mills Inc Salts of basic amino acids and linoleic acid
HU199775B (en) * 1988-03-09 1990-03-28 Nagy Peter Literati Process for production of formed by fatty acids salts of amin acids and medical compositions containing them
IT1264987B1 (it) * 1993-12-14 1996-10-17 Prospa Bv Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono
KR960013387A (ko) * 1994-10-13 1996-05-22 오동빈 Dha과립분말 및 그의 제조방법
CN1463745A (zh) * 2002-06-14 2003-12-31 丁强 一种全元营养素补充剂
EP2573188A2 (en) * 2005-03-02 2013-03-27 Metanomics GmbH Process for the production of fine chemicals
US7867538B2 (en) * 2005-12-20 2011-01-11 Archer Daniels Midland Company Processes of improving the quality of oil and products produced therefrom
CA2654031C (en) * 2006-06-05 2016-05-24 Ocean Nutrition Canada Limited Microcapsules with improved shells
WO2008003064A2 (en) * 2006-06-29 2008-01-03 Martek Biosciences Corporation Sweetened oil compositions and methods of making
MX2010004820A (es) * 2007-11-01 2010-08-10 Enzymotec Ltd Mezcla lipidica para nutricion infantil.
ES2618069T3 (es) * 2010-03-09 2017-06-20 Stepan Specialty Products, Llc Método para tratar un aceite comestible y el aceite obtenido de esta manera
WO2012002464A1 (ja) * 2010-06-30 2012-01-05 持田製薬株式会社 ω3脂肪酸の配合製剤
WO2014011895A2 (en) * 2012-07-11 2014-01-16 Thetis Pharmaceuticals Llc High solubility acid salts, intravenous dosage forms, nutrition supplementation and methods of use thereof

Also Published As

Publication number Publication date
CN107105746B (zh) 2020-11-10
MY179033A (en) 2020-10-26
IL252481A0 (en) 2017-07-31
KR20170094788A (ko) 2017-08-21
MX2017007846A (es) 2017-09-19
US10798962B2 (en) 2020-10-13
CL2017001614A1 (es) 2018-01-12
SA517381763B1 (ar) 2021-06-06
RU2017125962A (ru) 2019-01-24
TW201639464A (zh) 2016-11-16
RU2017125962A3 (pl) 2019-06-18
JP6861156B2 (ja) 2021-04-21
TWI695682B (zh) 2020-06-11
HUE048494T2 (hu) 2020-07-28
PE20171083A1 (es) 2017-08-03
SG11201704396XA (en) 2017-07-28
DK3236782T3 (da) 2020-04-27
KR102584130B1 (ko) 2023-10-04
BR112017013319B1 (pt) 2021-11-30
ZA201704820B (en) 2019-06-26
US20200375235A1 (en) 2020-12-03
MX384154B (es) 2025-03-14
BR112017013319A2 (pt) 2018-04-10
AU2015371376B2 (en) 2020-04-23
CA2969159A1 (en) 2016-06-30
RU2706202C2 (ru) 2019-11-15
CL2020000141A1 (es) 2020-06-05
AU2015371376A1 (en) 2017-06-22
JP2018502085A (ja) 2018-01-25
CO2017005847A2 (es) 2017-08-31
US11805798B2 (en) 2023-11-07
NZ732378A (en) 2024-07-05
ES2781863T3 (es) 2020-09-08
EP3236782A1 (en) 2017-11-01
US20170360072A1 (en) 2017-12-21
WO2016102323A1 (en) 2016-06-30
PH12017501145A1 (en) 2018-03-05
EP3236782B1 (en) 2020-02-05
IL252481B (en) 2021-08-31
CN107105746A (zh) 2017-08-29

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