FI90993B - Förfarande för framställning av glykopeptidantibiotika och mikroorganismodlingar som produceras dessa - Google Patents

Förfarande för framställning av glykopeptidantibiotika och mikroorganismodlingar som produceras dessa Download PDF

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Publication number
FI90993B
FI90993B FI874082A FI874082A FI90993B FI 90993 B FI90993 B FI 90993B FI 874082 A FI874082 A FI 874082A FI 874082 A FI874082 A FI 874082A FI 90993 B FI90993 B FI 90993B
Authority
FI
Finland
Prior art keywords
antibiotic
culture
nrrl
nocardia
orientalis
Prior art date
Application number
FI874082A
Other languages
English (en)
Finnish (fi)
Other versions
FI874082A (sv
FI874082A0 (sv
FI90993C (sv
Inventor
Walter Mitsuo Nakatsukasa
Robert L Hamill
James Albert Mabe
David Francis Mahoney
Raymond Che-Fong Yao
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI874082A0 publication Critical patent/FI874082A0/sv
Publication of FI874082A publication Critical patent/FI874082A/sv
Publication of FI90993B publication Critical patent/FI90993B/sv
Application granted granted Critical
Publication of FI90993C publication Critical patent/FI90993C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (4)

1. Förfarande för framställning av antibiotikum A82846 och komponenterna A82846A, 82846B och 82846C därav 5 med formeIn NH» ho__ i »o „0^ r 10. o 1 o JL οΙλ v„ ie / "4>»h r·
15. H }/ ~~i m-im^ \ ?h HN H^T o O J «o^jL y 'Ή T CH> ' Λ l h HOX OH OH 20 där X = H och Y = Cl (A82846A), X = Cl och Y = Cl (A82846B) eller X = H och Y = H (A82846C), kanne-t e c k n a t därav, att man odlar Nocardia orientalia
25 NRRL 18098, NRRL 18099 eller NRRL 18100 eller deras avkom-ma, som producerar A82846 i ett odlingsmedium, som inne-h&ller assimilerbara källor av koi, kväve och oorganiska salter under aeroba fermentationsbetingelser under vatten, och därefter avskiljer antibiotikumet ur fermentationsme- 30 diet och eventuellt omvandlar antibiotikumet tili ett sait, om det inte föreligger i saltform.
2. Förfarande enligt patentkrav 1, kanne- t e c k n a t därav, att man framställer A82846A eller ett farmaceutiskt godtagbart sait därav. 35
3. Förfarande enligt patentkrav 1, k ä n n e - 50 t e c k n a t därav, att man framställer A82846B eller ett farmaceutiskt godtagbart sait därav.
4. Biologiskt renad kultur, kännetecknad därav, att den är Nocardia orientalis NRRL 18098, NRKL 5 18099 eller NRRL 18100 eller deras avkommma, som produce- rar A82846. l!
FI874082A 1986-09-19 1987-09-18 Förfarande för framställning av glykopeptidantibiotika och mikroorganismodlingar som produceras dessa FI90993C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90979186A 1986-09-19 1986-09-19
US90979186 1986-09-19

Publications (4)

Publication Number Publication Date
FI874082A0 FI874082A0 (sv) 1987-09-18
FI874082A FI874082A (sv) 1988-03-20
FI90993B true FI90993B (sv) 1994-01-14
FI90993C FI90993C (sv) 1994-04-25

Family

ID=25427837

Family Applications (1)

Application Number Title Priority Date Filing Date
FI874082A FI90993C (sv) 1986-09-19 1987-09-18 Förfarande för framställning av glykopeptidantibiotika och mikroorganismodlingar som produceras dessa

Country Status (23)

Country Link
US (2) US5312738A (sv)
EP (1) EP0265071B1 (sv)
JP (2) JP2634174B2 (sv)
KR (1) KR960013093B1 (sv)
CN (1) CN1061095C (sv)
AU (1) AU608534B2 (sv)
CA (1) CA1339033C (sv)
CY (1) CY1691A (sv)
DE (1) DE3782720T2 (sv)
DK (1) DK167689B1 (sv)
EG (1) EG18377A (sv)
ES (1) ES2052574T3 (sv)
FI (1) FI90993C (sv)
GR (1) GR3006311T3 (sv)
HK (1) HK44393A (sv)
HU (1) HU198964B (sv)
IE (1) IE60132B1 (sv)
MX (1) MX168708B (sv)
NZ (1) NZ221856A (sv)
PH (1) PH24288A (sv)
PT (1) PT85742B (sv)
SU (1) SU1724015A3 (sv)
ZA (1) ZA877003B (sv)

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US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
EP0344234A1 (en) * 1987-09-19 1989-12-06 Beecham Group Plc Antibiotic compounds
US5534420A (en) * 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
JP2577133B2 (ja) * 1989-11-27 1997-01-29 スティフティング フォール ド テフニスヘ ウェッテンスハッペン 船舶のプロペラ
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
US5187082A (en) * 1990-08-16 1993-02-16 Eli Lilly And Company Process for producing A83850 antibiotics
RU2145609C1 (ru) * 1994-01-28 2000-02-20 Эли Лилли Энд Компани Производные гликопептида или их соли, способ получения, фармацевтическая композиция
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
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US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
ES2283107T3 (es) * 1998-05-01 2007-10-16 Eli Lilly And Company Glicopeptidos modificados en n1.
AU1571801A (en) * 1999-11-12 2001-05-30 Eli Lilly And Company Improved fermentation process
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US6734165B2 (en) * 2001-08-23 2004-05-11 The Trustees Of Columbia University In The City Of New York Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US20050289488A1 (en) * 2004-06-29 2005-12-29 I-Ju Chou System and method for mask defect detection
US7635598B2 (en) * 2004-07-08 2009-12-22 Biosearch Technologies, Inc. Inducible fluorescence assay
ES2327840T3 (es) 2004-12-23 2009-11-04 Gpc Biotech Ag Derivados de acido escuarico con actividad antiproliferativa.
CN101245068A (zh) 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
CN101284799B (zh) 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途
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CN101397333A (zh) 2007-09-27 2009-04-01 浙江医药股份有限公司新昌制药厂 去羟基万古霉素及其制备方法、和其药物组合物及其用途
CN101545000B8 (zh) * 2008-03-28 2018-09-21 上海来益生物药物研究开发中心有限责任公司 一种提高东方拟无枝酸菌发酵生产eco-0501的产量的方法
SI2757091T1 (en) 2008-04-01 2018-01-31 Biosearch Technologies, Inc. Stabilized nucleic acid black gas-fluorofor probe
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
CN101828693B (zh) 2009-03-09 2013-01-02 浙江医药股份有限公司新昌制药厂 制备低粘度高流动性类胡萝卜素油悬浮液的方法及其应用
CN101928331B (zh) * 2009-06-26 2014-05-28 上海来益生物药物研究开发中心有限责任公司 一种化合物及其应用
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CN102690332B (zh) * 2011-03-23 2017-06-27 浙江医药股份有限公司新昌制药厂 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途
CN102690330B (zh) * 2011-03-23 2014-10-08 浙江医药股份有限公司新昌制药厂 三取代糖肽类衍生物及药物组合物、以及其制备方法和用途
RU2011122942A (ru) 2011-06-08 2012-12-20 Общество С Ограниченной Ответственностью "Асинэкс Медхим" Новые ингибиторы киназ
JP5996187B2 (ja) * 2011-12-20 2016-09-21 株式会社ダイセル エクオールの製造方法
US10294275B2 (en) * 2013-03-13 2019-05-21 Yale University Site-selective functionalization of glycopeptide antibiotics
CN104805161A (zh) * 2014-01-29 2015-07-29 上海医药工业研究院 生产奥利万星前体a82846b的方法及培养基
EP3169345A4 (en) * 2014-07-17 2018-01-17 The Medicines Company High purity oritavancin and method of producing same
CN106190854B (zh) * 2015-04-29 2019-09-27 浙江海正药业股份有限公司 一种荒漠拟孢囊菌和奥利万星中间体的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
WO2018010475A1 (zh) * 2016-07-15 2018-01-18 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN106928323B (zh) * 2017-03-02 2021-08-20 重庆乾泰生物医药有限公司 一种高纯度奥利万星关键中间体a82846b的制备方法
CN108929860B (zh) * 2017-05-23 2023-08-22 上海来益生物药物研究开发中心有限责任公司 一种产chloroeremomycin的基因工程菌及其制备方法和应用
CN109971809B (zh) * 2019-04-02 2023-04-28 博瑞生物医药（苏州）股份有限公司 一种糖肽类抗生素中间体的发酵制备方法
CN109929895B (zh) * 2019-04-02 2021-05-18 博瑞生物医药泰兴市有限公司 一种酸降解液
CN113563426B (zh) * 2021-08-05 2023-03-31 丽珠集团福州福兴医药有限公司 奥利万星母核a82846b的分离纯化方法

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US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b

Also Published As

Publication number Publication date
DE3782720D1 (de) 1992-12-24
AU608534B2 (en) 1991-04-11
JPH09182581A (ja) 1997-07-15
HK44393A (en) 1993-05-14
GR3006311T3 (sv) 1993-06-21
EP0265071A1 (en) 1988-04-27
KR960013093B1 (ko) 1996-09-30
FI874082A (sv) 1988-03-20
IE872529L (en) 1988-03-19
PT85742A (en) 1987-10-01
DK489787A (da) 1988-03-21
NZ221856A (en) 1991-12-23
CN87106483A (zh) 1988-06-08
ZA877003B (en) 1989-04-26
IE60132B1 (en) 1994-06-01
JP2634174B2 (ja) 1997-07-23
DK489787D0 (da) 1987-09-17
JP2806912B2 (ja) 1998-09-30
HUT46365A (en) 1988-10-28
MX168708B (es) 1993-06-04
FI874082A0 (sv) 1987-09-18
US5843437A (en) 1998-12-01
EG18377A (en) 1993-04-30
PH24288A (en) 1990-05-29
CY1691A (en) 1994-01-14
HU198964B (en) 1989-12-28
CN1061095C (zh) 2001-01-24
DK167689B1 (da) 1993-12-06
DE3782720T2 (de) 1993-04-22
KR880004097A (ko) 1988-06-01
FI90993C (sv) 1994-04-25
AU7865887A (en) 1988-03-24
CA1339033C (en) 1997-04-01
JPS6393798A (ja) 1988-04-25
SU1724015A3 (ru) 1992-03-30
EP0265071B1 (en) 1992-11-19
ES2052574T3 (es) 1994-07-16
US5312738A (en) 1994-05-17
PT85742B (pt) 1990-06-29

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