FI72967B - Foerfarande foer framtaellning av farmaceutiskt aktiva 2-amino-3-bensoylfenylacetamidderivat. - Google Patents
Foerfarande foer framtaellning av farmaceutiskt aktiva 2-amino-3-bensoylfenylacetamidderivat. Download PDFInfo
- Publication number
- FI72967B FI72967B FI803002A FI803002A FI72967B FI 72967 B FI72967 B FI 72967B FI 803002 A FI803002 A FI 803002A FI 803002 A FI803002 A FI 803002A FI 72967 B FI72967 B FI 72967B
- Authority
- FI
- Finland
- Prior art keywords
- amino
- mol
- solution
- added
- menetelmä
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (4)
1. Förfarande för framställning av farmaceutiskt aktiva 2-amino-3-bensoyl-fenylacetamidderivat med formeln
0. R1 n / ch2-c-N ^ r2 χ_γΎ VV c=o Λ
1. Menetelmä farmaseuttisesti aktiivisten 2-amino-3- bentsoyylifenyyliasetamidijohdannaisten valmistamiseksi, joilla on kaava 1 O . R ·· / ch~-c-n x L 1 S^NH2 I c=o jossa 1 2 R ja R ovat toisistaan riippumatta vety tai alempi al-kyyli, tai R ja R muodostavat yhdessä viereisen typpi-atomin kanssa morfolinoryhmän, X on vety tai halogeeni, ja Y on vety tai halogeeni, tunnettu siitä, ette pelkistetään yhdiste, jolla on kaava SR30 r1 2 3 I I» CH-C-NC^^ 2 x~r T γ^Η2 c=o Λ O 2 2 jossa R , R , X ja Y tarkoittavat samaa kuin edellä ja 3 R on fenyyli tai alempi alkyyli. 19 72967
2. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että valmistetaan 2-amino-3-bentsoyyli-5-kloorifenyyliasetamidia.
3. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että valmistetaan 2-amino-3-bentsoyyli-fenyyliasetamidia.
4. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että valmistetaan 2-amino-3-(4-klooribent-soyyli)fenyyliasetamidia.
5. Patenttivaatimuksen 1 mukainen menetelmä, tunnettu siitä, että valmistetaan 2-amino-3-(4-fluoribent-soyyli)fenyyliasetamidia.
4- Y vV väri 1 2 R och R betecknar oberoende av varandra väte eller läg- 1 2 re alkyl, eller R och R bildar tillsammans med den när-belägna kväveatomen en morfolinogrupp,
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7886079A | 1979-09-26 | 1979-09-26 | |
| US7886079 | 1979-09-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI803002A FI803002A (fi) | 1981-03-27 |
| FI72967B true FI72967B (fi) | 1987-04-30 |
| FI72967C FI72967C (sv) | 1987-08-10 |
Family
ID=22146633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI803002A FI72967C (sv) | 1979-09-26 | 1980-09-24 | Förfarande för framtällning av farmaceutiskt aktiva 2-amino-3-bensoyl fenylacetamidderivat. |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5657751A (sv) |
| KR (1) | KR840000763B1 (sv) |
| AT (1) | AT374170B (sv) |
| AU (1) | AU532359B2 (sv) |
| BE (1) | BE885393A (sv) |
| BR (1) | BR8006042A (sv) |
| CA (1) | CA1128512A (sv) |
| CH (1) | CH646138A5 (sv) |
| CS (1) | CS227012B2 (sv) |
| DE (1) | DE3035688A1 (sv) |
| DK (1) | DK154136C (sv) |
| EG (1) | EG15020A (sv) |
| ES (2) | ES495329A0 (sv) |
| FI (1) | FI72967C (sv) |
| FR (1) | FR2465710A1 (sv) |
| GB (1) | GB2059963B (sv) |
| GR (1) | GR70049B (sv) |
| HK (1) | HK59383A (sv) |
| HU (1) | HU183215B (sv) |
| IE (1) | IE50268B1 (sv) |
| IL (1) | IL60999A (sv) |
| IN (3) | IN151313B (sv) |
| IT (1) | IT1133823B (sv) |
| KE (1) | KE3307A (sv) |
| LU (1) | LU82797A1 (sv) |
| MX (1) | MX7159E (sv) |
| NL (1) | NL8005346A (sv) |
| NO (1) | NO152128C (sv) |
| NZ (1) | NZ195061A (sv) |
| PH (1) | PH22628A (sv) |
| PL (1) | PL128998B1 (sv) |
| PT (1) | PT71839B (sv) |
| SE (1) | SE448626B (sv) |
| SG (1) | SG42983G (sv) |
| YU (3) | YU41734B (sv) |
| ZA (1) | ZA805476B (sv) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| US8084447B2 (en) | 2001-09-03 | 2011-12-27 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| CZ2009367A3 (cs) * | 2009-06-08 | 2010-06-16 | Farmak, A.S. | Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu |
| CN112794809B (zh) * | 2019-11-14 | 2023-12-29 | 南京济群医药科技股份有限公司 | 一种高纯度奈帕芬胺中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (sv) * | 1967-07-31 | 1971-03-24 | ||
| SE400966B (sv) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
-
1980
- 1980-09-04 ZA ZA00805476A patent/ZA805476B/xx unknown
- 1980-09-08 IL IL60999A patent/IL60999A/xx unknown
- 1980-09-08 AU AU62116/80A patent/AU532359B2/en not_active Ceased
- 1980-09-11 CS CS806196A patent/CS227012B2/cs unknown
- 1980-09-17 IE IE1946/80A patent/IE50268B1/en unknown
- 1980-09-20 EG EG80573A patent/EG15020A/xx active
- 1980-09-22 DE DE19803035688 patent/DE3035688A1/de active Granted
- 1980-09-22 GR GR62936A patent/GR70049B/el unknown
- 1980-09-22 BR BR8006042A patent/BR8006042A/pt unknown
- 1980-09-23 AT AT0474580A patent/AT374170B/de not_active IP Right Cessation
- 1980-09-23 PH PH24613A patent/PH22628A/en unknown
- 1980-09-24 SE SE8006668A patent/SE448626B/sv not_active IP Right Cessation
- 1980-09-24 LU LU82797A patent/LU82797A1/fr unknown
- 1980-09-24 FI FI803002A patent/FI72967C/sv not_active IP Right Cessation
- 1980-09-25 HU HU802347A patent/HU183215B/hu not_active IP Right Cessation
- 1980-09-25 NL NL8005346A patent/NL8005346A/nl not_active Application Discontinuation
- 1980-09-25 BE BE0/202226A patent/BE885393A/fr not_active IP Right Cessation
- 1980-09-25 CA CA361,068A patent/CA1128512A/en not_active Expired
- 1980-09-25 ES ES495329A patent/ES495329A0/es active Granted
- 1980-09-25 FR FR8020596A patent/FR2465710A1/fr active Granted
- 1980-09-25 CH CH719180A patent/CH646138A5/fr not_active IP Right Cessation
- 1980-09-25 PL PL1980226919A patent/PL128998B1/pl unknown
- 1980-09-25 YU YU2450/80A patent/YU41734B/xx unknown
- 1980-09-25 GB GB8030955A patent/GB2059963B/en not_active Expired
- 1980-09-25 KR KR1019800003740A patent/KR840000763B1/ko active
- 1980-09-25 DK DK405780A patent/DK154136C/da not_active IP Right Cessation
- 1980-09-25 MX MX809050U patent/MX7159E/es unknown
- 1980-09-25 NO NO802834A patent/NO152128C/no unknown
- 1980-09-25 PT PT71839A patent/PT71839B/pt unknown
- 1980-09-26 IN IN1092/CAL/80A patent/IN151313B/en unknown
- 1980-09-26 JP JP13415280A patent/JPS5657751A/ja active Granted
- 1980-09-26 IT IT24948/80A patent/IT1133823B/it active
- 1980-09-26 NZ NZ195061A patent/NZ195061A/en unknown
-
1981
- 1981-06-12 ES ES503019A patent/ES8204715A1/es not_active Expired
-
1982
- 1982-12-30 IN IN1508/CAL/82A patent/IN156254B/en unknown
- 1982-12-30 IN IN1509/CAL/82A patent/IN156255B/en unknown
-
1983
- 1983-03-28 YU YU730/83A patent/YU43305B/xx unknown
- 1983-03-28 YU YU731/83A patent/YU43306B/xx unknown
- 1983-07-19 SG SG42983A patent/SG42983G/en unknown
- 1983-07-21 KE KE3307A patent/KE3307A/xx unknown
- 1983-11-24 HK HK593/83A patent/HK59383A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: A.H. ROBINS CO INCORPORATED |