FI68626C - Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat Download PDFInfo
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- FI68626C FI68626C FI783932A FI783932A FI68626C FI 68626 C FI68626 C FI 68626C FI 783932 A FI783932 A FI 783932A FI 783932 A FI783932 A FI 783932A FI 68626 C FI68626 C FI 68626C
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- WXDSCXXENAZUJG-UHFFFAOYSA-M sodium;1-adamantyloxy(methoxycarbonyl)phosphinate Chemical compound [Na+].C1C(C2)CC3CC2CC1(OP([O-])(=O)C(=O)OC)C3 WXDSCXXENAZUJG-UHFFFAOYSA-M 0.000 description 1
- MSFWPPJYESXYPI-UHFFFAOYSA-M sodium;butoxy(methoxycarbonyl)phosphinate Chemical compound [Na+].CCCCOP([O-])(=O)C(=O)OC MSFWPPJYESXYPI-UHFFFAOYSA-M 0.000 description 1
- HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 description 1
- VLGUOEHLZNBDNO-UHFFFAOYSA-M sodium;ethoxy(ethoxycarbonyl)phosphinate Chemical compound [Na+].CCOC(=O)P([O-])(=O)OCC VLGUOEHLZNBDNO-UHFFFAOYSA-M 0.000 description 1
- PTLYWFMPCOFHDO-UHFFFAOYSA-M sodium;methoxy(phenylmethoxycarbonyl)phosphinate Chemical compound [Na+].COP([O-])(=O)C(=O)OCC1=CC=CC=C1 PTLYWFMPCOFHDO-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical class CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000014723 transformation of host cell by virus Effects 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
- C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
- C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5358177 | 1977-12-22 | ||
| GB5358177 | 1977-12-22 | ||
| GB5358277 | 1977-12-22 | ||
| GB5358377 | 1977-12-22 | ||
| GB5358077 | 1977-12-22 | ||
| GB5358077 | 1977-12-22 | ||
| GB5358377 | 1977-12-22 | ||
| GB5358277 | 1977-12-22 | ||
| GB7828555 | 1978-07-03 | ||
| GB7828553 | 1978-07-03 | ||
| GB7828548 | 1978-07-03 | ||
| GB7828552 | 1978-07-03 | ||
| GB7828555 | 1978-07-03 | ||
| GB7828553 | 1978-07-03 | ||
| GB7828548 | 1978-07-03 | ||
| GB7828552 | 1978-07-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI783932A7 FI783932A7 (fi) | 1979-06-23 |
| FI68626B FI68626B (fi) | 1985-06-28 |
| FI68626C true FI68626C (fi) | 1985-10-10 |
Family
ID=27571200
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI783932A FI68626C (fi) | 1977-12-22 | 1978-12-20 | Foerfarande foer framstaellning av nya terapeutiskt aktiva hydroxikarbonylfosfonsyraderivat |
| FI783931A FI65438C (fi) | 1977-12-22 | 1978-12-20 | Foerfarande foer framstaellning av farmakologiskt aktiva estrar av fosfonomyrsyra |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI783931A FI65438C (fi) | 1977-12-22 | 1978-12-20 | Foerfarande foer framstaellning av farmakologiskt aktiva estrar av fosfonomyrsyra |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US4386081A (de) |
| EP (2) | EP0003275B1 (de) |
| JP (2) | JPS54106431A (de) |
| AT (1) | AT369017B (de) |
| AU (1) | AU530031B2 (de) |
| CA (2) | CA1140049A (de) |
| DE (2) | DE2861729D1 (de) |
| DK (2) | DK148631C (de) |
| FI (2) | FI68626C (de) |
| HK (1) | HK33584A (de) |
| IE (1) | IE48011B1 (de) |
| MY (1) | MY8500058A (de) |
| NO (2) | NO154751C (de) |
| SG (1) | SG82383G (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140049A (en) * | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
| GB8501374D0 (en) * | 1985-01-18 | 1985-02-20 | Wellcome Found | Treatment of aids |
| US4806532A (en) * | 1985-10-08 | 1989-02-21 | Mayo Foundation For Medical Education And Research | Inhibition of epithelial phosphate transport |
| US6492352B1 (en) * | 1985-10-31 | 2002-12-10 | Astra Lakemedel Aktiebolag | Method for the control and treatment of acquired immunodeficiency syndrome (AIDS) |
| US5166386A (en) * | 1989-09-18 | 1992-11-24 | E. R. Squibb & Sons, Inc. | Process of making isoprenoid phosphinylformic acid squalene synthetase inhibitors |
| US5025003A (en) * | 1989-09-18 | 1991-06-18 | E. R. Squibb & Sons, Inc. | Isoprenoid phosphinylformic acid squalene synthetase inhibitors |
| US5463092A (en) * | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
| US5132414A (en) * | 1990-05-10 | 1992-07-21 | Dana-Farber Cancer Institute, Inc. | Dideoxynucleoside-5'-phosphonoformic acid compounds |
| US5696277A (en) * | 1994-11-15 | 1997-12-09 | Karl Y. Hostetler | Antiviral prodrugs |
| US7517858B1 (en) | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| US6096730A (en) * | 1997-07-24 | 2000-08-01 | University Of Kentucky Research Foundation | Phosphonated agents and their antiangiogenic and antitumorigenic use |
| IL134619A0 (en) * | 1997-08-18 | 2001-04-30 | Univ Kingston | Phosphono-carboxylate compounds for treating amyloidosis |
| US5869469A (en) * | 1997-08-18 | 1999-02-09 | Queen's University At Kingston | Phosphonocarboxylate compounds for treating amyloidosis |
| US20020022657A1 (en) * | 1998-02-11 | 2002-02-21 | Francine Gervais | Methods for modulating neuronal cell death |
| IL137751A0 (en) * | 1998-02-11 | 2001-10-31 | Neurochem Inc | Method for modulating macrophage activation |
| US20040002079A1 (en) * | 1998-02-11 | 2004-01-01 | Gunn Robert B. | Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness |
| US6329356B1 (en) | 1998-04-10 | 2001-12-11 | Neurochem, Inc. | Phosphono-carboxylate compounds for treating amyloidosis |
| US6310073B1 (en) | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| BR0010099A (pt) * | 1999-04-28 | 2002-06-04 | Univ Kingston | Métodos para modular a agregação de amilóides em um indivìduo, para o tratamento de um estado doentio associado com amiloidose, composição para modular amiloidose, e, métodos para inibir os depósitos de amilóide associados com iapp em um indivìduo, para inibir fibrilogenese iapp em um indivìduo, para reduzir os agregados de amilóides associados com iapp em um indivìduo, para modular dano associado com amilóides em células, e para modular amiloidose in vivo ou ex vivo |
| US6562836B1 (en) | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| CN1434706A (zh) | 1999-12-23 | 2003-08-06 | 神经化学公司 | 用于调节脑淀粉状蛋白性血管病的化合物和方法 |
| JP2005526102A (ja) * | 2002-04-01 | 2005-09-02 | ファイザー インコーポレイテッド | Ｃ型肝炎ウイルスｒｎａ依存性ｒｎａポリメラーゼのピラノンおよびピランジオン阻害剤 |
| DOP2003000641A (es) * | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
| US7148226B2 (en) * | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
| US20040214178A1 (en) * | 2003-04-24 | 2004-10-28 | Agouron Pharmaceuticals, Inc. | Reporter-selectable Hepatitis C virus replicon |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| GEP20094751B (en) * | 2004-08-18 | 2009-08-10 | Pfizer | Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same |
| ITMI20041822A1 (it) * | 2004-09-24 | 2004-12-24 | Pharmaproducts Uk Ltd | "agente terapeutico utile per il trattamento di neoplasie plasmacellulari" |
| CA2586334A1 (en) * | 2004-11-16 | 2006-06-08 | Neurochem (International) Limited | Compounds for the treatment of cns and amyloid associated diseases |
| US8044100B2 (en) | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
| CN101453999A (zh) * | 2005-12-22 | 2009-06-10 | 神经化学（国际）有限公司 | 肾病症、糖尿病肾病和血脂异常的治疗 |
| EP2862581B1 (de) | 2006-10-12 | 2021-08-11 | BHI Limited Partnership | Verfahren, Verbindungen, Zusammensetzungen und Medien zur Abgabe von 3-Amino-1-Propanesulfonsäure |
| CA2673022A1 (en) * | 2006-12-22 | 2008-07-03 | Bellus Health (International) Limited | Methods, compounds, and compositions for treating metabolic disorders and diabetes |
| US20080293648A1 (en) * | 2007-01-05 | 2008-11-27 | Saha Pharmaceuticals, Inc. | Compositions and Methods for Cancer Treatment |
| DE102012103717A1 (de) * | 2012-04-27 | 2013-11-14 | Westfälische Wilhelms-Universität Münster | Arzneimittel zur Behandlung von Tumorerkrankungen |
| EP3086397B1 (de) * | 2013-12-19 | 2018-10-10 | Ube Industries, Ltd. | Wasserfreie elektrolytlösung, elektrizitätsspeichervorrichtung damit und phosphonomethansäureverbindung zur verwendung darin |
| ES2578902B1 (es) * | 2014-12-29 | 2017-07-07 | Agencia Pública Empresarial Sanitaria Costa Del Sol | Uso de análogos del ión pirofosfato para el tratamiento de la infección por VPH |
| CN109400645A (zh) * | 2017-08-18 | 2019-03-01 | 四川海思科制药有限公司 | 一种磷酸衍生物及制备方法和用途 |
| WO2025106974A1 (en) * | 2023-11-17 | 2025-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Prodrug moieties and compounds comprising the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3155597A (en) * | 1961-06-23 | 1964-11-03 | Monsanto Co | Extractive separation process |
| US3997544A (en) * | 1968-05-24 | 1976-12-14 | E. I. Du Pont De Nemours And Company | Plant growth regulant carbamoylphosphonates |
| CH513590A (de) | 1968-05-24 | 1971-10-15 | Du Pont | Carbamoylphosphonat enthaltender Pflanzenwachstumsregler |
| US3846512A (en) * | 1968-05-24 | 1974-11-05 | Du Pont | Carbamoylphosphonates |
| US3533995A (en) * | 1968-08-27 | 1970-10-13 | Fmc Corp | Heat stabilization of polyester resin with alkyl dialkoxyphosphinyl formate |
| GB1317768A (en) | 1969-08-14 | 1973-05-23 | Du Pont | Plant growth regulants |
| US3849102A (en) * | 1969-08-14 | 1974-11-19 | Du Pont | Plant growth regulant method |
| US3767795A (en) * | 1971-02-25 | 1973-10-23 | Abbott Lab | Method for combating certain virus infection |
| HU171255B (hu) | 1973-07-23 | 1977-12-28 | Du Pont | Kompozicii dlja regulirovki rosta rastenijj |
| US3943201A (en) * | 1973-07-23 | 1976-03-09 | E. I. Du Pont De Nemours And Comapny | Alkoxy carboxycarbonylphosphonic acid esters |
| US4017297A (en) * | 1975-08-29 | 1977-04-12 | E. I. Du Pont De Nemours And Company | Phosphonates for the control of bindweed |
| US4092412A (en) * | 1976-04-30 | 1978-05-30 | Abbott Laboratories | Treatment of herpes simplex infections |
| US4052439A (en) * | 1976-04-30 | 1977-10-04 | Abbott Laboratories | Carboxylic esters of phosphonoacetic acid |
| CA1069526A (en) * | 1976-04-30 | 1980-01-08 | Thomas R. Herrin | Phosphorus esters of phosphonoacetic acid |
| SE7607496L (sv) * | 1976-07-01 | 1978-01-02 | Astra Laekemedel Ab | Sett for bekempning av virusinfektioner |
| CA1140049A (en) * | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
-
1978
- 1978-12-06 CA CA000317487A patent/CA1140049A/en not_active Expired
- 1978-12-06 CA CA000317520A patent/CA1144937A/en not_active Expired
- 1978-12-15 DK DK564178A patent/DK148631C/da not_active IP Right Cessation
- 1978-12-15 DK DK564278A patent/DK148632C/da not_active IP Right Cessation
- 1978-12-18 IE IE2493/78A patent/IE48011B1/en not_active IP Right Cessation
- 1978-12-19 EP EP78850027A patent/EP0003275B1/de not_active Expired
- 1978-12-19 EP EP78850028A patent/EP0003007B1/de not_active Expired
- 1978-12-19 AU AU42682/78A patent/AU530031B2/en not_active Expired
- 1978-12-19 DE DE7878850028T patent/DE2861729D1/de not_active Expired
- 1978-12-19 DE DE7878850027T patent/DE2861045D1/de not_active Expired
- 1978-12-20 FI FI783932A patent/FI68626C/fi not_active IP Right Cessation
- 1978-12-20 FI FI783931A patent/FI65438C/fi not_active IP Right Cessation
- 1978-12-21 NO NO784330A patent/NO154751C/no unknown
- 1978-12-21 NO NO784331A patent/NO156611C/no unknown
- 1978-12-22 JP JP15839978A patent/JPS54106431A/ja active Granted
- 1978-12-22 AT AT0921778A patent/AT369017B/de not_active IP Right Cessation
- 1978-12-22 JP JP15839878A patent/JPS54109951A/ja active Granted
-
1979
- 1979-11-13 US US06/093,167 patent/US4386081A/en not_active Expired - Lifetime
- 1979-11-13 US US06/093,166 patent/US4372894A/en not_active Expired - Lifetime
-
1982
- 1982-09-10 US US06/416,632 patent/US4536400A/en not_active Expired - Lifetime
- 1982-12-17 US US06/450,656 patent/US4591583A/en not_active Expired - Fee Related
-
1983
- 1983-12-23 SG SG823/83A patent/SG82383G/en unknown
-
1984
- 1984-04-18 HK HK335/84A patent/HK33584A/en not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY58/85A patent/MY8500058A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: ASTRA LAEKEMEDEL AB |