DK564178A - Fremgangsmaade til fremstilling af aromatiske fosforforbindelser - Google Patents

Fremgangsmaade til fremstilling af aromatiske fosforforbindelser

Info

Publication number
DK564178A
DK564178A DK564178A DK564178A DK564178A DK 564178 A DK564178 A DK 564178A DK 564178 A DK564178 A DK 564178A DK 564178 A DK564178 A DK 564178A DK 564178 A DK564178 A DK 564178A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
phosphorus compounds
aromatic phosphorus
aromatic
Prior art date
Application number
DK564178A
Other languages
English (en)
Other versions
DK148631C (da
DK148631B (da
Inventor
Aa J E Helgestrand
K N G Johansson
A Misiorny
J O Noren
G B Stening
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Publication of DK564178A publication Critical patent/DK564178A/da
Publication of DK148631B publication Critical patent/DK148631B/da
Application granted granted Critical
Publication of DK148631C publication Critical patent/DK148631C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
    • C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK564178A 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller fysiologisk acceptable salte og/eller optiske isomerer deraf DK148631C (da)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
GB5358077 1977-12-22
GB5358077 1977-12-22
GB5358377 1977-12-22
GB5358277 1977-12-22
GB5358377 1977-12-22
GB5358277 1977-12-22
GB5358177 1977-12-22
GB5358177 1977-12-22
GB7828553 1978-07-03
GB7828553 1978-07-03
GB7828552 1978-07-03
GB7828548 1978-07-03
GB7828555 1978-07-03
GB7828552 1978-07-03
GB7828548 1978-07-03
GB7828555 1978-07-03

Publications (3)

Publication Number Publication Date
DK564178A true DK564178A (da) 1979-06-23
DK148631B DK148631B (da) 1985-08-19
DK148631C DK148631C (da) 1986-03-03

Family

ID=27571200

Family Applications (2)

Application Number Title Priority Date Filing Date
DK564278A DK148632C (da) 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf
DK564178A DK148631C (da) 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller fysiologisk acceptable salte og/eller optiske isomerer deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK564278A DK148632C (da) 1977-12-22 1978-12-15 Analogifremgangsmaade til fremstilling af hydroxykarbonylfosfonsyremonoestere eller optiske antipoder og/eller fysiologisk acceptable salte deraf

Country Status (14)

Country Link
US (4) US4372894A (da)
EP (2) EP0003007B1 (da)
JP (2) JPS54109951A (da)
AT (1) AT369017B (da)
AU (1) AU530031B2 (da)
CA (2) CA1144937A (da)
DE (2) DE2861729D1 (da)
DK (2) DK148632C (da)
FI (2) FI68626C (da)
HK (1) HK33584A (da)
IE (1) IE48011B1 (da)
MY (1) MY8500058A (da)
NO (2) NO156611C (da)
SG (1) SG82383G (da)

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CA1144937A (en) * 1977-12-22 1983-04-19 Dke J.E. Helgstrand Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections
GB8501374D0 (en) * 1985-01-18 1985-02-20 Wellcome Found Treatment of aids
US4806532A (en) * 1985-10-08 1989-02-21 Mayo Foundation For Medical Education And Research Inhibition of epithelial phosphate transport
US6492352B1 (en) * 1985-10-31 2002-12-10 Astra Lakemedel Aktiebolag Method for the control and treatment of acquired immunodeficiency syndrome (AIDS)
US5166386A (en) * 1989-09-18 1992-11-24 E. R. Squibb & Sons, Inc. Process of making isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5025003A (en) * 1989-09-18 1991-06-18 E. R. Squibb & Sons, Inc. Isoprenoid phosphinylformic acid squalene synthetase inhibitors
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5132414A (en) * 1990-05-10 1992-07-21 Dana-Farber Cancer Institute, Inc. Dideoxynucleoside-5'-phosphonoformic acid compounds
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
US6096730A (en) * 1997-07-24 2000-08-01 University Of Kentucky Research Foundation Phosphonated agents and their antiangiogenic and antitumorigenic use
IL134619A0 (en) * 1997-08-18 2001-04-30 Univ Kingston Phosphono-carboxylate compounds for treating amyloidosis
US5869469A (en) * 1997-08-18 1999-02-09 Queen's University At Kingston Phosphonocarboxylate compounds for treating amyloidosis
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
US20020022657A1 (en) * 1998-02-11 2002-02-21 Francine Gervais Methods for modulating neuronal cell death
NZ550199A (en) * 1998-02-11 2008-07-31 Bellus Health Int Ltd Treatment of inflammation, abeta-induced cell toxicity, neuronal cell death or neuronal cell loss in subjects suffering from alzheimer's disease
US6329356B1 (en) 1998-04-10 2001-12-11 Neurochem, Inc. Phosphono-carboxylate compounds for treating amyloidosis
US6310073B1 (en) 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
DE60042896D1 (de) * 1999-04-28 2009-10-15 Bellus Health Int Ltd Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten
US6562836B1 (en) 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
KR20090016517A (ko) 1999-12-23 2009-02-13 벨루스 헬스 (인터내셔널) 리미티드 대뇌 아밀로이드 혈관병증을 조절하는 화합물 및 방법
AU2003215826A1 (en) * 2002-04-01 2003-10-13 Pfizer Inc. Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase
DOP2003000641A (es) * 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) * 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
US20040214178A1 (en) * 2003-04-24 2004-10-28 Agouron Pharmaceuticals, Inc. Reporter-selectable Hepatitis C virus replicon
US20070010573A1 (en) 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
AP2313A (en) * 2004-08-18 2011-10-31 Pfizer Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same.
ITMI20041822A1 (it) * 2004-09-24 2004-12-24 Pharmaproducts Uk Ltd "agente terapeutico utile per il trattamento di neoplasie plasmacellulari"
WO2006059245A2 (en) * 2004-11-16 2006-06-08 Neurochem (International) Limited Compounds for the treatment of cns and amyloid associated diseases
US8044100B2 (en) 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
ES2352801T3 (es) * 2005-12-22 2011-02-23 Kiacta Sàrl Tratamiento de nefropatía diabética.
CA2830727C (en) 2006-10-12 2016-11-29 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
CA2673022A1 (en) * 2006-12-22 2008-07-03 Bellus Health (International) Limited Methods, compounds, and compositions for treating metabolic disorders and diabetes
US20080293648A1 (en) * 2007-01-05 2008-11-27 Saha Pharmaceuticals, Inc. Compositions and Methods for Cancer Treatment
DE102012103717A1 (de) * 2012-04-27 2013-11-14 Westfälische Wilhelms-Universität Münster Arzneimittel zur Behandlung von Tumorerkrankungen
CN105830271B (zh) * 2013-12-19 2018-11-16 宇部兴产株式会社 非水电解液、使用了其的蓄电装置及其中使用的膦酰基甲酸化合物
ES2578902B1 (es) * 2014-12-29 2017-07-07 Agencia Pública Empresarial Sanitaria Costa Del Sol Uso de análogos del ión pirofosfato para el tratamiento de la infección por VPH
CN109400645A (zh) * 2017-08-18 2019-03-01 四川海思科制药有限公司 一种磷酸衍生物及制备方法和用途
WO2025106974A1 (en) * 2023-11-17 2025-05-22 The Board Of Trustees Of The Leland Stanford Junior University Prodrug moieties and compounds comprising the same

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US3155597A (en) * 1961-06-23 1964-11-03 Monsanto Co Extractive separation process
CH513590A (de) 1968-05-24 1971-10-15 Du Pont Carbamoylphosphonat enthaltender Pflanzenwachstumsregler
US3846512A (en) * 1968-05-24 1974-11-05 Du Pont Carbamoylphosphonates
US3997544A (en) * 1968-05-24 1976-12-14 E. I. Du Pont De Nemours And Company Plant growth regulant carbamoylphosphonates
US3533995A (en) * 1968-08-27 1970-10-13 Fmc Corp Heat stabilization of polyester resin with alkyl dialkoxyphosphinyl formate
US3849102A (en) * 1969-08-14 1974-11-19 Du Pont Plant growth regulant method
GB1317768A (en) 1969-08-14 1973-05-23 Du Pont Plant growth regulants
US3767795A (en) * 1971-02-25 1973-10-23 Abbott Lab Method for combating certain virus infection
BR7405998D0 (pt) 1973-07-23 1975-05-13 Du Pont Processos compostos e composicoes para controlar o crescimmento de plantas
US3943201A (en) * 1973-07-23 1976-03-09 E. I. Du Pont De Nemours And Comapny Alkoxy carboxycarbonylphosphonic acid esters
US4017297A (en) * 1975-08-29 1977-04-12 E. I. Du Pont De Nemours And Company Phosphonates for the control of bindweed
US4092412A (en) * 1976-04-30 1978-05-30 Abbott Laboratories Treatment of herpes simplex infections
CA1069526A (en) * 1976-04-30 1980-01-08 Thomas R. Herrin Phosphorus esters of phosphonoacetic acid
US4052439A (en) * 1976-04-30 1977-10-04 Abbott Laboratories Carboxylic esters of phosphonoacetic acid
SE7607496L (sv) * 1976-07-01 1978-01-02 Astra Laekemedel Ab Sett for bekempning av virusinfektioner
CA1144937A (en) * 1977-12-22 1983-04-19 Dke J.E. Helgstrand Aromatic derivatives, pharmaceutical compositions and methods for combatting virus infections

Also Published As

Publication number Publication date
AT369017B (de) 1982-11-25
NO156611B (no) 1987-07-13
FI65438B (fi) 1984-01-31
JPS54106431A (en) 1979-08-21
US4591583A (en) 1986-05-27
HK33584A (en) 1984-04-27
JPS6254118B2 (da) 1987-11-13
CA1144937A (en) 1983-04-19
NO784330L (no) 1979-06-25
NO154751B (no) 1986-09-08
ATA921778A (de) 1982-04-15
DK148631C (da) 1986-03-03
DK564278A (da) 1979-06-23
DK148632B (da) 1985-08-19
AU530031B2 (en) 1983-06-30
US4372894A (en) 1983-02-08
AU4268278A (en) 1979-06-28
DE2861045D1 (en) 1981-11-26
FI783932A7 (fi) 1979-06-23
EP0003007B1 (en) 1982-04-07
NO156611C (no) 1987-10-21
FI65438C (fi) 1984-05-10
JPS6330885B2 (da) 1988-06-21
US4536400A (en) 1985-08-20
EP0003007A3 (en) 1979-08-08
EP0003275A1 (en) 1979-08-08
EP0003275B1 (en) 1981-09-02
CA1140049A (en) 1983-01-25
JPS54109951A (en) 1979-08-29
NO784331L (no) 1979-06-25
DE2861729D1 (en) 1982-05-19
IE48011B1 (en) 1984-09-05
FI783931A7 (fi) 1979-06-23
DK148632C (da) 1986-03-03
NO154751C (no) 1986-12-17
FI68626C (fi) 1985-10-10
DK148631B (da) 1985-08-19
IE782493L (en) 1979-06-22
EP0003007A2 (en) 1979-07-11
US4386081A (en) 1983-05-31
SG82383G (en) 1985-03-08
MY8500058A (en) 1985-12-31
FI68626B (fi) 1985-06-28

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