FI62293C - Analogifoerfarande foer framstaellning av terapeutiskt verksamma nitroimidazolderivat - Google Patents
Analogifoerfarande foer framstaellning av terapeutiskt verksamma nitroimidazolderivat Download PDFInfo
- Publication number
- FI62293C FI62293C FI2669/74A FI266974A FI62293C FI 62293 C FI62293 C FI 62293C FI 2669/74 A FI2669/74 A FI 2669/74A FI 266974 A FI266974 A FI 266974A FI 62293 C FI62293 C FI 62293C
- Authority
- FI
- Finland
- Prior art keywords
- group
- formula
- methyl
- oxo
- tetrahydroimidazole
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 64
- 239000000203 mixture Substances 0.000 claims description 50
- -1 carbonyl-thiocarbonyl Chemical group 0.000 claims description 41
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 21
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 4
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
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- 229940058965 antiprotozoal agent against amoebiasis and other protozoal diseases nitroimidazole derivative Drugs 0.000 claims 1
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- 229940124597 therapeutic agent Drugs 0.000 claims 1
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 21
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- 239000011975 tartaric acid Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000003564 thiocarbonyl compounds Chemical class 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1366773 | 1973-09-24 | ||
| CH1366773A CH592653A5 (enrdf_load_stackoverflow) | 1973-09-24 | 1973-09-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI266974A7 FI266974A7 (enrdf_load_stackoverflow) | 1975-03-25 |
| FI62293B FI62293B (fi) | 1982-08-31 |
| FI62293C true FI62293C (fi) | 1982-12-10 |
Family
ID=4394325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI2669/74A FI62293C (fi) | 1973-09-24 | 1974-09-12 | Analogifoerfarande foer framstaellning av terapeutiskt verksamma nitroimidazolderivat |
Country Status (26)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5956254U (ja) * | 1982-10-05 | 1984-04-12 | 住友金属鉱山株式会社 | 擁壁ブロツク |
| DE4426757A1 (de) * | 1994-07-28 | 1996-02-01 | Bayer Ag | 2-Imidazolidinon-Derivate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2944061A (en) * | 1957-09-20 | 1960-07-05 | Acyl derivatives and process | |
| IL39283A (en) * | 1971-05-03 | 1976-01-30 | Ciba Geigy Ag | Substituted 2-oxo or thioxo-3-(5-nitro-imidazol-2-yl)-tetrahydroimidazoles and their manufacture |
| BE795068A (fr) * | 1972-02-08 | 1973-08-07 | Ciba Geigy | Nouveaux 4- ou 5-nitro-inmidazoles et procedes pour leur preparation |
-
1973
- 1973-09-24 CH CH1366773A patent/CH592653A5/xx not_active IP Right Cessation
-
1974
- 1974-08-21 DK DK447474A patent/DK447474A/da not_active Application Discontinuation
- 1974-08-22 IE IE1746/74A patent/IE40003B1/xx unknown
- 1974-08-26 IL IL45536A patent/IL45536A/xx unknown
- 1974-09-06 SE SE7411296A patent/SE416300B/xx not_active IP Right Cessation
- 1974-09-12 FI FI2669/74A patent/FI62293C/fi active
- 1974-09-14 DE DE2444070A patent/DE2444070A1/de not_active Ceased
- 1974-09-18 FR FR7431471A patent/FR2244498A1/fr active Granted
- 1974-09-20 NO NO743395A patent/NO141895C/no unknown
- 1974-09-20 NL NL7412482A patent/NL7412482A/xx not_active Application Discontinuation
- 1974-09-21 OA OA55302A patent/OA04828A/xx unknown
- 1974-09-23 PL PL1974185103A patent/PL95691B1/pl unknown
- 1974-09-23 PL PL1974174285A patent/PL96510B1/pl unknown
- 1974-09-23 RO RO7487513A patent/RO70190A/ro unknown
- 1974-09-23 BE BE148776A patent/BE820206A/xx not_active IP Right Cessation
- 1974-09-23 AT AT762174A patent/AT337692B/de not_active IP Right Cessation
- 1974-09-23 PL PL1974185100A patent/PL95689B1/pl unknown
- 1974-09-23 SU SU2063056A patent/SU542473A3/ru active
- 1974-09-23 AR AR255685A patent/AR212578A1/es active
- 1974-09-23 YU YU2559/74A patent/YU37337B/xx unknown
- 1974-09-23 DD DD181273A patent/DD114814A5/xx unknown
- 1974-09-23 BG BG029300A patent/BG22813A3/xx unknown
- 1974-09-23 PH PH16324A patent/PH13743A/en unknown
- 1974-09-23 BG BG027754A patent/BG22823A3/xx unknown
- 1974-09-24 CS CS746554A patent/CS195689B2/cs unknown
- 1974-09-24 HU HU74CI00001509A patent/HU171562B/hu unknown
- 1974-09-24 JP JP49110385A patent/JPS5910347B2/ja not_active Expired
- 1974-09-24 ES ES430352A patent/ES430352A1/es not_active Expired
-
1975
- 1975-01-01 AR AR258970A patent/AR207980A1/es active
- 1975-07-02 SU SU7502149414A patent/SU571191A3/ru active
- 1975-07-02 SU SU7502149413A patent/SU564812A3/ru active
-
1980
- 1980-11-24 YU YU2982/80A patent/YU37338B/xx unknown
- 1980-11-24 YU YU2983/80A patent/YU37339B/xx unknown
-
1981
- 1981-02-09 DO DO1981002973A patent/DOP1981002973A/es unknown
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