FI60707C - Foerfarande foer framstaellning av 2-(1,8-naftyridin-2-yl)-3-(1-piperazinyl)karbonyloxipyrroler anvaendbara saosom laekemedel - Google Patents

Foerfarande foer framstaellning av 2-(1,8-naftyridin-2-yl)-3-(1-piperazinyl)karbonyloxipyrroler anvaendbara saosom laekemedel Download PDF

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Publication number
FI60707C
FI60707C FI753127A FI753127A FI60707C FI 60707 C FI60707 C FI 60707C FI 753127 A FI753127 A FI 753127A FI 753127 A FI753127 A FI 753127A FI 60707 C FI60707 C FI 60707C
Authority
FI
Finland
Prior art keywords
formula
naphthyridin
piperazinyl
chloro
group
Prior art date
Application number
FI753127A
Other languages
English (en)
Finnish (fi)
Other versions
FI60707B (fi
FI753127A (de
Inventor
Claude Cotrel
Cornel Crisan
Claude Jeanmart
Naoum Messer
Original Assignee
Rhone Poulenc Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7436963A external-priority patent/FR2313060A1/fr
Priority claimed from FR7527161A external-priority patent/FR2322601A1/fr
Priority claimed from FR7527160A external-priority patent/FR2322600A1/fr
Priority claimed from FR7527162A external-priority patent/FR2322602A1/fr
Application filed by Rhone Poulenc Ind filed Critical Rhone Poulenc Ind
Publication of FI753127A publication Critical patent/FI753127A/fi
Publication of FI60707B publication Critical patent/FI60707B/fi
Application granted granted Critical
Publication of FI60707C publication Critical patent/FI60707C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI753127A 1974-11-07 1975-11-07 Foerfarande foer framstaellning av 2-(1,8-naftyridin-2-yl)-3-(1-piperazinyl)karbonyloxipyrroler anvaendbara saosom laekemedel FI60707C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
FR7436963A FR2313060A1 (fr) 1974-11-07 1974-11-07 Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
FR7436963 1974-11-07
FR7527161 1975-09-04
FR7527160 1975-09-04
FR7527161A FR2322601A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent
FR7527160A FR2322600A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de la pyrrolo (3,4-b) pyrazine, leur preparation et les compositions qui les contiennent
FR7527162A FR2322602A1 (fr) 1975-09-04 1975-09-04 Nouveaux derives de l'oxathiinno- et du dithiinnopyrrole, leur preparation et les compositions qui les contiennent
FR7527162 1975-09-04

Publications (3)

Publication Number Publication Date
FI753127A FI753127A (de) 1976-05-08
FI60707B FI60707B (fi) 1981-11-30
FI60707C true FI60707C (fi) 1982-03-10

Family

ID=27446274

Family Applications (1)

Application Number Title Priority Date Filing Date
FI753127A FI60707C (fi) 1974-11-07 1975-11-07 Foerfarande foer framstaellning av 2-(1,8-naftyridin-2-yl)-3-(1-piperazinyl)karbonyloxipyrroler anvaendbara saosom laekemedel

Country Status (27)

Country Link
US (1) US4220646A (de)
JP (2) JPS5422996B2 (de)
AR (2) AR208414A1 (de)
AT (2) AT343123B (de)
AU (1) AU503200B2 (de)
BE (1) BE835325A (de)
CA (1) CA1057755A (de)
CH (1) CH609057A5 (de)
CS (2) CS231957B2 (de)
CY (1) CY1045A (de)
DD (1) DD122684A5 (de)
DE (1) DE2550111C2 (de)
DK (1) DK141098B (de)
FI (1) FI60707C (de)
GB (1) GB1468497A (de)
HK (1) HK19380A (de)
HU (1) HU173108B (de)
IE (1) IE41928B1 (de)
IL (1) IL48423A (de)
LU (1) LU73738A1 (de)
NL (1) NL177405C (de)
NO (1) NO143576C (de)
OA (1) OA05162A (de)
PL (1) PL101248B1 (de)
SE (1) SE407063B (de)
SU (2) SU673173A3 (de)
YU (2) YU39583B (de)

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FR2371198A2 (fr) * 1976-11-22 1978-06-16 Rhone Poulenc Ind Nouveaux derives du dithiepinno (1,4)(2,3-c) pyrrole, leur preparation et les compositions qui les contiennent
US4533751A (en) * 1981-10-09 1985-08-06 Scm Corporation Preparation of 1,3-dienamines from myrcene and substituted myrcene
FR2525606A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Sante Nouveaux derives du dithiino (1,4) (2,3-c) pyrrole, leur preparation et les medicaments qui les contiennent
FR2607504B1 (fr) * 1986-12-02 1989-01-27 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2607506B1 (fr) * 1986-12-02 1989-01-06 Rhone Poulenc Sante Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
HU214331B (hu) * 1992-06-17 1998-03-02 Gyógyszerkutató Intézet Kft. Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5565567A (en) * 1993-06-04 1996-10-15 Henkel Corporation. Polymerizable N,N'-substituted piperazine acrylamide compounds
US5922820A (en) * 1993-06-04 1999-07-13 Henkel Corporation Polymerizable compounds
AU6956394A (en) * 1993-06-04 1995-01-03 Henkel Corporation Polymerizable compounds
WO1996009297A1 (en) 1994-09-23 1996-03-28 Arris Pharmaceutical Corporation Compositions and methods for treating mast-cell inflammatory condition
US5663357A (en) * 1995-11-22 1997-09-02 Allergan Substituted heteroarylamides having retinoid-like biological activity
US5756742A (en) * 1995-12-22 1998-05-26 Henkel Corporation Polymerizable compounds
US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
EP1396493A4 (de) * 2001-04-26 2005-08-03 Ajinomoto Kk Heterocyclische verbindungen
EP1490363B1 (de) 2002-03-29 2006-01-25 Indevus Pharmaceuticals, Inc. Verfahren zur herstellung von 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinon
AU2003285012A1 (en) * 2002-10-24 2004-05-13 Sepracor, Inc. Compositions comprising zopiclone derivatives and methods of making and using the same
UA79518C2 (en) * 2002-11-22 2007-06-25 Merck & Co Inc Process for preparation of phosphodiesterase-4 inhibitors
US6909002B2 (en) * 2002-11-22 2005-06-21 Merck & Co., Inc. Method of preparing inhibitors of phosphodiesterase-4
AR042194A1 (es) * 2002-11-22 2005-06-15 Merck & Co Inc Metodo para preparar inhibidores de fosfodiesterasa - 4
CA2548917C (en) 2003-12-11 2014-09-23 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
US20050232983A1 (en) * 2004-04-14 2005-10-20 Indevus Pharmaceuticals, Inc. Transdermal patch
JP2009500425A (ja) 2005-07-06 2009-01-08 セプラコア インコーポレーテッド エスゾピクロン及びトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−ｎ−メチル−１−ナフタレンアミン又はトランス４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロ−１−ナフタレンアミンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法
CA2614209A1 (en) * 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
EP2258358A3 (de) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
CN100569775C (zh) * 2007-12-19 2009-12-16 齐鲁天和惠世制药有限公司 佐匹克隆的晶型转换的方法
WO2010088385A1 (en) 2009-01-30 2010-08-05 Sepracor Inc. Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrol o [3,4-b] pyrazine and methods for measuring effectiveness of coating
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP6984656B2 (ja) * 2017-05-25 2021-12-22 信越化学工業株式会社 フルオロポリエーテル基含有ポリマー変性有機ケイ素化合物、表面処理剤及び物品
CN108129476A (zh) * 2017-11-27 2018-06-08 华中农业大学 一种杂环内酰胺衍生物及其用于作物病原菌杀菌剂的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR2101081B1 (de) * 1970-08-19 1974-01-11 Rhone Poulenc Sa
BE790408A (fr) * 1971-10-22 1973-04-20 Rhone Poulenc Sa Nouveaux derives de la pyrrolo (3,4-b) pyridine, leur preparation et les compositions medicinales qui les
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
BE793851A (fr) * 1972-01-10 1973-07-10 Rhone Poulenc Sa Nouveaux derives de l'isoindoline, leur preparation et les compositions medicinales qui les contiennent
AR207555A1 (es) * 1972-12-04 1976-10-15 Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles
OA04700A (fr) * 1973-05-15 1980-07-31 Rhone Poulenc Sa Nouveaux dérivés de la naphtyridine et leur procédé de préparation.

Also Published As

Publication number Publication date
DE2550111A1 (de) 1976-05-13
YU39583B (en) 1985-03-20
DE2550111C2 (de) 1983-09-15
CS598377A2 (en) 1984-01-16
IL48423A0 (en) 1976-01-30
HK19380A (en) 1980-04-18
AU503200B2 (en) 1979-08-30
ATA401977A (de) 1977-10-15
US4220646A (en) 1980-09-02
LU73738A1 (de) 1976-09-06
FI60707B (fi) 1981-11-30
YU281575A (en) 1983-01-21
YU192182A (en) 1983-01-21
DD122684A5 (de) 1976-10-20
CY1045A (en) 1980-08-01
CS751075A2 (en) 1984-01-16
NO143576C (no) 1981-03-11
AT343666B (de) 1978-06-12
CA1057755A (fr) 1979-07-03
NL7512732A (nl) 1976-05-11
IE41928B1 (en) 1980-04-23
ATA848675A (de) 1977-09-15
JPS558508B2 (de) 1980-03-04
SE407063B (sv) 1979-03-12
DK141098B (da) 1980-01-14
CS231958B2 (en) 1985-01-16
AU8633175A (en) 1977-05-12
AR208800A1 (es) 1977-02-28
NO143576B (no) 1980-12-01
JPS5170776A (de) 1976-06-18
NL177405C (nl) 1985-09-16
AR208414A1 (es) 1976-12-27
SU604496A3 (ru) 1978-04-25
HU173108B (hu) 1979-02-28
IE41928L (en) 1976-05-07
SE7512477L (sv) 1976-05-10
DK141098C (de) 1980-07-07
GB1468497A (en) 1977-03-30
PL101248B1 (pl) 1978-12-30
NL177405B (nl) 1985-04-16
CS231957B2 (en) 1985-01-16
OA05162A (fr) 1981-01-31
AT343123B (de) 1978-05-10
IL48423A (en) 1979-03-12
CH609057A5 (de) 1979-02-15
JPS5498790A (en) 1979-08-03
JPS5422996B2 (de) 1979-08-10
SU673173A3 (ru) 1979-07-05
BE835325A (fr) 1976-05-06
FI753127A (de) 1976-05-08
DK499275A (de) 1976-05-08
YU40087B (en) 1985-06-30
NO753713L (de) 1976-05-10

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