FI2694072T4 - Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa - Google Patents

Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa Download PDF

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Publication number
FI2694072T4
FI2694072T4 FIEP12764765.9T FI12764765T FI2694072T4 FI 2694072 T4 FI2694072 T4 FI 2694072T4 FI 12764765 T FI12764765 T FI 12764765T FI 2694072 T4 FI2694072 T4 FI 2694072T4
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Finland
Prior art keywords
combination
compound
use according
abiraterone
cancer
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FIEP12764765.9T
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English (en)
Finnish (fi)
Swedish (sv)
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Michelle Nannini
Deepak Sampath
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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FIEP12764765.9T 2011-04-01 2012-03-30 Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa FI2694072T4 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161470624P 2011-04-01 2011-04-01
US201161470803P 2011-04-01 2011-04-01
PCT/US2012/031679 WO2012135759A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and abiraterone, and methods of use

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FI2694072T4 true FI2694072T4 (fi) 2024-09-30

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US (7) US9346789B2 (enExample)
EP (4) EP2694070A4 (enExample)
JP (4) JP6239497B2 (enExample)
KR (4) KR102021157B1 (enExample)
CN (8) CN103857395A (enExample)
AU (4) AU2012236144B2 (enExample)
BR (4) BR112013025354A2 (enExample)
CA (4) CA2844699C (enExample)
DK (1) DK2694072T4 (enExample)
ES (3) ES2657750T3 (enExample)
FI (1) FI2694072T4 (enExample)
HK (1) HK1204575A1 (enExample)
HR (1) HRP20180223T4 (enExample)
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IL (4) IL228642A0 (enExample)
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MY (1) MY179607A (enExample)
PL (2) PL2694485T3 (enExample)
PT (1) PT2694072T (enExample)
RS (1) RS56759B2 (enExample)
RU (4) RU2013148732A (enExample)
SG (5) SG194048A1 (enExample)
SI (1) SI2694072T2 (enExample)
SM (1) SMT201800250T1 (enExample)
TR (1) TR201802093T4 (enExample)
WO (4) WO2012135759A1 (enExample)
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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
PT3289876T (pt) 2008-06-16 2022-10-28 Univ Tennessee Res Found Compostos para o tratamento do câncer
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
EP3238722B1 (en) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones
CN103298345B (zh) 2011-01-11 2016-12-14 诺瓦蒂斯公司 组合
CN103857395A (zh) 2011-04-01 2014-06-11 基因泰克公司 Akt抑制剂化合物和阿比特龙的组合及使用方法
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
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