CA2831937A1 - Combinations of akt inhibitor compounds and erlotinib, and methods of use - Google Patents

Combinations of akt inhibitor compounds and erlotinib, and methods of use Download PDF

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Publication number
CA2831937A1
CA2831937A1 CA2831937A CA2831937A CA2831937A1 CA 2831937 A1 CA2831937 A1 CA 2831937A1 CA 2831937 A CA2831937 A CA 2831937A CA 2831937 A CA2831937 A CA 2831937A CA 2831937 A1 CA2831937 A1 CA 2831937A1
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Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
cancer
formula
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Abandoned
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CA2831937A
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English (en)
French (fr)
Inventor
Michelle NANNINI
Deepak Sampath
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Genentech Inc
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Genentech Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46931958&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2831937(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2831937A1 publication Critical patent/CA2831937A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2831937A 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and erlotinib, and methods of use Abandoned CA2831937A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161470624P 2011-04-01 2011-04-01
US201161470803P 2011-04-01 2011-04-01
US61/470,624 2011-04-01
US61/470,803 2011-04-01
PCT/US2012/031671 WO2012135753A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and erlotinib, and methods of use

Publications (1)

Publication Number Publication Date
CA2831937A1 true CA2831937A1 (en) 2012-10-04

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ID=46931958

Family Applications (4)

Application Number Title Priority Date Filing Date
CA2831922A Active CA2831922C (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and vemurafenib, and methods of use
CA2844699A Active CA2844699C (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and abiraterone, and methods of use
CA2831935A Abandoned CA2831935A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
CA2831937A Abandoned CA2831937A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and erlotinib, and methods of use

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Application Number Title Priority Date Filing Date
CA2831922A Active CA2831922C (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and vemurafenib, and methods of use
CA2844699A Active CA2844699C (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and abiraterone, and methods of use
CA2831935A Abandoned CA2831935A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use

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US (7) US9150548B2 (enExample)
EP (4) EP2694071B1 (enExample)
JP (4) JP6239497B2 (enExample)
KR (4) KR20140025434A (enExample)
CN (8) CN107233343A (enExample)
AU (4) AU2012236144B2 (enExample)
BR (4) BR112013025353A8 (enExample)
CA (4) CA2831922C (enExample)
DK (1) DK2694072T4 (enExample)
ES (3) ES2657750T3 (enExample)
FI (1) FI2694072T4 (enExample)
HK (1) HK1204575A1 (enExample)
HR (1) HRP20180223T4 (enExample)
HU (1) HUE036513T2 (enExample)
IL (4) IL228637B (enExample)
LT (1) LT2694072T (enExample)
ME (1) ME02998B (enExample)
MX (4) MX2013011329A (enExample)
MY (1) MY179607A (enExample)
PL (2) PL2694072T5 (enExample)
PT (1) PT2694072T (enExample)
RS (1) RS56759B2 (enExample)
RU (4) RU2013148721A (enExample)
SG (5) SG194051A1 (enExample)
SI (1) SI2694072T2 (enExample)
SM (1) SMT201800250T1 (enExample)
TR (1) TR201802093T4 (enExample)
WO (4) WO2012135759A1 (enExample)
ZA (4) ZA201308064B (enExample)

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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CN104926815B (zh) 2008-01-04 2017-11-03 英特利凯恩有限责任公司 某些化学实体、组合物和方法
US8592465B2 (en) 2008-06-16 2013-11-26 University Of Tennessee Research Foundation Compounds for treatment of cancer
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