ES2620644T3 - Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso - Google Patents

Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso Download PDF

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Publication number
ES2620644T3
ES2620644T3 ES12764184.3T ES12764184T ES2620644T3 ES 2620644 T3 ES2620644 T3 ES 2620644T3 ES 12764184 T ES12764184 T ES 12764184T ES 2620644 T3 ES2620644 T3 ES 2620644T3
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compound
cancer
pharmaceutically acceptable
acceptable salt
formula
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ES12764184.3T
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English (en)
Spanish (es)
Inventor
Kui Lin
Michelle NANNINI
Elizabeth Punnoose
Deepak Sampath
Jeffrey Wallin
Premal Patel
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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  • Genetics & Genomics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
ES12764184.3T 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso Active ES2620644T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161470624P 2011-04-01 2011-04-01
US201161470803P 2011-04-01 2011-04-01
US201161470803P 2011-04-01
US201161470624P 2011-04-01
PCT/US2012/031720 WO2012135781A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use

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ES2620644T3 true ES2620644T3 (es) 2017-06-29

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ID=46931958

Family Applications (3)

Application Number Title Priority Date Filing Date
ES12764184.3T Active ES2620644T3 (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
ES12765234.5T Active ES2657750T3 (es) 2011-04-01 2012-03-30 Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos
ES12764765T Active ES2660263T5 (en) 2011-04-01 2012-03-30 Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments

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ES12765234.5T Active ES2657750T3 (es) 2011-04-01 2012-03-30 Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos
ES12764765T Active ES2660263T5 (en) 2011-04-01 2012-03-30 Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments

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US (7) US20150064171A1 (enExample)
EP (4) EP2694072B2 (enExample)
JP (4) JP6239497B2 (enExample)
KR (4) KR20140025434A (enExample)
CN (8) CN103874689B (enExample)
AU (4) AU2012236144B2 (enExample)
BR (4) BR112013025353A8 (enExample)
CA (4) CA2831922C (enExample)
DK (1) DK2694072T4 (enExample)
ES (3) ES2620644T3 (enExample)
FI (1) FI2694072T4 (enExample)
HK (1) HK1204575A1 (enExample)
HR (1) HRP20180223T4 (enExample)
HU (1) HUE036513T2 (enExample)
IL (4) IL228642A0 (enExample)
LT (1) LT2694072T (enExample)
ME (1) ME02998B (enExample)
MX (4) MX2013011329A (enExample)
MY (1) MY179607A (enExample)
PL (2) PL2694485T3 (enExample)
PT (1) PT2694072T (enExample)
RS (1) RS56759B2 (enExample)
RU (4) RU2013148721A (enExample)
SG (5) SG10201504303SA (enExample)
SI (1) SI2694072T2 (enExample)
SM (1) SMT201800250T1 (enExample)
TR (1) TR201802093T4 (enExample)
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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
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