FI115722B - Nytt förfarande för framställning av 7-(substituerade)-9-[(substituerad) amido] -6-demetyl-6-deoxitetracykliner och förfarande för framställning av mellanprodukter därav - Google Patents

Nytt förfarande för framställning av 7-(substituerade)-9-[(substituerad) amido] -6-demetyl-6-deoxitetracykliner och förfarande för framställning av mellanprodukter därav Download PDF

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Publication number
FI115722B
FI115722B FI933566A FI933566A FI115722B FI 115722 B FI115722 B FI 115722B FI 933566 A FI933566 A FI 933566A FI 933566 A FI933566 A FI 933566A FI 115722 B FI115722 B FI 115722B
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FI
Finland
Prior art keywords
methylpropyl
eller
amino
methyl
butyl
Prior art date
Application number
FI933566A
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English (en)
Finnish (fi)
Other versions
FI933566A0 (fi
FI933566A (fi
Inventor
Phaik-Eng Sum
Ving J Lee
Original Assignee
Wyeth Corp
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Filing date
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Publication of FI933566A0 publication Critical patent/FI933566A0/fi
Publication of FI933566A publication Critical patent/FI933566A/fi
Application granted granted Critical
Publication of FI115722B publication Critical patent/FI115722B/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI933566A 1992-08-13 1993-08-12 Nytt förfarande för framställning av 7-(substituerade)-9-[(substituerad) amido] -6-demetyl-6-deoxitetracykliner och förfarande för framställning av mellanprodukter därav FI115722B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92858892 1992-08-13
US07/928,588 US5284963A (en) 1992-08-13 1992-08-13 Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines

Publications (3)

Publication Number Publication Date
FI933566A0 FI933566A0 (fi) 1993-08-12
FI933566A FI933566A (fi) 1994-02-14
FI115722B true FI115722B (sv) 2005-06-30

Family

ID=25456483

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933566A FI115722B (sv) 1992-08-13 1993-08-12 Nytt förfarande för framställning av 7-(substituerade)-9-[(substituerad) amido] -6-demetyl-6-deoxitetracykliner och förfarande för framställning av mellanprodukter därav

Country Status (27)

Country Link
US (1) US5284963A (sv)
EP (1) EP0582790B1 (sv)
JP (1) JP3590643B2 (sv)
KR (1) KR100250603B1 (sv)
CN (1) CN1037680C (sv)
AT (1) ATE174903T1 (sv)
AU (1) AU674689B2 (sv)
CA (1) CA2103837C (sv)
CZ (1) CZ286261B6 (sv)
DE (1) DE69322708T2 (sv)
DK (1) DK0582790T3 (sv)
ES (1) ES2125927T3 (sv)
FI (1) FI115722B (sv)
GR (1) GR3029764T3 (sv)
HU (1) HU222886B1 (sv)
IL (3) IL119551A (sv)
LV (1) LV12273B (sv)
MX (1) MX9304649A (sv)
NO (1) NO303574B1 (sv)
NZ (1) NZ248358A (sv)
PH (1) PH30150A (sv)
PL (2) PL173606B1 (sv)
RU (1) RU2111958C1 (sv)
SG (1) SG68556A1 (sv)
SK (1) SK281698B6 (sv)
TW (1) TW221285B (sv)
ZA (1) ZA935891B (sv)

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US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
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US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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Also Published As

Publication number Publication date
ZA935891B (en) 1994-03-09
EP0582790A1 (en) 1994-02-16
CZ157793A3 (en) 1994-03-16
IL119551A (en) 2003-02-12
AU674689B2 (en) 1997-01-09
PL300064A1 (en) 1994-02-21
KR100250603B1 (ko) 2000-04-01
IL106674A0 (en) 1993-12-08
PL173606B1 (pl) 1998-03-31
TW221285B (sv) 1994-02-21
IL106674A (en) 1998-07-15
DK0582790T3 (da) 1999-08-23
EP0582790B1 (en) 1998-12-23
DE69322708T2 (de) 1999-04-29
CA2103837A1 (en) 1994-02-14
NZ248358A (en) 1996-04-26
RU2111958C1 (ru) 1998-05-27
ES2125927T3 (es) 1999-03-16
GR3029764T3 (en) 1999-06-30
CN1083047A (zh) 1994-03-02
IL119551A0 (en) 1997-02-18
FI933566A0 (fi) 1993-08-12
HUT64941A (en) 1994-03-28
JPH06184075A (ja) 1994-07-05
AU4460393A (en) 1994-02-17
CA2103837C (en) 2004-10-05
SG68556A1 (en) 1999-11-16
JP3590643B2 (ja) 2004-11-17
NO303574B1 (no) 1998-08-03
PH30150A (en) 1997-01-21
NO932870D0 (no) 1993-08-12
HU222886B1 (hu) 2003-12-29
CN1037680C (zh) 1998-03-11
SK84993A3 (en) 1994-06-08
FI933566A (fi) 1994-02-14
US5284963A (en) 1994-02-08
LV12273B (en) 1999-11-20
ATE174903T1 (de) 1999-01-15
KR940003923A (ko) 1994-03-14
DE69322708D1 (de) 1999-02-04
PL173923B1 (pl) 1998-05-29
CZ286261B6 (cs) 2000-02-16
MX9304649A (es) 1994-02-28
HU9302331D0 (en) 1993-10-28
LV12273A (lv) 1999-05-20
NO932870L (no) 1994-02-14
SK281698B6 (sk) 2001-07-10

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