FI112080B - 2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti - Google Patents

2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti Download PDF

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Publication number
FI112080B
FI112080B FI953592A FI953592A FI112080B FI 112080 B FI112080 B FI 112080B FI 953592 A FI953592 A FI 953592A FI 953592 A FI953592 A FI 953592A FI 112080 B FI112080 B FI 112080B
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FI
Finland
Prior art keywords
amino
methoxy
dihydro
compound
oxopurin
Prior art date
Application number
FI953592A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI953592A0 (fi
FI953592A (fi
Inventor
John J Nestor
Scott W Womble
Hans Maag
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI953592A0 publication Critical patent/FI953592A0/fi
Publication of FI953592A publication Critical patent/FI953592A/fi
Application granted granted Critical
Publication of FI112080B publication Critical patent/FI112080B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
FI953592A 1994-07-28 1995-07-27 2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti FI112080B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28189394A 1994-07-28 1994-07-28
US28189394 1994-07-28

Publications (3)

Publication Number Publication Date
FI953592A0 FI953592A0 (fi) 1995-07-27
FI953592A FI953592A (fi) 1996-01-29
FI112080B true FI112080B (fi) 2003-10-31

Family

ID=23079211

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953592A FI112080B (fi) 1994-07-28 1995-07-27 2-(2-amino-1,6-dihydro-6-oksopurin-9-yyli)metoksi-3-hydroksi-1-propanyyli-L-valinaatti

Country Status (33)

Country Link
EP (1) EP0694547B1 (fr)
JP (1) JP3090305B2 (fr)
KR (1) KR100358626B1 (fr)
CN (1) CN1045089C (fr)
AT (1) ATE179173T1 (fr)
AU (1) AU697107B2 (fr)
BR (1) BR9503468A (fr)
CA (1) CA2154721C (fr)
CO (1) CO4410181A1 (fr)
CY (2) CY2180B1 (fr)
CZ (1) CZ290511B6 (fr)
DE (3) DE694547T1 (fr)
DK (1) DK0694547T3 (fr)
ES (1) ES2083348T3 (fr)
FI (1) FI112080B (fr)
GR (2) GR960300021T1 (fr)
HK (1) HK1012339A1 (fr)
HU (1) HU216867B (fr)
IL (1) IL114735A (fr)
LU (1) LU91136I2 (fr)
MA (1) MA23631A1 (fr)
MY (1) MY114393A (fr)
NL (1) NL300071I2 (fr)
NO (2) NO312899B1 (fr)
NZ (1) NZ272652A (fr)
PE (1) PE32296A1 (fr)
PL (1) PL180609B1 (fr)
RU (1) RU2133749C1 (fr)
SA (1) SA95160158B1 (fr)
TR (1) TR199500895A2 (fr)
TW (1) TW434242B (fr)
UY (1) UY24006A1 (fr)
ZA (1) ZA956228B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
AU1592897A (en) * 1996-01-26 1997-08-20 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
ATE222909T1 (de) * 1996-01-26 2002-09-15 Hoffmann La Roche Verfahren zur herstellung von purin-derivaten
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
JP4425352B2 (ja) * 1997-02-10 2010-03-03 メディヴィル・アクチボラグ 非環状ヌクレオシド誘導体の合成
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
PT988304E (pt) * 1997-08-15 2001-10-31 Medivir Ab Analogos de nucleosidos tais como os antivirais que contem inibidores de transcritase reversa retroviral e de adn-polimerase do virus da hepatite b (hbv)
AU1711599A (en) * 1997-12-19 1999-07-12 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
WO1999051613A1 (fr) * 1998-04-03 1999-10-14 Medivir Ab Promedicaments de produits pharmaceutiques contenant du phosphore
KR20030015655A (ko) * 2001-08-17 2003-02-25 한미약품공업 주식회사 항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
EP1501797B1 (fr) * 2002-04-23 2009-08-05 Aventis Pharmaceuticals Inc. Ester de l'acide 3-amino-1h-indole-2-carboxylique et de l'acide 3-amino-benzo[b]thiophene-2-carboxylique utilisés en tant qu'inhibiteurs de l'expression du gene de l'interleukine-4
CA2771725C (fr) 2002-10-16 2015-08-18 Takeda Pharmaceutical Company Limited Preparation solide comprenant une base non toxique et un inhibiteur de pompe a proton
CN105596356A (zh) 2003-01-14 2016-05-25 吉里德科学公司 用于联合抗病毒治疗的组合物和方法
US20070129385A1 (en) * 2003-08-28 2007-06-07 Sharma Mukesh K Amorphous valganciclovir hydrochloride
JP5563735B2 (ja) 2004-06-16 2014-07-30 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド Ｐｐｉ多回剤形
PL1773878T3 (pl) * 2004-07-19 2015-07-31 Biocon Ltd Koniugaty insulina-oligomer, ich formulacje i zastosowania
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
BRPI0818286A2 (pt) 2007-10-12 2020-08-11 Takeda Pharmaceuticals North America, Inc. métodos de tratamento de distúrbios gastrointestinais independente da ingestão de alimento.
CN103562207B (zh) * 2011-05-31 2016-08-17 法尔玛赞公司 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
KR102312533B1 (ko) 2021-02-24 2021-10-15 주식회사 이웅 자동 스패너

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
IL77298A (en) * 1984-12-12 1999-11-30 Syntex Inc Process for the preparation of 2 -) alkanoyl oxymethoxy (- 1, 3 - propanediols, esters and sites for their use, their use for the preparation of progeny) H9 - guanine sweet
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

Also Published As

Publication number Publication date
CY2004003I1 (el) 2009-11-04
EP0694547A3 (fr) 1996-06-05
MY114393A (en) 2002-10-31
ES2083348T1 (es) 1996-04-16
KR960004345A (ko) 1996-02-23
LU91136I2 (fr) 2005-07-06
CY2004003I2 (el) 2009-11-04
CZ290511B6 (cs) 2002-08-14
NO952977D0 (no) 1995-07-27
UY24006A1 (es) 2001-07-31
CZ193995A3 (en) 1996-02-14
FI953592A0 (fi) 1995-07-27
DE10299032I1 (de) 2003-01-23
TW434242B (en) 2001-05-16
NL300071I2 (nl) 2002-03-01
NO2003001I2 (no) 2007-06-11
NL300071I1 (nl) 2002-02-01
NO952977L (no) 1996-01-29
CA2154721C (fr) 2001-01-02
ZA956228B (en) 1996-02-22
MA23631A1 (fr) 1996-04-01
TR199500895A2 (tr) 1996-06-21
DE694547T1 (de) 1996-10-24
DE69509173D1 (de) 1999-05-27
RU95113148A (ru) 1997-06-27
CO4410181A1 (es) 1997-01-09
CY2180B1 (en) 2002-08-23
SA95160158B1 (ar) 2006-05-20
RU2133749C1 (ru) 1999-07-27
AU697107B2 (en) 1998-09-24
NZ272652A (en) 1996-12-20
JP3090305B2 (ja) 2000-09-18
CA2154721A1 (fr) 1996-01-29
HUT73246A (en) 1996-07-29
ES2083348T3 (es) 1999-08-01
FI953592A (fi) 1996-01-29
CN1122804A (zh) 1996-05-22
JPH0841061A (ja) 1996-02-13
KR100358626B1 (ko) 2003-01-14
CN1045089C (zh) 1999-09-15
IL114735A (en) 1998-06-15
PE32296A1 (es) 1996-08-07
PL309812A1 (en) 1996-02-05
BR9503468A (pt) 1996-02-27
HU9502238D0 (en) 1995-09-28
EP0694547B1 (fr) 1999-04-21
NO312899B1 (no) 2002-07-15
GR960300021T1 (en) 1996-04-30
IL114735A0 (en) 1995-11-27
DK0694547T3 (da) 2000-01-03
ATE179173T1 (de) 1999-05-15
DE69509173T2 (de) 1999-10-21
HK1012339A1 (en) 1999-07-30
PL180609B1 (pl) 2001-03-30
HU216867B (hu) 1999-09-28
EP0694547A2 (fr) 1996-01-31
DE10299032I2 (de) 2006-06-14
AU2719595A (en) 1996-02-08
GR3030678T3 (en) 1999-11-30

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Legal Events

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SPCF Supplementary protection certificate application filed

Spc suppl protection certif: L20040001

SPCE Application for extension of a supplementary protection certificate [pediatric extension]

Spc suppl protection certif: L20040001

MA Patent expired
SPCP Extension of a supplementary protection certificate [pediatric extension]

Spc suppl protection certif: 241

Extension date: 20170320